Query: allergy Immmunology

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Prevalence of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Patients using Two Different Diagnostic Criteria.
Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence. PMID: 31702121 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - November 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Histamine-release test in angioedema patients without urticaria - a retrospective cohort study of 404 patients.
Authors: Authried G, Prasad SC, Rasmussen ER, Bygum A Abstract Summary: A subset of patients with angioedema (AE) and urticaria has histamine releasing autoantibodies. The histamine release test (HR-test) has been used as a tool in chronic urticaria to define the autoimmune subgroup and may possibly guide the clinician to a more personalized therapy, like omalizumab and cyclosporine. The prevalence and value of positive histamine releasing autoantibodies in monosymptomatic AE is sparsely described in the literature. The purpose of this study was to report the prevalence of positive histamine releasing autoantibodie...
Source: European Annals of Allergy and Clinical Immunology - November 11, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Children with Asthma have Fixed Airway Obstruction through Childhood Unaffected by Exacerbations
ConclusionChildren with asthma with exacerbations compared to asthma children without exacerbations are characterized by increased airway obstruction since infancy through childhood. The airway obstruction is a fixed trajectory without progression due to exacerbations, suggesting that exacerbations are a consequence rather than a cause of diminished airway caliber in childhood.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 9, 2019 Category: Allergy & Immunology Source Type: research

Predicting the response to bronchial thermoplasty
ConclusionThe most severely afflicted patients had the greatest improvements in ACQ, exacerbation frequency and medication requirement.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 9, 2019 Category: Allergy & Immunology Source Type: research

Penicillin Allergy: The Impact of a False Diagnosis.
Authors: Cardoso BK, Farinha SM, Martins M, Lobão B, Tomaz E, Inácio F PMID: 31703189 [PubMed - in process]
Source: Acta Medica Portuguesa - November 9, 2019 Category: General Medicine Tags: Acta Med Port Source Type: research

Update on Early Introduction of Peanut to Prevent Allergy Development: Challenges with Implementation
AbstractPurpose of ReviewThis review summarizes the evidence leading towards the development of new guidelines that recommend early introduction of peanut to prevent the development of peanut allergy. It also reviews the current understanding of challenges faced with implementation of these recommendations on a widespread basis.Recent FindingsPrior recommendations to avoid feeding allergenic foods to infants have been updated and reversed. This paradigm shift in advice has created an opportunity on a population level to try and halt the recent increase in prevalence of peanut allergy. However, challenges with implementatio...
Source: Current Allergy and Asthma Reports - November 9, 2019 Category: Allergy & Immunology Source Type: research

When every second counts: ampoule versus adrenaline auto-injector administration for life-threatening allergy.
Authors: McDonald EM, Cooper E PMID: 31697666 [PubMed - in process]
Source: New Zealand Medical Journal - November 8, 2019 Category: General Medicine Tags: N Z Med J Source Type: research

“Real world assessment of asthma control and severity in children, adolescents, and adults with asthma: Relationships to care settings and co-morbidities”
ConclusionsWe identified several demographics and co-morbidities that are independently associated with the specialist care setting, persistent asthma and poor asthma control. Awareness of these relationships may be helpful for clinicians caring for asthma patients.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 8, 2019 Category: Allergy & Immunology Source Type: research

Anaphylaxis to baobab fruit: the paradox of "natural healthy food".
Authors: Martini M, Mistrello G, Amato S, Bilò MB, Agolini S, Corsi A, Tontini A, Antonicelli L Abstract Summary: The nocebo reaction, namely the undesirable effect of an inert substance (placebo), is a phenomenon rarely investigated in literature. A better knowledge of this reaction may help clinicians in the management of these patients in clinical practice. Patients with drug adverse reactions (ADR) undergoing the drug challenge test are an ideal model for studying the nocebo effect, and the study aims to investigate their clinical and psychological features. One hundred and twenty patients (Mage = 46.59, SD = ...
Source: European Annals of Allergy and Clinical Immunology - November 8, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Deep learning for pollen allergy surveillance from twitter in Australia
The paper introduces a deep learning-based approach for real-time detection and insights generation about one of the most prevalent chronic conditions in Australia - Pollen allergy. The popular social media pl...
Source: BMC Medical Informatics and Decision Making - November 8, 2019 Category: Information Technology Authors: Jia Rong, Sandra Michalska, Sudha Subramani, Jiahua Du and Hua Wang Tags: Research Article Source Type: research

