Transcriptional analysis of immune genes in Epstein –Barr virus-associated gastric cancer and association with clinical outcomes
AbstractBackgroundEpstein –Barr virus-associated gastric cancer (EBVaGC) has traditionally been associated with high expression of PD-L1 and immune infiltration. Correlations between PD-L1 and other immune-related gene (IRG) expressions in EBVaGC have not been previously described.MethodsWe performed NanoString® transcriptomic profiling and PD-L1 immunohistochemistry (IHC) (using the FDA approved Dako PD-L1 IHC 22C3) on EBVaGC samples from gastric cancer patients undergoing primary tumor resections at Samsung Medical Centre, South Korea. For controls, EBV-negative samples from the previously reported Asian Cancer...
Source: Gastric Cancer - June 18, 2018 Category: Gastroenterology Source Type: research

After propensity score matching in long-term oncologic outcomes of robotic gastrectomy for gastric cancer compared with laparoscopic gastrectomy
(Source: Gastric Cancer)
Source: Gastric Cancer - June 16, 2018 Category: Gastroenterology Source Type: research

FoxM1 is regulated by both HIF-1 α and HIF-2α and contributes to gastrointestinal stromal tumor progression
ConclusionsOur data demonstrated the critical role of FoxM1 in promoting GIST progression and uncovered a novel HIF-1 α/HIF-2α-FoxM1 axis. These findings identify FoxM1 as a possible new molecular target for designing novel therapeutic treatments to control GIST progression. (Source: Gastric Cancer)
Source: Gastric Cancer - June 15, 2018 Category: Gastroenterology Source Type: research

Correction to: Favorable long-term outcomes of one-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer treated at a high-volume center
In the original publication of this article, the 5-year OS rates of the S-1 group in the ACTS-GC according to TNM-6 were described incorrectly in Table  4. The revised Table 4 is given in this correction. (Source: Gastric Cancer)
Source: Gastric Cancer - June 13, 2018 Category: Gastroenterology Source Type: research

Outcomes of endoscopic submucosal dissection for gastric epithelial neoplasm in chronic kidney disease patients: propensity score-matched case –control analysis
ConclusionsESD for gastric epithelial neoplasms can be performed in stage 3 CKD patients with comparable efficacy and safety to that performed in non-CKD patients. Stage 4 and 5 CKD patients should be closely monitored for bleeding events after ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - June 12, 2018 Category: Gastroenterology Source Type: research

The clinical implications of FDG-PET/CT differ according to histology in advanced gastric cancer
This study aims to evaluate the prognostic impact of SUVmax in preoperative18F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma.MethodsAs a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves. In addition, another 173 patients from an independent institution was assessed as an external validation set.ResultsIn multivariate analysis, high SUVmax in preoperative18F-FDG PET/CT of AGC was negatively correlated ...
Source: Gastric Cancer - June 9, 2018 Category: Gastroenterology Source Type: research

Early tumor shrinkage and depth of response in patients with advanced gastric cancer: a retrospective analysis of a randomized phase III study of first-line S-1 plus oxaliplatin vs. S-1 plus cisplatin
AbstractBackgroundWe investigated early tumor shrinkage (ETS) and depth of response (DpR) using data from the G-SOX study comparing S-1 plus oxaliplatin with S-1 plus cisplatin as the first-line treatment for advanced gastric cancer (AGC).MethodsETS was determined as % decrease in the sum of the longest diameters of the target lesions at the first evaluation of week 6 compared to baseline. DpR was the maximum % shrinkage during the study treatment. The impact of ETS (cutoff value 20%) and DpR (continuous value) on progression-free survival (PFS) and overall survival (OS) were assessed by the log-rank test and Cox regressio...
Source: Gastric Cancer - June 9, 2018 Category: Gastroenterology Source Type: research

Discordancy and changes in the pattern of programmed death ligand 1 expression before and after platinum-based chemotherapy in metastatic gastric cancer
ConclusionsPD-L1 expression can change during chemotherapy. Moreover, changes in patterns of PD-L1 expression might be associated with patient prognosis and response to chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - June 2, 2018 Category: Gastroenterology Source Type: research

