Query: allergy Immmunology

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Early-life exposure to air pollution and childhood allergic diseases: An update on the link and its implications.
Authors: Lu C, Norbäck D, Li Y, Deng Q Abstract INTRODUCTION: Although mounting evidence has linked environmental factors with childhood allergies, some specific key issues still remain unclear: what is the main environmental factor? what is the critical timing window? And whether these contribute to the development of disease? AREAS COVERED: This selective review summarizes recent epidemiological studies into the association between early-life exposure to indoor and outdoor air pollution, and childhood allergic diseases. A literature search was conducted in the PubMed and Web of Science for peer-reviewed arti...
Source: Expert Review of Clinical Immunology - August 4, 2020 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Risk factors and characteristics of biphasic anaphylaxis
Publication date: Available online 4 August 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Magdalena Kraft, Kathrin Scherer Hofmeier, Franziska Ruëff, Claudia Pföhler, Jean-Marie Renaudin, Maria Beatrice Bilò, Regina Treudler, Roland Lang, Ewa Cichoka-Jarosz, Montserrat Fernandez-Rivas, George Christoff, Nikolaos G. Papadopoulus, Luis Felipe Ensina, Jonathan O’B Hourihane, Ioana Maris, Alice Köhli, Blanca E. García, Uta Jappe, Christian Vogelberg, Hagen Ott
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 4, 2020 Category: Allergy & Immunology Source Type: research

Dr. Fauci warns against dining out, playing sports, going to school and church but refuses to condemn protestors' violent mass gatherings
(Natural News) The head of the National Institute of Allergy and Infectious Disease (NSAID) and the former face of the federal coronavirus task force, Dr. Anthony Fauci has not only become a media darling, posing for magazines and interviews of self-congratulation, but he has also made some detailed suggestions that have convinced people to live...
Source: NaturalNews.com - August 4, 2020 Category: Consumer Health News Source Type: news

Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice
The Radiation and Nuclear Countermeasures Program at the National Institute of Allergy and Infectious Diseases (NIAID) mandated that medical countermeasures for treating Acute Radiation Syndrome (ARS) must have efficacy when administered at least 24 h after radiation exposure. At this time point, many cells within key target tissues, such as the hematopoietic system and the gastrointestinal (GI) tract, will already be dead. Therefore, drugs that promote the regeneration of surviving cells may improve outcomes. The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) regulates stem and progenitor cell self-renewal and...
Source: Health Physics - August 4, 2020 Category: Radiology Tags: PAPERS Source Type: research

NIH launches clinical trial to test antibody treatment in hospitalized COVID-19 patients
(NIH/National Institute of Allergy and Infectious Diseases) Patients admitted with COVID-19 at select hospitals may now volunteer to enroll in a clinical trial to test the safety and efficacy of a potential new treatment for the disease. The Phase 3 randomized, controlled trial, known as ACTIV-3, and as a " master protocol, " is designed to expand to test multiple kinds of monoclonal antibody treatments. It also can enroll additional volunteers in the middle of the trial, if a specific investigational treatment shows promise.
Source: EurekAlert! - Infectious and Emerging Diseases - August 4, 2020 Category: Infectious Diseases Source Type: news

NIH trial to test antibodies and other therapeutics for mild, moderate COVID-19
(NIH/National Institute of Allergy and Infectious Diseases) A Phase 2 clinical trial will evaluate the safety and efficacy of potential new therapeutics for COVID-19, including an investigational therapeutic based on synthetic monoclonal antibodies (mAbs) to treat the disease. Researchers sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, are working with clinical sites to identify potential patient volunteers currently infected with SARS-CoV-2, the virus which causes COVID-19, who have mild to moderate disease not requiring hospitalization.
Source: EurekAlert! - Infectious and Emerging Diseases - August 4, 2020 Category: Infectious Diseases Source Type: news

