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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
Responses of porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses
Cell Signal. 2021 May 17:110047. doi: 10.1016/j.cellsig.2021.110047. Online ahead of print.ABSTRACTThe WNT (Wingless and Int-1) proteins play a role in stem cell development and cell differentiation. Mutations in the WNT proteins lead to the development of various tumours, including gastric tumours. Porcupine (PORCN) is a palmitoyltransferase and Wntless (WLS) is a chaperone protein that modify and fold the WNT proteins respectively and are involved in their proper secretion and binding to the frizzled (FZD) receptor and the lipoprotein receptor-related protein 5 or 6 (LRP5/6). We investigated how modifications of PORCN an...
Source: Cellular Signalling - May 20, 2021 Category: Cytology Authors: Rowida Mohamed Catherine Kennedy William G Willmore Source Type: research
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells
Acta Pharmacol Sin. 2021 May 12. doi: 10.1038/s41401-021-00672-x. Online ahead of print.ABSTRACTPrevious reports suggested that cinnamaldehyde (CA), the bioactive ingredient in Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities. However, the role and molecular mechanisms of CA in GC are not completely understood. In the present study, we found that CA-induced ER stress and cell death via the PERK-CHOP axis and Ca2+ release in GC cells. Inhibition of ER stress using specific-siRNA blocked CA-induced cell death. Interestingly, CA treatment resulted in autophagic cell death by inducing Beclin-1, A...
Source: Acta Pharmacologica Sinica - May 13, 2021 Category: Drugs & Pharmacology Authors: Tae Woo Kim Source Type: research
SPARC enhances 5-FU chemosensitivity in gastric cancer by modulating epithelial-mesenchymal transition and apoptosis
Biochem Biophys Res Commun. 2021 Apr 25;558:134-140. doi: 10.1016/j.bbrc.2021.04.009. Online ahead of print.ABSTRACTPrevious studies have shown that secreted protein acidic and rich in cysteine (SPARC) proteins can inhibit the development of cancer cells in various ways, such as by inhibiting angiogenesis and inhibiting cell proliferation. In fact, SPARC proteins may have an effect on the chemoresistance of gastric cancer cells to 5-Fluorouracil (5-FU), which needs further research in the future. Therefore, the purpose of this study was to explore the relationship between SPARC proteins and the chemosensitivity of gastric ...
Source: Biochemical and Biophysical Research communications - April 28, 2021 Category: Biochemistry Authors: Ju Ma Yongchen Ma Shanwen Chen Shihao Guo Jianwen Hu Taohua Yue Junling Zhang Jing Zhu Pengyuan Wang Guowei Chen Yucun Liu Source Type: research
LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway
ConclusionsThe present results indicate that LRRC8A functions as a mediator of and/or biomarker for GC.
Source: Gastric Cancer - April 16, 2021 Category: Gastroenterology Source Type: research
ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research