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein –Barr virus status, and cancer genome alterations in metastatic gastric cancer
AbstractBackgroundRecently, the U.S. Food and Drug Administration approved pembrolizumab for patients (pts) with PD-L1-positive metastatic gastric cancer (MGC) based on 22C3 immunohistochemistry (IHC) assay. However, little is known about detailed clinicopathological features of 22C3 PD-L1 expression in MGC.Patients and methodsPts with histologically confirmed MGC were eligible for this prospective observational study. PD-L1 expression (22C3) on tumor cell (TC) or immune cell (IC) and mismatch repair (MMR) were analyzed by IHC. Epstein –Barr virus (EBV) was detected by in situ hybridization. The expressions of tyrosi...
Source: Gastric Cancer - June 1, 2018 Category: Gastroenterology Source Type: research

Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
ConclusionImmune and inflammatory associated processes and potassium transporting might participate in the development of GC. Besides,NMI andRAC1 might represent two new key genes related to GC. Our findings might give new insight into the biological mechanism and immunotherapy for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - June 1, 2018 Category: Gastroenterology Source Type: research

Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial
ConclusionsThe presence of apparent peritoneal metastasis might be a predictive factor for selecting w-nab-PTX for pretreated AGC patients.Trial registration numberJapicCTI-132059. (Source: Gastric Cancer)
Source: Gastric Cancer - May 31, 2018 Category: Gastroenterology Source Type: research

International consensus on a complications list after gastrectomy for cancer
ConclusionThe list of defined complications (soon to be validated in an international multicenter study) and the ongoing development of an electronic datasheet app to record them provide the basic infrastructure to reach the ultimate goals of standardized international data collection, establishment of benchmark results, and fostering of quality-improvement projects. (Source: Gastric Cancer)
Source: Gastric Cancer - May 30, 2018 Category: Gastroenterology Source Type: research

Risk factors for lymph node metastasis in non-sentinel node basins in early gastric cancer: sentinel node concept
ConclusionsMacrometastasis in SN basins, lymphatic invasion, and number of identified SNs  ≥ 5 are risk factors for LN metastasis in non-SN basins among gastric cancer patients. We identified a prediction model with CART analysis; patients with macrometastasis in SN basins and lymphatic invasion were considered to be at the highest risk for LN metastasis. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2018 Category: Gastroenterology Source Type: research

Questionnaire survey on adjuvant chemotherapy for elderly patients after gastrectomy indicates their vulnelabilities
ConclusionIn general practice, surgery alone can be regarded as the standard of care for stage II and III gastric cancer patients over 80  years old. The feasibility and efficacy of S-1 adjuvant chemotherapy should be elucidated in a randomized control trial considering the vulnerabilities of the elderly. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2018 Category: Gastroenterology Source Type: research

New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression
AbstractBackgroundGastric cancer with lymphoid stroma (GCLS) is characterized by prominent stromal infiltration of T-lymphocytes. The aim of this study was to investigate GCLS biology through analysis of clinicopathological features, EBV infection, microsatellite instability (MSI), immune gene-expression profiling and PD-L1 status in neoplastic cells and tumor immune microenvironment.MethodsTwenty-four GCLSs were analyzed by RNA in situ hybridization for EBV (EBER), PCR/fragment analysis for MSI, immunohistochemistry (PD-L1, cytokeratin, CD3, CD8), co-immunofluorescence (CK/PD-L1, CD68/PD-L1), NanoString gene-expression as...
Source: Gastric Cancer - May 19, 2018 Category: Gastroenterology Source Type: research

Temporary self-expandable metallic stent placement in post-gastrectomy complications
ConclusionsSelf-expandable metallic stent placement is an effective and safe treatment for post-gastrectomy anastomosis site leakage, stricture, and obstruction, which can decrease the risk of reoperation related mortality and modalities. (Source: Gastric Cancer)
Source: Gastric Cancer - May 14, 2018 Category: Gastroenterology Source Type: research

