Japanese gastric cancer treatment guidelines 2018 (5th edition)
(Source: Gastric Cancer)
Source: Gastric Cancer - February 14, 2020 Category: Gastroenterology Source Type: research

5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients
ConclusionOur device for automated detection of LN metastasis using 5-ALA can be a useful tool for intraoperative diagnosis. (Source: Gastric Cancer)
Source: Gastric Cancer - February 11, 2020 Category: Gastroenterology Source Type: research

Randomized phase II/III study of 5-fluorouracil/ l -leucovorin versus 5-fluorouracil/ l -leucovorin plus paclitaxel administered to patients with severe peritoneal metastases of gastric cancer (JCOG1108/WJOG7312G)
ConclusionsChemotherapy was indicated for patients with severe peritoneal metastases excluding patients with PS 2 having massive ascites and inadequate oral intake simultaneously. FLTAX did not confer a significant survival benefit but may be preferred because of longer PFS and acceptable toxicity. (Source: Gastric Cancer)
Source: Gastric Cancer - February 8, 2020 Category: Gastroenterology Source Type: research

Trends of incidence and prognosis of gastric neuroendocrine neoplasms: a study based on SEER and our multicenter research
AbstractBackgroundTo investigate the recent epidemiological trends of gastric neuroendocrine neoplasms (GNENs) and establish a new tool to estimate the prognosis of gastric neuroendocrine carcinoma (GNEC) and gastric neuroendocrine tumor (GNET).MethodsNomograms were established based on a retrospective study on patients diagnosed with GNENs from 1975 to 2016 in Surveillance, Epidemiology and End Results database. External validation was performed among 246 GNENs patients in Jiangsu province to verify the discrimination and calibration of the nomograms.ResultsThe age-adjusted incidence of GNENs has increased from 0.309 to 6...
Source: Gastric Cancer - February 5, 2020 Category: Gastroenterology Source Type: research

Treatment option of endoscopic stent insertion or gastrojejunostomy for gastric outlet obstruction due to gastric cancer: a propensity score-matched analysis
ConclusionsPropensity score matching demonstrated that endoscopic stent placement resulted in less postoperative morbidity than and a similar food intake and equivalent survival times to gastrojejunostomy. These results suggest the utility of stent therapy. (Source: Gastric Cancer)
Source: Gastric Cancer - January 25, 2020 Category: Gastroenterology Source Type: research

Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study
AbstractBackgroundStatins have shown to reduce the risk of various cancers. However, their effects on metachronous recurrence (MR) after endoscopic resection (ER) for early gastric cancer (EGC) are unknown. We evaluate their effects on MR development after ER for EGC.MethodsWe selected 11,568 patients who received ER for EGC from 2002 to 2011 from the Korean National Health Insurance database and classified into 2 groups: control and statins using propensity score matching. Metachronous recurrence was defined as the second ER or gastrectomy performed 6  months after the first ER.ResultsMean follow-up period was 8.8 &t...
Source: Gastric Cancer - January 24, 2020 Category: Gastroenterology Source Type: research

Sentinel node mapping for post-endoscopic resection gastric cancer: multicenter retrospective cohort study in Japan
ConclusionsOur findings clarified the feasibility of SN mapping based on the SN basin concept in patients with gastric cancer who previously underwent ER. (Source: Gastric Cancer)
Source: Gastric Cancer - January 11, 2020 Category: Gastroenterology Source Type: research

Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study
AbstractBackgroundAddition of trastuzumab to first-line palliative chemotherapy in gastroesophageal cancer patients with HER2 overexpression has shown to improve survival. Real-world data on HER2 assessment and administration of trastuzumab are lacking. The aim of this study was to assess HER2 testing, trastuzumab administration, and overall survival (OS) in a nationwide cohort of metastatic gastroesophageal cancer patients.MethodsData of patients with synchronous metastatic gastroesophageal adenocarcinoma diagnosed in 2010 –2016 that received palliative systemic treatment (n = 2846) were collected from...
Source: Gastric Cancer - January 11, 2020 Category: Gastroenterology Source Type: research

