The Cholegas trial: long-term results of prophylactic cholecystectomy during gastrectomy for cancer —a randomized-controlled trial
ConclusionsConcomitant PC during gastric surgery for malignancies, although reducing the absolute number of biliary abnormalities, has no significant impact on the natural course of patients. (Source: Gastric Cancer)
Source: Gastric Cancer - September 22, 2018 Category: Gastroenterology Source Type: research

How long should we continue gastric cancer screening? From an epidemiological point of view
In this study we aimed to estimate how long gastric cancer screening is deemed necessary in the future from epidemiologic perspectives.MethodsFollowing the Japanese guidelines for gastric cancer screening 2014, recommendation of providing population-based gastric cancer screening is judged by balancing benefits and harms. Benefits and harms are estimated by number needed to screen (NNS)  
Source: Gastric Cancer - September 21, 2018 Category: Gastroenterology Source Type: research

Impact of upfront randomization for postoperative treatment on quality of surgery in the CRITICS gastric cancer trial
ConclusionSurgical quality parameters were similar in both study arms in the CRITICS gastric cancer trial, indicating that upfront randomization for postoperative treatment had no impact on the quality of surgery. A Maruyama Index below five was associated with better overall survival. (Source: Gastric Cancer)
Source: Gastric Cancer - September 20, 2018 Category: Gastroenterology Source Type: research

Effect of Helicobacter pylori eradication on the incidence of gastric cancer: a systematic review and meta-analysis
ConclusionReal world data showed that large-scale eradication therapy has been performed mostly for benign conditions in Japan. Since eradication effects in preventing gastric cancer are conceivably greater there, GC incidence may decline faster in Japan than expected from the previous meta-analyses data which were based on multi-national, mixed populations with differing screening quality and disease progression. (Source: Gastric Cancer)
Source: Gastric Cancer - September 11, 2018 Category: Gastroenterology Source Type: research

Equivalent feasibility and safety of perioperative care by ERAS in open and laparoscopy-assisted distal gastrectomy for gastric cancer: a single-institution ancillary study using the patient cohort enrolled in the JCOG0912 phase III trial
ConclusionThis study showed that the regimen of perioperative care performed by the ERAS program for LADG was equally feasible and safe for ODG with additional pain control. Less pain observed in LADG was not so apparent advantage for completion and safety of ERAS care. (Source: Gastric Cancer)
Source: Gastric Cancer - September 7, 2018 Category: Gastroenterology Source Type: research

Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer
ConclusionsThese results suggest that NIS regulates tumor progression by affecting IFN signaling, and that its strong expression is related to a worse prognosis in patients with GC. These results provide an insight into the role of NIS as a mediator and/or a biomarker for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - September 6, 2018 Category: Gastroenterology Source Type: research

Downregulation of miR-142-5p promotes tumor metastasis through directly regulating CYR61 expression in gastric cancer
ConclusionsThe newly identified miR-142-5p-CYR61-Wnt/ β-catenin axis partially illustrates the molecular mechanism of GC recurrence and represents a novel prognosis biomarker for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - September 3, 2018 Category: Gastroenterology Source Type: research

Near infrared photoimmunotherapy using a fiber optic diffuser for treating peritoneal gastric cancer dissemination
In this study, we investigate in vitro and in vivo efficacy of trastuzumab (tra)-IR700DX NIR-PIT on a human epidermal growth factor receptor type 2 (HER2)-positive gastric cancer cell line.MethodsNIR-PIT effects were investigated in vitro and in vivo. Disseminated peritoneal implants mice were separated into 5 groups: (1) no treatment; (2) tra-IR700 i.v. only; (3) NIR light only; (4) NIR-PIT; (5) repeated NIR-PIT. The peritoneal cavity was irradiated with NIR light using a fiber optic diffuser delivered through the catheter.ResultsSpecific binding and cell-specific killing was observed after NIR-PIT in vitro. In the in viv...
Source: Gastric Cancer - August 31, 2018 Category: Gastroenterology Source Type: research

Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma
AbstractBackground and aimsClinicopathological characteristics of gastric cancer (GC) are changing, especially in the West with a decreasing incidence of distal, intestinal-type tumours and the corresponding increasing proportion of tumours with Laur én diffuse or WHO poorly cohesive (PC) including signet ring cell (SRC) histology. To accurately assess the behaviour and the prognosis of these GC subtypes, the standardization of pathological definitions is needed.MethodsA multidisciplinary expert team belonging to the European Chapter of International Gastric Cancer Association (IGCA) identified 11 topics on patholog...
Source: Gastric Cancer - August 25, 2018 Category: Gastroenterology Source Type: research

Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination
AbstractHelicobacter pylori affect around 50% of the population worldwide. More importantly, the gastric infection induced by this bacterium is deemed to be associated with the progression of distal gastric carcinoma and gastric mucosal lymphoma in the  human.H. pylori infection and its prevalent genotype significantly differ across various geographical regions. Based on numerous virulence factors,H. pylori can target different cellular proteins to modulate the variety of inflammatory responses and initiate numerous “hits” on the gastric mucosa. Such reactions lead to serious complications, including gastr...
Source: Gastric Cancer - August 25, 2018 Category: Gastroenterology Source Type: research

Nature versus nurture: the impact of nativity and site of treatment on survival for gastric cancer
AbstractBackgroundThe prognosis of gastric cancer patients is better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place of birth and the place of treatment influences survival outcomes in Korean and US patients with localized gastric cancer.MethodsPatients with localized gastric adenocarcinoma undergoing potentially curative gastrectomy from 1989 to 2010 were identified from the SEER registry and two single institution databases from the US and Korea. Patients were categorized into three groups: Koreans born/treated in Korea (...
Source: Gastric Cancer - August 22, 2018 Category: Gastroenterology Source Type: research

Mutation heterogeneity between primary gastric cancers and their matched lymph node metastases
ConclusionsThe abundance and spatial distribution of mutations may provide clues on the evolutionary relationship between primary and matched LN genomes. Gene-level analyses further distinguished the early addicted cancer drivers such asTP53 mutations from late acquired region-specific mutations. (Source: Gastric Cancer)
Source: Gastric Cancer - August 21, 2018 Category: Gastroenterology Source Type: research

A feasibility study of laparoscopic total gastrectomy for clinical stage I gastric cancer: a prospective multi-center phase II clinical trial, KLASS 03
ConclusionsLTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - August 20, 2018 Category: Gastroenterology Source Type: research

ADAMTS5 acts as a tumor suppressor by inhibiting migration, invasion and angiogenesis in human gastric cancer
ConclusionADAMTS5 is downregulated in GC and suppresses tumor metastasis and angiogenesis by inhibiting ETS1-mediated changes in MVD and potentially acts as a novel prognostic marker and a potential therapeutic target in human GC. (Source: Gastric Cancer)
Source: Gastric Cancer - August 13, 2018 Category: Gastroenterology Source Type: research

Potential for local resection with sentinel node basin dissection for early gastric cancer based on the distribution of primary sites
ConclusionWe found that>  50% of the patients indicated for SN navigation surgery, particularly those with tumors in the upper third of the stomach, potentially could undergo partial resection with SNBD. (Source: Gastric Cancer)
Source: Gastric Cancer - August 11, 2018 Category: Gastroenterology Source Type: research

A randomized controlled trial of postoperative intravenous acetaminophen plus thoracic epidural analgesia vs. thoracic epidural analgesia alone after gastrectomy for gastric cancer
ConclusionsIn gastric cancer surgery patients, routine i.v. acetaminophen in combination with TEA provides superior postoperative pain management compared with TEA alone. (Source: Gastric Cancer)
Source: Gastric Cancer - August 7, 2018 Category: Gastroenterology Source Type: research

Solid-type poorly differentiated adenocarcinoma of the stomach: clinicopathological and molecular characteristics and histogenesis
We examined the expression of p53, mismatch-repair proteins, and mucin core glycoproteins; microsatellite status; and mutations inKRAS andBRAF, as well as clinicopathological features, in 54 cases of PDA of the stomach (31 solid-type PDAs and 23 non-solid-type PDAs).ResultsThe proportion (51.6%) of MSI in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5%) (p = 0.00022). The proportion of absent expression of MLH1 (58.1%) and PMS2 (51.6%) in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5 and 8%) (p 
Source: Gastric Cancer - August 7, 2018 Category: Gastroenterology Source Type: research