Nivolumab Plus Ipilimumab or Pembrolizumab Most Cost-Effective for Newly Diagnosed Advanced Melanoma Nivolumab Plus Ipilimumab or Pembrolizumab Most Cost-Effective for Newly Diagnosed Advanced Melanoma
BRAF and MEK inhibitors might be used in a second-line setting after BRAF pathogenic variant is confirmed.Reuters Health Information
Source: Medscape Allergy Headlines - August 4, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Telemedicine Helps but Also Highlights Health Disparities During Pandemic Telemedicine Helps but Also Highlights Health Disparities During Pandemic
The COVID-19 pandemic has accelerated the expansion of telemedicine across the U.S., which has opened up access to doctor ' s offices for families with limited resources.Reuters Health Information
Source: Medscape Allergy Headlines - August 4, 2020 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news

Large US COVID-19 Vaccine Trials Will Exclude Pregnant Women for Now Large US COVID-19 Vaccine Trials Will Exclude Pregnant Women for Now
The first two COVID-19 vaccines to enter large-scale U.S. trials will not be tested in pregnant women this year, researchers told Reuters.Reuters Health Information
Source: Medscape Allergy Headlines - August 4, 2020 Category: Allergy & Immunology Tags: Ob/Gyn & Women ' s Health News Source Type: news

FDA OKs Two Blood Tests to Estimate SARS-CoV-2 Antibodies FDA OKs Two Blood Tests to Estimate SARS-CoV-2 Antibodies
The numbers of antibodies can act as a baseline, but the information they yield is limited. The FDA cautions against using the results as an indicator to relax precautions.FDA Approvals
Source: Medscape Allergy Headlines - August 4, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Alert Source Type: news

U.S. Government to Launch ' Overwhelming ' COVID-19 Vaccine Campaign by November U.S. Government to Launch ' Overwhelming ' COVID-19 Vaccine Campaign by November
The US government anticipates launching a promotions campaign by November to encourage Americans to get vaccinated against COVID, contingent on evidence that a vaccine will be available by year ' s end.Reuters Health Information
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

ACS Disagrees With CDC on HPV Vaccination in Adults ACS Disagrees With CDC on HPV Vaccination in Adults
The American Cancer Society ' s new guidance on human papillomavirus vaccination diverges from the Centers for Disease Control and Prevention ' s recommendations.Medscape Medical News
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

US to Pay $2.1 Bln to Sanofi, GSK, in COVID-19 Vaccine Deal US to Pay $2.1 Bln to Sanofi, GSK, in COVID-19 Vaccine Deal
The U.S. government will pay $2.1 billion to Sanofi SA and GlaxoSmithKline Plc for COVID-19 vaccines to cover 50 million people and to underwrite the drugmakers ' testing and manufacturing.Reuters Health Information
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

China-Backed Hackers ' Targeted COVID-19 Vaccine Firm Moderna ' China-Backed Hackers ' Targeted COVID-19 Vaccine Firm Moderna '
Chinese government-linked hackers targeted biotech firm Moderna, a US-based coronavirus vaccine research developer, in a bid to steal data, according to a US security official tracking Chinese hacking.Reuters Health Information
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Video Source Type: news

Trump ' s Planning for US Rollout of Coronavirus Vaccine Is Falling Short, Officials Warn Trump ' s Planning for US Rollout of Coronavirus Vaccine Is Falling Short, Officials Warn
As scientists work to develop a vaccine for the novel coronavirus, public health officials and senior US lawmakers are sounding alarms about the Trump administration ' s lack of planning for the rollout.Reuters Health Information
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Lilly Initiates Phase 3 Trial of LY-CoV555 for Prevention of COVID-19 at Long-Term Care Facilities in Partnership with the National Institute of Allergy and Infectious Diseases (NIAID)
More than 40 percent of coronavirus deaths in the U.S. linked to long-term care facilities; urgent need for therapeutic strategies to prevent COVID-19 in this vulnerable population First-of-its-kind study will enroll up to 2,400 residents and staff at l... Biopharmaceuticals Eli Lilly, COVID-19, SARS-CoV-2, LY-CoV555
Source: HSMN NewsFeed - August 3, 2020 Category: Pharmaceuticals Source Type: news