Implementation of a Pharmacist-Driven Detailed Penicillin Allergy Interview.
Conclusions and Relevance: Implementation of pharmacist-driven DPAIs can provide updated and corrected allergy information within the EHR, allowing for de-escalation and/or optimization of antimicrobial therapy. PMID: 31701755 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - November 8, 2019 Category: Drugs & Pharmacology Authors: Mann KL, Wu JY, Shah SS Tags: Ann Pharmacother Source Type: research

Recent developments in understanding the mechanisms of food allergy
Purpose of review The prevalence of food allergy is rising globally. This review will discuss recent discoveries regarding the immunologic mechanisms that drive the initial sensitization and allergic response to food antigens, which may inform prevention and treatment strategies. Recent findings Tolerance to food antigens is antigen-specific and promoted by oral exposure early in life and maternal transfer of immune complexes via breast milk. IgG can inhibit both the initiation and effector phases of allergic responses to food antigens in mice, and high levels of food-specific IgG4 are associated with acquisition of t...
Source: Current Opinion in Pediatrics - November 7, 2019 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

The clinical and immune outcomes after food allergen immunotherapy emphasizing the development of tolerance
Purpose of review The present review serves to outline the direction of food allergy immunotherapy research with an emphasis on clinical and immunologic outcomes. It helps to delineate sustained unresponsiveness achieved from food immunotherapy as the clinical outcome most similar to immune tolerance. Recent findings We will discuss the difference between immune tolerance, desensitization, and sustained unresponsiveness in relation to food immunotherapy by discussing the clinical and immunologic changes which have been recently discovered. Summary Research has recently shown that oral immunotherapy is most efficaci...
Source: Current Opinion in Pediatrics - November 7, 2019 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Advances in aeroallergen immunotherapy
Purpose of review Allergic rhinoconjunctivitis is the most common manifestation of allergic disease. This break in the normal natural function of the immune system to ignore harmless molecules such as pollen and pet dander to now aggressively react has lead to a substantial disease burden that is not always recognized and adequately treated. Recent findings Individual molecular component testing may increase the predictive value of blood sIgE and clinical symptoms. Defining the most symptoms inducing allergenic protein has led to advances in peptide-based allergen immunotherapy. There have been steady consistent repor...
Source: Current Opinion in Pediatrics - November 7, 2019 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Evaluation in a severe asthma expert center improves asthma outcomes regardless of step-up in asthma therapy
Publication date: Available online 6 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Camille Bègne, Aurélien Justet, Clairelyne Dupin, Camille Taillé
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 7, 2019 Category: Allergy & Immunology Source Type: research

Epidemiology and Trends of Hereditary Hemorrhagic Telangiectasia in the United States.
PMID: 31698927 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - November 7, 2019 Category: ENT & OMF Authors: Ferry AM, Wright AE, Baillargeon G, Kuo YF, Chaaban MR Tags: Am J Rhinol Allergy Source Type: research

Elevated serum IgE, oral corticosteroid dependence and IL-17/22 expression in highly neutrophilic asthma
Information on the clinical traits associated with bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess the clinical, functional and biological features of neutrophilic asthma and identify possible predictors of bronchial neutrophilia. The inflammatory phenotype of 70 mild-to-severe asthma patients was studied cross-sectionally based on the eosinophilic/neutrophilic counts in their bronchial lamina propria. Patients were classified as neutrophilic or non-neutrophilic. Neutrophilic asthma patients (neutrophil count cut-off: 47.17 neutrophils·mm–2;...
Source: European Respiratory Journal - November 7, 2019 Category: Respiratory Medicine Authors: Bullone, M., Carriero, V., Bertolini, F., Folino, A., Mannelli, A., Di Stefano, A., Gnemmi, I., Torchio, R., Ricciardolo, F. L. M. Tags: Lung biology and experimental studies, Asthma and allergy Original Articles: Asthma and basic science Source Type: research

