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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling
This study investigated the pathogenic role and mechanism of ARHGEF10L in cervical tumors.METHODS: The HeLa cell line, which was derived from cervical carcinoma, was transfected with ARHGEF10L-overexpressing plasmids or anti-ARHGEF10L siRNA. Cell counting kit-8 assays, wound-healing assays, and cell apoptosis assays were performed to investigate the effects of ARHGEF10L on cell activities. A Rho pull-down assay and RNA-sequencing analysis were performed to investigate the pathogenic pathway of ARHGEF10L involvement in cervical tumors.RESULTS: ARHGEF10L overexpression promoted cell proliferation and migration, reduced cell ...
Source: Evidence-based Complementary and Alternative Medicine - April 9, 2021 Category: Complementary Medicine Authors: Junyi Tang Kehua Fang Chang Li Xiaotian Chang Source Type: research
BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation
This study aimed to explore the expression of BOP1 in GC and its potential mechanisms in regulating GC growth, and the relationship between BOP1 level in cancer tissues and survival was also analyzed. The expression of BOP1 was examined by immunohistochemistry (IHC) in a cohort containing 387 patients with primary GC. Cultured GC cells were treated by siRNA to knock down the BOP1 expression, and examined by CCK-8 assay and plate clone formation to assess cell proliferationin vitro. Apoptotic rate of cultured GC cells was detected by flow cytometry with double staining of AnnxinV/PI. The xenografted mouse model was used to ...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 1, 2021 Category: Research Source Type: research
GSE163164 Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down
Contributors : B DIVYA ; G KUMARESANSeries Type : Expression profiling by arrayOrganism : Homo sapiensYin Yang 1 (YY1) is a ubiquitous transcription factor belonging to the GLI-Kruppel class of zinc finger proteins regulating diverse biological processes including cell proliferation, development, DNA damage responses and also involved in carcinogenesis. The protein is involved in repressing and activating a diverse number of promoters.In order to study the role of the transcription factor YY1 in gastric cancer, transcriptome wide gene expression analysis was performed upon silencing the YY1 gene in gastric cancer cell line...
Source: GEO: Gene Expression Omnibus - March 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
IL ‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway
In conclusion, it was found that ST2 was highly expressed in GC tissues. IL‑33/ST2 promoted the malignant progression of GC cells by inducing the activation of ERK1/2, JNK and p38.PMID:33760194 | DOI:10.3892/mmr.2021.12000
Source: Molecular Medicine Reports - March 24, 2021 Category: Molecular Biology Authors: Ning Huang Xing Cui Wen Li Chunlai Zhang Liqing Liu Jinxing Li Source Type: research
lncRNA OGFRP1 promotes tumor progression by activating the AKT/mTOR pathway in human gastric cancer
Aging (Albany NY). 2021 Mar 19;13. doi: 10.18632/aging.202731. Online ahead of print.ABSTRACTAs biomolecules of great clinical value, lncRNAs play a crucial role as regulators in the processes of tumor origin, metastasis, and recurrence. Thus, lncRNAs are urgently needed for research in gastric cancer. We elucidated the specific function of OGFRP1, both in vitro and in vivo. OGFRP1 was expressed at abnormally high levels in gastric cancer samples (n = 408) compared to normal samples (n = 211). Similar results were obtained in 30 clinical case samples. Interference of OGFRP1 markedly blocked cell proliferation and migration...
Source: Aging - March 21, 2021 Category: Biomedical Science Authors: Jingzhou Zhang Xiujuan Xu Junfeng Yin Jiaqi Tang Nan Hu Yidong Hong Ziyan Song Baoxiang Bian Fenglei Wu Source Type: research
Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXR α Axis and Deactivating the Wnt/β-Catenin Pathway
Cell Transplant. 2021 Jan-Dec;30:963689721996346. doi: 10.1177/0963689721996346.ABSTRACTX-linked ectodermal dysplasia receptor (XEDAR) is a new member of the tumor necrosis factor receptor (TNFR) family that induces cell death. The purpose of this study is to determine the tumor-suppressive potential of XEDAR in the development and differentiation of gastric cancer (GC). XEDAR levels were analyzed in human GC tissues and adjacent normal tissues by immunohistochemistry (IHC), quantitative real-time reverse transcription PCR (RT-qPCR), and Western blot analysis. We found that XEDAR expression was significantly downregulated ...
Source: Cell Transplantation - February 27, 2021 Category: Cytology Authors: Xinwu Zhang Di Zhang Xiaoli Sun Shunle Li Yun Sun Hongjun Zhai Source Type: research
