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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

GPs should avoid antibiotics for non-bullous impetigo
NICE proposes use of antiseptic creams instead Related items fromOnMedica Single-dose malaria drug eliminates parasite from liver Patients often avoid vaccinations due to fear of side effects Double check patients with ‘penicillin’ allergy to avoid MRSA risk Ibuprofen not a safe alternative to antibiotics for uncomplicated UTIs Inhaled corticosteroids linked to higher infection risk
Source: OnMedica Latest News - August 14, 2019 Category: UK Health Source Type: news

Allergen presensitization drives an eosinophil-dependent arrest in lung-specific helminth development
This study investigates the relationship between helminth infection and allergic sensitization by assessing the influence of preexisting allergy on the outcome of helminth infections, rather than the more traditional approach in which the helminth infection precedes the onset of allergy. Here we used a murine model of house dust mite–induced (HDM-induced) allergic inflammation followed by Ascaris infection to demonstrate that allergic sensitization drives an eosinophil-rich pulmonary type 2 immune response (Th2 cells, M2 macrophages, type 2 innate lymphoid cells, IL-33, IL-4, IL-13, and mucus) that directly hinders larva...
Source: Journal of Clinical Investigation - August 5, 2019 Category: Biomedical Science Authors: Pedro H. Gazzinelli-Guimaraes, Rafael de Queiroz Prado, Alessandra Ricciardi, Sandra Bonne-Année, Joshua Sciurba, Erik P. Karmele, Ricardo T. Fujiwara, Thomas B. Nutman Source Type: research

A near-fatal Valley Fever case opens doors to new treatment method
Of the 8,000 Californians who will contract Valley Fever this year, most will recover without treatment, and those with more serious cases will require an antifungal medication that clears the infection. But a few will experience a life-threatening form of the disease that ravages the body for reasons unknown.Now, an experimental treatment used by physicians atUCLA Mattel Children ’s Hospital that cured a 4-year-old boy may provide an explanation — and a method for manipulating the immune system to combat not just Valley Fever, but a host of infections.In February 2018, the Gonzalez-Martinez family traveled 200 miles f...
Source: UCLA Newsroom: Health Sciences - July 10, 2019 Category: Universities & Medical Training Source Type: news

Biologics for Asthma and Risk of Infection
Monoclonal antibodies block specific inflammatory pathways involved in the pathogenesis of asthma. These pathways are important in host defense against pathogens, and in particular, against parasites. Despite theoretical concerns about infection risk, biologics seem to have a favorable safety profile. Data from large clinical trials and postmarketing surveillance for these drugs have not shown increases in severe infections, including those from parasitic organisms. This may be due to redundancy of effector cells within the immune system. Certain drugs have special considerations and precautions, and therefore, the prescri...
Source: Immunology and Allergy Clinics of North America - July 6, 2019 Category: Allergy & Immunology Authors: Joao Pedro Lopes, Mauli Desai Source Type: research

Giardiasis : An overview.
CONCLUSION: Metronidazole, tinidazole, and nitazoxanide are the drugs of choice. Resistance to common antigiardial drugs has increased in recent years. As such, the search for new molecular targets for antigiardial drugs is urgently needed. In general, treatment of asymptomatic carriers is not recommended. Purification of water supply is an important preventive measure. PMID: 31210116 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 20, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Eosinophils: Nemeses of Pulmonary Pathogens?
AbstractPurpose of ReviewEosinophils are short-lived granulocytes that contain a variety of proteins and lipids traditionally associated with host defense against parasites. The primary goal of this review is to examine more recent evidence that challenged this rather outdated role of eosinophils in the context of pulmonary infections with helminths, viruses, and bacteria.Recent FindingsWhile eosinophil mechanisms that counter parasites, viruses, and bacteria are similar, the kinetics and impact may differ by pathogen type. Major antiparasitic responses include direct killing and immunoregulation, as well as some mechanism...
Source: Current Allergy and Asthma Reports - June 18, 2019 Category: Allergy & Immunology Source Type: research

Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses
ConclusionsPediatric hypereosinophilia has an incidence of 54.4 per 100,000 persons per year, with children < 1 year and 6-11 years of age accounting for the majority of affected patients. Pediatric hypereosinophilia is not uncommon and remains under recognized, highlighting a need for clinicians to identify patients that meet criteria for hypereosinophilia and to pursue a thorough evaluation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 23, 2019 Category: Allergy & Immunology Source Type: research

The Complicated Dance of Infections and Asthma
The interaction between asthma and infections is a complicated one, and that is the focus of this issue of the Immunology and Allergy Clinics of North America. Infections, both viral and bacterial, have been associated with development and exacerbation of asthma, while parasitic infections may actually help protect against asthma. Furthermore, as our drug armamentarium begins to focus on biologics, which can selectively impair components of the immune response, there is concern that treated patients with asthma will be at risk of developing opportunistic infections.
Source: Immunology and Allergy Clinics of North America - May 20, 2019 Category: Allergy & Immunology Authors: Mitchell H. Grayson Tags: Preface Source Type: research

Microbes, Infections, and Their Relationship to Asthma
Examining the impact of bacteria, viruses, fungi, and parasites on human disease has been a complicated undertaking that began centuries ago and has led to profound effects on human history, including the development of interventions such as sanitation technologies, antibiotics, and vaccinations. In recent decades, we have also begun to appreciate the potential detrimental effects of altering natural patterns of microbial species that coexist with us, including the importance of changes in the early-life microbiome on the development of asthma and other allergic diseases.
Source: Immunology and Allergy Clinics of North America - May 10, 2019 Category: Allergy & Immunology Authors: Stephen A. Tilles Tags: Foreword Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes
Conclusion: ROS promote CD8+ T cell activation by facilitating autoantigen cross-presentation by DCs. ROS scavengers could potentially represent an important component of therapies aiming to disrupt autoantigen presentation and activation of CD8+ T cells in individuals at-risk for developing T1D. In Type 1 Diabetes (T1D), pancreatic β cells are attacked by a T cell mediated autoimmune response and lose their ability to produce insulin (1–3). While a number of immune cell subsets are involved throughout the development of T1D, cytotoxic CD8+ T cells (CTLs) function as primary effectors of ...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Dangerous ' Kissing ' Bug Marches North in US Dangerous ' Kissing ' Bug Marches North in US
The bugs carry a parasite that causes Chagas disease, which can lead to serious heart and stomach problems.WebMD Health News
Source: Medscape Allergy Headlines - April 29, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions
Conclusions and Future Perspectives It is now evident that NK/ILC family plays a pivotal role in the immune defenses. Recent studies in murine and human settings demonstrated that the expression of several inhibitory checkpoints, that may be detrimental in the tumor context, is not restricted to T lymphocytes, revealing an important, yet poorly appreciated, contribution of their expression on innate immune cells. Thus, in the recent years different immunotherapy approaches, based on the blockade of inhibitory NK cell receptors, have been developed in order to unleash NK cell cytotoxicity. This is particularly important in...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Systems Biology Analysis of the Effect and Mechanism of Qi-Jing-Sheng-Bai Granule on Leucopenia in Mice
Conclusion In summary, our data reveal the therapeutic mechanism of QJSB by integrative application of transcriptomics-based network pharmacology and metabolomics technologies. QJSB exerts protective effect against leucopenia in mice through participating in multi-pathways, mainly including accelerating cell proliferation and differentiation, regulating metabolism response pathways and modulating immunologic function. Ethics Statement All animal studies were performed according to the institutional ethical guidelines of animal care and were approved by the Committee on the Ethics of Animal Experiments of the Second Mili...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research