Gastrointestinal Manifestations in Common Variable Immunodeficiency (CVID) are Associated with An Altered Immunophenotype Including B- and T-cell Dysregulation
Publication date: Available online 5 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Sara Barmettler, Mei-Sing Ong, Jocelyn R. Farmer, Nancy Yang, Mark Cobbold, Jolan E. Walter, Aidan Long, Carlos A. Camargo
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Burden of emergency department utilization and abdominal imaging for hereditary angioedema
Publication date: Available online 5 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Brian T. Cheng, Jonathan I. Silverberg, Jonathan D. Samet, Anna B. Fishbein
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Importance of patients' photographs for urticaria diagnosis
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Emmanuelle Amsler, Angèle Soria, Marie-Sylvie Doutre, Urticaria Group (GUS) of French Dermatological Society
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

CMV-Seropositive Mothers of SCID: To Breastfeed or Not?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jolan E. Walter, Jennifer Heimall
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

The role of breast-feeding in cytomegalovirus transmission and hematopoietic stem cell transplant outcomes in infants with severe combined immunodeficiency
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): William J. Kelty, Shona A. Beatty, Shuya Wu, Imelda Celine Hanson, Gail J. Demmler-Harrison, Caridad A. Martinez, Jordan S. Orange, Carla M. Davis
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Forced Oscillometry: A New Tool for Assessing Airway Function—Is It Ready for Prime Time?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jonathan Ram, Jenny Pineda-Cely, William J. Calhoun
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Carbonic Anhydrase Inhibitors: Epidemiology, Genetics, and Insights into Mechanisms
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jason A. Trubiano, David A. Ostrov, Elizabeth J. Phillips
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Chronic Urticaria/Angioedema (CUA): Which Diagnostics, if any, Inform Etiology and Response to Treatment?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Reynold M. Karr
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Endotype-Phenotype Correlation in Chronic Rhinosinusitis: Is It Time to Think Beyond Polyposis?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Larry Borish, Daniel L. Hamilos
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Redefining Precision Medicine in Disorders of Immune Dysregulation
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jennifer W. Leiding, Mark Ballow
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Peanut Oral Immunotherapy: Is It Safer in Preschoolers than in Older Age Groups?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Rima Rachid
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Disparate Eosinophilic Phenotypes with Age: Impact on Eligibility for Anti–IL-5 Therapies in Severe Asthma
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Pieter-Paul Hekking, W. Gerald Teague
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

“The Dilemma of the American Conscience”: The Delivery of Health Care for Asthma in Pregnancy Based on Health Insurance Status in the United Status: A Call to Action
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Sigrid Payne DaVeiga
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

The Safety and Efficacy of Anti–IL-13 Treatment with Tralokinumab (CAT-354) in Moderate to Severe Asthma: A Systematic Review and Meta-Analysis
ConclusionThis pooled analysis of 6 RCTs suggested that tralokinumab was well tolerated and it modestly improved FEV1 and forced vital capacity in patients with moderate to severe asthma. It did not render clinically important improvements in asthma-related quality of life, and nor did it reduce asthma exacerbations.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of epinephrine's expiration date: A US Food and Drug Administration's perspective
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jennifer Lan, Miya Paterniti, Craig Bertha, Julia Pinto, Giuseppe Randazzo, Ramesh Sood, Sally Seymour
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

“Everybody's Got Asthma” – When Misunderstanding and Public Opinion Become Obstacles to the Care of Patients with Severe Asthma
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Sigrid Payne DaVeiga, Helen Reddel
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

e-Consults in Allergy and Immunology: “Why Am I Here?”
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Jay M. Portnoy, Alicia C. Brush, Richard W. Honsinger
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

There's an App for That, But Does It Work?
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Ann Chen Wu
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

The Good, the Bad, and the Unknown of Telemedicine in Asthma and Allergy Practice
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Ann Chen Wu, Narmeen Rehman, Jay Portnoy
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

