The adipokine vaspin reduces apoptosis in human hepatocellular carcinoma (Hep-3B) cells, associated with lower levels of NO and superoxide anion.
Authors: Skonieczna M, Hudy D, Hejmo T, Buldak RJ, Adamiec M, Kukla M Abstract BACKGROUND: Among adipose-derived factors, adipocytokines play roles as hormones and signaling mediators for apoptotic pathway. Among of them, vaspin, regulates the metabolism of adipose tissue itself as an endocrine organ, and stimulates adipocytes to maturation, differentiation, etc. Damaged adipocytes, present in obesity and hepatocellular carcinoma (HCC) respond with over-production of inflammatory cytokines. Such pro-inflammatory stimulation remains under adipokine control. Pro-inflammatory pathways are connected to oxidative stress...
Source: BMC Pharmacology and Toxicology - September 13, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.
Authors: Afridi R, Khan AU, Khalid S, Shal B, Rasheed H, Ullah MZ, Shehzad O, Kim YS, Khan S Abstract BACKGROUND: Poncirin is flavanone derivative (isolated from Poncirus trifoliata) with known pharmacological activities such as anti-tumor, anti-osteoporotic, anti-inflammatory and anti-colitic. The present study aimed to explore the anti-allodynic and anti-hyperalgesic potentials of poncirin in murine models of inflammatory pain. METHODS: The analgesic potential of poncirin was evaluated in formalin-, acetic acid-, carrageenan- and Complete Freund's Adjuvant (CFA)-induced inflammatory pain models in mice. Anti-...
Source: BMC Pharmacology and Toxicology - September 13, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis.
CONCLUSIONS: Our results provide a new molecular mechanism for the treatment of CORT-induced neurotoxicity by CGA, and suggest CGA may be a potential substance which is can alleviate depression. PMID: 31500666 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - September 12, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Adverse drug reactions due to opioid analgesic use in New South Wales, Australia: a spatial-temporal analysis.
CONCLUSIONS: These results suggest that there is significant spatial-temporal variation in opioid-related ADRs and future interventions should target vulnerable populations and high-risk geographical areas to improve safer use of pharmaceutical opioid analgesics. PMID: 31488223 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - September 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Effect of green tea on the gastrointestinal absorption of amoxicillin in rats.
CONCLUSIONS: Our results suggest a potentially relevant interaction between green tea and amoxicillin, worth being further studied in humans. PMID: 31470904 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - September 2, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy.
CONCLUSIONS: Both topical and systemic gabapentin exhibit a propensity to attenuate CIPN in a cisplatin paradigm. Gabapentin applied topically may therefore provide an adjunctive or alternative route for CIPN management upon cessation of systemic medications due to intolerable side-effects. PMID: 31462283 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 30, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Use of long acting injectable aripiprazole before and through pregnancy in bipolar disorder: a case report.
CONCLUSION: As far as we know, this is the first case report on aripiprazole LAI use during pregnancy. Although we exercise caution in drawing conclusions from a single case, and each case should be weighed up individually, aripiprazole LAI could be a therapeutic option in similar circumstances. PMID: 31462311 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 30, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways.
CONCLUSIONS: This case suggests that concurrent genetic polymorphisms can impair multiple apixaban elimination pathways and thus substantially increase its exposure. PMID: 31464657 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 30, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Tigecycline-induced sustained severe hypoglycemia: a case report.
CONCLUSION: This is the first report of sustained severe hypoglycemia due to tigecycline. Oversecretion of insulin appears to have been the cause of the hypoglycemia in our patient. The mechanism needs to be investigated. PMID: 31426870 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 22, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Analysis of severe adverse effects following community-based ivermectin treatment in the Democratic Republic of Congo.
CONCLUSION: Co-endemicity of loiasis and onchocerciasis is one of the key factors responsible for the occurrence of SAE following ivermectin treatment. Mobilization of resources necessary to the appropriate management of SAE and awareness of populations are essential to achieve onchocerciasis control in DRC. PMID: 31420005 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 20, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats.
CONCLUSIONS: Our studies demonstrate that the four phenyl-ring substituted etomidate analogs form a novel class of compounds that are devoid of sedative-hypnotic activities and suppress plasma concentrations of adrenocortical steroids but vary in their effects on plasma concentrations of androgenic steroids. PMID: 31383012 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - August 7, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.
CONCLUSION: Our results reveal that extracellular 5-HT is the cause of a syndrome and activity of postsynaptic receptors critical for the course of syndrome intensification. Although the high-dose has the potential to initiate serotonergic injury due to high MDMA concentrations present in the brain, whether an injury is observed depends upon the drug environment via the levels of reactive oxygen species generated. This suggests that brain MDMA concentration is the determinant in the injury initiation while reactive oxygen species generation associated with the injury intensification. It is concluded that the two adverse ev...
