Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies
CONCLUSION: In summary, this study outlines a potential source of toxicity for PLB due to the powerful enhancement of XO activity, which may provide the crucial reminding for the PLB-containing preparation development and clinical application.PMID:34274011 | PMC:PMC8286619 | DOI:10.1186/s40360-021-00511-z (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 18, 2021 Category: Drugs & Pharmacology Authors: Liang Yue Nan Jiang Anguo Wu Wenqiao Qiu Xin Shen Dalian Qin Hong Li Jing Lin Sicheng Liang Jianming Wu Source Type: research

Plumbagin can potently enhance the activity of xanthine oxidase: in vitro, in vivo and in silico studies
CONCLUSION: In summary, this study outlines a potential source of toxicity for PLB due to the powerful enhancement of XO activity, which may provide the crucial reminding for the PLB-containing preparation development and clinical application.PMID:34274011 | DOI:10.1186/s40360-021-00511-z (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 18, 2021 Category: Drugs & Pharmacology Authors: Liang Yue Nan Jiang Anguo Wu Wenqiao Qiu Xin Shen Dalian Qin Hong Li Jing Lin Sicheng Liang Jianming Wu Source Type: research

Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence
CONCLUSION: The study provides the evidence of cardioprotective potentials of esculetin against isoproterenol induced myocardial infarction by antioxidant and myocardial membrane stabilization along with in vitro protection from arsenic induced ROS cell necrosis or apoptosis in H9C2 cells.PMID:34266475 | PMC:PMC8281642 | DOI:10.1186/s40360-021-00510-0 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Chitikela P Pullaiah Vinod K Nelson Sushma Rayapu Narasimha Kumar G V Thyagaraju Kedam Source Type: research

Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
CONCLUSION: These findings revealed a critical role of Rabeprazole in cell pyroptosis in patients with H. pylori infection, suggesting that targeting cell pyroptosis is an alternative strategy in improving H. pylori treatment.PMID:34266494 | DOI:10.1186/s40360-021-00509-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Jing Xie Long Fan Liya Xiong Peiyu Chen Hongli Wang Huan Chen Junhong Zhao Zhaohui Xu Lanlan Geng Wanfu Xu Sitang Gong Source Type: research

Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence
CONCLUSION: The study provides the evidence of cardioprotective potentials of esculetin against isoproterenol induced myocardial infarction by antioxidant and myocardial membrane stabilization along with in vitro protection from arsenic induced ROS cell necrosis or apoptosis in H9C2 cells.PMID:34266475 | DOI:10.1186/s40360-021-00510-0 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Chitikela P Pullaiah Vinod K Nelson Sushma Rayapu Narasimha Kumar G V Thyagaraju Kedam Source Type: research

Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
CONCLUSION: These findings revealed a critical role of Rabeprazole in cell pyroptosis in patients with H. pylori infection, suggesting that targeting cell pyroptosis is an alternative strategy in improving H. pylori treatment.PMID:34266494 | DOI:10.1186/s40360-021-00509-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Jing Xie Long Fan Liya Xiong Peiyu Chen Hongli Wang Huan Chen Junhong Zhao Zhaohui Xu Lanlan Geng Wanfu Xu Sitang Gong Source Type: research

Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence
CONCLUSION: The study provides the evidence of cardioprotective potentials of esculetin against isoproterenol induced myocardial infarction by antioxidant and myocardial membrane stabilization along with in vitro protection from arsenic induced ROS cell necrosis or apoptosis in H9C2 cells.PMID:34266475 | DOI:10.1186/s40360-021-00510-0 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Chitikela P Pullaiah Vinod K Nelson Sushma Rayapu Narasimha Kumar G V Thyagaraju Kedam Source Type: research

Rabeprazole inhibits inflammatory reaction by inhibition of cell pyroptosis in gastric epithelial cells
CONCLUSION: These findings revealed a critical role of Rabeprazole in cell pyroptosis in patients with H. pylori infection, suggesting that targeting cell pyroptosis is an alternative strategy in improving H. pylori treatment.PMID:34266494 | DOI:10.1186/s40360-021-00509-7 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 16, 2021 Category: Drugs & Pharmacology Authors: Jing Xie Long Fan Liya Xiong Peiyu Chen Hongli Wang Huan Chen Junhong Zhao Zhaohui Xu Lanlan Geng Wanfu Xu Sitang Gong Source Type: research