Controlling Healthcare-Associated Respiratory Infections Controlling Healthcare-Associated Respiratory Infections
What strategies may help reduce the incidence of healthcare-associated respiratory viral infections? Which are most effective?Current Opinion in Infectious Diseases
Source: Medscape Allergy Headlines - August 3, 2020 Category: Allergy & Immunology Tags: Infectious Diseases Journal Article Source Type: news

Clinical Factors Affecting the Therapeutic Efficacy of Evening Primrose Oil on Mastalgia
ConclusionEPO can be used in the treatment of mastalgia without significant side effects. HRT, IUD-with-levonorgestrel, iron deficiency, overt hypothyroidism, and Hashimoto thyroiditis significantly affect the efficacy of EPO on mastalgia.
Source: Annals of Surgical Oncology - August 3, 2020 Category: Cancer & Oncology Source Type: research

Skin Barrier Dysfunction in Contact Dermatitis and Atopic Dermatitis-Treatment Implications
AbstractPurpose of reviewA variety of skin diseases are associated with impaired barrier function. The crucial pillars in therapy of previously mentioned conditions are avoidance of triggers, skin protection and individually adapted medical therapy. Until recently, besides of topical corticosteroids, the treatment options were limited. However, a variety of new therapies of skin barrier-related skin diseases became available over the last years. Our goal was to investigate new findings and treatment options in skin diseases with barrier dysfunction, emphasizing on contact dermatitis, hand eczema and atopic dermatitis.Recen...
Source: Current Treatment Options in Allergy - August 3, 2020 Category: Allergy & Immunology Source Type: research

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis
AbstractThe pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic se...
Source: Clinical and Translational Allergy - August 3, 2020 Category: Allergy & Immunology Source Type: research

The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries
AbstractPurpose of ReviewOlfactory dysfunction in upper airway viral infections (common cold, acute rhinosinusitis) is common (>  60%). During the COVID-19 outbreak, frequency of sensory disorders (smell and/or taste) in affected patients has shown a high variability from 5 to 98%, depending on the methodology, country, and study.Recent FindingsA sudden, severe, isolated loss of smell and/or taste, in the absence of other upper airway inflammatory diseases (allergic rhinitis, chronic rhinosinusitis, nasal polyposis), should alert individuals and physicians on being potentially affected by COVID-19. The evaluation of s...
Source: Current Allergy and Asthma Reports - August 3, 2020 Category: Allergy & Immunology Source Type: research

Patient Characteristics and Risk Factors for Home Epinephrine-Treated Reactions During Oral Immunotherapy for Food Allergy
Publication date: Available online 1 August 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Liat Nachshon, Naama Schwartz, Lior Tsviban, Michael B. Levy, Michael Goldberg, Naama Epstein-Rigby, Yitzhak Katz, Arnon Elizur
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 2, 2020 Category: Allergy & Immunology Source Type: research

Reply to “Appointment characteristics during COVID-19 restrictions—a Canadian Allergy/Immunology Centre perspective”
Publication date: Available online 18 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Allison Ramsey, S. Shahzad Mustafa
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 2, 2020 Category: Allergy & Immunology Source Type: research

Impulse oscillometry bronchodilator response and asthma control
Publication date: Available online 31 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Chris RuiWen Kuo, Rory Chan, Brian Lipworth
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 2, 2020 Category: Allergy & Immunology Source Type: research

Asthma Medication Use and Risk of Birth Defects: National Birth Defects Prevention Study, 1997–2011
Publication date: Available online 31 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Meredith M. Howley, Eleni A. Papadopoulos, Carla M. Van Bennekom, Alissa R. Van Zutphen, Suzan L. Carmichael, JeanPierre W. Munsie, Michele L. Herdt, Marilyn L. Browne, National Birth Defects Prevention Study
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 2, 2020 Category: Allergy & Immunology Source Type: research

Seasonality of food-related anaphylaxis admissions and associations with temperature and pollen levels
Publication date: Available online 31 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Holly C.Y. Lam, Paul J. Turner, Debbie Hemming, Deborah L. Jarvis
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 2, 2020 Category: Allergy & Immunology Source Type: research