Phase II study of trastuzumab with modified docetaxel, cisplatin, and 5 fluorouracil in metastatic HER2-positive gastric cancer
ConclusionThe combination of mDCF and trastuzumab is effective and safe in patients with metastatic HER2-positive gastric or GE junction adenocarcinoma and can be considered as an option for selected patients. This trial is registered at ClinicalTrials.gov, number NCT00515411. (Source: Gastric Cancer)
Source: Gastric Cancer - August 7, 2018 Category: Gastroenterology Source Type: research

Clinicopathological differences in signet ring cell adenocarcinoma between early and advanced gastric cancer
ConclusionThe clinical features and prognosis of signet ring cell adenocarcinoma are different between early and advanced gastric cancer. Signet ring cell adenocarcinoma is a poor prognostic factor in advanced gastric cancer after curative resection. (Source: Gastric Cancer)
Source: Gastric Cancer - August 1, 2018 Category: Gastroenterology Source Type: research

E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function
ConclusionsE-cadherin loss leads to disturbances in receptor signalling and plasma membrane trafficking and organisation, creating druggable vulnerabilities. (Source: Gastric Cancer)
Source: Gastric Cancer - July 31, 2018 Category: Gastroenterology Source Type: research

CD44 + cytokeratin-positive tumor cells in blood and bone marrow are associated with poor prognosis of patients with gastric cancer
ConclusionCD44+ phenotype of cytokeratin-positive cells in blood and bone marrow is an independent prognostic factor in patients with gastric cancer. (Source: Gastric Cancer)
Source: Gastric Cancer - July 28, 2018 Category: Gastroenterology Source Type: research

Endoscopic submucosal dissection for papillary adenocarcinoma of the stomach: low curative resection rate but favorable long-term outcomes after curative resection
ConclusionsGiven the favorable long-term outcomes after curative resection, ESD might be indicated for papillary EGC according to the current Japanese guidelines. As papillary EGC has considerable lymphovascular and submucosal invasion rates, careful histological examination is required to accurately determine whether curative ESD is achieved. (Source: Gastric Cancer)
Source: Gastric Cancer - July 23, 2018 Category: Gastroenterology Source Type: research

Risk factors for 30-day hospital readmission after radical gastrectomy: a single-center retrospective study
ConclusionsCRP on POD3  ≥ 12 mg/dl, laparoscopic surgery, and TG were identified as independent risk factors for readmission. (Source: Gastric Cancer)
Source: Gastric Cancer - July 13, 2018 Category: Gastroenterology Source Type: research

Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer
AbstractBackgroundThe systemic inflammation score (SIS), based on preoperative serum albumin (Alb) level and lymphocyte-to-monocyte ratio (LMR), has been shown to be a novel prognostic score for some tumors. We investigate the prognostic value of the SIS in patients with resectable gastric cancer (GC).MethodsPatients with GC who underwent curative resection between December 2008 and December 2013 were included. Time-dependent receiver operating characteristics analysis (t-ROC), concordance index (C-index) and AUC were used to compare the prognostic impact.ResultsTotally, 1786 patients with resectable GC were included in th...
Source: Gastric Cancer - July 7, 2018 Category: Gastroenterology Source Type: research

First report of an Asian family with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) revealed with the germline mutation of the APC exon 1B promoter region
AbstractA 48-year-old Japanese female with left hypochondralgia presented at our hospital. Esophagogastroduodenoscopy (EGD) revealed gastric cancers and carpeting fundic gland polyposis (FGPs) withoutHelicobacter pylori infection. Computed tomography showed multiple liver metastases. Total colonoscopy revealed a colonic tubular adenoma but not polyposis. She was diagnosed as having advanced gastric cancer with liver metastasis and received chemotherapy. Her mother had died from gastric cancer, and her elderly brother and niece had FGPs as revealed by EGD. Thus, the pedigree was diagnosed as gastric adenocarcinoma and proxi...
Source: Gastric Cancer - July 2, 2018 Category: Gastroenterology Source Type: research

Human epidermal growth factor receptor 2-, epidermal growth factor receptor-, and mesenchymal epithelial transition factor-positive sites of gastric cancer using surgical samples
ConclusionsTo avoid underestimating expression status, biopsies must be taken from MuP for HER2, InP for EGFR, and both proportions for c-MET. (Source: Gastric Cancer)
Source: Gastric Cancer - June 27, 2018 Category: Gastroenterology Source Type: research

