LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research

Effects of human collagen α-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts
BMB Rep. 2021 Jun 3:5324. Online ahead of print.ABSTRACTCollagen type I is the most abundant form of collagen in human tissues, and is composed of two identical α-1 type I chains and an α-2 type I chain organized in a triple helical structure. A previous study has shown that human collagen α-2 type I (hCOL1A2) promotes collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). However, the biological effects of human collagen α-1 type I (hCOL1A1) on various skin properties have not been investigated. Here, we isolate and identify the hCOL1A1-collagen effecti...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Su Jin Hwang Su Hwan Kim Woo-Young Seo Yelin Jeong Min Cheol Shin Dongryeol Ryu Sang Bae Lee Young Jin Choi KyeongJin Kim Source Type: research

The role of NUMB/ NUMB isoforms in cancer stem cells
BMB Rep. 2021 Jun 3:5340. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss o...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Hye Yeon Choi Jaekwon Seok Geun-Ho Kang Kyung Min Lim Ssang-Goo Cho Source Type: research

Porphyromonas gingivalis exacerbates the progression of fatty liver disease via CD36-PPAR γ pathway
In conclusion, our results indicate that P. gingivalis can induce the progression of fatty liver disease in HFD-fed mice through the upregulation of CD36-PPARγ axis.PMID:34078528 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Ji-Su Ahn Ji Won Yang Su-Jeong Oh Ye Young Shin Min-Jung Kang Hae Ryoun Park Yoojin Seo Hyung-Sik Kim Source Type: research

Proprioception, the regulator of motor function
BMB Rep. 2021 Jun 3:5344. Online ahead of print.ABSTRACTIn animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive ne...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Kyeong Min Moon Jimin Kim Yurim Seong Byunchang Suh KyeongJin Kang Han Kyoung Choe Kyuhyung Kim Source Type: research

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation
In this study, we present a novel mechanism for RPT, as an arginase inhibitor, to increase cytosolic Ca2+ concentration in a L-Arg-dependent manner and enhance endothelial function through eNOS activation.PMID:34078530 (Source: BMB Reports)
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Bon-Hyeock Koo Jonghoon Lee Younghyun Jin Hyun Kyo Lim Sungwoo Ryoo Source Type: research

Perspectives on Immune Checkpoint Ligands: Expression, Regulation, and Clinical Implications
BMB Rep. 2021 Jun 3:5347. Online ahead of print.ABSTRACTIn the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of I...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jihyun Moon Yoo Min Oh Sang-Jun Ha Source Type: research

LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice
This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112...
Source: BMB Reports - June 3, 2021 Category: Biochemistry Authors: Jiyeong Jeong Chaeyoon Oh Jiwon Kim Chul-Gyu Yoo Keun Il Kim Source Type: research