Construction of 124 I-trastuzumab for noninvasive PET imaging of HER2 expression: from patient-derived xenograft models to gastric cancer patients
AbstractPurposeHere, we sought to develop a PET radioligand based on trastuzumab labeled with124I,124I-trastuzumab, to evaluate its distribution, internal dosimetry, and initial PET images of HER2-positive lesions in gastric cancer (GC) patients.MethodsIn animal studies, micro-PET imaging and bio-distribution were performed to examine the specificity of124I-trastuzumab in HER2-positive and HER2-negative mouse models. Subsequently,124I-trastuzumab was applied in human clinic trial. Six gastric cancer patients with metastases underwent124I-trastuzumab PET imaging, with18F-FDG PET/CT in each to compare.ResultsIn animal studie...
Source: Gastric Cancer - January 9, 2020 Category: Gastroenterology Source Type: research

Risk factors and prognosis of gastric stasis, a crucial problem after laparoscopic pylorus-preserving gastrectomy for early middle-third gastric cancer
ConclusionsE-stasis after LPPG occurs in 7.6% of patients. Age, DM, and intraabdominal infection are significantly related to E-stasis. E-stasis is associated with poorer nutritional and functional outcomes even at 1  year postoperatively. (Source: Gastric Cancer)
Source: Gastric Cancer - January 8, 2020 Category: Gastroenterology Source Type: research

Utility of continuous glucose monitoring following gastrectomy
ConclusionsCGM demonstrated diurnal glycemic variability and nocturnal hypoglycemia in patients undergoing gastrectomy. Because some hypoglycemic patients did not develop symptoms and glycemic variability was not necessarily associated with dumping symptom, dumping syndrome must only partially explain the postoperative glucose fluctuations. (Source: Gastric Cancer)
Source: Gastric Cancer - January 8, 2020 Category: Gastroenterology Source Type: research

Survival after neoadjuvant approaches to gastroesophageal junction cancer
AbstractBackgroundGastroesophageal junction (GEJ) cancers can be treated with equipoise using neoadjuvant chemoradiation (NACRT) or chemotherapy alone (NAC), but the comparative outcomes are unclear.Methods Patients with non-metastatic T2-4 or N1-3 GEJ adenocarcinoma who underwent definitive surgery and NAC or NACRT were selected from the National Cancer Database. The primary outcome was overall survival (OS). Multivariable regression and propensity score analysis were used to adjust for age, comorbi dity, and other characteristics.ResultsWe identified 2435 patients treated with NACRT and 648 patients treated with NAC...
Source: Gastric Cancer - January 1, 2020 Category: Gastroenterology Source Type: research

Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world
This study examined the adherence to the guidelines and the concordance of the pathological diagnosis of high-risk GISTs.Patients and methodsAmong 541 patients with high-risk GISTs recruited to the prospective registry between Dec. 2012 and Dec. 2015, 534 patients were analyzed after central pathology with KIT and DOG1 IHC and genotyping ofKIT andPDGFRA.ResultsOf the 534 patients, 432 (81%) received imatinib adjuvant therapy at a starting dose of 400 or 300  mg/day. Multivariate analysis indicated that age (HR 0.71; 95% CI 0.58–0.88), tumor size (HR for >  10 cm vs   10 vs 
Source: Gastric Cancer - January 1, 2020 Category: Gastroenterology Source Type: research

Peritoneal metastasis in gastric cancer: results from the German database
ConclusionsCRS and HIPEC in selected patients with gastric cancer and peritoneal spread can improve survival when they are treated in centers. An accurate staging and patient selection are of major importance to achieve long-term survival. (Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2020 Category: Gastroenterology Source Type: research

