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Cancer: Gastric (Stomach) Cancer

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Total 1410 results found since Jan 2013.

Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5
ConclusionCENPK promotes GC cell proliferation and migration via interacting with XRCC5 and may be a novel prognostic factor or therapeutic target for CENPK.
Source: Gastric Cancer - June 17, 2022 Category: Gastroenterology Source Type: research

GSE148795 Study of transcriptional effects of FOXS1 silencing and TGF-beta treatment in SNU-449 hepatocellular carcinoma cell line
Conclusions: FOXS1 is a novel TGFβ target and a key mediator of EMT. Its induction in cancer is associated with a poor prognosis. Thus, determining the exp ression of FOXS1 in advanced tumors in which the pro-metastatic arm of TGFβ is activated could help to identify patients who may benefit from targeted therapies using TGFβ inhibitors.
Source: GEO: Gene Expression Omnibus - June 15, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/ β-catenin signaling pathway in lung adenocarcinoma
CONCLUSIONS: Our data reveal the oncogenic role of JAML in LUAD, indicating that JAML may be a predictive biomarker and novel therapeutic target for LUAD.PMID:35672776 | DOI:10.1186/s12967-022-03457-w
Source: Cancer Control - June 7, 2022 Category: Cancer & Oncology Authors: Qian Wu Rui Li Qing-Xiang Wang Meng-Yu Zhang Ting-Ting Liu Yi-Qing Qu Source Type: research

The impact of PIK3R1 mutations and insulin-PI3K-glycolytic pathway regulation in prostate cancer
CONCLUSIONS: Our findings describe a novel genomic feature in metastatic prostate cancer and suggest that PIK3R1 alteration may be a key event for insulin-PI3K-glycolytic pathway regulation in prostate cancer.PMID:35670774 | DOI:10.1158/1078-0432.CCR-21-4272
Source: Clinical Genitourinary Cancer - June 7, 2022 Category: Cancer & Oncology Authors: Goutam Chakraborty Subhiksha Nandakumar Rahim Hirani Bastien Nguyen Konrad H Stopsack Christoph Kreitzer Sai Harisha Rajanala Romina Ghale Ying Z Mazzu Naga Vara Kishore Pillarsetty Gwo-Shu Mary Lee Howard I Scher Michael J Morris Tiffany Traina Pedram Ra Source Type: research

Conditional medium of gastric cancer mesenchymal stem cells promotes PD-L1 expression in gastric cancer cells and tumor growth via upregulating VGLL4
Conclusion GCMSCs-CM promotes the expression of PD-L1 and tumor growth by upregulating VGLL4 in gastric cancer cells.PMID:35583061
Source: Cancer Control - May 18, 2022 Category: Cancer & Oncology Authors: Ying Ding Wei Zhu Qianqian Wang Bin Chen Mei Wang Yuanyuan Zhao Source Type: research

Cancers, Vol. 14, Pages 2369: lncRNAs UC.145 and PRKG1-AS1 Determine the Functional Output of DKK1 in Regulating the Wnt Signaling Pathway in Gastric Cancer
Sangkil Lee DKK1 inhibits the canonical Wnt signaling pathway that is known to be involved in various cancers. However, whether DKK1 acts as an oncogene or tumor suppressor gene remains controversial. Furthermore, the DKK1-regulating mechanism in gastric cancer has not yet been defined. The aim of this study was to explore whether the ultraconserved region UC.145 regulates epigenetic changes in DKK1 expression in gastric cancer. Microarray analysis revealed that UC.145 exhibited the highest binding affinity to EZH2, a histone methyltransferase. The effects of UC.145 inactivation were assessed in gastric cancer cell lin...
Source: Cancers - May 11, 2022 Category: Cancer & Oncology Authors: Jung-ho Yoon Hyojoo Byun Cristina Ivan George A. Calin Dahyun Jung Sangkil Lee Tags: Article Source Type: research

LMP2A inhibits the expression of KLF5 through the mTORC1 pathway in EBV-associated gastric carcinoma
CONCLUSION: LMP2A downregulated KLF5 expression by inhibiting the mTORC1 pathway in EBV positive GC cells. KLF5 might play an oncogene-like role by promoting the migration of GC cells and inducing autophagy.PMID:35500764 | DOI:10.1016/j.virusres.2022.198792
Source: Cell Research - May 2, 2022 Category: Cytology Authors: Dandan Liu Duo Shi Lin Xu Lingling Sun Shuzhen Liu Bing Luo Source Type: research

Inhibition of CCCTC Binding Factor-Programmed Cell Death Ligand 1 Axis Suppresses Emergence of Chemoresistance Induced by Gastric Cancer-Derived Mesenchymal Stem Cells
ConclusionStudy results demonstrate a mechanism where GCMSC-CM promotes GC chemoresistance by upregulating CTCF-PD-L1 and provide strong evidence in support of targeting CTCF-PD-L1 signaling as a strategy to prevent resistance in the clinic.
Source: Frontiers in Immunology - April 27, 2022 Category: Allergy & Immunology Source Type: research

Functions and Clinical Significance of CACNA2D1 in Gastric Cancer
CONCLUSIONS: The present study indicates that CACNA2D1 regulates the apoptosis signaling pathway and may have potential as a biomarker for cancer growth and as a therapeutic target for GC.PMID:35445337 | DOI:10.1245/s10434-022-11752-5
Source: Ann Oncol - April 21, 2022 Category: Cancer & Oncology Authors: Hiroyuki Inoue Atsushi Shiozaki Toshiyuki Kosuga Hiroki Shimizu Michihiro Kudou Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eiichi Konishi Eigo Otsuji Source Type: research