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Cancer: Gastric (Stomach) Cancer
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Total 1410 results found since Jan 2013.
Functions and Clinical Significance of CACNA2D1 in Gastric Cancer
CONCLUSIONS: The present study indicates that CACNA2D1 regulates the apoptosis signaling pathway and may have potential as a biomarker for cancer growth and as a therapeutic target for GC.PMID:35445337 | DOI:10.1245/s10434-022-11752-5
Source: Ann Oncol - April 21, 2022 Category: Cancer & Oncology Authors: Hiroyuki Inoue Atsushi Shiozaki Toshiyuki Kosuga Hiroki Shimizu Michihiro Kudou Takuma Ohashi Tomohiro Arita Hirotaka Konishi Shuhei Komatsu Takeshi Kubota Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eiichi Konishi Eigo Otsuji Source Type: research
Polymorphisms of an oncogenic gene, mesothelin, predict the risk and prognosis of gastric cancer in a Chinese Han population
This study aims to explore the biological function of MSLN in gastric cancer and to evaluate the association of MSLN polymorphism (rs3764247, rs3764246, rs12597489, rs1057147, rs3765319) with the risk and prognosis of gastric cancer. Small interfering RNA (siRNA) transfection and MSLN overexpression were performed in human gastric cancer cell lines, respectively. The proliferation of tumor cells was evaluated by Cell counting kit 8(CCK-8) and colony formation assay. Wound healing assay and transwell assay were used to elucidate gastric cancer cell migration and invasion rates. We conducted a case-control study involving 86...
Source: Cancer Control - April 9, 2022 Category: Cancer & Oncology Authors: Kuan Shen Kanghui Liu Yuanhang Wang Peidong Ni Jian Xiao Fan Hao Xinyi Zhou Zekuan Xu Li Yang Source Type: research
Disruption of the CCDC43-FHL1 interaction triggers apoptosis in gastric cancer cells
Exp Cell Res. 2022 Mar 16:113107. doi: 10.1016/j.yexcr.2022.113107. Online ahead of print.ABSTRACTThe coiled-coil domain-containing protein 43 (CCDC43) is essential to promote gastric cancer (GC) proliferation and invasion, while four and a half LIM domains 1 (FHL1) involves GC cells apoptosis. We attempted to address inter-relationship between CCDC43 and FHL1 in modulating GC cells growth and apoptosis. Levels of protein expression were assessed by western blot, immunofluorescence. Using EdU, plate colony formation, Matrigel invasion and animal models, we evaluated the function in vitro and in vivo. Apoptosis was evaluate...
Source: Experimental Cell Research - March 20, 2022 Category: Cytology Authors: Yaying Chen Miaomiao Pei Jiaying Li Zhi Wang Side Liu Li Xiang Jieming Zhang Linjie Hong Jianjiao Lin Weiyu Dai Yizhi Xiao Hongsong Hu Weimei Tang Guangnan Liu Qiong Yang Zhizhao Lin Xiaoling Jiang Yusi Wang Xiaosheng Wu Zheng Guo Jide Wang Source Type: research
EBV-Induced CXCL8 Upregulation Promotes Vasculogenic Mimicry in Gastric Carcinoma via NF- κB Signaling
In conclusion, EBV-upregulated CXCL8 expression promotes VM formation in GC via NF-κB signaling, and CXCL8 might serve as a novel anti-tumor target for EBVaGC.
Source: Frontiers in cellular and infection microbiology - March 7, 2022 Category: Microbiology Source Type: research
The E3 Ubiquitin Ligase TRIM11 Facilitates Gastric Cancer Progression by Activating the Wnt/ < em > β < /em > -Catenin Pathway via Destabilizing Axin1 Protein
CONCLUSION: Collectively, our findings not only establish a pivotal TRIM11-Axin1-β-catenin axis in driving GC progression but also indicate that TRIM11 serves as a valuable therapeutic target for the treatment of GC patients.PMID:35237324 | PMC:PMC8885197 | DOI:10.1155/2022/8264059
Source: Journal of Oncology - March 3, 2022 Category: Cancer & Oncology Authors: Ling Zhou Heng Wang Min Zhong Zhi Fang Yi Le Fengting Nie Juanjuan Zhou Jianping Xiong Xiaojun Xiang Ziling Fang Source Type: research
Metformin is a Novel Suppressor for Vimentin in Human Gastric Cancer Cell Line
In this study, AGS gastric cancer cells were treated with metformin and vimentin-specific siRNA (vim-siRNA) for 48 h. The impact of metformin and vim-siRNA on vimentin downregulation in AGS cells were analyzed by quantitative PCR and Western blot. Following treatment with metformin and vim-siRNA, cell motility, migration and invasion abilities of AGS cells were also analyzed. The results showed that inhibition of vimentin due to metformin was comparable with the vim-siRNA. Furthermore, wound-healing and invasion assays showed a significant decrease in migration and invasion of AGS cells following metformin and vim-siRNA tr...
Source: Cancer Control - February 18, 2022 Category: Cancer & Oncology Authors: Shiva Valaee Mehdi Shamsara Mohammad Mehdi Yaghoobi Source Type: research
ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway
Conclusionω-6 PUFAs reinforce the metastatic potential of gastric cancer cells via COX-2/PGE2; ω-3 PUFAs inhibit the metastatic potential of gastric cancer via COX-1/PGE3 signaling axis.
Source: Frontiers in Oncology - February 17, 2022 Category: Cancer & Oncology Source Type: research
GSE196262 DUB1 suppresses Hippo signaling via modulating TAZ protein in gastric cancer
Contributors : Dehai Wang ; Yinlu Ding ; Jian Zhu ; Peng SuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe Hippo pathway functions as a tumor-suppressor pathway in human cancers, while the dys-function of Hippo pathway is frequently observed in malignancies. Although the YAP/TAZ activity is tightly controlled by the phosphorylation cascade of MST-LATS-YAP/TAZ axis, it is still unclear why YAP/TAZ protein is activated in human cancers, even Hippo pathway is still active. Besides phosphorylation, recent studies implicate that several post-translational modifications also play critic...
Source: GEO: Gene Expression Omnibus - February 12, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Overexpression of DAPK1-mediated inhibition of IKKbeta/CSN5/PD-L1 axis enhances natural killer cell killing ability and inhibits tumor immune evasion in gastric cancer
Cell Immunol. 2021 Dec 10;372:104469. doi: 10.1016/j.cellimm.2021.104469. Online ahead of print.ABSTRACTGastric cancer (GC) originates from the stomach and is a prevalent human malignancy. Dysfunction of death associated protein kinase 1 (DAPK1) has been identified as a major regulator involved in the development and progression of GC. However, there's limited data regarding the regulatory mechanism of GC. Herein, we investigated role of DAPK1 in natural killer (NK) cell killing ability and immune evasion of GC cells and mediated pathway. Samples from GC-related gene expression profile and clinical samples from 67 patients...
Source: Cellular Immunology - February 3, 2022 Category: Allergy & Immunology Authors: Zhiyuan Guo Cheng Zhou Linsen Zhou Zhiqiang Wang Xinguo Zhu Xiangming Mu Source Type: research