Evaluation of serum markers for gastric cancer and its precursor diseases among high incidence and mortality rate of gastric cancer area
AbstractBackgroundMongolia has the highest mortality rate of gastric cancer. The early detection of cancer and down-staging screening for high risk patients are essential. Therefore, we aimed to validate serum markers for stratifying patients for further management.MethodsEndoscopy and histological examination were performed to determine high risk and gastric cancer patients. Rapid urease test, culture and histological tests were performed to diagnoseHelicobacter pylori infection. Serum pepsinogen (PG) I and II and anti-H. pylori IgG were measured by ELISA. Receiver Operating Characteristic analysis was used to extract the...
Source: Gastric Cancer - June 22, 2018 Category: Gastroenterology Source Type: research

Combinatory low methylation statuses of SAT- α and L1 are associated with shortened survival time in patients with advanced gastric cancer
ConclusionNot only tumoral L1 hypomethylation, but also tumoral SAT- α hypomethylation was found to be independent prognostic parameters in patients with advanced gastric cancer. SAT-α methylation status can be used to further divide gastric cancers with L1 hypomethylation into subsets of gastric cancers with better and worse prognosis. (Source: Gastric Cancer)
Source: Gastric Cancer - June 20, 2018 Category: Gastroenterology Source Type: research

Transcriptional analysis of immune genes in Epstein –Barr virus-associated gastric cancer and association with clinical outcomes
AbstractBackgroundEpstein –Barr virus-associated gastric cancer (EBVaGC) has traditionally been associated with high expression of PD-L1 and immune infiltration. Correlations between PD-L1 and other immune-related gene (IRG) expressions in EBVaGC have not been previously described.MethodsWe performed NanoString® transcriptomic profiling and PD-L1 immunohistochemistry (IHC) (using the FDA approved Dako PD-L1 IHC 22C3) on EBVaGC samples from gastric cancer patients undergoing primary tumor resections at Samsung Medical Centre, South Korea. For controls, EBV-negative samples from the previously reported Asian Cancer...
Source: Gastric Cancer - June 18, 2018 Category: Gastroenterology Source Type: research

After propensity score matching in long-term oncologic outcomes of robotic gastrectomy for gastric cancer compared with laparoscopic gastrectomy
(Source: Gastric Cancer)
Source: Gastric Cancer - June 16, 2018 Category: Gastroenterology Source Type: research

FoxM1 is regulated by both HIF-1 α and HIF-2α and contributes to gastrointestinal stromal tumor progression
ConclusionsOur data demonstrated the critical role of FoxM1 in promoting GIST progression and uncovered a novel HIF-1 α/HIF-2α-FoxM1 axis. These findings identify FoxM1 as a possible new molecular target for designing novel therapeutic treatments to control GIST progression. (Source: Gastric Cancer)
Source: Gastric Cancer - June 15, 2018 Category: Gastroenterology Source Type: research

Correction to: Favorable long-term outcomes of one-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer treated at a high-volume center
In the original publication of this article, the 5-year OS rates of the S-1 group in the ACTS-GC according to TNM-6 were described incorrectly in Table  4. The revised Table 4 is given in this correction. (Source: Gastric Cancer)
Source: Gastric Cancer - June 13, 2018 Category: Gastroenterology Source Type: research

Outcomes of endoscopic submucosal dissection for gastric epithelial neoplasm in chronic kidney disease patients: propensity score-matched case –control analysis
ConclusionsESD for gastric epithelial neoplasms can be performed in stage 3 CKD patients with comparable efficacy and safety to that performed in non-CKD patients. Stage 4 and 5 CKD patients should be closely monitored for bleeding events after ESD. (Source: Gastric Cancer)
Source: Gastric Cancer - June 12, 2018 Category: Gastroenterology Source Type: research

The clinical implications of FDG-PET/CT differ according to histology in advanced gastric cancer
This study aims to evaluate the prognostic impact of SUVmax in preoperative18F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma.MethodsAs a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves. In addition, another 173 patients from an independent institution was assessed as an external validation set.ResultsIn multivariate analysis, high SUVmax in preoperative18F-FDG PET/CT of AGC was negatively correlated ...
Source: Gastric Cancer - June 9, 2018 Category: Gastroenterology Source Type: research