A genetic origin for acid –base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours
ConclusionsA genetic origin that drives mitochondria alteration would initiate the gastric chronic inflammation instead of the classical IL-17 secretion-mediated mechanism explanation. Gastric euchlorhydria restoration is suggested to be indicated for mitochondrial recover. Our results open a new window to understand gastric neoplasms formation but also the inflammatory mechanisms and autoimmune disorders conducted by genetic origin that composes a premalignant scenario. (Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2020 Category: Gastroenterology Source Type: research

A message from the new editor-in-chief
(Source: Gastric Cancer)
Source: Gastric Cancer - January 1, 2020 Category: Gastroenterology Source Type: research

A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data
AbstractBackgroundNivolumab showed improvement in overall survival (OS) in ATTRACTION-2, the first phase 3 study in patients with gastric/gastroesophageal junction (G/GEJ) cancer treated with  ≥ 2 chemotherapy regimens. The 2-year follow-up results of ATTRACTION-2 are presented herein.MethodsATTRACTION-2 was a randomized, double-blind, placebo-controlled, phase 3 trial (49 sites; Japan, South Korea, and Taiwan). The median (min –max) follow-up period was 27.3 (24.1–36.3) months. The primary endpoint was OS. A subanalysis of OS was performed based on best overall response and tumor-programm...
Source: Gastric Cancer - December 20, 2019 Category: Gastroenterology Source Type: research

eIF4EBP3 was downregulated by methylation and acted as a tumor suppressor by targeting eIF4E/ β-catenin in gastric cancer
ConclusionThese results suggest that eIF4EBP3 is a novel TSG methylated in gastric cancer that may play important roles in GC development and liver metastasis and indicate eIF4EBP3 as a potential metastasis and survival biomarker for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - December 18, 2019 Category: Gastroenterology Source Type: research

Diabetes mellitus is associated with an increased risk of gastric cancer: a cohort study
ConclusionsIn this large cohort with endoscopic follow-up, DM was independently associated with increased gastric cancer incidence. The increased risk was independent of mucosal atrophy and intestinal metaplasia and was consistent in participants with newly developed DM during follow-up. Patients with DM may require more intensive endoscopic follow-up for gastric cancer screening. (Source: Gastric Cancer)
Source: Gastric Cancer - December 18, 2019 Category: Gastroenterology Source Type: research

Economic impacts of care by high-volume providers for non-curative esophagogastric cancer: a population-based analysis
We examined the cost-effectiveness of care by high-volume medical oncology providers for non-curative management of EGC.MethodsWe conducted a population-based cohort study of non-curative EGC over 2005 –2017 by linking administrative datasets. High-volume was defined as ≥ 11 patients/provider/year. Healthcare costs ($USD/patient/month-survived) were computed from diagnosis to death or end of follow-up from the perspective of the healthcare system. Multivariable quantile regression examined the association between care by high-volume providers and costs. Sensitivity analyses were conducted by varying ...
Source: Gastric Cancer - December 13, 2019 Category: Gastroenterology Source Type: research

Correction to: Esophagogastric junction adenocarcinomas: individualization of resection with special considerations for Siewert type II, and Nishi types EG, E  = G and GE cancers
The authors would like to correct the error in the publication of the original article. The correction detail is given below: (Source: Gastric Cancer)
Source: Gastric Cancer - December 12, 2019 Category: Gastroenterology Source Type: research

CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p
ConclusionsCircDUSP16 facilitates the tumorigenesis and invasion of GC cells by sponging miR-145-5p, and may provide a novel therapeutic target for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - November 27, 2019 Category: Gastroenterology Source Type: research

Identification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer
ConclusionsWe present a molecular signature that can identify diffuse-type GC patients who display different clinical behaviors as well as responses to chemotherapy or ICI treatment. (Source: Gastric Cancer)
Source: Gastric Cancer - November 26, 2019 Category: Gastroenterology Source Type: research

