Probing into Therapeutic Anti-cancer Potential of Apigenin: Recent Trends and Future Directions.
CONCLUSION: Studies related to the anti-inflammatory and anticancer potential of apigenin have been explored through this review article. Moreover, the patent analysis of apigenin has further strengthened its therapeutic role. Probing into the therapeutic properties of apigenin, further add value to this molecule in terms of its down regulation of major inflammatory and cancer associated signaling pathways. The article simultaneously would assist the scientific community to precisely understand the role of apigenin and design novel anti-cancer therapies. PMID: 31418666 [PubMed - as supplied by publisher] (Source: Recen...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 17, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Inflammatory Response and Endothelial Dysfunction Following Cardiopulmonary Bypass: Pathophysiology and Pharmacological Targets.
CONCLUSION: Inflammatory response and endothelial dysfunction following cardiopulmonary bypass are the price to pay for the benefits offered during cardiac surgery procedures. Counteracting the detrimental effect of extracorporeal circulation appears to be crucial to improve clinical outcomes in pediatric and adult cardiac surgery. The intrinsic complexity and the tight interplay of the factors involved might require a holistic approach against inflammation and endothelial response. PMID: 31339081 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 25, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Ferulic Acid: A Promising Therapeutic phytochemical and recent patents advances.
CONCLUSION: Ferulic acids are known to contrarily down-manage an assortment of extracellular and intracellular atomic targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like a malignant growth, diabetes, cardiovascular and neurodegenerative. The current review deals with the antioxidant property of ferulic acid and the recent patent describe the role of ferulic acid against human diseases. PMID: 31223096 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammat...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 22, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Giardiasis : An overview.
CONCLUSION: Metronidazole, tinidazole, and nitazoxanide are the drugs of choice. Resistance to common antigiardial drugs has increased in recent years. As such, the search for new molecular targets for antigiardial drugs is urgently needed. In general, treatment of asymptomatic carriers is not recommended. Purification of water supply is an important preventive measure. PMID: 31210116 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 20, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Molecular Allergy Diagnostics as an Adjunct to Conventional Diagnostics in a Secondary Pediatric Referral Center.
CONCLUSIONS: Most patients in a secondary pediatric referral center with suspected IgE mediated allergy can be managed by conventional diagnostic methods. MA diagnostics may be useful in small and selected subgroups as in patients with suspected peanut allergy, however, may not be helpful in all cases. PMID: 31187717 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 14, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Allergic Contact Dermatitis To Fentanyl TTS With Good Tolerance To Systemic Fentanyl.
CONCLUSION: We present the case of allergic contact dermatitis (ACD) due to hypersensitivity to fentanyl with good tolerance to buprenorphine. Positive PT in this patient suggests a type IV hypersensitivity mechanism. Allergic reactions to opioids are frequently immediate, but delayed reactions could appear, especially when the drug is administered topically. PMID: 31131754 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 29, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Travelers' Diarrhea: A Clinical Review.
CONCLUSION: Although travelers' diarrhea is usually self-limited, many travelers prefer expedient relief of the diarrhea, especially when they are traveling for extended periods by air or ground. Judicious use of an antimotility agent and antimicrobial therapy reduces the duration and severity of diarrhea. PMID: 31084597 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 16, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Chronic Urticaria: An Overview of Treatment and Recent Patents.
CONCLUSION: CU is idiopathic in majority of cases. On average, the duration of CU is around two to five years. Treatment is primarily symptomatic. Second generation antihistamines are first line. Omaluzimab has been a remarkable advance in the management of CU and improves quality of life beyond symptom control. PMID: 30924425 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - March 30, 2019 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Urinary Tract Infection in Children.
CONCLUSION: Currently, a second or third generation cephalosporin and amoxicillin-clavulanate are drugs of choice in the treatment of acute uncomplicated UTI. Parenteral antibiotic therapy is recommended for infants ≤ 2 months, and any child who is toxic-looking, hemodynamically unstable, immunocompromised, unable to tolerate oral medication, or not responding to oral medication. A combination of intravenous ampicillin and intravenous/intramuscular gentamycin or a third-generation cephalosporin can be used in those situations. Routine antimicrobial prophylaxis is rarely justified, but continuous antimicrobial prophylaxi...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 31, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

The Inhibitory Role of M2000 ( β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line.
CONCLUSION: Our study which was conducted in colonic epithelial cell model, shows that M2000 can be considered as a new anti-inflammatory agent in IBD. However, more comprehensive experimental and clinical studies are required to recognize the molecular mechanism of M2000 and also its safety and efficacy. PMID: 30539708 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 14, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Anti-Arthritic Effect of Garcinol Enriched Fraction Against Adjuvant Induced Arthritis.
