Effect of double-layer structure in intramucosal gastric signet-ring cell carcinoma on lymph node metastasis: a retrospective, single-center study
Conclusions“DLS absent” is a risk factor of LNM detected by the multivariate analysis. In pT1a (M), LVI absent, UL absent, tumor size >  20 mm, sig-GC, no LNM occurred in “DLS present” cases. (Source: Gastric Cancer)
Source: Gastric Cancer - December 6, 2018 Category: Gastroenterology Source Type: research

Phase 1 trial of avelumab (anti-PD-L1) in Japanese patients with advanced solid tumors, including dose expansion in patients with gastric or gastroesophageal junction cancer: the JAVELIN Solid Tumor JPN trial
ConclusionsAvelumab showed acceptable safety in Japanese patients with advanced solid tumors and clinical activity in patients with advanced gastric cancer/gastroesophageal junction cancer and disease progression after chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - December 4, 2018 Category: Gastroenterology Source Type: research

Clinical implications of CTNNA1 germline mutations in asymptomatic carriers
AbstractIn 2017, we implementedCTNNA1 germline analysis in probands suspected of having hereditary diffuse gastric cancer. Here, we report the results from a retrospective series of 41 cases, including the identification of a new family with aCTNNA1 mutation and the first prophylactic total gastrectomy in an asymptomatic carrier after a normal upper endoscopy. Diffuse gastric cancer foci with loss of catenin alpha-1 expression were seen in the resected tissue, suggesting thatCTNNA1 andCDH1 germline mutations behave in a similar manner. Life-changing prophylactic total gastrectomy should therefore also be considered inCTNNA...
Source: Gastric Cancer - December 4, 2018 Category: Gastroenterology Source Type: research

Clinical advantages of robotic gastrectomy for clinical stage I/II gastric cancer: a multi-institutional prospective single-arm study
ConclusionsRG for cStage I/II GC is safe and feasible. It may be effective in reducing morbidity with LG. (Source: Gastric Cancer)
Source: Gastric Cancer - December 3, 2018 Category: Gastroenterology Source Type: research

A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2)
ConclusionsIn the Japanese subpopulation, patients receiving nivolumab had longer OS, similar to the overall population, with a manageable safety profile. The interaction between nivolumab and ramucirumab will be clarified in ongoing clinical trials. (Source: Gastric Cancer)
Source: Gastric Cancer - December 1, 2018 Category: Gastroenterology Source Type: research

Neoadjuvant chemoradiotherapy or chemotherapy for gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis
AbstractObjectiveThe preferred neoadjuvant treatment for gastroesophageal junction (GEJ) adenocarcinoma is still matter of debate. We conducted a meta-analysis to assess the different impact of neoadjuvant combined chemotherapy and radiotherapy (CTRT) versus chemotherapy (CT) alone.MethodsA comprehensive search was performed in EMBASE, PubMed, and Cochrane Library databases from inception to 30th June 2018. Studies comparing survival of patients who underwent CTRT or CT alone before surgery for GEJ adenocarcinoma were included. Hazard ratio (HR) for overall survival (OS) was extracted, and a random-effects model was used f...
Source: Gastric Cancer - November 27, 2018 Category: Gastroenterology Source Type: research

Number of retrieved lymph nodes is an independent prognostic factor after total gastrectomy for patients with stage III gastric cancer: propensity score matching analysis of a multi-institution dataset
AbstractBackgroundThe prognostic significance of the number of retrieved lymph nodes (RLNs) in gastric cancer remains controversial. Therefore, we designed a multicenter collaborative database to investigate the correlation between the number of RLNs and prognosis of patients with advanced gastric cancer after curative resection.MethodsWe retrospectively analyzed 1103 patients who underwent gastrectomy for stage II/III gastric cancer between 2010 and 2014. Lymph nodes, which were retrieved by surgeons from surgically resected specimens, were validated by pathologists. A target population and the optimal cutoff were determi...
Source: Gastric Cancer - November 27, 2018 Category: Gastroenterology Source Type: research

Perioperative risk calculator for distal gastrectomy predicts overall survival in patients with gastric cancer
ConclusionsWe elucidated the associations among risk calculator values and OS rates of patients with gastric cancer. Time-dependent ROC curve analysis suggested that the AUC value of the risk model for operative mortality was high, indicating that this risk calculator would be useful for not only short-term outcomes, but also long-term outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - November 26, 2018 Category: Gastroenterology Source Type: research

Correction to: Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer
In the original publication of this article, Table  4 was published incorrectly. The correct Table 4 is given below. (Source: Gastric Cancer)
Source: Gastric Cancer - November 22, 2018 Category: Gastroenterology Source Type: research