Source: BMC Pharmacology and Toxicology - August 7, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: study protocol for factorial design randomised controlled trial.
DISCUSSION: Current treatment of CSOM in our region shows that eradication of bacterial pathogens from the middle ear space and dry ears is often not achieved. This trial will evaluate the efficacy of adjunctive treatments of antiseptic ear washes and oral antibiotics. Clinical, microbiological and hearing outcomes will be reported. TRIAL REGISTRATION: This trial (ACTRN12614000234617) was registered with ANZCTR on 05 April 2014. PMID: 31351491 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 30, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives?
Authors: Noor S, Ismail M, Ali Z Abstract BACKGROUND: Pneumonia patients are usually hospitalized due to severe nature of the disease or for the management of comorbid illnesses or associated symptoms. Such patients are prescribed with multiple medications which increase the likelihood of potential drug-drug interactions (pDDIs). Therefore, in this study the prevalence, levels (severity and documentation), predictors (risk factors), and clinical relevance of pDDIs among inpatients diagnosed with pneumonia have been investigated. METHODS: Clinical records of 431 hospitalized patients with pneumonia were checked ...
Source: BMC Pharmacology and Toxicology - July 28, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Relationship between drug application and mortality rate in Chinese older coronary artery disease/chronic heart failure patients with and without low glomerular filtration rate.
Authors: Fu S, Ping P, Ye P, Luo L Abstract BACKGROUND: This analysis was designed to investigate the relationship between drug application and mortality rate in Chinese older coronary artery disease (CAD)/chronic heart failure (CHF) patients with and without low glomerular filtration rate (GFR). METHODS: All 1050 Chinese hospitalized patients with diagnosed CAD were included in this analysis, and Cox Regression was used to analyze the relationship between drug application and mortality rate after multivariate adjustment. Low GFR was defined as GFR 
Source: BMC Pharmacology and Toxicology - July 28, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Influence of N-acetyl-L-cysteine against bisphenol a on the maturation of mouse oocytes and embryo development: in vitro study.
CONCLUSION: BPA affects mouse oocyte maturation and subsequent early embryonic developmental competence following IVF by increasing intracytoplasmic oxidative stress in mature oocytes. NAC can reduce these harmful effects to a certain extent. PMID: 31331389 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 25, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels.
CONCLUSION: Our results show that the SPR-based method is well suited for identifying small molecule binders of KCNH channels and can facilitate drug discovery for other ion channels as well. PMID: 31315662 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 20, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Development of a mortality score to assess risk of adverse drug reactions among hospitalized patients with moderate to severe chronic kidney disease.
CONCLUSION: Mortality prediction model among hospitalized stages 3 to 5 CKD patients experienced ADR was developed in this study. This prediction model adds new knowledge to the healthcare system despite its modest performance coupled with its high sensitivity and specificity. This tool is clinically useful and effective in identifying potential CKD patients at high risk of ADR-related mortality during hospitalization using routinely performed clinical data. PMID: 31287030 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 11, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

The effects of thiamine pyrophosphate on ethanol induced optic nerve damage.
CONCLUSIONS: There was an apparent destruction in ethanol administered group in histopathological analyses with an augmented level of oxidative stress markers and all those alterations were prevented with concomitant thiamine pyrophosphate administration. These protective effects of thiamine pyrophosphate are extremely important in chronic ethanol consumption. Clinical studies are warranted to define the exact role of thiamine pyrophosphate in prevention of ethanol induced optic neuropathy. PMID: 31277705 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Acute versus chronic methotrexate poisoning; a cross-sectional study.
Authors: Ahmadzadeh A, Zamani N, Hassanian-Moghaddam H, Hadeiy SK, Parhizgar P Abstract BACKGROUND: Data is limited on comparison of acute and chronic methotrexate (MTX) poisoning. Methotrexate is an anti-folate drug that may be prescribed in some malignant or chronic inflammatory conditions. The aim of the current study was to compare signs and symptoms, complications, treatment and final outcome of acute and chronic MTX toxicity. METHOD: In a retrospective study in a referral center between March 2010 and March 2018, all patients who had been referred with the history of MTX poisoning and hospitalized due to ...
Source: BMC Pharmacology and Toxicology - July 5, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle.