Authors: Warriar P, Barve K, Prabhakar B Abstract BACKGROUND: Garcinia indica also known as kokum is used in traditional system of medicine for relieving inflammation and rheumatic pain. Garcinol, a benzophenone obtained from its fruit rind is reported to have anti-inflammatory effect via modulating arachidonic acid metabolism, suppressing iNOS expression, NF-κB activation and COX-2 expression. It has also been studied for antioxidant and anticancer activity. Apart from these, few patents claim that Garcinol also has anti-obesity and hepatoprotective effect and has a potential to be used for treatment of rena...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 22, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Inhaled Biologicals for the Treatment of Cystic Fibrosis.
CONCLUSION: Here, we summarize new patented peptides that have been developed in the last few years and advanced technologies for inhaled drug delivery to treat Cystic Fibrosis. PMID: 30318010 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - October 16, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Flare-Up Phenomenon of Intradermal Test with Anaphylactic Reaction to Paracetamol (Acetaminophen).
CONCLUSION: We present an anaphylactic shock due to sensitization to paracetamol because of a type I hypersensitivity mechanism, diagnosed by SBOCT and a positive IDT because of flare-up phenomenon, in a patient with previous pyrazolones allergy and with tolerance to other NSAIDs. Some relevant patents are also summarized in this paper. PMID: 30255762 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 28, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Patent Selections.
Authors: PMID: 30229706 [PubMed - in process] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 21, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Acknowledgements to contributors.
ACKNOWLEDGEMENTS TO CONTRIBUTORS. Recent Pat Inflamm Allergy Drug Discov. 2018;12(2):189 Authors: PMID: 30229707 [PubMed - in process] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 21, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Advances in Developing Prophylactics and Therapeutics to Counter Inflammatory, Allergic and Infectious Diseases.
Authors: Munjal A, Iqbal HMN, Dhama K PMID: 30152277 [PubMed - in process] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 30, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Prevention of cardiovascular diseases with anti-inflammatory and anti-oxidant nutraceuticals and herbal products: An overview of pre-clinical and clinical studies.
CONCLUSION: It is concluded that nutraceuticals possess enormous health benefits and their interventions can be highly beneficial in the prevention/reduction of CVDs and related disorders such as atherosclerosis, hypertension, heart attack and stroke. The findings of this review provide an update on the emerging uses of nutraceuticals, functional foods, and herbal remedies in humans. Nevertheless, large-scale randomized, placebo-controlled, double-blind clinical trials are needed to confirm the health benefit claims about nutraceuticals and herbal products to establish their long-term safety and to resolve the controversy ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 17, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Impact of ocular compatible Lipoids and Castor oil in fabrication of Brimonidine tartrate nanoemulsions by 33 full factorial Design.
CONCLUSION: The nanoemulsion of Brimonidine tartrate was prepared successfully by using castor oil, Lipoid S75 (Fat free soybean phospholipids with 70% phosphatidylcholine), Lipoid E80 (Egg phospholipids with 80% phosphatidylcholine) and PF- 68. The optimised formula demonstrated the lower droplet size, satisfactory zeta potential, and high drug loading reproducible drug release profile. PMID: 30058499 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - August 2, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Complications of Diabetes: An Insight into Genetic Polymorphism and Role of Insulin.
Authors: Aleem S Abstract BACKGROUND: Diabetes Mellitus (DM) is an advanced and chronic endocrine disorder characterized by an insufficiency of insulin secretion from pancreatic β-cells and liver, adipose tissues, and skeletal muscles. OBJECTIVE: The main objective of this study is to understand the mechanism and genes which are responsible for the prevalence of diabetes. The study also covers various types of diabetic complications with special reference to insulin role and defects. METHODS: The scientific literature and patents were reviewed and analyzed based on their suitability and relevance to th...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 20, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Role of Curcumin in Regulation of TNF- α Mediated Brain Inflammatory Responses.
CONCLUSION: Cytokines get upregulated during neurodegenerative diseases as a result of which inflammatory responses are initiated in the brain. Curcumin is reported to have anti-inflammatory properties and thereby its supplementation may help in reducing the inflammation. Future researches on this area will further explain the mode of action of curcumin in alleviating neuroinflammation. PMID: 29972106 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 6, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Community-Acquired Pneumonia in Children.