PODXL, negatively regulated by KLF4, promotes the EMT and metastasis and serves as a novel prognostic indicator of gastric cancer
ConclusionsKLF4/PODXL signaling pathway assumes an irreplaceable role in tumorigenesis, invasion and metastasis of human GC and PODXL serves as an independent prognostic indicator for GC patients. (Source: Gastric Cancer)
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

ypTNM staging after neoadjuvant chemotherapy in the Chinese gastric cancer population: an evaluation on the prognostic value of the AJCC eighth edition cancer staging system
This study aims to evaluate the new ypTNM staging system in Chinese gastric cancer patients.MethodsWe conducted retrospective survival and regression analyses using a database of gastric cancer patients who underwent neoadjuvant chemotherapy at the Peking University Cancer Hospital and Institute from January 2007 to January 2015.ResultsA total of 473 patients were included in the study with 28 pathological complete response (pCR) cases, 3 ypT0N1 cases, 65 stage I cases, 126 stage II cases, and 251 stage III cases. The pCR cases had similar survival to stage I patients (p >  0.05). The 3-year disease-free s...
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study
This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer.MethodsWe prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2  years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH)2VD], 25-hydroxy vitamin D [25(OH)VD], and estradiol were measured before surgery and every 3  months u...
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006 –2014 using propensity score matching
AbstractBackgroundThe benefit of preoperative chemoradiation (CXRT) over preoperative chemotherapy alone ( “chemotherapy” hereafter) is unknown. By analyzing the National Cancer Database (NCDB), we investigated whether preoperative CXRT improves the incidence of primary tumor pathologic complete response (ypT0) and overall survival (OS) compared with preoperative chemotherapy in patients with gastric cancer.MethodsPatients with non-metastatic gastric adenocarcinoma who underwent CXRT or chemotherapy followed by gastrectomy were included. Propensity score matching with a ratio of 1:1 was implemented to reduce se...
Source: Gastric Cancer - May 5, 2018 Category: Gastroenterology Source Type: research

Comparative effectiveness of adjuvant treatments for resected gastric cancer: a network meta-analysis
ConclusionsS-1-based chemotherapy and XELOX are likely to be the most effective adjuvant treatments for patients with resected gastric cancer. 5-FU alone provided little survival benefits as compared with surgery alone. Further clinical trials may be required to investigate S-1-based and XELOX-based adjuvant treatment strategies. (Source: Gastric Cancer)
Source: Gastric Cancer - May 4, 2018 Category: Gastroenterology Source Type: research

Salvage chemotherapy with the combination of oxaliplatin, leucovorin, and 5-fluorouracil in advanced gastric cancer refractory or intolerant to fluoropyrimidines, platinum, taxanes, and irinotecan
ConclusionsSalvage chemotherapy with the combination of oxaliplatin, leucovorin, and 5-fluorouracil has a potential activity and is tolerable for heavily treated AGC with appropriate dose modification and patient selection. (Source: Gastric Cancer)
Source: Gastric Cancer - April 16, 2018 Category: Gastroenterology Source Type: research

Body mass index and mortality in patients with gastric cancer: a large cohort study
AbstractBackgroundThe effects of obesity on prognosis in gastric cancer are controversial.AimsTo evaluate the association between body mass index (BMI) and mortality in patients with gastric cancer.MethodsA single-institution cohort of 7765 patients with gastric cancer undergoing curative gastrectomy between October 2000 and June 2016 was categorized into six groups based on BMI: underweight (
Source: Gastric Cancer - April 12, 2018 Category: Gastroenterology Source Type: research

Poor prognosis in Epstein –Barr virus-negative gastric cancer with lymphoid stroma is associated with immune phenotype
This study analyzed the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and the density of tumor-infiltrating lymphocytes (TILs) including CD3+ and CD8+ T cells, as well as their prognostic significance in patients with GCLS.MethodsThe study included 58 patients with GCLS (29 EBV+ and 29 EBV −) who underwent curative resection. Expression of CD3, CD8, PD-1, and PD-L1 in tumor cells and TILs was analyzed using a quantitative multispectral imaging system (Opal™), with these results validated by immuno-histochemical assays for PD-L1 on whole slide sections.ResultsThe...
Source: Gastric Cancer - April 7, 2018 Category: Gastroenterology Source Type: research

SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3  K signaling
ConclusionsOur results indicate that the activation of FAK signaling is critical for proliferation of both imatinib-sensitive and -resistant GIST cells and the interference with FAK/AKT pathway might be beneficial for therapeutic target. (Source: Gastric Cancer)
Source: Gastric Cancer - April 5, 2018 Category: Gastroenterology Source Type: research

Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis
ConclusionThe observedALDH2–alcohol drinking interaction and the direct effect ofALDH2 Lys alleles may suggest the involvement of acetaldehyde in the development of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - April 3, 2018 Category: Gastroenterology Source Type: research