Early tumor shrinkage and depth of response in patients with advanced gastric cancer: a retrospective analysis of a randomized phase III study of first-line S-1 plus oxaliplatin vs. S-1 plus cisplatin
AbstractBackgroundWe investigated early tumor shrinkage (ETS) and depth of response (DpR) using data from the G-SOX study comparing S-1 plus oxaliplatin with S-1 plus cisplatin as the first-line treatment for advanced gastric cancer (AGC).MethodsETS was determined as % decrease in the sum of the longest diameters of the target lesions at the first evaluation of week 6 compared to baseline. DpR was the maximum % shrinkage during the study treatment. The impact of ETS (cutoff value 20%) and DpR (continuous value) on progression-free survival (PFS) and overall survival (OS) were assessed by the log-rank test and Cox regressio...
Source: Gastric Cancer - June 9, 2018 Category: Gastroenterology Source Type: research

Discordancy and changes in the pattern of programmed death ligand 1 expression before and after platinum-based chemotherapy in metastatic gastric cancer
ConclusionsPD-L1 expression can change during chemotherapy. Moreover, changes in patterns of PD-L1 expression might be associated with patient prognosis and response to chemotherapy. (Source: Gastric Cancer)
Source: Gastric Cancer - June 2, 2018 Category: Gastroenterology Source Type: research

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein –Barr virus status, and cancer genome alterations in metastatic gastric cancer
AbstractBackgroundRecently, the U.S. Food and Drug Administration approved pembrolizumab for patients (pts) with PD-L1-positive metastatic gastric cancer (MGC) based on 22C3 immunohistochemistry (IHC) assay. However, little is known about detailed clinicopathological features of 22C3 PD-L1 expression in MGC.Patients and methodsPts with histologically confirmed MGC were eligible for this prospective observational study. PD-L1 expression (22C3) on tumor cell (TC) or immune cell (IC) and mismatch repair (MMR) were analyzed by IHC. Epstein –Barr virus (EBV) was detected by in situ hybridization. The expressions of tyrosi...
Source: Gastric Cancer - June 1, 2018 Category: Gastroenterology Source Type: research

Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
ConclusionImmune and inflammatory associated processes and potassium transporting might participate in the development of GC. Besides,NMI andRAC1 might represent two new key genes related to GC. Our findings might give new insight into the biological mechanism and immunotherapy for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - June 1, 2018 Category: Gastroenterology Source Type: research

Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial
ConclusionsThe presence of apparent peritoneal metastasis might be a predictive factor for selecting w-nab-PTX for pretreated AGC patients.Trial registration numberJapicCTI-132059. (Source: Gastric Cancer)
Source: Gastric Cancer - May 31, 2018 Category: Gastroenterology Source Type: research

International consensus on a complications list after gastrectomy for cancer
ConclusionThe list of defined complications (soon to be validated in an international multicenter study) and the ongoing development of an electronic datasheet app to record them provide the basic infrastructure to reach the ultimate goals of standardized international data collection, establishment of benchmark results, and fostering of quality-improvement projects. (Source: Gastric Cancer)
Source: Gastric Cancer - May 30, 2018 Category: Gastroenterology Source Type: research

Risk factors for lymph node metastasis in non-sentinel node basins in early gastric cancer: sentinel node concept
ConclusionsMacrometastasis in SN basins, lymphatic invasion, and number of identified SNs  ≥ 5 are risk factors for LN metastasis in non-SN basins among gastric cancer patients. We identified a prediction model with CART analysis; patients with macrometastasis in SN basins and lymphatic invasion were considered to be at the highest risk for LN metastasis. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2018 Category: Gastroenterology Source Type: research

Questionnaire survey on adjuvant chemotherapy for elderly patients after gastrectomy indicates their vulnelabilities
ConclusionIn general practice, surgery alone can be regarded as the standard of care for stage II and III gastric cancer patients over 80  years old. The feasibility and efficacy of S-1 adjuvant chemotherapy should be elucidated in a randomized control trial considering the vulnerabilities of the elderly. (Source: Gastric Cancer)
Source: Gastric Cancer - May 24, 2018 Category: Gastroenterology Source Type: research

