Astaxanthin induces NADPH oxidase activation and receptor ‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells

In conclusion, ASX induced necroptotic cell death by increasing NADPH oxidase activity, ROS levels, LDH release and the number of propidium iodide‑positive cells, as well as activating necroptosis‑regulating proteins, RIP1/RIP3/MLKL, in gastric cancer AGS cells. The results of this study demonstrated the necroptotic effect of ASX on gastric cancer AGS cells, which required NADPH oxidase activation and RIP1/RIP3/MLKL signaling in vitro.PMID:34608499 | DOI:10.3892/mmr.2021.12477
Source: Molecular Medicine Reports - Category: Molecular Biology Authors: Source Type: research