Loading and release of  cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid
CONCLUSIONS: The simulation results manifested a significant contribution of DMAA-TMC in the adsorption and release of cancer chemotherapy drugs in normal and neoplastic tissues. The interaction of copolymer also improves the biocompatibility and biodegradability of the SWCNT. Smart drug delivery carrier can be a valuable nanohybrid for loading, transporting, and releasing of cancer chemotherapy drugs.PMID:34261533 | DOI:10.1186/s40360-021-00508-8 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 15, 2021 Category: Drugs & Pharmacology Authors: Mohammad Dahri Hossein Akbarialiabad Ahmad Miri Jahromi Reza Maleki Source Type: research

In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
CONCLUSIONS: These results indicate that melittin at its safe dose could not exhibit antimicrobial activity, which hinders its application in clinical practice.PMID:34261542 | DOI:10.1186/s40360-021-00503-z (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 15, 2021 Category: Drugs & Pharmacology Authors: Parvin Askari Mohammad Hasan Namaei Kiarash Ghazvini Mehran Hosseini Source Type: research

Loading and release of  cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid
CONCLUSIONS: The simulation results manifested a significant contribution of DMAA-TMC in the adsorption and release of cancer chemotherapy drugs in normal and neoplastic tissues. The interaction of copolymer also improves the biocompatibility and biodegradability of the SWCNT. Smart drug delivery carrier can be a valuable nanohybrid for loading, transporting, and releasing of cancer chemotherapy drugs.PMID:34261533 | DOI:10.1186/s40360-021-00508-8 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 15, 2021 Category: Drugs & Pharmacology Authors: Mohammad Dahri Hossein Akbarialiabad Ahmad Miri Jahromi Reza Maleki Source Type: research

In vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
CONCLUSIONS: These results indicate that melittin at its safe dose could not exhibit antimicrobial activity, which hinders its application in clinical practice.PMID:34261542 | DOI:10.1186/s40360-021-00503-z (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 15, 2021 Category: Drugs & Pharmacology Authors: Parvin Askari Mohammad Hasan Namaei Kiarash Ghazvini Mehran Hosseini Source Type: research

Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence
CONCLUSION: Cannabis is shown to be a TC risk factor for all ethnicities including Caucasian-American and African-American ancestries, albeit at different rates. For both ancestries cannabis legalization elevated TCR. Dose-response and causal relationships are demonstrated.PMID:34246312 | PMC:PMC8272900 | DOI:10.1186/s40360-021-00505-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 11, 2021 Category: Drugs & Pharmacology Authors: Albert Stuart Reece Gary Kenneth Hulse Source Type: research

Causal inference multiple imputation investigation of the impact of cannabinoids and other substances on ethnic differentials in US testicular cancer incidence
CONCLUSION: Cannabis is shown to be a TC risk factor for all ethnicities including Caucasian-American and African-American ancestries, albeit at different rates. For both ancestries cannabis legalization elevated TCR. Dose-response and causal relationships are demonstrated.PMID:34246312 | DOI:10.1186/s40360-021-00505-x (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 11, 2021 Category: Drugs & Pharmacology Authors: Albert Stuart Reece Gary Kenneth Hulse Source Type: research

Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats
CONCLUSION: Evidence from this study suggests that melittin is beneficial for the prevention of acute hepatic failure in antitubercular drug-induced hepatoxicity and could be used as a potential therapeutic agent.PMID:34217369 | PMC:PMC8254969 | DOI:10.1186/s40360-021-00507-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 4, 2021 Category: Drugs & Pharmacology Authors: Khalid Mohammed Naji Bushra Yahya Al-Khatib Nora Saif Al-Haj Myrene R D'souza Source Type: research

Hepatoprotective activity of melittin on isoniazid- and rifampicin-induced liver injuries in male albino rats
CONCLUSION: Evidence from this study suggests that melittin is beneficial for the prevention of acute hepatic failure in antitubercular drug-induced hepatoxicity and could be used as a potential therapeutic agent.PMID:34217369 | DOI:10.1186/s40360-021-00507-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 4, 2021 Category: Drugs & Pharmacology Authors: Khalid Mohammed Naji Bushra Yahya Al-Khatib Nora Saif Al-Haj Myrene R D'souza Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | PMC:PMC8229300 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | PMC:PMC8235616 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | PMC:PMC8229300 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | PMC:PMC8235616 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | PMC:PMC8229300 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | PMC:PMC8235616 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | PMC:PMC8229300 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | PMC:PMC8235616 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers
BMC Pharmacol Toxicol. 2021 Jun 25;22(1):37. doi: 10.1186/s40360-021-00500-2.NO ABSTRACTPMID:34172076 | DOI:10.1186/s40360-021-00500-2 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Nahum M éndez-Sánchez Miguel Dibildox-Martinez Jahir Sosa-Noguera Ram ón Sánchez-Medal Francisco J Flores-Murrieta Source Type: research