CONCLUSION: In previously healthy children under the age of 5 years, high dose amoxicillin is the treatment of choice. For those with type 1 hypersensitivity to penicillin, clindamycin, azithromycin, clarithromycin, and levofloxacin are reasonable alternatives. For children with a non-type 1 hypersensitivity to penicillin, cephalosporins such as cefixime, cefprozil, cefdinir, cefpodoxime, and cefuroxime should be considered. In previously healthy children over the age of 5 years, macrolides such as azithromycin and clarithromycin are the drugs of choice. PMID: 29932038 [PubMed - as supplied by publisher] (Source: Recen...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Effect of prolonged anti-HM1: IMSS Entamoeba histolytica antibody activity in Humoral and Cellular Immunity of experimentally induced animal model.
CONCLUSION: Thus our study demonstrated the efficacy of amoebic antigen in immune response mechanism and how they provoked inflammation and act as immunomodulator. This article also summarized some relevant patents with respect to E. histolytica against inflammation and other diseases. PMID: 29932039 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Evaluation of the Effect of α-L-Guluronic Acid (G2013) on COX-1, COX-2 Activity and Gene Expression for Introducing this Drug as a Novel NSAID with Immunomodulatory Property.
This study was aimed to investigate the effects of G2013 on the gene expression and activity of COX-1/COX-2 enzymes in order to introduce a novel NSAID for the treatment of inflammatory diseases. METHOD: The mRNA expression levels of COX-1/COX-2 were measured by qRT-PCR. The PGE2 concentration in culture media was determined using ELISA method. RESULTS: Our results demonstrated that the low and high dose of G2013 could significantly reduce the gene expression of COX-1 and COX-2, as compared to the control treated with LPS (p
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 10, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Febrile Infection-Related Epilepsy Syndrome (FIRES): An Overview of Treatment and Recent Patents.
CONCLUSION: FIRES is a rare epilepsy syndrome of unclear etiology in which children, usually of school age, suddenly develop very frequent seizures after a mild febrile illness. Seizures in FIRES are typically recalcitrant and difficult to treat. The prognosis is poor. PMID: 29745347 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 12, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Omalizumab in the therapy of pediatric asthma.
CONCLUSION: Omalizumab significantly improved the clinical management of severe and uncontrolled pediatric asthma; however, pre-treament IgE levels limited the use of omalizumab in some patients and the cost of the therapy is still relevant;moreover, the optimal duration of the treatment with omalizumab in children has yet to be determined. Finally, the recent generation of a mutant IgE-Fc fragment being resistant to omalizumab binding, might open further therapeutic applications. PMID: 29714140 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 2, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

In vitro and In vivo Immunomodulating Properties of Mesenchymal Stem Cells.
CONCLUSION: Present review is focused on the use of MSCs due to their unique immunomodulatory characteristics. MSCs reach to the site of inflammation and interact with immune cells to bring immunosuppressive and anti-inflammatory effects. Along with these unique therapeutic properties MSCs may be a useful therapeutic approach for various disorders. PMID: 29485014 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - March 1, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Allergoids for allergy treatment.
Conclusion In the last years, the partial understanding of the mechanism of action and the generation of clinical evidence of different types of allergoids, linked to their excellent safety profile and their convenience for a quick build up phase, have made of allergoids an excellent product for allergy treatment. PMID: 29473530 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Diabetic Complications and Insight into Antidiabetic Potentialities of Ethno-medicinal Plants: A review.
CONCLUSION: This review may be helpful for researchers, diabetic patient and decision makers in the field of ethnobotanical sciences. These efforts may also provide treatment to everyone and focus on the role of traditional novel medicine plants that have anti-diabetic abilities. PMID: 29473531 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

The Promising Pharmacological Effects and Therapeutic/Medicinal applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals.
CONCLUSIONS: Present review gives the insight towards major components of pomegranate as well as their pharmacological activities against pathological disorders. In spite of many beneficial properties of Punica granatum L., more research evidence on molecular basis are needed to find out the molecular mechanism of action in various animals and human models to validate the usefulness of Punica granatum L. as a potent therapeutic agent. PMID: 29473532 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Bacterial conjunctivitis in childhood: etiology, clinical manifestations, diagnosis, and management.
CONCLUSION: The present consensus supports the use of topical antibiotics for bacterial conjunctivitis. Topical antibiotics shorten the course of the disease, reduce discomfort, prevent person-to-person transmission and reduce the rate of reinfection. PMID: 29380707 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 31, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Prednisolone effects on urine cross-linked N-telopeptides of type I collagen (Ntx) diurnal rhythms in children.