Prevalence and clinical characteristics of allergic rhinitis in the elderly Korean population
ConclusionsThe elderly population has a distinct clinical presentation, including a low prevalence of allergic rhinitis, and an increased incidence of rhinorrhea symptoms, compared with the general adult population. The management of allergic rhinitis in elderly patients may therefore require a different therapeutic approach to improve rhinorrhea rather than nasal obstruction.
Source: European Archives of Oto-Rhino-Laryngology - August 2, 2020 Category: ENT & OMF Source Type: research

GSE148240 Airborne particulate matter from goat farm increases acute allergic airway responses in mice increases acute allergic airway responses in mice
Contributors : Mariman Rob ; Liu DingyuSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responsesMethods: Fine (
Source: GEO: Gene Expression Omnibus - August 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

“I want to really crack this nut”: an analysis of parent-perceived policy needs surrounding food allergy
In Canada, anaphylaxis-level food allergy constitutes a legal disability. Yet, no nationwide policies exist to support families. We sought to understand what parents of children with food allergy perceive as t...
Source: BMC Public Health - August 1, 2020 Category: Consumer Health News Authors: Elissa M. Abrams, Elinor Simons, Jennifer Gerdts, Orla Nazarko, Beatrice Povolo and Jennifer L. P. Protudjer Tags: Research article Source Type: research

Contact Tracing Is Failing in Many States. Here ’s Why.
Inadequate testing and protracted delays in producing results have crippled tracking and hampered efforts to contain major outbreaks.
Source: NYT Health - August 1, 2020 Category: Consumer Health News Authors: Jennifer Steinhauer and Abby Goodnough Tags: Contact Tracing (Public Health) Tests (Medical) Coronavirus (2019-nCoV) States (US) Medicine and Health Centers for Disease Control and Prevention National Institute of Allergy and Infectious Diseases Arizona Austin (Tex) California Fl Source Type: news

Delayed corticosteroid hypersensitivity: a clinical management proposal.
Conclusions. Although the lack of standardization, the allergy workup proves useful to differentiate patients sensitized to one or few molecules from polysensitized and to identify the culprit drugs. Intradermal and challenge test are necessary to complete the diagnostic workup. The results suggest the possibility of a different management of patients. Patients of pattern one can be only patch tested with a limited series of CS belonging to the 3 groups. They don't need an extensive exclusion of steroids use. The pattern 2 and 3 must be submitted instead to a complete allergological individual evaluation to identify altern...
Source: European Annals of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Drug use and abuse and the risk of adverse events in soccer players: results from a survey in Italian second league players.
Conclusions. This study shows that drug misuse/abuse in soccer is a real matter of debate, especially with regards to NSAIDs, exposing athletes to predictable and/or unpredictable risks for their health. PMID: 32729317 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Speculations on red meat allergy due to á-Gal; its connection to coronary artery disease, suggested dietary guidance and allergy testing.
Authors: Pitsios C, Dimitriou A, Vassilopoulou E PMID: 32729316 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Association between the density and type of trees around urban schools and exhaled nitric oxide levels in schoolchildren.
Authors: Paciência I, Cavaleiro Rufo J, Ribeiro AI, Mendes FC, Farraia M, Silva D, Delgado L, Moreira A Abstract Summary: Greenspaces in school's neighbourhood represent an important environment to promote healthy development. The aim of this study was to assess the association between the density and type of trees around schools and exhaled nitric oxide (NO) levels in schoolchildren. Data on 845 children from 20 primary schools in Porto was analysed. Airway inflammation was assessed by measuring exhaled NO level. The density and type of trees were quantified within a 500 m buffer around schools. Associations were...
Source: European Annals of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

The show must go on. The impacts of SARS-CoV-2 pandemic on cutaneous allergology and patch testing.
Authors: Alpalhão M, Filipe P PMID: 32729314 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Impact of penicillin allergy records on antibiotic costs and length of hospital stay: a single-centre observational retrospective cohort
Publication date: September 2020Source: Journal of Hospital Infection, Volume 106, Issue 1Author(s): N. Powell, K. Honeyford, J. Sandoe
Source: Journal of Hospital Infection - August 1, 2020 Category: Infectious Diseases Source Type: research