The role of oxaliplatin in the adjuvant setting of different Lauren ’s type of gastric adenocarcinoma after D2 gastrectomy: a real-world study
AbstractBackgroundTo compare the efficacy of oxaliplatin-based and oxaliplatin-free adjuvant chemotherapies in patients with different Lauren type gastric cancers after D2 gastrectomy.MethodsFrom our established gastric cancer database, patients with pathological stage II and III gastric cancer who received adjuvant chemotherapy after D2 gastrectomy at Zhongshan Hospital of Fudan University were analyzed. Patients who received different adjuvant chemotherapy regimens were divided into two subgroups: oxaliplatin-based and oxaliplatin-free subgroup. Clinical outcomes were analyzed according to pathological stage and differen...
Source: Gastric Cancer - November 13, 2018 Category: Gastroenterology Source Type: research

Combined detection of serum autoantibodies as diagnostic biomarkers in esophagogastric junction adenocarcinoma
ConclusionsAutoantibodies against an optimized TAA panel as serum biomarkers appear to help identify the present of early stage EJA. (Source: Gastric Cancer)
Source: Gastric Cancer - November 13, 2018 Category: Gastroenterology Source Type: research

Prognostic significance of serum alkaline phosphatase and lactate dehydrogenase levels in patients with unresectable advanced gastric cancer
ConclusionsHigh level of ALP is an independent, worse prognosis factor for patients receiving chemotherapy for unresectable and recurrent gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - November 11, 2018 Category: Gastroenterology Source Type: research

Comparison between gastric and esophageal classification system among adenocarcinomas of esophagogastric junction according to AJCC 8th edition: a retrospective observational study from two high-volume institutions in China
This study aimed to illuminate the 8th TNM-EC or TNM-GC system which was more rational for type II, especially for patients underwent transhiatal approaches.MethodsWe collected the database of patients with AEG who underwent radical surgical resection from two high-volume institutions in China: West China Hospital (N = 773) and Xi Jing Hospital of Fourth Military University (N = 637). The cases were randomly matched into 705 training cohort and 705 validation cohort. All the cases were reclassified by the 8th edition of TNM-EC and TNM-GC. The distribution of patients in each stage, the hazard ra...
Source: Gastric Cancer - November 2, 2018 Category: Gastroenterology Source Type: research

Gastrokine 1 protein is a potential theragnostic target for gastric cancer
ConclusionsThe GKN1 is secreted and internalized in the gastric epithelium by exosome-driven transfer, which inhibits gastric tumorigenesis and supports the clinical application of GKN1 protein in gastric cancer diagnosis and treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Favorable long-term outcomes of one-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer treated at a high-volume center
ConclusionsSurvival outcome shown in this study of patients treated with 1-year adjuvant S-1 after D2 gastrectomy at a high-volume cancer hospital will provide a reference for future adjuvant trials targeting JC-14/TNM-7 stage II/III disease. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Cancer –adipose tissue interaction and fluid flow synergistically modulate cell kinetics, HER2 expression, and trastuzumab efficacy in gastric cancer
ConclusionWe have demonstrated that cancer –adipocyte interaction and physical microenvironment mutually modulate gastric cancer cell kinetics. Further elucidation of the microenvironmental regulation in gastric cancer will be very important for the development of strategies involving molecular targeted therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Gastric washing by distilled water can reduce free gastric cancer cells exfoliated into the stomach lumen
ConclusionsCancer cells can be highly exfoliated from the tumor surface into the gastric lumen by endoscopic irrigation in large gastric cancer with lymphatic involvement. Gastric washing by DW can lead to cytoclasis of free cancer cells; therefore, it may minimize the possibility of cancer-cell seeding in procedures carrying potential risks of tumor-cell seeding upon transluminal communication, such as endoscopic full-thickness resection and laparoscopy –endoscopy cooperative surgery. (Source: Gastric Cancer)
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Prognostic factors in patients treated with second-line chemotherapy for advanced gastric cancer: results from the randomized prospective phase III FFCD-0307 trial
AbstractAimThe aim of this study was to determine prognostic factors in patients treated with second-line therapy (L2) for locally advanced or metastatic gastric and gastro-esophageal junction (GEJ) adenocarcinoma in a randomized phase III study with predefined L2.MethodsIn the FFCD-0307 study, patients were randomly assigned to receive in L1 either epirubicin, cisplatin, and capecitabine (ECX arm) or fluorouracil, leucovorin, and irinotecan (FOLFIRI arm). L2 treatment was predefined (FOLFIRI for the ECX arm and ECX for the FOLFIRI arm). Chi square tests were used to compare the characteristics of patients treated in L2 wi...
Source: Gastric Cancer - October 11, 2018 Category: Gastroenterology Source Type: research