Authors: Wolthers OD, Heuck CC Abstract Recently, methods for mimicking endogenous cortisol rhythms hereby potentially reducing the risk of systemic adverse effects of exogenous corticosteroids have been patented. Methods for sensitive detection of adverse effects on bone turnover of various doses, administration routes and regimens of exogenous corticosteroids have been patented. Urine cross-linked N-telopeptides of type I collagen (Ntx) have been established as a sensitive bone resorption marker and urine levels of Ntx have been found to exhibit a distinct diurnal rhythm. OBJECTIVE: To assess whether the timi...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 27, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Anti-Inflammatory Drugs and Herbs with Special Emphasis on Herbal Medicines for Countering Inflammatory Diseases and Disorders - A Review.
CONCLUSION: Natural herbs are safe, effective and better options as anti-inflammatory agents than synthetic ones. The phytoconstituents are as effective with the comparable mechanism of action as synthetic molecules. Future research should focus on molecular mechanisms of different beneficial applications of these herbal plants in various diseases. Recent patents on anti-inflammatory drugs and herbal plants have been covered which provide insight into the current status and future prospects in this field. PMID: 29336271 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 18, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Complementary, alternative and integrative medicine for childhood atopic dermatitis.
CONCLUSIONS: AD is a complex disease. The psychodynamics of the child and his/her family is the reason for the often suboptimal outcomes. Both Western and CAM practitioners should collaborate to create a mutually encouraging environment for the advances of IM. CAM and IM publications and patents are reviewed. Evidence of their efficacy is generally lacking. Further research is needed. PMID: 29189188 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 4, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Stevens Johnson Syndrome versus Jarisch Herxheimer Reaction in an HIV positive patient with secondary syphilis.
CONCLUSIONS: although the diagnosis of SJS has established criteria, the possibility of overlap with infectious illness and/or with its treatment, may complicate the diagnosis. PMID: 29076438 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - October 29, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Influence of Shift Work on Manual Dexterity and Reaction Time in Tunisian Nurses.
CONCLUSION: We concluded to an impaired cognitive performance speed in the over 10-year seniority groups in both schedules. Recommendations should be focused on implementing periodic assessment of cognitive performance based on O'Connor finger dexterity test and time reaction test and on implementing effective preventive measures in hospitals after ten years of seniority at work. PMID: 29076439 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - October 29, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Herpes labialis: An Update.
CONCLUSION: For episodic treatment, oral antiviral agents, such as acyclovir (Zovirax), valacyclovir (Valtrex) and famciclovir (Famvir), are superior to topical antiviral therapy. Valacyclovir and famciclovir have greater oral bioavailability and are better absorbed than acyclovir, require less frequent dosing, but are more expensive and are not approved for children. Topical antiviral agents such as 5% acyclovir cream/ointment (Zovirax) ± hydrocortisone (Xerese), 1% penciclovir (Denavir) cream, and 50 mg Buccal Adhesive Tablet (ABT-50 mg) can also be used for episodic treatment of herpes labialis. These topical age...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - October 5, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Recent Patents and Emerging Therapeutics on Ocular Inflammation and Allergy.
CONCLUSION: This review presented a brief background on the disease condition, types, treatment, advancement in the delivery approaches, focus on emerging therapeutics, related patents and clinical trials for the treatment of the allergic conjunctivitis, dry eye syndrome, and uveitis. PMID: 28901856 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 15, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Emerging role of CD44 receptor as a potential target in disease diagnosis: A patent review.
CONCLUSION: A thorough understanding of CD44-receptor structure, expression and diverse functions towards different cell types would offer an opportunity to develop better therapeutic approaches in near future by overcoming all the shortcomings of toxicity and efficacy. The present review includes recent patents of CD44 receptor targeting approaches that have been presented in the different agencies: European (EP), US, and World Intellectual Property Organization (WIPO) and a general analysis of the future developments and trends in this emerging area. PMID: 28891438 [PubMed - as supplied by publisher] (Source: Recent ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - September 13, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Acute Otitis Media in Children.
CONCLUSION: Antimicrobial treatment is indicated in all children under two years of age as well as in children ≥ two years of age who have a temperature ≥39oC; are toxic looking; have otalgia >48 hours; have bilateral otitis media or otorrhea; have craniofacial abnormalities; are immunocompromised; or have uncertain access to follow-up. Amoxicillin is the drug of choice. Observation without antibiotic is an option in immunocompetent children ≥ two years of age who have an acute uncomplicated otitis media and non-severe illness if appropriate follow-up can be arranged. PMID: 28707578 [PubMed - as supplie...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 15, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

The quality of life and professional future among Tunisian workers suffering from occupational asthma.
