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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
HER2 promotes epithelial-mesenchymal transition through regulating osteopontin in gastric cancer
CONCLUSIONS: These findings indicate that HER2 may promote EMT via the regulation of OPN in GCs.PMID:34634565 | DOI:10.1016/j.prp.2021.153643
Source: Pathology, Research and Practice - October 11, 2021 Category: Pathology Authors: Yalan Liu Lingli Chen Dongxian Jiang Lijuan Luan Jie Huang Yingyong Hou Chen Xu Source Type: research
The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer
ConclusionsATP1A1 appears to regulate tumor progression by altering IFN signaling, and high ATP1A1 expression levels were associated with poor postoperative survival in GC patients. The present results provide novel insights into the function of ATP1A1 as a mediator and/or biomarker of GC.
Source: Gastric Cancer - October 11, 2021 Category: Gastroenterology Source Type: research
Astaxanthin induces NADPH oxidase activation and receptor ‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells
In conclusion, ASX induced necroptotic cell death by increasing NADPH oxidase activity, ROS levels, LDH release and the number of propidium iodide‑positive cells, as well as activating necroptosis‑regulating proteins, RIP1/RIP3/MLKL, in gastric cancer AGS cells. The results of this study demonstrated the necroptotic effect of ASX on gastric cancer AGS cells, which required NADPH oxidase activation and RIP1/RIP3/MLKL signaling in vitro.PMID:34608499 | DOI:10.3892/mmr.2021.12477
Source: Molecular Medicine Reports - October 5, 2021 Category: Molecular Biology Authors: Sori Kim Hanbit Lee Joo Weon Lim Hyeyoung Kim Source Type: research
Circular RNA circNF1 siRNA Silencing Inhibits Glioblastoma Cell Proliferation by Promoting the Maturation of miR-340
This study aimed to analyze the role of circNF1 in glioblastoma (GBM). The expression of circNF1, mature miR-340, and miR-340 precursor in paired GBM and non-cancer tissues from GBM patients (n = 50) was analyzed by RT-qPCR. GBM cells were transfected with circNF1 siRNA, followed by the analysis of the expression of mature miR-340 and miR-340 precursor, to study the effects of circNF1 knockdown on the maturation of miR-340. The CCK-8 assay was carried out to explore the role of circNF1 and miR-340 in the proliferation of GBM cells. circNF1 expression was found to be upregulated in GBM and was correlated with patient surviv...
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming
Acta Pharmacol Sin. 2021 Aug 30. doi: 10.1038/s41401-021-00750-0. Online ahead of print.ABSTRACTHelichrysetin (HEL), a chalcone isolated from Alpinia katsumadai Hayata, has an antitumor activity in human lung and cervical cancers. However, the inhibitory effect and underlying mechanism of HEL in gastric cancer have not been elucidated. Here, HEL significantly inhibited the growth of gastric cancer MGC803 cells in vitro and in vivo. HEL decreased expression and transcriptional regulatory activity of c-Myc and mRNA expression of c-Myc target genes. HEL enhanced mitochondrial oxidative phosphorylation (OXPHOS) and reduced gly...
Source: Acta Pharmacologica Sinica - August 31, 2021 Category: Drugs & Pharmacology Authors: Ping Wang Jin-Mei Jin Xiao-Hui Liang Ming-Zhu Yu Chun Yang Fei Huang Hui Wu Bei-Bei Zhang Xiao-Yan Fei Zheng-Tao Wang Ren Xu Hai-Lian Shi Xiao-Jun Wu Source Type: research
Effect and mechanism of action of SLP-2 on the apoptosis and autophagy of gastric cancer cells
In conclusion, SLP-2 silencing can inhibit proliferation and induce apoptosis and autophagy of gastric cancer cells, and this effect may be related to the inhibition of ANXA2/β-catenin signaling pathway.PMID:34457062 | PMC:PMC8358623 | DOI:10.3892/ol.2021.12968
Source: Oncology Letters - August 30, 2021 Category: Cancer & Oncology Authors: Shengsen Yang Yun Huang Hongyan Zhang Fang Wang Liangui Shao Xuehong Wang Source Type: research
