Histological diversity and molecular characteristics in gastric cancer: relation of cancer stem cell-related molecules and receptor tyrosine kinase molecules to mixed histological type and more histological patterns
ConclusionsWe displayed the relationship between histological diversity and molecular features in GC, and we hope that the present data can contribute to the early diagnosis and prevention, and effective treatment of GC. (Source: Gastric Cancer)
Source: Gastric Cancer - October 28, 2020 Category: Gastroenterology Source Type: research

Tumor suppressor ATP4B serve as a promising biomarker for worsening of gastric atrophy and poor differentiation
ConclusionsOur data suggest that decreasing ATP4B is an indicator for gastric mucosa malignant transformation and GC aggressive phenotype and it plays an inhibitory role in gastric cancer as a tumor suppressor via regulating mitochondrial metabolism and apoptosis pathway. (Source: Gastric Cancer)
Source: Gastric Cancer - October 27, 2020 Category: Gastroenterology Source Type: research

LncRNA HOTAIR promotes the growth and metastasis of gastric cancer by sponging miR-1277-5p and upregulating COL5A1
ConclusionsHOTAIR regulates GC growth by sponging miR-1277-5p and upregulating COL5A1, and COL5A1-mediated GC cell proliferation may be mediated by effects on the tumor microenvironment, which provides novel targets for GC treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - October 16, 2020 Category: Gastroenterology Source Type: research

Association of surgeon and hospital volume with postoperative mortality after total gastrectomy for gastric cancer: data from 71,307 Japanese patients collected from a nationwide web-based data entry system
ConclusionsWe demonstrate hospital volume has an impact on postoperative mortality after TG in a nationwide population study. These findings suggest centralization may improve outcomes after TG. (Source: Gastric Cancer)
Source: Gastric Cancer - October 9, 2020 Category: Gastroenterology Source Type: research

Apatinib exhibits synergistic effect with pyrotinib and reverses acquired pyrotinib resistance in HER2-positive gastric cancer via stem cell factor/c-kit signaling and its downstream pathways
ConclusionThese results highlight the effectiveness of pyrotinib combined with apatinib in HER2-positive GC and acquired pyrotinib resistance, thus providing a theoretical basis for new treatment methods. (Source: Gastric Cancer)
Source: Gastric Cancer - October 8, 2020 Category: Gastroenterology Source Type: research

Diagnostic performance in gastric cancer is higher using endocytoscopy with narrow-band imaging than using magnifying endoscopy with narrow-band imaging
AbstractBackgroundFor diagnosing gastric cancer, differences in the diagnostic performance between endocytoscopy with narrow-band imaging and magnifying endoscopy with narrow-band imaging have not been reported. We aimed to clarify these differences by analyzing diagnoses made by endoscopists in Japan.MethodsThis single-center retrospective cohort study used 106 cancerous and 106 non-cancerous images obtained via both modalities (total, 424 images) for diagnosis. Sixty-one endoscopists with varying experience levels from 45 institutions were included. Diagnostic accuracy, sensitivity, specificity, and positive and negative...
Source: Gastric Cancer - October 2, 2020 Category: Gastroenterology Source Type: research

External validity of docetaxel triplet trials in advanced gastric cancer: are there patients who still benefit?
ConclusionOur study confirms the effect of DPF is highly dependent on several clinical –pathological variables, with discreet and gradually declining benefit over platinum doublets in later years, at the expense of increased toxicity. These results may help to underpin the idea that external validity of AGC trials should be revised regularly. (Source: Gastric Cancer)
Source: Gastric Cancer - September 23, 2020 Category: Gastroenterology Source Type: research

Prognostic significance of sarcopenia in microsatellite-stable gastric cancer patients treated with programmed death-1 inhibitors
ConclusionsCT-determined sarcopenia is an independent prognostic factor for PFS in patients with MSS GC treated with PD-1 inhibitors. (Source: Gastric Cancer)
Source: Gastric Cancer - September 23, 2020 Category: Gastroenterology Source Type: research