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
AbstractActivated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory resp...
Source: Clinical Reviews in Allergy and Immunology - August 1, 2020 Category: Allergy & Immunology Source Type: research

Proteomic analysis of nasal mucus samples of healthy and chronic rhinosinusitis patients
Chronic rhinosinusitis (CRS) has a complex and multifactorial pathogenesis with a heterogeneous inflammatory profile. Proteomic analysis of nasal mucus may enable further understanding of protein abundances and biological processes present in CRS and its endotypes compared to healthy patients.
Source: Journal of Allergy and Clinical Immunology - August 1, 2020 Category: Allergy & Immunology Authors: Stephen Shih-Teng Kao, Ahmed Bassiouni, Mahnaz Ramezanpour, John Finnie, Nusha Chegeni, Alex D. Colella, Timothy K. Chataway, Peter-John Wormald, Sarah Vreugde, Alkis James Psaltis Source Type: research

Leukotriene-Associated Rash in Aspirin-Exacerbated Respiratory Disease
Publication date: Available online 29 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Tanya M. Laidlaw, Deborah H. Gakpo, Jillian C. Bensko, Kathleen Buchheit
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 31, 2020 Category: Allergy & Immunology Source Type: research

Implementation of the Addendum Guidelines for Peanut Allergy Prevention by U.S. Allergists, a Survey conducted by the NIAID, in Collaboration with the AAAAI
An online survey assessed usage of the 2017 Addendum Guidelines for the Prevention of Peanut Allergy by allergists. Most responders reported fully or partially implementing the Guidelines, but barriers to implementation were identified.
Source: Journal of Allergy and Clinical Immunology - July 31, 2020 Category: Allergy & Immunology Authors: Jacqueline L. Johnson, Ruchi S. Gupta, Lucy A. Bilaver, Jack W. Hu, Jennifer Martin, Jialing Jiang, Alexandria Bozen, Matthew M. Davis, Jamie Reese, Susan Cooper, Alkis Togias, Samuel J. Arbes Source Type: research

Correspondence: International Registry of Otolaryngologist ‐Head and Neck Surgeons with COVID‐19
International Forum of Allergy& Rhinology, Accepted Article.
Source: International Forum of Allergy and Rhinology - July 31, 2020 Category: Allergy & Immunology Authors: Justin H. Turner Tags: CORRESPONDENCE AND REPLY Source Type: research

Allergists/Immunologists Contextualize and Provide Relevance to Immunology in a Preclerkship Undergraduate Medical Education Curriculum
A call to develop more clinician educators in allergy and immunology was recently published. 1 The authors communicated the paucity of Allergy/Immunology (A/I) specialists focused on medical education. This will foreseeably result in diminishing interest in the field of A/I for medical students and residents due to reduced exposure to these specialists. Waning interest in A/I as a career is already reflected in the declining numbers of candidates for every A/I fellowship position (1.7 in 2010 as compared to 1.2 in 2020).
Source: Annals of Allergy, Asthma and Immunology - July 31, 2020 Category: Allergy & Immunology Authors: Marie Cavuoto Petrizzo, Doreen M. Olvet, Joel N.H. Stern Tags: Letters Source Type: research

Clinical course and outcomes in patients with asthma hospitalized for SARS-CoV-2 pneumonia:a single-center, retrospective study.
The data on the clinical characteristics and outcomes of asthmatics with SARS-CoV-2 infection are scarce, but are of paramount importance to evaluate the relationship between COVID-19 and asthma. Given the characteristics of the virus, one would expect to observe an increased prevalence of asthma and wheezing exacerbations in COVID-19 patients with allergy and asthma comorbidity, a typical consequence in case of a viral respiratory infection (1). In this single-centre, observational study, we investigated asthmatic patients with confirmed SARS-CoV-2 pneumonia who were admitted to our hospital (Fondazione Poliambulanza Isti...
Source: Annals of Allergy, Asthma and Immunology - July 31, 2020 Category: Allergy & Immunology Authors: Carlo Lombardi, Elena Roca, Barbara Bigni, Marcello Cottini, Giovanni Passalacqua Tags: Letters Source Type: research

Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.
CONCLUSIONS: None of the established therapeutic options are curative. However, newer treatment modalities including excimer laser, interleukin-31 antibodies and biologics are evolving so that there may be significant advances in treatment in the near future. AA can be psychosocially devastating. It is important to assess the quality of life, degree of anxiety, social phobia and mood of the patients and their families. Psychological support is imperative for those who are adversely affected psychosocially. PMID: 32723274 [PubMed - as supplied by publisher]
Source: Recent Patents on Inflammation and Allergy Drug Discovery - July 30, 2020 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Personalized Approach of Severe Eosinophilic Asthma Patients Treated with Mepolizumab and Benralizumab
Conclusions: This real-life study provides new insights for the personalized approach to severe asthma therapy. Although preliminary, the results indicate that besides eosinophils, KL-6 and sL-selectin are useful as biomarkers of early response that can also involve in the pathogenesis of severe asthma.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - July 30, 2020 Category: Allergy & Immunology Source Type: research

Increased Serum Periostin Levels and Eosinophils in Nasal Polyps Are Associated with the Preventive Effect of Endoscopic Sinus Surgery for Asthma Exacerbations in Chronic Rhinosinusitis Patients
Conclusion: Preoperative increased serum periostin and eosinophils in NPs are associated with the preventive effect of ESS for asthma exacerbations in CRS patients comorbid with asthma.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - July 30, 2020 Category: Allergy & Immunology Source Type: research

Diagnostic modalities based on flow cytometry for chronic granulomatous disease: a multicenter study in a well-defined cohort
Publication date: Available online 28 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Hatice Ezgi Baris, Ismail Ogulur, Bengu Akcam, Ayca Kiykim, Dilek Karagoz, Berkay Saraymen, Gamze Akgun, Sevgi Bilgic Eltan, Sezin Aydemir, Zeynep Akidagi, Esma Bentli, Ercan Nain, Nurhan Kasap, Dilek Baser, Derya Ufuk Altintas, Yildiz Camcioglu, Gözde Yesil, Ahmet Ozen, Mustafa Yavuz Koker, Elif Karakoc-Aydiner
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 30, 2020 Category: Allergy & Immunology Source Type: research

New Ways of Working
Publication date: Available online 28 July 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jayne MacMahon, Aideen Byrne
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 30, 2020 Category: Allergy & Immunology Source Type: research

One-year sustained impact of supervised epinephrine autoinjector administration during food challenge on parent confidence
Patients with food allergy may experience frequent accidental allergic reactions which are often not recognized or adequately treated with epinephrine.1,2 Reasons for not administering the epinephrine autoinjector (EAI) when necessary include: EAI wasn ’t available, lack of knowledge about how to use the EAI or symptoms of an allergic reaction, and fear that administering the EAI will cause more harm than good.2 Our previous study provided hands-on experience for parents and children to administer an EAI under medical supervision for an allergic reaction during an oral food challenge (OFC).
Source: Annals of Allergy, Asthma and Immunology - July 30, 2020 Category: Allergy & Immunology Authors: Lianne Soller, Timothy Teoh, Ingrid Baerg, Tiffany Wong, Edmond S. Chan Tags: Letters Source Type: research

Design, quality, safety and efficacy of extensively hydrolyzed formula for management of cow's milk protein allergy: What are the challenges?
Abstract Cow's milk protein allergy (CMPA) is one of the most common food allergies in infancy. Clinical food allergy guidelines recommend an extensively hydrolyzed formula (EHF) as the first-line treatment in nonbreastfed infants with CMPA. Designing and commercializing EHF poses both technical and regulatory challenges. Each manufacturing step, from sourcing of raw materials to release of the final product, needs to be managed in accordance with comprehensive quality systems. To avoid cross-contamination via externally sourced ingredients, suppliers should be carefully selected based on quality requirements. Str...
Source: Advances in Food and Nutrition Research - July 29, 2020 Category: Nutrition Authors: Nutten S, Schuh S, Dutter T, Heine RG, Kuslys M Tags: Adv Food Nutr Res Source Type: research