Adherence with operative standards in the treatment of gastric cancer in the United States
AbstractBackgroundDespite multiple clinical trials and practice guidelines for the treatment of gastric cancer, oncologic outcomes have not improved in the United States. One potential reason could be differences in the quality of surgery as performed in a controlled trial versus in practice.MethodsUsing the National Cancer Database, rates of adherence with operative standards for gastrectomy for cancer were analyzed. Of the numerous evidence-based operative standards outlined in the manual, two were reliably measured in the NCDB: (1) achieving and R0 resection, and (2) having  >  16 lymph nodes examined. ...
Source: Gastric Cancer - November 19, 2019 Category: Gastroenterology Source Type: research

Correction to: Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways
Recently published the priming (Source: Gastric Cancer)
Source: Gastric Cancer - November 15, 2019 Category: Gastroenterology Source Type: research

Assessment of lymphatic flow based on the sentinel node concept in early gastric adenocarcinoma that satisfies expanded endoscopic resection criteria
ConclusionsPatients with intramucosal, nonulcerated, undifferentiated adenocarcinoma measuring 20  mm or less could develop a lymphatic network. For these patients, careful follow-up is required after ER. (Source: Gastric Cancer)
Source: Gastric Cancer - November 14, 2019 Category: Gastroenterology Source Type: research

Esophagogastric junction adenocarcinomas: individualization of resection with special considerations for Siewert type II, and Nishi types EG, E=G and GE cancers
AbstractFor Siewert type II adenocarcinoma of the esophagogastric junction (AEG II), or similar tumors classified as Nishi EG, E=G, GE, the type of surgical resection and reconstruction should be individualized. Criteria for decision making mainly focus on the oral extent of esophageal infiltration, the cT and cN category and the functional status of the patient. For cT1/cT2 adenocarcinomas, which are non-poorly cohesive, intestinal type of Lauren Grading 1 or 2 without clinical signs of lymph node metastasis at the distal stomach, a limited transhiatal proximal gastrectomy with double tract reconstruction is recommended. ...
Source: Gastric Cancer - November 6, 2019 Category: Gastroenterology Source Type: research

Combination of L1 methylation and tumor-infiltrating lymphocytes as prognostic marker in advanced gastric cancer
ConclusionsOur findings indicate that tumoral-L1-methylation level is correlated with TIL density and that combinatory statuses might help to find a subset of GCs with worse clinical outcome in GCs with low-L1-methylation status or a subset of GCs with better clinical outcome in GCs with high-L1-methylation status. (Source: Gastric Cancer)
Source: Gastric Cancer - November 5, 2019 Category: Gastroenterology Source Type: research

Gastrectomy case volume and textbook outcome: an analysis of the Population Registry of Esophageal and Stomach Tumours of Ontario (PRESTO)
ConclusionsHigher case volume can impact certain measures of quality of care but may not address all care structures necessary for ideal Textbook recovery. Future quality improvement strategies should consider using case-mix adjusted Textbook Outcome rates as a surgical quality metric. (Source: Gastric Cancer)
Source: Gastric Cancer - November 4, 2019 Category: Gastroenterology Source Type: research

Correction to: Developing real-world comparators for clinical trials in chemotherapy-refractory patients with gastric cancer or gastroesophageal junction cancer
ping real-world comparators for (Source: Gastric Cancer)
Source: Gastric Cancer - November 3, 2019 Category: Gastroenterology Source Type: research

Variation in receipt of therapy and survival with provider volume for medical oncology in non-curative esophago-gastric cancer: a population-based analysis
We examined receipt of therapy and outcomes in the non-curative management of EGC based on medical oncology provider volume.MethodsWe conducted a population based retrospective cohort study of non-curative EGC over 2005 –2017 by linking administrative healthcare datasets. The volume of new EGC consultations per medical oncology provider per year was calculated and divided into quintiles. High-volume (HV) medical oncologists were defined as the 4–5th quintiles. Outcomes were receipt of chemotherapy and overall s urvival (OS). Multivariate logistic and Cox-proportional hazards regressions examined the association...
Source: Gastric Cancer - October 18, 2019 Category: Gastroenterology Source Type: research

Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways
ConclusionEpigenetic priming with 5-aza-dC can improve the sensitivity of gastric cancer cells to SN38 and CDDP. (Source: Gastric Cancer)
Source: Gastric Cancer - September 25, 2019 Category: Gastroenterology Source Type: research

Risk factors for nonalcoholic fatty liver disease after gastrectomy for gastric cancer
This study aimed to identify the risk factors for NAFLD after gastrectomy for gastric cancer.MethodsA total of 721 patients who underwent gastrectomy for gastric cancer and plane abdominal computed tomography (CT) preoperatively and 1 year after surgery were included in this study. NAFLD was defined as having a mean hepatic CT attenuation value of  
Source: Gastric Cancer - September 25, 2019 Category: Gastroenterology Source Type: research

Developing real-world comparators for clinical trials in chemotherapy-refractory patients with gastric cancer or gastroesophageal junction cancer
ConclusionsWe successfully developed RW cohorts for comparison with data from clinical trials, with comparable baseline characteristics. Survival in US patients receiving RW care was similar to that seen in Asian patients receiving placebo in ATTRACTION-2; survival with nivolumab in CheckMate 032 appeared favorable compared with US RW clinical practice. (Source: Gastric Cancer)
Source: Gastric Cancer - September 23, 2019 Category: Gastroenterology Source Type: research

Different phenotypes of gastric fundic gland polyposis and cancer in patients with familial adenomatous polyposis depending on Helicobacter pylori infection
AbstractA 37-year-old male with tarry stool presented to our hospital. Esophagogastroduodenoscopy revealed advanced gastric cancer, fundic gland polyposis (FGPsis), and negativity forHelicobacter pylori (HP) infection. Computed tomography exhibited multiple liver tumors. Total colonoscopy (TCS) demonstrated 139 tubular adenomas. He was diagnosed as having unresectable gastric cancer and received systemic chemotherapy. His sister and mother had colorectal adenomatous polyposis as revealed by TCS. His sister had FGPsis and was negative forHP infection, whereas his mother had early gastric cancer withHP infection but not FGPs...
Source: Gastric Cancer - September 16, 2019 Category: Gastroenterology Source Type: research

The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma
ConclusionOur study expounded the facilitation of perilipin2 in regulating the proliferation and apoptosis of gastric carcinoma cells by modification in Ferroptosis pathway, and we interpreted that the mechanism of gastric neoplasm caused by obesity, we also discovered that pr/set domain 11 and importin 7 are novel transcription factors relevant to gastric carcinoma. Furthermore, perilipin2  probably serves not only as a diagnostic biomarker, but also a new therapeutic target. (Source: Gastric Cancer)
Source: Gastric Cancer - September 13, 2019 Category: Gastroenterology Source Type: research

Long-term outcomes of preoperative docetaxel with cisplatin plus S-1 therapy for gastric cancer with extensive nodal metastasis (JCOG1002)
ConclusionsAdding docetaxel to CS in preoperative chemotherapy for extensive nodal metastasis improved neither short-term outcomes nor long-term survival. Preoperative chemotherapy with CS followed by D2  + PAN dissection and postoperative S-1 remains the standard of care for patients with extensive nodal metastasis. (Source: Gastric Cancer)
Source: Gastric Cancer - September 12, 2019 Category: Gastroenterology Source Type: research