CONCLUSIONS: Single administration to acrylamide and ethanol had negative effects on cortical bone structure of mice after one remodeling cycle. However, we identified possible antagonistic impact of these toxins on the structure of the cortical bone. PMID: 31262364 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - July 4, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Safety and effectiveness of low-dose amikacin in nontuberculous mycobacterial pulmonary disease treated in Toronto, Canada.
CONCLUSIONS: Patients with NTM PD treated with low-dose intravenous amikacin frequently developed ototoxicity, which was associated with female sex, and total dose of amikacin per bodyweight. Physicians should carefully consider dose, treatment duration, and long term prognosis in balancing risks and benefits of intravenous amikacin in NTM PD. PMID: 31159865 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 6, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Countrywide prevalence of critical drug interactions in Hungarian outpatients: a retrospective analysis of pharmacy dispensing data.
CONCLUSIONS: There were 1.8 million cases of co-dispensing each year, where prescribers' and community pharmacists' role in recognizing and managing potentially serious interactions was or would have been critical. The method presented to identify high-risk DDIs can serve as a starting point for the much-needed improvement of routine interaction screening. PMID: 31151485 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 4, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Microbial epidemiology and antimicrobial resistance patterns of wound infection in Ethiopia: a meta-analysis of laboratory-based cross-sectional studies.
CONCLUSION: Generally, the wound culture positivity was found very high indicating the likelihood of poly-microbial contamination. S. aureus is by far the most common bacterial isolate recovered from wound infection. The high estimate of resistance was observed among β-lactam antibiotics in all bacterial isolates. Ciprofloxacin and gentamicin were relatively effective in treating wound infections with poly-microbial etiology. PMID: 31146791 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - June 1, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Assessment of effect modification of statins on new-onset diabetes based on various medical backgrounds: a retrospective cohort study.
CONCLUSIONS: In patients with various clinical backgrounds, those who received statin therapy had a higher risk of new-onset diabetes at 5 and 10 years than those who did not receive it. Effect modification of statins on new-onset diabetes was not found in patient populations defined according to various comorbid diseases or concomitant drugs. PMID: 31138326 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 31, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Epinecidin-1, a highly potent marine antimicrobial peptide with anticancer and immunomodulatory activities.
CONCLUSION: Due to significant antimicrobial activities tested on bacteria such as Staphylococcus aureus and Helicobacter pylori and also wound healing properties, Epi-1 has high potential to be considered as an important candidate for the production of new drugs and treatment of various infections including diabetic foot ulcer and peptic ulcer. Moreover, adjuvant-like properties of Epi-1 make it a suitable candidate for the studies related to an adjuvant. Other attractive properties such as anticancer effects have also been reported for this peptide which encourages further studies on this peptide. PMID: 31138331 [Pub...
Source: BMC Pharmacology and Toxicology - May 31, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study.
Authors: Shibeshi W, Sheth AN, Admasu A, Berha AB, Negash Z, Yimer G Abstract BACKGROUND: Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phase of treatment of multi-drug resistant tuberculosis (MDR-TB) patients. Data are scarce on injectable-induced nephrotoxicity and ototoxicity in Ethiopian MDR-TB patients. The aim of this study was to assess the prevalence, management of nephrotoxicity and ototoxic symptoms and treatment outcomes of patients treated for MDR...
Source: BMC Pharmacology and Toxicology - May 29, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Dexamethasone suppresses the differentiation of stem Leydig cells in rats in vitro.
CONCLUSIONS: DEX suppressed the differentiation of rat Leydig cells in vitro and glucocorticoid-induced effects acted through NR3C1. This suppression partially targets on Cyp17a1 and Scarb1 gene expression. PMID: 31133074 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 29, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Study of the principles in the first phase of experimental pharmacology: the basic step with assumption hypothesis.
CONCLUSION: Adequate investigation time for acute toxicity study was therefore essential for comprehensive analysis of pharmacological property of tested chemicals at different level of doses. PMID: 31113474 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 24, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

One-year outcome of combination therapy with intravitreal aflibercept and photodynamic therapy for polypoidal choroidal vasculopathy.
Authors: Weng HY, Huang TL, Chang PY, Wang JK Abstract BACKGROUND: To investigate the one-year visual and anatomical outcomes of combination therapy with intravitreal aflibercept (IVA) and photodynamic therapy (PDT) for treating polypoidal choroidal vasculopathy (PCV). METHODS: This was a retrospective case-series study, including 30 eyes from 30 patients with treatment-naïve PCV treated by combination therapy with IVA and PDT. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), complete polyp regression rate, and dry macula rate were recorded every 3 months during 12-month follow-...
Source: BMC Pharmacology and Toxicology - May 17, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Near fatal intoxication by nicotine and propylene glycol injection: a case report of an e-liquid poisoning.