Correction to: Open versus minimally invasive total gastrectomy after neoadjuvant chemotherapy: results of a European randomized trial
In the original publication of the article, the co-author name “Christoph Reiβfelder” was incorrectly published. (Source: Gastric Cancer)
Source: Gastric Cancer - September 23, 2020 Category: Gastroenterology Source Type: research

MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer
ConclusionsMAGEA10 represents a promising predictive marker for early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - September 22, 2020 Category: Gastroenterology Source Type: research

Assessment of diagnostic value of fluorescent lymphography-guided lymphadenectomy for gastric cancer
ConclusionsFluorescent lymphography-guided lymphadenectomy can be a useful method for radical lymphadenectomy by facilitating the complete dissection of all potentially positive LN stations. Fluorescent lymphography-guided lymphadenectomy appears to be a reasonable alternative to conventional systematic lymphadenectomy for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - September 17, 2020 Category: Gastroenterology Source Type: research

Autophagy induced by Helicobacter pylori infection is necessary for gastric cancer stem cell emergence
ConclusionIn conclusion, all these data show thatH.  pylori-induced autophagy is implicated in gastric CSC emergence and could represent an interesting therapeutic target. (Source: Gastric Cancer)
Source: Gastric Cancer - September 16, 2020 Category: Gastroenterology Source Type: research

Expression of the immune checkpoint molecule V-set immunoglobulin domain-containing 4 is associated with poor prognosis in patients with advanced gastric cancer
This study aimed to investigate the expression of a new IC molecule, V-set Ig domain-containing 4 (VSIG4), and its clinical significance in AGC and other major cancers.MethodsWe analyzed the expression of VSIG4 and its correlation with survival in various carcinomas, including 882 surgically resected samples from patients with stage II –III AGC (two academic hospitals).ResultsVSIG4 positivity in AGC was significantly associated with overall survival (OS; Hazard ratio (HR)  = 2.661, 95% confidence interval [CI] = 2.012–3.519,P 
Source: Gastric Cancer - September 13, 2020 Category: Gastroenterology Source Type: research

Promising aberrant DNA methylation marker to predict gastric cancer development in individuals with family history and long-term effects of H. pylori eradication on DNA methylation
AbstractObjectiveIt remains unknown whether individuals with a family history (FH) of gastric cancer (GC) are associated with aberrant DNA methylation. The aim of this study was to investigate the association between aberrant DNA methylation and FH of GC.DesignUsing quantitative MethyLight assay,MOS,miR124a-3,NKX6-1,EMX1,CDH1, andTWIST1 methylation levels in the noncancerous gastric mucosa was compared between subjects with and without FH based on GC andHelicobacter pylori (Hp) infection. Changes in the methylation levels were evaluated over time after Hp eradication.ResultsIn Hp-positive GC patients,MOS (P 
Source: Gastric Cancer - September 10, 2020 Category: Gastroenterology Source Type: research

Multi-institutional development and validation of a nomogram to predict recurrence after curative resection of gastric neuroendocrine/mixed adenoneuroendocrine carcinoma
AbstractObjectiveTo establish a novel nomogram to predict individual 1, 3, and 5 years disease-free survival (DFS) of patients with gastric neuroendocrine carcinoma/mixed adenoneuroendocrine carcinoma [(MA)NEC].BackgroundAmong patients undergoing radical resection of gastric (MA)NEC, there is still a high tendency for relapse.MethodsA retrospective analysis of 777 patients with gastric (MA)NEC at 23 centers in China from 2004 to 2015 was performed. Based on the established nomogram, which included age, ASA, pT, pN and Ki67, the overall patients were divided into low-risk group (LRG) and high-risk group (HRG).ResultsThe med...
Source: Gastric Cancer - September 10, 2020 Category: Gastroenterology Source Type: research

