Ethnic ‑specific associations between body mass index and gastric cancer: a Mendelian randomization study in European and Korean populations
(Source: Gastric Cancer)
Source: Gastric Cancer - March 18, 2024 Category: Gastroenterology Source Type: research

Adjuvant treatment for locally advanced gastric cancer: an Asian perspective
AbstractStandard adjuvant treatment for locally advanced gastric cancer (LAGC) is regionally different. Whereas perioperative chemotherapy is the standard in Western populations, D2 gastrectomy followed by adjuvant chemotherapy has been the standard in East Asia. Recently, the pivotal phase 3 PRODIGY and RESOLVE studies have demonstrated survival benefits of adding neoadjuvant chemotherapy to surgery followed by adjuvant chemotherapy over up-front surgery followed by adjuvant chemotherapy in Asian patients. Based on these results, neoadjuvant chemotherapy is considered one of the viable options for patients with LAGC. In t...
Source: Gastric Cancer - March 15, 2024 Category: Gastroenterology Source Type: research

Specific lineage transition of tumor-associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis
ConclusionsFor the first time, we identified an immunosuppressive macrophage transition from CTShigh to C1Qhigh TAM in ascites from patients with PM-GC. This may contribute to developing potential TAM-targeted immunotherapies for PM-GC.Graphical AbstractSchematic of the immune TME of ascites and the crosstalk with aDTCs in patients with PM-GC. In ascites with TAM-dominant TME, the ascitic TAMs undergo CTS-to-C1Q transition to support multiple phases of aDTC dissemination, including aDTC homing, proliferation, immune escape, and therapeutic resistance. While in ascites with T-cell-dominant TME, enriched T cells do not imply...
Source: Gastric Cancer - March 9, 2024 Category: Gastroenterology Source Type: research

Perioperative chemotherapy with docetaxel plus oxaliplatin and S-1 (DOS) versus oxaliplatin plus S-1 (SOX) for the treatment of locally advanced gastric or gastro-esophageal junction adenocarcinoma (MATCH): an open-label, randomized, phase 2 clinical trial
ConclusionsPerioperative DOS improved MPR significantly and tended to produce longer PFS compared to SOX in LAG/GEJ cancer in Asia, and might be considered as a preferred option for perioperative chemotherapy and worth further investigation. (Source: Gastric Cancer)
Source: Gastric Cancer - March 8, 2024 Category: Gastroenterology Source Type: research

Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma
ConclusionsdMMR status can be a useful prognostic predictor, and CXCR2 and MDSCs can be novel therapeutic targets in patients with solid-type PDA. (Source: Gastric Cancer)
Source: Gastric Cancer - March 5, 2024 Category: Gastroenterology Source Type: research

Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
ConclusionsThe findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90  mg for men and 75 mg for women). (Source: Gastric Cancer)
Source: Gastric Cancer - March 4, 2024 Category: Gastroenterology Source Type: research

Patient metabolic profile defined by liver and muscle 18F-FDG PET avidity is independently associated with overall survival in gastric cancer
ConclusionsElevated LRF ratio, a patient-specific PET –CT-based metabolic parameter, was independently associated with an improvement in OS in patients with metastatic gastric cancer. With prospective validation, LRF ratio may be a useful, host-specific metabolic parameter for prognostication in gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - March 4, 2024 Category: Gastroenterology Source Type: research

Racial disparities of gastric cancer in the USA: an overview of epidemiology, global screening guidelines, and targeted screening in a heterogeneous population
This article aims to provide context to gastric cancer epidemiology globally, review risk factors for developing gastric cancer, highlight racial and ethnic disparities in gastric cancer burden in the USA, examine current guidelines that exist in high incidence countries, and suggest future studies examining the efficacy of additional screening in high-risk populations to reduce gastric cancer mortality and disparate burden on ethnic minorities in the USA. (Source: Gastric Cancer)
Source: Gastric Cancer - March 4, 2024 Category: Gastroenterology Source Type: research

Statin use in relation to long-term survival after gastrectomy for gastric adenocarcinoma: a Swedish population-based cohort study
ConclusionsPerioperative use of statins does not seem to improve the 5-year survival in patients who undergo gastrectomy with curative intent for gastric adenocarcinoma in Sweden. (Source: Gastric Cancer)
Source: Gastric Cancer - March 2, 2024 Category: Gastroenterology Source Type: research

Discrepant effect of high-density lipoprotein cholesterol on esophageal and gastric cancer risk in a nationwide cohort
ConclusionsLow HDL-C increased the risk of gastric cancer, wherein high HDL-C was associated with esophageal cancer risk with discrepancies by sex and smoking status. (Source: Gastric Cancer)
Source: Gastric Cancer - February 28, 2024 Category: Gastroenterology Source Type: research

Gastric fundic gland polyposis and cancer development after eradication of Helicobacter pylori in patient with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS)
AbstractA 44-year-old woman with gastric cancer (GC) and fundic gland polyposis (FGPs) was referred to our hospital for further diagnosis and treatment. She successfully underwent eradication therapy for Helicobacter pylori (HP) 6  years ago, but did not exhibit FGPs at that time. When she underwent an esophagogastroduodenoscopy 2, 4, and 5 years after the eradication of HP, her imaging results revealed the existence of FGPs which gradually increased in her gastric fundus and body. Gastric adenocarcinoma and proximal polypo sis of the stomach (GAPPS) was suspected and a mutational analysis was performed, revealing anAPC ...
Source: Gastric Cancer - February 26, 2024 Category: Gastroenterology Source Type: research

Impact of preoperative prealbumin levels on long-term prognosis in patients with gastric cancer after gastrectomy: a retrospective cohort study
ConclusionsPreoperative prealbumin levels correlated with OS in patients with gastric cancer after gastrectomy; the lower the prealbumin level, the worse is the prognosis. Prealbumin levels may be associated with other-cause survival. (Source: Gastric Cancer)
Source: Gastric Cancer - February 24, 2024 Category: Gastroenterology Source Type: research

Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023
(Source: Gastric Cancer)
Source: Gastric Cancer - February 22, 2024 Category: Gastroenterology Source Type: research

Killer cell lectin-like receptor G2 facilitates aggressive phenotypes of gastric cancer cells via dual activation of the ERK1/2 and JAK/STAT pathways
ConclusionsKLRG2 knockdown attenuated the malignant phenotypes of GC cells via downregulation of JAK/STAT and MAPK-ERK1/2 pathway activity and upregulation of p38 MAPK and p53. Targeted suppression of KLRG2 may serve as a new treatment approach for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - February 22, 2024 Category: Gastroenterology Source Type: research

Elucidating molecular mechanisms and therapeutic synergy: irreversible HER2-TKI plus T-Dxd for enhanced anti-HER2 treatment of gastric cancer
ConclusionIn summary, our research reveals the molecular mechanisms of irreversible HER2-TKIs in regulating HER2 protein expression by promoting HER2 internalization. These findings advance our comprehension of targeted therapy for GC and provide a promising therapeutic combination strategy with enhanced efficacy against HER2-positive GC. (Source: Gastric Cancer)
Source: Gastric Cancer - February 22, 2024 Category: Gastroenterology Source Type: research