CONCLUSION: Even a small quantity of intravenous (IV) e-liquid can lead to an acute intoxication and fatal outcomes due to the toxic effects of nicotine. This case might help emergency doctors cope with acute intoxication by injection of e-liquid and increase their comprehension of the two main substances, nicotine and propylene glycol with overview of their pharmacodynamics and kinetic effects. PMID: 31077262 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 12, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Evaluation of prophylactic dosages of Enoxaparin in non-surgical elderly patients with renal impairment.
CONCLUSION: Peak anti-Xa levels provided by enoxaparin 20 mg were lower than the desired range for thromboprophylaxis in comparison to enoxaparin 30 mg. TRIAL REGISTRATION: The trial was retrospectively registered on ClinicalTrials.gov identifier: NCT03158792 . Registered: May 18, 2017. PMID: 31064405 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 9, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice.
CONCLUSION: Abatacept may play a role in inducing granulomatous hepatitis with a sarcoidosis-like reaction. Additional data including transaminases, antinuclear antibodies (ANA), Antimitochondrial antibodies (AMA) and other auto antibodies should be tested. PMID: 31064410 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 9, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

A study on combination of daptomycin with selected antimicrobial agents: in vitro synergistic effect of MIC value of 1  mg/L against MRSA strains.
CONCLUSION: The combination of daptomycin plus fosfomycin may be an effective therapeutic option for MRSA infection. PMID: 31060599 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Nature and prevalence of adverse drug reaction of antiretroviral medications in Halibet National Referral Hospital: a retrospective study.
This study was aimed at assessing the prevalence, nature, seriousness and possible risk factors of ART associated ADRs in Halibet National Referral Hospital in Eritrea. METHOD: A three month retrospective, longitudinal, descriptive study of patients treated with ART between September 2005 and December 2016 was conducted in Halibet National Referral Hospital. Demographic characteristics, treatment details, reaction and outcome details, laboratory investigations and other information was abstracted manually from patients' clinical cards. Statistical analysis was conducted using both univariate and multivariate analysis a...
Source: BMC Pharmacology and Toxicology - May 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Effects of neprilysin-renin inhibition in comparison with neprilysin-angiotensin inhibition on the neurohumoral changes in rats with heart failure.
CONCLUSION: Sacubitril in combination with aliskiren or with ramipril effectively reduced plasma cardiac biomarkers, such as CK-MB, MMP9, and NT-proBNP, in rats with heart failure. Both combinations showed significant remediation of renal function through increasing GFR, urine flow, and total solute excretion, as well as reducing plasma level of renin. Net results revealed that the sacubitril-aliskiren combination has similar remediating effects on neurohumoral changes compared to the sacubitril-ramipril combination. PMID: 31053170 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 7, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Apigenin and hesperidin augment the toxic effect of doxorubicin against HepG2 cells.
CONCLUSION: The obtained results indicate the existence of a very effective cytotoxic mechanism in the HepG2 cells of the combined effect of doxorubicin and apigenin (or hesperidin), not related to the oxidative stress. To explain this synergy mechanism, further research is needed, The observed intensification of the cytotoxic effect of doxorubicin by this flavonoids may be a promising direction of the research on the therapy of hepatocellular carcinoma, especially in a chemoembolization. PMID: 31053173 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - May 7, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Characterization and preventability of adverse drug events as cause of emergency department visits: a prospective 1-year observational study.
CONCLUSION: ADEs are a frequent cause of ED visits. The commonly used antibiotics and anti-inflammatory drugs should be carefully managed, as they are widely involved in mild to severe ADEs. Polytherapy is associated with the occurrence of serious, as well as certainly preventable ADEs, while older age only with serious events. A greater sensitivity to drug monitoring programs among health professionals is needed. PMID: 31029178 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 29, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Clinical experience with tigecycline in the treatment of hospital-acquired pneumonia caused by multidrug resistant Acinetobacter baumannii.
CONCLUSIONS: Our results suggest that tigecycline is one of the potential choices for the treatment of hospital-acquired pneumonia caused by MDRAB, especially with a MIC≤2 mg/L. In addition, a longer duration of tigecycline treatment may be required to insure better clinical outcomes. PMID: 31023357 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 28, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Quality of albendazole tablets legally circulating in the pharmaceutical market of Addis Ababa, Ethiopia: physicochemical evaluation.
