Silence of URI in gastric cancer cells promotes cisplatin-induced DNA damage and apoptosis

In conclusion, our results suggest that URI is involved in the cisplatin-induced DNA damage response via the ATM/CHK2 pathway, and silencing URI can increase cisplatin-induced DNA damage and enhance drug sensitivity in gastric cancer cells.PMID:37034221 | PMC:PMC10077030

Source: Cell Research - April 10, 2023 Category: Cytology Authors: Huiqin Bian Yu Gu Chen Chen Jinnan Chen Fei Zhang Zhonghai Xu Qian Wang Rui Mi Xuan Wu Yaojuan Lu Qiping Zheng Junxia Gu Source Type: research