Effect of hospital and surgeon volume on postoperative outcomes after distal gastrectomy for gastric cancer based on data from 145,523 Japanese patients collected from a nationwide web-based data entry system
AbstractBackgroundDespite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system.MethodsWe extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015. The primary outcome was operative mortality. Hospital volume was divided into 3 tertiles: low (1 –22 cases per year), medium...
Source: Gastric Cancer - October 9, 2018 Category: Gastroenterology Source Type: research

A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin, and S-1, followed by gastrectomy with D2 lymph node dissection for high-risk advanced gastric cancer: results of the KDOG1001 trial
ConclusionsNeoadjuvant chemotherapy with DCS was feasible and showed a sufficient R0 resection rate. A future study with a sufficient follow-up period should confirm survival outcomes. (Source: Gastric Cancer)
Source: Gastric Cancer - October 3, 2018 Category: Gastroenterology Source Type: research

Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis
AbstractIntroductionThere has recently been increased interest in the assessment of body composition in patients with gastric cancer for the purpose of prognostication. This systematic review and meta-analysis aim to evaluate the current literature on body composition assessment in patients with gastric cancer and its impact on peri-operative outcomes.MethodsA systematic literature search was conducted for studies reporting assessment of body composition in patients with gastric cancers. Meta-analysis of postoperative outcomes (overall and major complications, anastomotic leaks, pulmonary complications) and survival was pe...
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

The inhibition of thymidine phosphorylase can reverse acquire 5FU resistance in gastric cancer cells
ConclusionsIn MKN45/F2R cells, the reduction of FdUMP through the TP –TK pathway caused 5FU resistance, and the inhibition of TP reversed the resistance to 5FU, suggesting that the combination of 5FU and TPI is a promising cancer therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

Body composition assessment and sarcopenia in patients with gastric cancer: a systematic review and meta-analysis
AbstractIntroductionThere has recently been increased interest in the assessment of body composition in patients with gastric cancer for the purpose of prognostication. This systematic review and meta-analysis aim to evaluate the current literature on body composition assessment in patients with gastric cancer and its impact on peri-operative outcomes.MethodsA systematic literature search was conducted for studies reporting assessment of body composition in patients with gastric cancers. Meta-analysis of postoperative outcomes (overall and major complications, anastomotic leaks, pulmonary complications) and survival was pe...
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

The inhibition of thymidine phosphorylase can reverse acquire 5FU resistance in gastric cancer cells
ConclusionsIn MKN45/F2R cells, the reduction of FdUMP through the TP –TK pathway caused 5FU resistance, and the inhibition of TP reversed the resistance to 5FU, suggesting that the combination of 5FU and TPI is a promising cancer therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - October 1, 2018 Category: Gastroenterology Source Type: research

EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions
ConclusionsEBVaGC cells expressing high levels of PD-L1 suppress T-cell proliferation, and the IFN- γ signaling pathway is involved in the expression of PD-L1. (Source: Gastric Cancer)
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
ConclusionsOur findings suggest that the SCC method is a simple, safe, and effective approach for preventing delayed bleeding after gastric ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

EBV-associated gastric cancer evades T-cell immunity by PD-1/PD-L1 interactions
ConclusionsEBVaGC cells expressing high levels of PD-L1 suppress T-cell proliferation, and the IFN- γ signaling pathway is involved in the expression of PD-L1. (Source: Gastric Cancer)
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
ConclusionsOur findings suggest that the SCC method is a simple, safe, and effective approach for preventing delayed bleeding after gastric ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer —a randomized-controlled trial
ConclusionsConcomitant PC during gastric surgery for malignancies, although reducing the absolute number of biliary abnormalities, has no significant impact on the natural course of patients. (Source: Gastric Cancer)
Source: Gastric Cancer - September 22, 2018 Category: Gastroenterology Source Type: research

How long should we continue gastric cancer screening? From an epidemiological point of view
In this study we aimed to estimate how long gastric cancer screening is deemed necessary in the future from epidemiologic perspectives.MethodsFollowing the Japanese guidelines for gastric cancer screening 2014, recommendation of providing population-based gastric cancer screening is judged by balancing benefits and harms. Benefits and harms are estimated by number needed to screen (NNS)  
Source: Gastric Cancer - September 21, 2018 Category: Gastroenterology Source Type: research

Impact of upfront randomization for postoperative treatment on quality of surgery in the CRITICS gastric cancer trial
ConclusionSurgical quality parameters were similar in both study arms in the CRITICS gastric cancer trial, indicating that upfront randomization for postoperative treatment had no impact on the quality of surgery. A Maruyama Index below five was associated with better overall survival. (Source: Gastric Cancer)
Source: Gastric Cancer - September 20, 2018 Category: Gastroenterology Source Type: research

Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis
ConclusionReal world data showed that large-scale eradication therapy has been performed mostly for benign conditions in Japan. Since eradication effects in preventing gastric cancer are conceivably greater there, GC incidence may decline faster in Japan than expected from the previous meta-analyses data which were based on multi-national, mixed populations with differing screening quality and disease progression. (Source: Gastric Cancer)
Source: Gastric Cancer - September 11, 2018 Category: Gastroenterology Source Type: research

Equivalent feasibility and safety of perioperative care by ERAS in open and laparoscopy-assisted distal gastrectomy for gastric cancer: a single-institution ancillary study using the patient cohort enrolled in the JCOG0912 phase III trial
ConclusionThis study showed that the regimen of perioperative care performed by the ERAS program for LADG was equally feasible and safe for ODG with additional pain control. Less pain observed in LADG was not so apparent advantage for completion and safety of ERAS care. (Source: Gastric Cancer)
Source: Gastric Cancer - September 7, 2018 Category: Gastroenterology Source Type: research

Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer
ConclusionsThese results suggest that NIS regulates tumor progression by affecting IFN signaling, and that its strong expression is related to a worse prognosis in patients with GC. These results provide an insight into the role of NIS as a mediator and/or a biomarker for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - September 6, 2018 Category: Gastroenterology Source Type: research

Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer
ConclusionsThe newly identified miR-142-5p-CYR61-Wnt/ β-catenin axis partially illustrates the molecular mechanism of GC recurrence and represents a novel prognosis biomarker for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - September 3, 2018 Category: Gastroenterology Source Type: research

Two-point measurement of amylase in drainage fluid predicts severe postoperative pancreatic fistula after gastric cancer surgery
ConclusionTwo-point measurement of D-AMY may be an efficient tool for achieving individualized management of POPF following radical gastrectomy. (Source: Gastric Cancer)
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

Predictors of heterogeneity in the first-line treatment of patients with advanced/metastatic gastric cancer in the U.S.
This study was designed to describe the treatment patterns of patients with gastric cancer and to understand the factors associated with treatment choices to inform evidence-based care.MethodsA retrospective observational study was conducted using two real-world databases to describe treatment trends and to quantify variability in treatment patterns of patients diagnosed with advanced/metastatic gastric cancer between 1/1/2007 and 9/30/2014 in the U.S. Heterogeneity was measured by the Herfindahl –Hirschman Index (HHI). Predictors (baseline clinical, treatment, and demographic variables) of treatment regimen choice w...
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

Clinical outcomes of intraoperative manual dilatation of pylorus in pylorus-preserving gastrectomy: a retrospective analysis
ConclusionSimple intraoperative manual dilatation of pylorus may provide prevention from pyloric stenosis caused by pyloric spasms for patients who undergo PPG. (Source: Gastric Cancer)
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

Phase II study of oxaliplatin, irinotecan and S-1 therapy in patients with advanced gastric cancer: the Korean Cancer Study Group ST14-11
ConclusionThese data suggest that the OIS regimen is effective and relatively well tolerated in patients with advanced gastric cancer. Given that all the patients treated, but one, had a good performance status, these results must be confirmed in a patient population more representative of regular clinical practice.Trial RegistrationClinicalTrials.gov Identifier: NCT02527785. (Source: Gastric Cancer)
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

Quantitative assessment of fluorescence intensity of ICG in sentinel nodes in early gastric cancer
AbstractBackgroundThe sentinel node (SN) detection by dual tracer method using indocyanine green (ICG) and a radioisotope (RI) has been recommended for early gastric cancer. However, institutions are limited due to radioactivity in the RI method. The greatest advantage of the RI method is that it objectively assesses RI uptake as a numerical value. The aim of the present study was to verify the usefulness of ICG fluorescence intensity in SN.MethodsSeventeen patients with early gastric cancer were enrolled in this study. RI uptake by each lymph node was measured using Navigator GPS and fluorescence nodes were identified usi...
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

Total vs proximal gastrectomy for adenocarcinoma of the upper third of the stomach: a propensity-score-matched analysis of a multicenter western experience (On behalf of the Italian Research Group for Gastric Cancer –GIRCG)
AbstractBackgroundThe aim of this study is to compare surgical outcomes including postoperative complications and prognosis between total gastrectomy (TG) and proximal gastrectomy (PG) for proximal gastric cancer (GC). Propensity-score-matching analysis was performed to overcome patient selection bias between the two surgical techniques.MethodsAmong 457 patients who were diagnosed with GC between January 1990 and December 2010 from four Italian institutions, 91 underwent PG and 366 underwent TG. Clinicopathologic features, postoperative complications, and survivals were reviewed and compared between these two groups retros...
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research

HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells
ConclusionsThese results uncovered the novel interaction between HOTAIR and Runx3, and provided potential therapeutic targets on the metastasis of gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - September 1, 2018 Category: Gastroenterology Source Type: research