Tree nut, peanut, and peanut butter consumption and the risk of gastric and esophageal cancer subtypes: the Netherlands Cohort Study
ConclusionsOur findings suggest that increased tree nut and peanut consumption is inversely associated with GNCA risk and possibly with ESCC risk, but not with the risk of the other esophageal and gastric cancer subtypes. (Source: Gastric Cancer)
Source: Gastric Cancer - March 28, 2018 Category: Gastroenterology Source Type: research

Diagnostic accuracy of demarcation using magnifying endoscopy with narrow-band imaging for Helicobacter pylori -uninfected undifferentiated-type early gastric cancer
ConclusionsBecause neutrophil infiltration was classified as mild or none, the accuracy of diagnostic demarcation was high in theH. pylori-uninfected andH. pylori eradication groups. (Source: Gastric Cancer)
Source: Gastric Cancer - March 13, 2018 Category: Gastroenterology Source Type: research

Clinical outcomes of intraoperative manual dilatation of pylorus in pylorus-preserving gastrectomy: a retrospective analysis
ConclusionSimple intraoperative manual dilatation of pylorus may provide prevention from pyloric stenosis caused by pyloric spasms for patients who undergo PPG. (Source: Gastric Cancer)
Source: Gastric Cancer - March 13, 2018 Category: Gastroenterology Source Type: research

A randomized phase II multicenter trial to explore efficacy of weekly intraperitoneal in comparison with intravenous paclitaxel administered immediately after gastrectomy to the patients with high risk of peritoneal recurrence: final results of the INPACT trial
ConclusionsWe were unable to prove superiority of the IP paclitaxel over IV paclitaxel delivered after surgery to control advanced gastric cancer with high risk of peritoneal recurrence. (Source: Gastric Cancer)
Source: Gastric Cancer - March 13, 2018 Category: Gastroenterology Source Type: research

Quantitative assessment of fluorescence intensity of ICG in sentinel nodes in early gastric cancer
AbstractBackgroundThe sentinel node (SN) detection by dual tracer method using indocyanine green (ICG) and a radioisotope (RI) has been recommended for early gastric cancer. However, institutions are limited due to radioactivity in the RI method. The greatest advantage of the RI method is that it objectively assesses RI uptake as a numerical value. The aim of the present study was to verify the usefulness of ICG fluorescence intensity in SN.MethodsSeventeen patients with early gastric cancer were enrolled in this study. RI uptake by each lymph node was measured using Navigator GPS and fluorescence nodes were identified usi...
Source: Gastric Cancer - March 7, 2018 Category: Gastroenterology Source Type: research

Ramucirumab for the treatment of metastatic gastric or gastroesophageal junction adenocarcinoma following disease progression on first-line platinum- or fluoropyrimidine-containing combination therapy in Japanese patients: a phase 2, open-label study
ConclusionsThese findings suggest that ramucirumab monotherapy has clinical activity and a manageable safety profile in Japanese patients with gastric cancer after disease progression following first-line chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - March 5, 2018 Category: Gastroenterology Source Type: research

Selective survival advantage associated with primary tumor resection for metastatic gastric cancer in a Western population
AbstractBackgroundThe prognosis of metastatic gastric cancer (GC) remains dismal, with a median survival of 10  months. Historically, primary tumor resection was not thought to confer any survival benefit. Although high-level data exist guiding treatment of metastatic GC for patients in the East, no such data exist for Western patients despite inherent ethnic differences in GC biology.MethodsThe 2006 –2012 National Cancer Database was queried for adult patients with metastatic gastric adenocarcinoma. Patients were classified into those who underwent primary tumor resection and chemotherapy (PTRaC) and those who ...
Source: Gastric Cancer - March 1, 2018 Category: Gastroenterology Source Type: research

Helicobacter pylori -induced modulation of the promoter methylation of Wnt antagonist genes in gastric carcinogenesis
This study aimed to investigate the changes in the promoter methylation and gene expression of multiple Wnt antagonists between the chronic infection and eradication ofHelicobacter pylori (H. pylori) in gastric carcinogenesis.MethodsThe levels of methylation and corresponding mRNA expression of seven Wnt antagonist genes (SFRP1, -2, -5, DKK1, -2, -3, WIF1) were compared among the patients withH. pylori-positive gastric cancers (GCs), andH. pylori-positive andH. pylori-negative controls, by quantitative MethyLight assay and real-time reverse transcription (RT)-polymerase chain reaction (PCR), respectively. The changes of th...
Source: Gastric Cancer - March 1, 2018 Category: Gastroenterology Source Type: research

Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection
AbstractBackgroundControlling Nutritional Status (CONUT), as calculated from serum albumin, total cholesterol concentration, and total lymphocyte count, was previously shown to be useful for nutritional assessment. The current study investigated the potential use of CONUT as a prognostic marker in gastric cancer patients after curative resection.MethodsPreoperative CONUT was retrospectively calculated in 416 gastric cancer patients who underwent curative resection at Kumamoto University Hospital from 2005 to 2014. The patients were divided into two groups: CONUT-high ( ≥4) and CONUT-low (≤3), according to time-depend...
Source: Gastric Cancer - March 1, 2018 Category: Gastroenterology Source Type: research

A multicenter, randomized trial comparing efficacy and safety of paclitaxel/capecitabine and cisplatin/capecitabine in advanced gastric cancer
ConclusionsFirst-line chemotherapy with PACX is effective with milder toxicities in advanced gastric cancer, but could not replace XP. (Source: Gastric Cancer)
Source: Gastric Cancer - February 27, 2018 Category: Gastroenterology Source Type: research

A phase II trial of capecitabine plus cisplatin (XP) for patients with advanced gastric cancer with early relapse after S-1 adjuvant therapy: XParTS-I trial
AbstractBackgroundsIn Japan, standard regimens for advanced gastric cancer (AGC) include S-1 chemotherapy. The standard treatment for early relapse after adjuvant chemotherapy with fluoropyrimidine alone is platinum-based chemotherapy, while the standard treatment for early relapse after adjuvant chemotherapy with fluoropyrimidine plus platinum is second-line chemotherapy. To evaluate the efficacy and safety of capecitabine plus cisplatin (XP) treatment for AGC patients who relapse within 6  months after S-1-based therapy, we conducted a multicenter phase II trial (NCT01412294).MethodsHER2-negative gastric cancer pati...
Source: Gastric Cancer - February 27, 2018 Category: Gastroenterology Source Type: research

Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status
ConclusionMolecular profiles stratified by SCNAs based on microsatellite status may be useful for elucidation of the mechanisms of early gastric carcinogenesis. (Source: Gastric Cancer)
Source: Gastric Cancer - February 21, 2018 Category: Gastroenterology Source Type: research

Nishi Memorial Award in Gastric Cancer
(Source: Gastric Cancer)
Source: Gastric Cancer - February 21, 2018 Category: Gastroenterology Source Type: research

The significance of OLGA and OLGIM staging systems in the risk assessment of gastric cancer: a systematic review and meta-analysis
ConclusionsThis correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - February 19, 2018 Category: Gastroenterology Source Type: research

Family history of cancer in first-degree relatives and risk of gastric cancer and its precursors in a Western population
ConclusionsFamily history of gastric cancer is strongly associated with specific subtypes of gastric cancer as well as with gastric atrophy, a risk factor for developing this malignancy. (Source: Gastric Cancer)
Source: Gastric Cancer - February 17, 2018 Category: Gastroenterology Source Type: research

The efficacy and safety of targeted therapy with or without chemotherapy in advanced gastric cancer treatment: a network meta-analysis of well-designed randomized controlled trials
ConclusionsApatinib, regorafenib, and rilotumumab improved patient PFS and OS. When combined with chemotherapy, ramucirumab and rilotumumab had high efficacy but low tolerability, and bevacizumab had moderate efficacy and tolerability for PFS. Without chemotherapy, ramucirumab and regorafenib had relatively high therapeutic efficacy tolerability for PFS. (Source: Gastric Cancer)
Source: Gastric Cancer - February 17, 2018 Category: Gastroenterology Source Type: research

Two-point measurement of amylase in drainage fluid predicts severe postoperative pancreatic fistula after gastric cancer surgery
ConclusionTwo-point measurement of D-AMY may be an efficient tool for achieving individualized management of POPF following radical gastrectomy. (Source: Gastric Cancer)
Source: Gastric Cancer - February 13, 2018 Category: Gastroenterology Source Type: research