Clinical outcomes of endoscopic resection for undifferentiated intramucosal early gastric cancer larger than 2  cm
ConclusionThe risk of LN or distant metastasis was not negligible, but as low as 1% for patients undergoing non-curative ER for UD EGC, with tumor size  >  2 cm as the only non-curative factor. Close observation may be an alternative to surgery, especially for older patients or those with poor physical status. (Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2020 Category: Gastroenterology Source Type: research

A deep learning method for delineating early gastric cancer resection margin under chromoendoscopy and white light endoscopy
ConclusionsENDOANGEL has the potential to assist endoscopists in delineating the resection extent of EGC under CE or WLE during ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Prognostic value of postoperative C-reactive protein elevation versus complication occurrence: a multicenter validation study
AbstractBackgroundSeveral studies have shown that postoperative complications worsen the prognosis of patients with malignancies. However, our previous study showed that C-reactive protein (CRP) elevation over 12  mg/dL was a more reliable prognostic indicator than complication occurrence. This large-scale, multicenter validation study aimed to confirm the prognostic value of postoperative CRP elevation in resectable gastric cancer.MethodsData of 1456 patients with pT2 –T4 gastric cancer who underwent R0 resection were collected from 21 institutions. The prognostic value of the highest postoperative serum level ...
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling
ConclusionOur results suggest that Uc.63+  could be involved in GC progression by regulating GC cell growth and migration via NF-κB signaling (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Brain metastases in patients with upper gastrointestinal cancer is associated with proximally located adenocarcinoma and lymph node metastases
ConclusionPatients with proximally located adenocarcinoma, or with lymph node metastases are at a higher risk for BRMs and patients fare better after treatment of isolated BRM. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Therapeutic value of splenectomy to dissect splenic hilar lymph nodes for type 4 gastric cancer involving the greater curvature, compared with other types
ConclusionSplenectomy for No. 10 dissection may be oncologically valid for type 4 gastric cancer involving the greater curvature. A safer procedure for No. 10 dissection should be established. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Phosphoproteomic analysis identifies CLK1 as a novel therapeutic target in gastric cancer
ConclusionsOur data indicates that CLK1 plays a crucial role in the regulation of splicing process in gastric cancer and that CLK1 can act as a novel therapeutic target in gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Adenocarcinoma of the esophagogastric junction; going up or down?
(Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2020 Category: Gastroenterology Source Type: research

Gastric cancer is highly prevalent in Lynch syndrome patients with atrophic gastritis
ConclusionLS patients, particularly those with atrophic gastritis, are at high risk of gastric neoplasm and often develop multiple tumors. Endoscopic surveillance for gastric cancer is recommended for LS patients, especially those with atrophic gastritis. (Source: Gastric Cancer)
Source: Gastric Cancer - August 12, 2020 Category: Gastroenterology Source Type: research

Survival analysis of a prospective multicenter observational study on surgical palliation among patients receiving treatment for malignant gastric outlet obstruction caused by incurable advanced gastric cancer
ConclusionApart from preoperative PS and postoperative chemotherapy, the present study identified better baseline QOL, improvement in postoperative QOL, and improvement in oral intake as prognostic factors among patients who underwent palliative surgery for advanced gastric cancer with GOO. (Source: Gastric Cancer)
Source: Gastric Cancer - August 12, 2020 Category: Gastroenterology Source Type: research

Docetaxel plus S-1 versus cisplatin plus S-1 in unresectable gastric cancer without measurable lesions: a randomized phase II trial (HERBIS-3)
AbstractBackgroundCisplatin plus S-1 (CS) is the standard first-line chemotherapy for advanced gastric cancer (AGC) in Japan. A previous phase III trial showed that docetaxel plus S-1 (DS) was effective for AGC without measurable lesions, but no studies have compared these two regimens.MethodsEligible patients had unresectable or recurrent HER2-negative AGC without measurable lesions. Patients were randomized to DS (docetaxel 40  mg/m2 on day 1, S-1 80 –120 mg on days 1–14, every 3 weeks) or CS (cisplatin 60 mg/m2 on day 8, S-1 80 –120 mg on days 1–21, every 5 weeks). T...
Source: Gastric Cancer - August 9, 2020 Category: Gastroenterology Source Type: research