Is surgery alone sufficient for treating T1 gastric cancer with extensive lymph node metastases?
AbstractBackgroundWhether or not surgery alone is sufficient for treating patients with pathological stage T1N2M0 (Stage IIA), T1N3a/bM0 (Stage IIB/IIIB), and T3N0M0 (Stage IIA) gastric cancer who were not indicated for adjuvant treatment according to the Japanese gastric cancer treatment guideline remains unclear.MethodsWe retrospectively reviewed the clinical records of 236 patients who had been diagnosed with pT1N2-3b/pT3N0 gastric cancer and undergone R0 gastrectomy with lymph node dissection between January 2000 and December 2012 at the National Cancer Center Hospital, Japan.ResultsThe 5-year recurrence-free survival ...
Source: Gastric Cancer - September 11, 2019 Category: Gastroenterology Source Type: research

Feasibility of further expansion of the indications for endoscopic submucosal dissection in undifferentiated-type early gastric cancer
ConclusionsIntramucosal P-UD EGC patients with absence of ulcerative findings, absence of lymphatic invasion, absence of vascular invasion, and tumor diameters of  ≤ 40 mm did not show LNM. We suggest expanding indications for ESD to include these patients. (Source: Gastric Cancer)
Source: Gastric Cancer - September 5, 2019 Category: Gastroenterology Source Type: research

Significance of CT attenuation and F-18 fluorodeoxyglucose uptake of visceral adipose tissue for predicting survival in gastric cancer patients after curative surgical resection
AbstractBackgroundThe purpose of this study was to investigate the prognostic significance of computed tomography (CT) attenuation and F-18 fluorodeoxyglucose (FDG) uptake of visceral adipose tissue (VAT) to predict peritoneal recurrence-free survival (RFS) as well as RFS and overall survival (OS) in patients with advanced gastric cancer (AGC).MethodsWe retrospectively enrolled 117 patients with AGC who underwent staging FDG positron emission tomography (PET)/CT and subsequent curative surgical resection. CT attenuation and FDG uptake (SUV) of VAT and maximum FDG uptake of primary tumor (SUVmaxT) were measured from PET/CT ...
Source: Gastric Cancer - September 4, 2019 Category: Gastroenterology Source Type: research

Identification of the clinically most relevant postoperative complications after gastrectomy: a population-based cohort study
ConclusionSurgical improvement programs should focus on preventing or managing anastomotic leakage and pulmonary complications, since these complications have the greatest overall impact on clinical outcomes after gastrectomy. (Source: Gastric Cancer)
Source: Gastric Cancer - September 3, 2019 Category: Gastroenterology Source Type: research

DLX6-AS1/miR-204-5p/OCT1 positive feedback loop promotes tumor progression and epithelial –mesenchymal transition in gastric cancer
ConclusionsThis study revealed that OCT1-induced DLX6-AS1 promoted GC progression and the EMT via the miR-204-5p/OCT1 axis, suggesting that this lncRNA might be a promising prognostic biomarker and therapeutic target for GC. (Source: Gastric Cancer)
Source: Gastric Cancer - August 28, 2019 Category: Gastroenterology Source Type: research

Prognostic impacts of the combined positive score and the tumor proportion score for programmed death ligand-1 expression by double immunohistochemical staining in patients with advanced gastric cancer
This study aimed to elucidate the role of TPS and CPS as prognostic biomarkers.MethodsA total of 191 patients with GC who received curative gastrectomy were retrospectively enrolled. Double immunohistochemistry of PD-L1 and ionized calcium binding adaptor molecule 1 was performed to clearly distinguish PD-L1 expression between tumor cells and macrophages. Survival analysis for PD-L1 expression by TPS and CPS was performed.ResultsPD-L1 positivity was detected in 39 patients (20.4%) by TPS and in 137 patients (71.7%) by CPS. Patients with PD-L1 positivity by CPS experienced significantly shorter overall survival (OS) (P 
Source: Gastric Cancer - August 26, 2019 Category: Gastroenterology Source Type: research

Comment on: “Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features. Gastric Cancer, 2019: 1–10” by Wang et al.
(Source: Gastric Cancer)
Source: Gastric Cancer - August 23, 2019 Category: Gastroenterology Source Type: research

