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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

Interpreting serum tryptase levels in cases of anaphylaxis and concomitant bacterial infection
Mast cells are innate immune cells located near host-environment interfaces, where they can detect diverse stimuli and respond with preformed and de novo synthesized mediators and cytokines. They are involved in host defense against bacterial, viral, or parasitic infection1. By releasing proteases (chymase, tryptase), cytokines/chemokines (TNF- α, CXCL1/KC) and histamine, they promote tissue inflammation, leukocyte recruitment and blood vessel permeability2.
Source: Annals of Allergy, Asthma and Immunology - April 26, 2023 Category: Allergy & Immunology Authors: Luc ía Gonzalez-Torres, Vanesa García-Paz, Leticia Vila Tags: Letters Source Type: research

Eosinophilic Lung Diseases
The eosinophilic lung diseases may manifest as chronic eosinophilic pneumonia, acute eosinophilic pneumonia, or as the L öffler syndrome (generally of parasitic etiology). The diagnosis of eosinophilic pneumonia is made when both characteristic clinical-imaging features and alveolar eosinophilia are present. Peripheral blood eosinophils are generally markedly elevated; however, eosinophilia may be absent at presentat ion. Lung biopsy is not indicated except in atypical cases after multidisciplinary discussion. The inquiry to possible causes (medications, toxic drugs, exposures, and infections especially parasitic) must be...
Source: Immunology and Allergy Clinics of North America - April 12, 2023 Category: Allergy & Immunology Authors: Vincent Cottin Source Type: research

Ticks Carry More Diseases Than Just Lyme. Here ’ s What You Need to Know
Chris Rose lost ten years of his health—not to mention his gallbladder—to a single tick bite. The tick bit in 2010 and Rose, now a 50-year-old network engineer in Chapel Hill, N.C., thought little of it at the time. “It was one of those lone star ticks,” he says, “and I just picked it off me. It wasn’t a big deal.” Before long, however, Rose began developing crushing chest pains, abdominal discomfort, diarrhea, and other symptoms. Doctors screened him for heart disease, irritable bowel syndrome, and gallstones, and even removed his gallbladder to see if that might ease the intesti...
Source: TIME: Health - April 5, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Disease healthscienceclimate Source Type: news

Tuft cells - the immunological interface and role in disease regulation
Int Immunopharmacol. 2023 Mar 27;118:110018. doi: 10.1016/j.intimp.2023.110018. Online ahead of print.ABSTRACTTuft cells, also known as taste chemosensory cells, accumulate during parasite colonization or infection and have powerful immunomodulatory effects on substances that could be detrimental, as well as possible anti-inflammatory or antibacterial effects. Tuft cells are the primary source of interleukin (IL)-25. They trigger extra Innate lymphoid type-2 cells (ILC2) in the intestinal lamina propria to create cytokines (type 2); for instance, IL-13, which leads to an increase in IL-25. As tuft cells can produce biologi...
Source: International Immunopharmacology - March 29, 2023 Category: Allergy & Immunology Authors: Safia Iqbal Md Rezaul Karim Deok-Chun Yang Ramya Mathiyalagan Se Chan Kang Source Type: research

Deadly parasite threatens California sea otters
Melissa Miller knew something was off when she began to examine a sea otter that had died in San Simeon, a coastal California town about halfway between San Francisco and Los Angeles, in the winter of 2020. Nearly all of the animal’s body fat was inflamed. “It felt like there were little bumps all through it,” she says—a condition the veterinary pathologist had never seen in her 25 years examining sea otters for the California Department of Fish and Wildlife. She also found unusual lesions in the pancreas and heart. When Miller looked at the sea otter’s tissues under a microscope, she spotted a familiar foe:...
Source: ScienceNOW - March 22, 2023 Category: Science Source Type: news