CONCLUSIONS: Our study revealed the need to implement early preventive measures and to establish a systematic review of the permanent partial disability rate attributed to workers suffering from occupational asthma before the end of the legal period of five years. PMID: 28669330 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 5, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Molluscum contagiosum: an update.
CONCLUSION: The choice of treatment method should depend on the physician's comfort level with the various treatment options, the patient's age, the number and severity of lesions, location of lesions, and the preference of the child/parents. In general, physical destruction of the lesion, in particular, cryotherapy with liquid nitrogen and chemical destruction with cantharidin are the methods of choice for the majority of patients. PMID: 28521677 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - May 20, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Management of status asthmaticus in children.
CONCLUSIONS: Supplemental oxygen should be given to maintain an oxygen saturation of ≥92% in room air. Mainstay of pharmacologic treatment of status asthmaticus includes short-acting, β2 agonists such as salbutamol (albuterol) administered by metered-dose inhaler with spacer or, preferably, by nebulizer and oral corticosteroids. There is no advantage to intravenous corticosteroids unless the child cannot tolerate oral corticosteroids (e.g., protracted vomiting), or unable to take oral corticosteroid (e.g., intubated or unconscious). Inhaled ipratropium bromide and intravenous magnesium sulfate should be considered ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - February 1, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Flavone Analogues as Antimicrobial Agents.
CONCLUSION: Some of the 3- hydroxyl flavones derivatives (1b, 3b, 4b, and 5b) and 3- methyl flavanone derivatives (3a, 1a, 2a and 4a) were found to elicit potent antimicrobial activity. The study revealed that 3-hydroxy flavone derivatives were found to be most active against Gram negative, while 3-methyl flavanone derivatives were active against Gram positive bacteria. PMID: 28103779 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 22, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Cutaneous larva migrans.
CONCLUSION: The pruritic serpiginous track is pathognomonic. Oral ivermectin is the treatment of choice. PMID: 28078983 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 14, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Rifaximin - Chitosan Nanoparticles for Inflammatory Bowel Disease ( IBD).
CONCLUSION: Nanoparticles with small particle size found to have high encapsulation efficiency and relatively high loading capacity and predetermined in vitro release profile. PMID: 28034350 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - January 1, 2017 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Probiotics in Curing Allergic and Inflammatory Conditions - Research Progress and Futuristic Vision.
CONCLUSION: Present review gives an insight towards potent utility of this branch of beneficial microbial therapy in allergy and inflammations, which is still in the emerging phase and more scientific evidences need to be explored regarding exploration of the mechanisms of action, further experimental trials and validation of controlled clinical studies in humans along with designing novel strategies for monitoring the possible microbial changes in their composition and metabolism associated with their interaction upon host immune system. PMID: 28029082 [PubMed - as supplied by publisher] (Source: Recent Patents on Inf...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 29, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Heat Shock Proteins: Therapeutic perspectives in inflammatory disorders.
Authors: Khandia R, Munjal AK, Iqbal HM, Dhama K Abstract Heat shock proteins (HSPs) are the highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune diseases and inflammatory disorders. Virtually in all the inflammatory diseases, immune response towards HSPs is developed. HSPs modulate the process of infl...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 18, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Recent trends in nanotechnology-based drugs and formulations for targeted therapeutic delivery.
Authors: Iqbal HM, Villalba A, Khandia R, Munjal A, Dhama K Abstract In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is es...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - December 18, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Cytotoxicity and Anti-inflammatory Activity of Flavonoid Derivatives Targeting NF-kappaB.
CONCLUSION: The compound (10b) was found to be most potent as both anti-inflammatory and cytotoxic agents. In silico approach was in good tune with the wet lab experiments. The promising compounds have shown to induce cell cycle arrest at G2/M Phase. PMID: 27842477 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 16, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

A Magnetic Resonance Spectroscopy study of lovastatin for treating Bipolar Mood disorder, A-4 week Randomized Double Blind, Placebo- Controlled Clinical Trial.
CONCLUSION: Using MRS after treating with Lovastatin showed lovastatin increases NAA in cingulate gyrus, indicating the possible effect of NAA for increasing the reduced viable neuron. Moreover, the increment of Cr by lovastatin in the left basal ganglia suggests the role of lovastatin for maintaining energy homeostasis, anti-apoptotic activity and ATP production in bipolar disorder.Some patents on the use of lovastatin as an adjuant therapy for treating bipolar patients and depression in MDD patients are also outlined. This trial was registered in the Iranian Clinical Trials Registry (http://www.irct.ir/)(IRCT201302203930...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - November 4, 2016 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research