Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody
In conclusion, our study suggests that cell surface GRP94 may be a potential therapeutic target in GC, and that antibody-based targeting of cell surface GRP94 may be an effective strategy for inhibiting GRP94-mediated GC growth and angiogenesis.PMID:38449302 (Source: BMB Reports)
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Hyun Jung Kim Yea Bin Cho Kyun Heo Ji Woong Kim Ha Gyeong Shin Eun-Bi Lee Seong-Min Park Jong Bae Park Sukmook Lee Source Type: research
Mitofusin-2 enhances cervical cancer progression through Wnt/ β-catenin signaling
BMB Rep. 2024 Mar 7:6097. Online ahead of print.ABSTRACTOverexpression of mitofusin-2 (MFN2), a mitochondrial fusion protein, is frequently associated with poor prognosis in cervical cancer patients. Here, I aimed to investigate the involvement of MFN2 in cervical cancer progression and determine the effect of MFN2 on prognosis in cervical cancer patients. After generating MFN2-knockdown SiHa cells derived from squamous cell carcinoma, I investigated the effect of MFN2 on SiHa cell proliferation using the Cell Counting Kit-8 assay and determined the mRNA levels of proliferation markers. Colony-forming ability and tumorigen...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sung Yong Ahn Source Type: research
Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types
BMB Rep. 2024 Mar 7:6157. Online ahead of print.ABSTRACTWhole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and progn...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Eunhyong Chang Joon-Yong An Source Type: research
Detecting DNA hydroxymethylation: exploring its role in genome regulation
BMB Rep. 2024 Mar 7:6164. Online ahead of print.ABSTRACTDNA methylation is one of the most extensively studied epigenetic regulatory mechanisms, known to play crucial roles in various organisms. It has been implicated in the regulation of gene expression and chromatin changes, ranging from global alterations during cell state transitions to locus-specific modifications. 5-hydroxymethylcytosine (5hmC) is produced by a major oxidation, from 5-methylcytosine (5mC), catalyzed by the ten eleven translocation (TET) enzymes, and is gradually being recognized for its significant role in genome regulation. With the development of s...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sun-Min Lee Source Type: research
Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody
In conclusion, our study suggests that cell surface GRP94 may be a potential therapeutic target in GC, and that antibody-based targeting of cell surface GRP94 may be an effective strategy for inhibiting GRP94-mediated GC growth and angiogenesis.PMID:38449302 (Source: BMB Reports)
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Hyun Jung Kim Yea Bin Cho Kyun Heo Ji Woong Kim Ha Gyeong Shin Eun-Bi Lee Seong-Min Park Jong Bae Park Sukmook Lee Source Type: research
Mitofusin-2 enhances cervical cancer progression through Wnt/ β-catenin signaling
BMB Rep. 2024 Mar 7:6097. Online ahead of print.ABSTRACTOverexpression of mitofusin-2 (MFN2), a mitochondrial fusion protein, is frequently associated with poor prognosis in cervical cancer patients. Here, I aimed to investigate the involvement of MFN2 in cervical cancer progression and determine the effect of MFN2 on prognosis in cervical cancer patients. After generating MFN2-knockdown SiHa cells derived from squamous cell carcinoma, I investigated the effect of MFN2 on SiHa cell proliferation using the Cell Counting Kit-8 assay and determined the mRNA levels of proliferation markers. Colony-forming ability and tumorigen...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sung Yong Ahn Source Type: research
Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types
BMB Rep. 2024 Mar 7:6157. Online ahead of print.ABSTRACTWhole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and progn...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Eunhyong Chang Joon-Yong An Source Type: research
Detecting DNA hydroxymethylation: exploring its role in genome regulation
BMB Rep. 2024 Mar 7:6164. Online ahead of print.ABSTRACTDNA methylation is one of the most extensively studied epigenetic regulatory mechanisms, known to play crucial roles in various organisms. It has been implicated in the regulation of gene expression and chromatin changes, ranging from global alterations during cell state transitions to locus-specific modifications. 5-hydroxymethylcytosine (5hmC) is produced by a major oxidation, from 5-methylcytosine (5mC), catalyzed by the ten eleven translocation (TET) enzymes, and is gradually being recognized for its significant role in genome regulation. With the development of s...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sun-Min Lee Source Type: research
Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody
In conclusion, our study suggests that cell surface GRP94 may be a potential therapeutic target in GC, and that antibody-based targeting of cell surface GRP94 may be an effective strategy for inhibiting GRP94-mediated GC growth and angiogenesis.PMID:38449302 (Source: BMB Reports)
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Hyun Jung Kim Yea Bin Cho Kyun Heo Ji Woong Kim Ha Gyeong Shin Eun-Bi Lee Seong-Min Park Jong Bae Park Sukmook Lee Source Type: research
Mitofusin-2 enhances cervical cancer progression through Wnt/ β-catenin signaling
BMB Rep. 2024 Mar 7:6097. Online ahead of print.ABSTRACTOverexpression of mitofusin-2 (MFN2), a mitochondrial fusion protein, is frequently associated with poor prognosis in cervical cancer patients. Here, I aimed to investigate the involvement of MFN2 in cervical cancer progression and determine the effect of MFN2 on prognosis in cervical cancer patients. After generating MFN2-knockdown SiHa cells derived from squamous cell carcinoma, I investigated the effect of MFN2 on SiHa cell proliferation using the Cell Counting Kit-8 assay and determined the mRNA levels of proliferation markers. Colony-forming ability and tumorigen...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sung Yong Ahn Source Type: research
Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types
BMB Rep. 2024 Mar 7:6157. Online ahead of print.ABSTRACTWhole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and progn...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Eunhyong Chang Joon-Yong An Source Type: research
Detecting DNA hydroxymethylation: exploring its role in genome regulation
BMB Rep. 2024 Mar 7:6164. Online ahead of print.ABSTRACTDNA methylation is one of the most extensively studied epigenetic regulatory mechanisms, known to play crucial roles in various organisms. It has been implicated in the regulation of gene expression and chromatin changes, ranging from global alterations during cell state transitions to locus-specific modifications. 5-hydroxymethylcytosine (5hmC) is produced by a major oxidation, from 5-methylcytosine (5mC), catalyzed by the ten eleven translocation (TET) enzymes, and is gradually being recognized for its significant role in genome regulation. With the development of s...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sun-Min Lee Source Type: research
Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody
In conclusion, our study suggests that cell surface GRP94 may be a potential therapeutic target in GC, and that antibody-based targeting of cell surface GRP94 may be an effective strategy for inhibiting GRP94-mediated GC growth and angiogenesis.PMID:38449302 (Source: BMB Reports)
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Hyun Jung Kim Yea Bin Cho Kyun Heo Ji Woong Kim Ha Gyeong Shin Eun-Bi Lee Seong-Min Park Jong Bae Park Sukmook Lee Source Type: research
Mitofusin-2 enhances cervical cancer progression through Wnt/ β-catenin signaling
BMB Rep. 2024 Mar 7:6097. Online ahead of print.ABSTRACTOverexpression of mitofusin-2 (MFN2), a mitochondrial fusion protein, is frequently associated with poor prognosis in cervical cancer patients. Here, I aimed to investigate the involvement of MFN2 in cervical cancer progression and determine the effect of MFN2 on prognosis in cervical cancer patients. After generating MFN2-knockdown SiHa cells derived from squamous cell carcinoma, I investigated the effect of MFN2 on SiHa cell proliferation using the Cell Counting Kit-8 assay and determined the mRNA levels of proliferation markers. Colony-forming ability and tumorigen...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Sung Yong Ahn Source Type: research
Whole-genome doubling is a double-edged sword: the heterogeneous role of whole-genome doubling in various cancer types
BMB Rep. 2024 Mar 7:6157. Online ahead of print.ABSTRACTWhole-genome doubling (WGD), characterized by the duplication of an entire set of chromosomes, is commonly observed in various tumors, occurring in approximately 30-40% of patients with different cancer types. The effect of WGD on tumorigenesis varies depending on the context, either promoting or suppressing tumor progression. Recent advances in genomic technologies and large-scale clinical investigations have led to the identification of the complex patterns of genomic alterations underlying WGD and their functional consequences on tumorigenesis progression and progn...
Source: BMB Reports - March 7, 2024 Category: Biochemistry Authors: Eunhyong Chang Joon-Yong An Source Type: research