Pigeon mite: An underdiagnosed cause of papular urticaria
CONCLUSION: Bird mite infestation should be considered in the differential diagnosis of recurrent pruritus and urticaria, refractory to conventional treatments. Physicians should be aware of this mite infestation in approach to any patient with papular urticaria.PMID:36916094 | DOI:10.15586/aei.v51i2.667
Source: Allergologia et Immunopathologia - March 14, 2023 Category: Allergy & Immunology Authors: Saber Gharagozlou Marzieh Tavakol Mohammad Gharagozlou Source Type: research

Unraveling the role of Breg cells in digestive tract cancer and infectious immunity
Over the past two decades, regulatory B cells (Breg cells or Bregs) have emerged as an immunosuppressive subset of B lymphocytes playing a key role in inflammation, infection, allergy, transplantation, and cancer. However, the involvement of Bregs in various pathological conditions of the gastrointestinal tract is not fully understood and is the subject of much recent research. In this review, we aimed to summarize the current state of knowledge about the origin, phenotype, and suppressive mechanisms of Bregs. The relationship between the host gut microbiota and the function of Bregs in the context of the disturbance of mu...
Source: Frontiers in Immunology - December 23, 2022 Category: Allergy & Immunology Source Type: research

News at a glance: Earth ’s top geological sites, cameras on sharks, and China’s space station
NATURAL HISTORY Science society lists Earth’s top ‘geoheritage’ sites The International Union of Geological Sciences last week marked its 60th anniversary by announcing a list of 100 “geoheritage” sites that have substantially influenced understanding of Earth’s deep history . The global list, released in collaboration with UNESCO, is meant to foster conservation and tourism. The sites include familiar ones, such as the Grand Canyon’s “great unconformity,” a billion-year gap in the rock record erased by erosion. More exotic examples include limestones in Germany that preserve Arc...
Source: Science of Aging Knowledge Environment - November 3, 2022 Category: Geriatrics Source Type: research

Antibody weapon against malaria shows promise in Africa
A new way to prevent malaria that showed promise in 9 U.S. volunteers deliberately exposed to parasite-laden mosquitoes last year has now shown its mettle in a real-world situation in Africa. A study published today in the New England Journal of Medicine showed that a single dose of lab-produced monoclonal antibodies can protect recipients from infection for up to 6 months during Mali’s intense malaria season. Monoclonal antibodies are expensive to produce and can be cumbersome to administer if they are infused straight into the bloodstream. That makes some researchers skeptical that the new ones to thwa...
Source: ScienceNOW - November 1, 2022 Category: Science Source Type: news

Unrecognized parasitic infection as a cause of persistent eosinophilia in an inner-city allergy clinic population
Persistent peripheral blood eosinophilia (absolute eosinophil count (AEC)> 500 cells/mL) is frequently a manifestation of a serious medical problem. Nevertheless, previous studies have shown that patients with persistent eosinophilia are often not adequately evaluated for possible underlying causes.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: P. Regula, M. Beronilla, H. Jakubowicz, A. Fizitskaya, D. Ferastraoaru, M. Ramesh, D. Rosenstreich, G. Hudes Tags: Other: Eosinophil Related Conditions/Eosinophilia/Hypereosinophilia Clemens von Pirquet Award – 2 Place Source Type: research

Dupilumab induced hypereosinophilic syndrome (hes)
We describe a case of HES manifesting with altered mental status two months after starting therapy with dupilumab.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: A. Abulhamail, T. Kelbel, J. Lin, L. Funderburk Tags: M028 Source Type: research

Identification of microbial taxa present in Ctenocephalides felis (cat flea) reveals widespread co-infection and associations with vector phylogeny
Ctenocephalides felis, the cat flea, is the most common ectoparasite of cats and dogs worldwide. As a cause of flea allergy dermatitis and a vector for two genera of zoonotic pathogens (Bartonella and Rickettsia ...
Source: Parasites and Vectors - October 31, 2022 Category: Microbiology Authors: Charlotte Manvell, Hanna Berman, Benjamin Callahan, Edward Breitschwerdt, William Swain, Kelli Ferris, Ricardo Maggi and Erin Lashnits Tags: Research Source Type: research