Efficacy and tolerability of ramucirumab monotherapy or in combination with paclitaxel in gastric cancer patients from the Expanded Access Program Cohort by the Korean Cancer Study Group (KCSG)
ConclusionIn the Korean EAP cohort, ramucirumab showed similar efficacy to the results of the previous trials for gastric cancer. However, the level of GI perforation was slightly increased in the ramucirumab plus paclitaxel group. (Source: Gastric Cancer)
Source: Gastric Cancer - February 9, 2018 Category: Gastroenterology Source Type: research

Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication
AbstractBackgroundThe risk stratification of healthy individuals afterHelicobacter pylori eradication is an urgent issue. The assessment of aberrant DNA methylation accumulated in gastric tissues with normal appearance, which can reflect overall epigenomic damage, is a promising strategy. We aimed to establish novel epigenetic cancer risk markers forH. pylori-eradicated individuals.MethodsGastric mucosa was collected from eight healthy volunteers withoutH. pylori infection (G1), 75 healthy individuals with gastric atrophy (G2), and 94 gastric cancer patients (G3) afterH. pylori eradication. Genome-wide analysis was conduct...
Source: Gastric Cancer - February 9, 2018 Category: Gastroenterology Source Type: research

Introducing laparoscopic total gastrectomy for gastric cancer in general practice: a retrospective cohort study based on a nationwide registry database in Japan
AbstractBackground Although laparoscopic total gastrectomy (LTG) is considered a technically demanding procedure with safety issues, it has been performed in several hospitals in Japan. Data from a nationwide web-based data entry system for surgical procedures (NCD) that started enrollment in 2011 are now available for analysis.MethodsA retrospective cohort study was conducted using data from 32,144 patients who underwent total gastrectomy and were registered in the NCD database between January 2012 and December 2013. Mortality and morbidities were compared between patients who received LTG and those who underwent open t...
Source: Gastric Cancer - February 9, 2018 Category: Gastroenterology Source Type: research

Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer –GIRCG)
AbstractBackgroundThe aim of this study is to compare surgical outcomes including postoperative complications and prognosis between total gastrectomy (TG) and proximal gastrectomy (PG) for proximal gastric cancer (GC). Propensity-score-matching analysis was performed to overcome patient selection bias between the two surgical techniques.MethodsAmong 457 patients who were diagnosed with GC between January 1990 and December 2010 from four Italian institutions, 91 underwent PG and 366 underwent TG. Clinicopathologic features, postoperative complications, and survivals were reviewed and compared between these two groups retros...
Source: Gastric Cancer - February 8, 2018 Category: Gastroenterology Source Type: research

HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells
ConclusionsThese results uncovered the novel interaction between HOTAIR and Runx3, and provided potential therapeutic targets on the metastasis of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - February 7, 2018 Category: Gastroenterology Source Type: research

Ramucirumab for the treatment of patients with gastric or gastroesophageal junction cancer in community oncology practices
This study was designed to describe ramucirumab monotherapy or combination therapy use in a community oncology practice setting.MethodsThis was a retrospective observational cohort study to describe the treatment of adult patients with gastric or GEJ cancer who initiated ramucirumab treatment between 4/21/14 and 6/30/16 within the US Oncology Network. Kaplan –Meier method and Cox proportional hazards regression analyses were used to assess clinical outcomes. Multivariable logistic regression models were used to assess patient-level predictors of ramucirumab monotherapy or combination therapy.ResultsA total of 505 pat...
Source: Gastric Cancer - February 3, 2018 Category: Gastroenterology Source Type: research

Predictors of heterogeneity in the first-line treatment of patients with advanced/metastatic gastric cancer in the U.S.
This study was designed to describe the treatment patterns of patients with gastric cancer and to understand the factors associated with treatment choices to inform evidence-based care.MethodsA retrospective observational study was conducted using two real-world databases to describe treatment trends and to quantify variability in treatment patterns of patients diagnosed with advanced/metastatic gastric cancer between 1/1/2007 and 9/30/2014 in the U.S. Heterogeneity was measured by the Herfindahl –Hirschman Index (HHI). Predictors (baseline clinical, treatment, and demographic variables) of treatment regimen choice w...
Source: Gastric Cancer - February 1, 2018 Category: Gastroenterology Source Type: research