Mitochondrial GRIM-19 deficiency facilitates gastric cancer metastasis through oncogenic ROS-NRF2-HO-1 axis via a NRF2-HO-1 loop
ConclusionsOur data suggest that GRIM-19 deficiency accelerates GC metastasis through the oncogenic ROS-NRF2-HO-1 axis via a positive-feedback NRF2-HO-1 loop. Therefore, this study not only offers novel insights into the role of oncogenic NRF2 in tumor progression, but also provides new strategies to alleviate the dark side of NRF2 by targeting HO-1. (Source: Gastric Cancer)
Source: Gastric Cancer - August 7, 2020 Category: Gastroenterology Source Type: research

Open versus minimally invasive total gastrectomy after neoadjuvant chemotherapy: results of a European randomized trial
ConclusionThese findings provide evidence that MITG after neoadjuvant therapy is not inferior regarding oncological quality of resection in comparison to OTG in Western patients with resectable gastric cancer. In addition, no differences in postoperative complications and recovery were seen. (Source: Gastric Cancer)
Source: Gastric Cancer - July 30, 2020 Category: Gastroenterology Source Type: research

Reappraise role of No. 10 lymphadenectomy for proximal gastric cancer in the era of minimal invasive surgery during total gastrectomy: a pooled analysis of 4 prospective trial
ConclusionsLSPSHL for LAPGC is safe and feasible when performed by experienced surgeons. LSPSHL could be recommended for the high-priority group patients even without invasion of the Gre. (Source: Gastric Cancer)
Source: Gastric Cancer - July 25, 2020 Category: Gastroenterology Source Type: research

Preservation of hepatic branch of the vagus nerve reduces the risk of gallstone formation after gastrectomy
ConclusionsPreservation of hepatic branch of the vagus nerve can be recommended for LDG as well as LPPG of early gastric cancer patients to reduce postoperative gallstone formation. (Source: Gastric Cancer)
Source: Gastric Cancer - July 22, 2020 Category: Gastroenterology Source Type: research

HDAC6/HNF4 α loop mediated by miR-1 promotes bile acids-induced gastric intestinal metaplasia
ConclusionsOur findings show that the HDAC6/HNF4 α loop regulated by miR-1 plays a critical role in gastric IM. Blocking the activation of this loop could be a potential approach to preventing BA-induced gastric IM or even gastric cancer (GC). (Source: Gastric Cancer)
Source: Gastric Cancer - July 22, 2020 Category: Gastroenterology Source Type: research

A multicenter phase II study of TAS-114 in combination with S-1 in patients with pretreated advanced gastric cancer (EPOC1604)
ConclusionsTAS-114 with S-1 showed only modest antitumor activity with acceptable safety profiles for patients heavily pretreated with AGC. (Source: Gastric Cancer)
Source: Gastric Cancer - July 21, 2020 Category: Gastroenterology Source Type: research

Influence of anticoagulants on the risk of delayed bleeding after gastric endoscopic submucosal dissection: a multicenter retrospective study
ConclusionsThe effects of DOACs on delayed bleeding varied between agents, but dabigatran therapy was associated with the lowest risk of delayed bleeding. Switching oral anticoagulants to dabigatran during the perioperative period could be a reasonable option to reduce the risk of delayed bleeding after gastric ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - July 17, 2020 Category: Gastroenterology Source Type: research

The incidences of metachronous multiple gastric cancer after various types of gastrectomy: analysis of data from a nationwide Japanese survey
This study evaluated the incidences of MMGC according to specific gastrectomy types, including pylorus-preserving gastrectomy (PPG), proximal gastrectomy (PG), and function-preserving gastrectomy (FPG), which was categorized as segmental gastrectomy and local resection.MethodsWe conducted a questionnaire survey of the Japanese Society for Gastro-Surgical Pathophysiology members, who were asked to report their institutional numbers of radical gastrectomy cases for cancer between 2003 and 2012. The cases were categorized according to whether the remnant stomach ’s status was followed for >  5 year...
Source: Gastric Cancer - July 11, 2020 Category: Gastroenterology Source Type: research