CONCLUSIONS: All batches of albendazole circulating in the market in Addis Ababa did not fulfil either physical or chemical quality standards. The most important finding of this research was the presence of drugs with lower level of API than the acceptable limit. This can lead to treatment failure and favour the emergence of parasites that are resistant to drugs. Therefore, there should be a thorough evaluation of drugs before approval. The study also revealed the importance of occasional assessment of drugs circulating even in the legal market. PMID: 31023365 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 28, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Beta-blockers for the primary prevention of anthracycline-induced cardiotoxicity: a meta-analysis of randomized controlled trials.
CONCLUSIONS: In cancer patients with anthracycline therapy, prophylactic β blockers were associated with reduced risk of heart failure, decreased left ventricular diameter, improved left ventricular systolic function, and alleviative cardiomyocyte injury. PMID: 31023386 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 28, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

A case of delayed neurological manifestation following carbon monoxide poisoning in Sri Lanka: epidemiology of exposure and literature review.
CONCLUSION: Though, it is uncommon in a tropical country like Sri Lanka, clinicians should have high degree of suspicion with the correct circumstances, as it is a challenge for the emergency physicians, even in countries with higher rate of CO poisoning. The exact mechanisms of acute and delayed toxicity, preventive methods and the suggested treatments are yet to be elucidated and this needs further attention and studies. PMID: 30953563 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 8, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure.
Authors: Freundt JK, Frommeyer G, Spieker T, Wötzel F, Grotthoff JS, Stypmann J, Hempel G, Schäfers M, Jacobs AH, Eckardt L, Lange PS Abstract BACKGROUND: The development of heart failure is accompanied by complex changes in cardiac electrophysiology and functional properties of cardiomyocytes and fibroblasts. Histone deacetylase (HDAC) inhibitors hold great promise for the pharmaceutical therapy of several malignant diseases. Here, we describe novel effects of the class I HDAC inhibitor Entinostat on electrical and structural remodeling in an in vivo model of pacing induced heart failure. METHODS: Ra...
Source: BMC Pharmacology and Toxicology - March 9, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Dipeptidyl peptidase 4 (DPP-4) inhibitors and cardiovascular outcomes in patients with type 2 diabetes mellitus (T2DM): a systematic review and meta-analysis.
CONCLUSION: The current analysis showed that treatment with DPP-4 inhibitors did not significantly increase cardiovascular outcomes in these patients with T2DM indicating that those drugs might be safe to use in terms of cardiovascular events. PMID: 30832701 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - March 6, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Correction to: Superior silybin bioavailability of silybin-phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers.
Authors: Méndez-Sánchez N, Dibildox-Martinez M, Sosa-Noguera J, Sánchez-Medal R, Flores-Murrieta FJ Abstract AbstractFollowing publication of the original article [1], the author reported their given name have been erroneously tagged as their family names. PMID: 30795809 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 25, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats.
CONCLUSIONS: CNBP with noticeable antioxidant property showed gastroprotective activity in the testing rodents via alteration of HSP70 protein expression. Also, antioxidant enzyme activities which were changed after treatment with CNBP in the animals could be elucidated as its gastroprotective properties. PMID: 30770761 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 17, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Identification of novel candidate indicators for assessing zinc status during pregnancy in mice from microarray data.
CONCLUSION: CXCR2, ANXA1, and CCR3 as well as olfactory receptor-related genes (proteins) may be used as biomarkers to assess zinc status in mice. PMID: 30770772 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 17, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Burden of paraquat poisoning in the department of Antioquia, Colombia.
CONCLUSION: The rate of DALYs reported here is higher than that reported by all chemical poisonings. Better strategies to regulate and restrict the market of this dangerous products are required in Colombia. PMID: 30767779 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 16, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.
CONCLUSIONS: Re-exposure to rifampicin in sensitised individuals may cause acute severe hypersensitivity reactions. Due to its indications in the management of mycobacterial and implant-associated infections, rifampicin is a drug which might be given decades apart, which poses a risk that information about previous intolerance is lost. PMID: 30755272 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - February 15, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/ β-catenin signaling.
Atypical antipsychotics induce human osteoblasts apoptosis via Wnt/β-catenin signaling. BMC Pharmacol Toxicol. 2019 Feb 12;20(1):10 Authors: Li P, Wang Y, Liu X, Zhou Z, Wang J, Zhou H, Zheng L, Yang L Abstract BACKGROUND: There is evidence that atypical antipsychotics (APs) increase risk of osteoporosis in schizophrenia patients, however the mechanism is unclear. The aim of the study was to explore the molecular mechanisms about Wnt/β-catenin signal pathway underlying the osteal side effects of APs. METHODS: We cultured human osteoblast cell line hFob1. 19 (OB) treatments with olanzapine...
Source: BMC Pharmacology and Toxicology - February 15, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research