New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression
AbstractBackgroundGastric cancer with lymphoid stroma (GCLS) is characterized by prominent stromal infiltration of T-lymphocytes. The aim of this study was to investigate GCLS biology through analysis of clinicopathological features, EBV infection, microsatellite instability (MSI), immune gene-expression profiling and PD-L1 status in neoplastic cells and tumor immune microenvironment.MethodsTwenty-four GCLSs were analyzed by RNA in situ hybridization for EBV (EBER), PCR/fragment analysis for MSI, immunohistochemistry (PD-L1, cytokeratin, CD3, CD8), co-immunofluorescence (CK/PD-L1, CD68/PD-L1), NanoString gene-expression as...
Source: Gastric Cancer - May 19, 2018 Category: Gastroenterology Source Type: research

Temporary self-expandable metallic stent placement in post-gastrectomy complications
ConclusionsSelf-expandable metallic stent placement is an effective and safe treatment for post-gastrectomy anastomosis site leakage, stricture, and obstruction, which can decrease the risk of reoperation related mortality and modalities. (Source: Gastric Cancer)
Source: Gastric Cancer - May 14, 2018 Category: Gastroenterology Source Type: research

PODXL, negatively regulated by KLF4, promotes the EMT and metastasis and serves as a novel prognostic indicator of gastric cancer
ConclusionsKLF4/PODXL signaling pathway assumes an irreplaceable role in tumorigenesis, invasion and metastasis of human GC and PODXL serves as an independent prognostic indicator for GC patients. (Source: Gastric Cancer)
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

ypTNM staging after neoadjuvant chemotherapy in the Chinese gastric cancer population: an evaluation on the prognostic value of the AJCC eighth edition cancer staging system
This study aims to evaluate the new ypTNM staging system in Chinese gastric cancer patients.MethodsWe conducted retrospective survival and regression analyses using a database of gastric cancer patients who underwent neoadjuvant chemotherapy at the Peking University Cancer Hospital and Institute from January 2007 to January 2015.ResultsA total of 473 patients were included in the study with 28 pathological complete response (pCR) cases, 3 ypT0N1 cases, 65 stage I cases, 126 stage II cases, and 251 stage III cases. The pCR cases had similar survival to stage I patients (p >  0.05). The 3-year disease-free s...
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study
This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer.MethodsWe prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2  years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH)2VD], 25-hydroxy vitamin D [25(OH)VD], and estradiol were measured before surgery and every 3  months u...
Source: Gastric Cancer - May 10, 2018 Category: Gastroenterology Source Type: research

Preoperative chemoradiation therapy induces primary-tumor complete response more frequently than chemotherapy alone in gastric cancer: analyses of the National Cancer Database 2006 –2014 using propensity score matching
AbstractBackgroundThe benefit of preoperative chemoradiation (CXRT) over preoperative chemotherapy alone ( “chemotherapy” hereafter) is unknown. By analyzing the National Cancer Database (NCDB), we investigated whether preoperative CXRT improves the incidence of primary tumor pathologic complete response (ypT0) and overall survival (OS) compared with preoperative chemotherapy in patients with gastric cancer.MethodsPatients with non-metastatic gastric adenocarcinoma who underwent CXRT or chemotherapy followed by gastrectomy were included. Propensity score matching with a ratio of 1:1 was implemented to reduce se...
Source: Gastric Cancer - May 5, 2018 Category: Gastroenterology Source Type: research

Comparative effectiveness of adjuvant treatments for resected gastric cancer: a network meta-analysis
ConclusionsS-1-based chemotherapy and XELOX are likely to be the most effective adjuvant treatments for patients with resected gastric cancer. 5-FU alone provided little survival benefits as compared with surgery alone. Further clinical trials may be required to investigate S-1-based and XELOX-based adjuvant treatment strategies. (Source: Gastric Cancer)
Source: Gastric Cancer - May 4, 2018 Category: Gastroenterology Source Type: research

Salvage chemotherapy with the combination of oxaliplatin, leucovorin, and 5-fluorouracil in advanced gastric cancer refractory or intolerant to fluoropyrimidines, platinum, taxanes, and irinotecan
ConclusionsSalvage chemotherapy with the combination of oxaliplatin, leucovorin, and 5-fluorouracil has a potential activity and is tolerable for heavily treated AGC with appropriate dose modification and patient selection. (Source: Gastric Cancer)
Source: Gastric Cancer - April 16, 2018 Category: Gastroenterology Source Type: research