Serum levels of ANOS1 serve as a diagnostic biomarker of gastric cancer: a prospective multicenter observational study
AbstractBackgroundDevelopment of high-performance serum biomarkers will likely improve treatment outcomes of patients with gastric cancer (GC). We previously identified the candidate serum markers, anosmin 1 (ANOS1), dihydropyrimidinase-like 3 (DPYSL3), and melanoma-associated antigen D2 (MAGE-D2) and evaluated their clinical significance through a single-center retrospective analysis. Here we conducted a prospective multicenter observational study aimed at validating the diagnostic performance of these potential markers.MethodsWe analyzed serum levels before and after surgery of the three potential biomarkers in patients ...
Source: Gastric Cancer - August 3, 2019 Category: Gastroenterology Source Type: research

Conversion therapy for peritoneal lavage cytology-positive type 4 and large type 3 gastric cancer patients selected as candidates for R0 resection by diagnostic staging laparoscopy
ConclusionConversion therapy might be a promising treatment for P0CY1 type 4 and large type 3 gastric cancer patients. Re-SL was useful for selecting candidates for R0 resection. (Source: Gastric Cancer)
Source: Gastric Cancer - July 26, 2019 Category: Gastroenterology Source Type: research

Feasibility of laparoscopic gastrectomy for patients with poor physical status: a retrospective cohort study based on a nationwide registry database in Japan
AbstractBackgroundLaparoscopic gastrectomy (LG) is an established minimally invasive procedure for gastric cancer. However, it is controversial whether LG is useful for patients with poor physical status classified into higher classes of the American Society of Anesthesiologists physical status (ASA-PS) classification. The aim of this study was to determine the feasibility of LG in patients with ASA-PS class  ≥ 3.MethodsWe extracted data for a total of 28,160 patients with an ASA-PS class  ≥ 3 who underwent distal or total gastrectomy for gastric cancer between January 2013 and December 20...
Source: Gastric Cancer - July 22, 2019 Category: Gastroenterology Source Type: research

Convolutional neural network for the diagnosis of early gastric cancer based on magnifying narrow band imaging
ConclusionsOur CNN system showed high accuracy, sensitivity and specificity in the diagnosis of early gastric cancer. It is anticipated that more progress will be made in optimization of the CNN diagnostic system and further development of artificial intelligence in the medical field. (Source: Gastric Cancer)
Source: Gastric Cancer - July 22, 2019 Category: Gastroenterology Source Type: research

Factors associated with technical difficulty of endoscopic submucosal dissection for early gastric cancer that met the expanded indication criteria: post hoc analysis of a multi-institutional prospective confirmatory trial (JCOG0607)
AbstractBackgroundThere are few reports on the technical difficulty of gastric endoscopic submucosal dissection (ESD). The aim of this study was to investigate the factors associated with the technical difficulty of ESD for early gastric cancer (EGC) using the data from the multicenter non-randomized confirmatory trial of expanded indication criteria of ESD (JCOG0607).MethodsThe major inclusion criteria were as follows: (1) histologically proven intestinal-type adenocarcinoma; (2) cT1aN0M0; (3) lesion without finding of ulcer (UL-negative) with  >  2 cm in size, or UL-positive with ≤ ...
Source: Gastric Cancer - July 18, 2019 Category: Gastroenterology Source Type: research

Meta-analysis of two randomized phase III trials (TCOG GI-0801 and ECRIN TRICS) of biweekly irinotecan plus cisplatin versus irinotecan alone as second-line treatment for advanced gastric cancer
ConclusionsBoth BIRIP and CPT-11 may be good therapeutic options for patients with AGC as second-line treatment.Clinical trial registrationUMIN 000025367. (Source: Gastric Cancer)
Source: Gastric Cancer - July 15, 2019 Category: Gastroenterology Source Type: research