Safety assessment of subtilisin QK in rats
CONCLUSION: The results showed that oral consumption of subtilisin QK is of low toxicological concern. No adverse effects were observed at doses of 2500, 7500, and 25,000 FU/kg in the 28-day subchronic toxicity, and the no-observed-adverse-effect level (NOAEL) of subtilisin QK was 25,000 FU/kg.PMID:34172094 | DOI:10.1186/s40360-021-00506-w (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 26, 2021 Category: Drugs & Pharmacology Authors: Shuai Xiao Dingbang Hu Ya Gao Yang Ai Sang Luo Song Chen Ben Wang Li Zhou Yanshan Dong Yefu Wang Source Type: research

In-silico evaluation of Malawi essential medicines and reactive metabolites for potential drug-induced toxicities
This study assessed the Malawi Essential Medicines List (MEML) for structural alerts and reactive metabolites with the potential for drug-induced toxicities.METHODS: This in-silico screening study used StopTox, ToxAlerts and LD-50 values toxicity models to assess the MEML drugs. A total of 296 drugs qualified for the analysis (those that had defined chemical structures) and were screened in each software programme. Each model had its own toxicity endpoints and the models were compared for consensus of their results.RESULTS: In the StopTox model, 86% of the drugs had potential to cause at least one toxicity including 55% th...
Source: BMC Pharmacology and Toxicology - June 17, 2021 Category: Drugs & Pharmacology Authors: Ibrahim Chikowe Alfred Chipanda Phiri Kirios Patrick Mbewe Dunstan Matekenya Source Type: research

In-silico evaluation of Malawi essential medicines and reactive metabolites for potential drug-induced toxicities
This study assessed the Malawi Essential Medicines List (MEML) for structural alerts and reactive metabolites with the potential for drug-induced toxicities.METHODS: This in-silico screening study used StopTox, ToxAlerts and LD-50 values toxicity models to assess the MEML drugs. A total of 296 drugs qualified for the analysis (those that had defined chemical structures) and were screened in each software programme. Each model had its own toxicity endpoints and the models were compared for consensus of their results.RESULTS: In the StopTox model, 86% of the drugs had potential to cause at least one toxicity including 55% th...
Source: BMC Pharmacology and Toxicology - June 17, 2021 Category: Drugs & Pharmacology Authors: Ibrahim Chikowe Alfred Chipanda Phiri Kirios Patrick Mbewe Dunstan Matekenya Source Type: research

Effect of perioperative use of parecoxib on chronic post-surgical pain in elderly patients after hepatectomy: a prospective randomized controlled study
This study aimed to test the superiority of parecoxib vs. placebo in preventing chronic post-hepatectomy pain in elderly patients under combined general-epidural anesthesia.METHODS: A total of 105 elderly patients undergoing hepatectomy under combined general-epidural anesthesia were randomized into the parecoxib or placebo group. The primary outcome was the proportion of patients with CPSP 3 months postoperatively. The secondary outcomes included the Short-Form McGill Pain Questionnaire score in CPSP-positive responders, acute pain intensity, postoperative analgesic demand, inflammatory markers change, and postoperative c...
Source: BMC Pharmacology and Toxicology - June 16, 2021 Category: Drugs & Pharmacology Authors: Xiaodong Ge Yan Pan Danfeng Jin Ying Wang Shengjin Ge Source Type: research

Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin
CONCLUSION: Co-administration of doses of remogliflozin etabonate (500 mg BID or 750 mg BID) greater than the commercial dose (100 mg BID) with metformin (2000 mg BID) was shown to be safe and effective during the observation period.TRIAL REGISTRATION: ClinicalTrials.gov , NCT00519480 . Registered:22 August 2007.PMID:34120651 | DOI:10.1186/s40360-021-00502-0 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 14, 2021 Category: Drugs & Pharmacology Authors: Robert Dobbins Elizabeth K Hussey Robin O'Connor-Semmes Susan Andrews Wenli Tao William O Wilkison Bentley Cheatham Katare Sagar Barkate Hanmant Source Type: research