COLA (Conferences On-Line Allergy) at 10 Years — Evolution of an Online Fellowship Curriculum
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Paul J. Dowling, Rubin Kader, Jay M. PortnoyOnline learning has been present since the early days of the Internet. As with any new technology, users look to make their life easier and to save time. Experts in medical education are no different than other users. They want to adapt new technologies to their fullest. Medical educators have been challenged with keeping education interesting and up to date, while maximizing their resources. The challenges with any online educational program ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Direct-to-Consumer Telemedicine
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s):
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s):
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Increasing Clinic Efficiency: Lean Allergy
Publication date: November–December 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 8Author(s): Hannah G. Russell, Mike S. Tankersley
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Temporal Trends in Prevalence of Food Allergy in Canada
Publication date: Available online 6 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Ann E. Clarke, Susan Elliott, Yvan St. Pierre, Lianne Soller, Sebastien La Vieille, Moshe Ben-Shoshan
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

One-day ultrarush desensitization for Hymenoptera venom anaphylaxis in patients with and without mast cell disorders with adjuvant omalizumab
Publication date: Available online 6 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Matthew Giannetti, Jared Silver, Raied Hufdhi, Mariana Castells
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study
ConclusionBiphasic reactions and clinically significant biphasic reactions occurred in 7.2% and 5.1% of ED anaphylaxis patients, respectively. Delayed epinephrine administration was associated with biphasic reactions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma
Publication date: Available online 5 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Alessandro Marcon, Pierpaolo Marchetti, Josep M. Antó, Lucia Cazzoletti, Isa Cerveri, Angelo Corsico, Diogenes Seraphim Ferreira, Judith Garcia-Aymerich, David Gislason, Joachim Heinrich, Rain Jõgi, Ane Johannessen, Bénédicte Leynaert, Andrei Malinovschi, Isabelle Pin, Nicole Probst-Hensch, Joost Weyler, Christer Janson, Deborah Jarvis, Simone Accordini
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

A Case of Acquired Hereditary Angioedema
Publication date: Available online 5 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Bret K. Sohn, John M. Fahrenholz, Joseph A. Awad, Howard A. Fuchs
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 6, 2019 Category: Allergy & Immunology Source Type: research

Is it time to rethink the allergy training requirements for pediatric residents?
The past several decades have seen an increase in both prevalence and complexity of allergic diseases in children1. Unfortunately, the number of physicians pursuing training fellowships in Allergy and Immunology (AI) has steadily declined2. As such, primary care pediatricians (PCPs) play a crucial role in managing childhood allergic disorders, often representing the only physicians available for evaluation3. Yet, pediatrician-reported comfort in management of allergic conditions remains insufficient4.
Source: Annals of Allergy, Asthma and Immunology - November 6, 2019 Category: Allergy & Immunology Authors: Peter Capucilli, David R. Stukus Tags: Letters Source Type: research

Food Allergy Immunotherapy with Adjuvants
Treatment of immunoglobulin E –mediated food allergy has traditionally been limited to allergen avoidance and emergency treatment after accidental ingestion. In recent years, significant progress has been made with oral, sublingual, and epicutaneous immunotherapy in the treatment of food allergy; however, these emerging treatm ent options have important limitations in efficacy, durability of effect, and safety. These limitations have already spurred interest in the development of adjuvant therapies to increase efficacy, produce more durable immunologic changes, and/or reduce treatment-related adverse reactions.
Source: Immunology and Allergy Clinics of North America - November 6, 2019 Category: Allergy & Immunology Authors: Rory E. Nicolaides, Christopher P. Parrish, J. Andrew Bird Source Type: research

Persistent cow ’s milk allergy is associated with decreased childhood growth: A longitudinal study
Children with persistent cow ’s milk allergy appear smaller and lighter than their peers with isolated peanut/tree nut allergy, and these findings persist to adolescence.
Source: Journal of Allergy and Clinical Immunology - November 6, 2019 Category: Allergy & Immunology Authors: Karen A. Robbins, Robert A. Wood, Corinne A. Keet Source Type: research