Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
Triamcinolone acetonide alleviates benign biliary stricture by ameliorating biliary fibrosis and inflammation
BMB Rep. 2024 Mar 25:6139. Online ahead of print.ABSTRACTWe conducted a comprehensive series of molecular biological studies aimed at unraveling the intricate mechanisms underlying the anti-fibrotic effects of triamcinolone acetonide (TA) when used in conjunction with fully covered self-expandable metal stents (FCSEMS) for the management of benign biliary strictures (BBS). To decipher the molecular mechanisms responsible for the anti-fibrotic effects of corticosteroids on gallbladder mucosa, we conducted a comprehensive analysis. This analysis included various methodologies such as immunohistochemistry, ELISA, real-time PC...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Seyeon Joo See Young Joo Su Yeon Lee Yeseong Hwang Minki Kim Jae Woong Jeong Sung Ill Jang Sungsoon Fang Source Type: research
CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma
BMB Rep. 2024 Mar 25:6113. Online ahead of print.ABSTRACTHepatocellular Carcinoma (HCC), the predominant primary hepatic malignancy, is the prime contributor to mortality. Despite the availability of multiple surgical interventions, patient outcomes remain suboptimal. Immunotherapies have emerged as effective strategies for HCC treatment with multiple clinical advantages. However, their curative efficacy is not always satisfactory, limited by the dysfunctional T cell status. Thus, there is a pressing need to discover novel potential biomarkers indicative of T cell exhaustion (Tex) for personalized immunotherapies. One prom...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Shibo Wei Yan Zhang Baeki E Kang Wonyoung Park He Guo Seungyoon Nam Jong-Sun Kang Jee-Heon Jeong Yunju Jo Dongryeol Ryu Yikun Jiang Ki-Tae Ha Source Type: research
The contribution of the nervous system in the cancer progression
BMB Rep. 2024 Mar 25:6191. Online ahead of print.ABSTRACTCancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are ass...
Source: BMB Reports - March 25, 2024 Category: Biochemistry Authors: Hongryeol Park Chan Hee Lee Source Type: research