RP11-323N12.5 promotes the malignancy and immunosuppression of human gastric cancer by increasing YAP1 transcription
ConclusionsRP11-323N12.5 was the most up-regulated lncRNA in human GC and it promotedYAP1 transcription by binding to c-MYC within theYAP1 promoter in both GC and T cells.RP11-323N12.5 is an ideal therapeutic target in human GC due to its tumor-promoting and immunosuppression characteristics. (Source: Gastric Cancer)
Source: Gastric Cancer - July 3, 2020 Category: Gastroenterology Source Type: research

Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer
ConclusionsLVI, ulcer, submucosal invasion, and positive vertical margin are independently associated with LN or distant metastasis after non-curative ER of undifferentiated-type EGC. Surgical resection is strongly recommended for patients with two or more risk factors. (Source: Gastric Cancer)
Source: Gastric Cancer - July 3, 2020 Category: Gastroenterology Source Type: research

Resistance to FGFR1-targeted therapy leads to autophagy via TAK1/AMPK activation in gastric cancer
ConclusionsWe elucidated the molecular mechanisms underlying primary resistance to FGFR1 inhibitors in GC, and revealed that the inhibition of FGFR1 and TAK1 signaling could present a potential novel therapeutic strategy for FGFR1 inhibitor-resistant GC patients. (Source: Gastric Cancer)
Source: Gastric Cancer - July 1, 2020 Category: Gastroenterology Source Type: research

Inhibition of EZH2 and activation of ERR γ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway
ConclusionThe FOXM1 signaling pathway underlying the ERR γ-mediated gastric cancer suppression was identified. Furthermore, combined treatment with EZH2 inhibitor and ERRγ agonist synergistically suppressed GC progression by inhibiting this signaling pathway, suggesting its high potential in treating GC patients. (Source: Gastric Cancer)
Source: Gastric Cancer - June 10, 2020 Category: Gastroenterology Source Type: research

Epstein –Barr virus-associated gastric cancer: disease that requires special approach
AbstractEpstein –Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenot ype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations ofPIK3CA,ARID1A andBCOR,and PD-L1 andPD-L2 amplifications, as well. The aim of this review...
Source: Gastric Cancer - June 7, 2020 Category: Gastroenterology Source Type: research

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer
ConclusionsThe present findings provide a rationale for the selective sensitivity of EZH2 inhibitors against ARID1A-deficient GC and suggest the potential efficacy of targeted therapy using EZH2 inhibitors in this patient population. (Source: Gastric Cancer)
Source: Gastric Cancer - June 5, 2020 Category: Gastroenterology Source Type: research

Development and validation of a deep learning system for ascites cytopathology interpretation
ConclusionsWe demonstrate that the integration of DL can improve the efficiency of healthcare. The DL system we developed using TL techniques achieved accurate cytopathology interpretation, and had great potential to be integrated into clinician workflow. (Source: Gastric Cancer)
Source: Gastric Cancer - June 3, 2020 Category: Gastroenterology Source Type: research

Mucin expression in gastric- and gastro-oesophageal signet-ring cell cancer: results from a comprehensive literature review and a large cohort study of Caucasian and Asian gastric cancer
AbstractBackgroundThe literature on the prognostic relevance of signet-ring cell (SRC) histology in gastric cancer (GC) is controversial which is most likely related to inconsistent SRC classification based on haematoxylin –eosin staining. We hypothesised that mucin stains can consistently identify SRC-GC and predict GC patient outcome.MethodsWe performed a comprehensive literature review on mucin stains in SRC-GC and characterised the mucin expression in 851 Caucasian GC and 410 Asian GC using Alcian Blue (AB)-Periodic Acid-Schiff (PAS), MUC2 (intestinal-type mucin), and MUC5AC (gastric-type mucin). The relationship...
Source: Gastric Cancer - June 1, 2020 Category: Gastroenterology Source Type: research

Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal dissemination
In this study, we examined the relationship between IL-17A and tissue fibrosis in peritoneal dissemination and elucidated the mechanism of fibrosis induced by IL-17A using human peritoneal mesothelial cells (HPMCs) and a mouse xenograft model.MethodsSeventy gastric cancer patients with peritoneal dissemination were evaluated. The correlation between IL-17A and fibrosis was examined by immunofluorescence and immunohistochemistry. A fibrosis tumor model was developed based on subcutaneous transplantation of co-cultured cells (HPMCs and human gastric cancer cell line MKN-45) into the dorsal side of nude mice. Mice were subseq...
Source: Gastric Cancer - June 1, 2020 Category: Gastroenterology Source Type: research

Clinical outcomes of laparoscopic and endoscopic cooperative surgery for submucosal tumors on the esophagogastric junction: a retrospective single-center analysis
ConclusionsWe demonstrated the feasibility and safety of LECS for SMTs even on the EGJ. Fundoplication after LECS may be an approach for the prevention of postoperative reflux esophagitis. Future research is warranted to validate the efficacy of the addition of fundoplication. (Source: Gastric Cancer)
Source: Gastric Cancer - May 30, 2020 Category: Gastroenterology Source Type: research

Current status of immune checkpoint inhibitors for gastric cancer
AbstractRecent breakthrough results from immune checkpoint inhibitors (ICI) have paved the way to a new era of cancer immunotherapy. In particular, inhibition of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis with ICI including nivolumab and pembrolizumab has been emerging as a novel treatment strategy for advanced gastric cancers (GC). In a meta-analysis for anti-PD-1/PD-L1 therapy in GC, the objective response rate was 12.0% and the disease control ratio was 34.7%. The ICI treatment in GC provided modest survival benefit and especially, anti-PD-1 treatment could improve the 12-month and 18-month overall...
Source: Gastric Cancer - May 27, 2020 Category: Gastroenterology Source Type: research

Metformin use reduced the risk of stomach cancer in diabetic patients in Korea: an analysis of Korean NHIS-HEALS database
ConclusionsMetformin users with DM in the Korean population were at lower risk of stomach cancer incidence after controlling for potential confounding factors. (Source: Gastric Cancer)
Source: Gastric Cancer - May 26, 2020 Category: Gastroenterology Source Type: research

Jab1 promotes gastric cancer tumorigenesis via non-ubiquitin proteasomal degradation of p14ARF
ConclusionJab1 is upstream of p14ARF and promote gastric cancer cell proliferation in vitro and in vivo. Furthermore, Jab1 decreased the expression of p14ARF though ubiquitination independent proteasomal degradation. Therefore, the connection of Jab1 and p14ARF may provide new methods for the treatment of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - May 25, 2020 Category: Gastroenterology Source Type: research

Preoperative risk factors for postoperative intra-abdominal infectious complication after gastrectomy for gastric cancer using a Japanese web-based nationwide database
ConclusionUsing nationwide clinical practice data, we created a preoperative risk model for postgastrectomy PIIC for gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - May 20, 2020 Category: Gastroenterology Source Type: research

Lymph node-only metastatic gastric/gastroesophageal junction cancer and efficacy of immunotherapy
(Source: Gastric Cancer)
Source: Gastric Cancer - May 17, 2020 Category: Gastroenterology Source Type: research

Optimal extent of lymph node dissection for remnant advanced gastric carcinoma after distal gastrectomy: a retrospective analysis of more than 3000 patients from the nationwide registry of the Japanese Gastric Cancer Association
ConclusionsThe therapeutic strategy for RGC remains the same, regardless of the histology of the primary disease during the initial surgery. Total gastrectomy and dissection of the perigastric LNs (Nos. 1 –4), suprapancreatic LNs (Nos. 7–9 and 11), and LNs at the splenic hilum (No. 10) are justified. (Source: Gastric Cancer)
Source: Gastric Cancer - May 16, 2020 Category: Gastroenterology Source Type: research