Issue Information
International Forum of Allergy&Rhinology, Volume 9, Issue 7, Page 709-711, July 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Evidence ‐based medicine in an evolving field
International Forum of Allergy&Rhinology, Volume 9, Issue 7, Page 713-714, July 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Authors: David W. Kennedy Tags: EDITORIAL Source Type: research

Erratum for August 2019 Edition of the Journal “Safety and efficacy of a novel bioabsorbable, steroid‐eluting sinus stent”
International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Tags: ERRATUM Source Type: research

Sinonasal mucoepidermoid carcinoma: a review of the National Cancer Database
ConclusionMucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5 ‐year survival for SN‐MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associated with survival. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Authors: Vasiliki Triantafillou, Ivy W. Maina, Edward C. Kuan, Michael A. Kohanski, Charles C. Tong, Neil N. Patel, Ryan M. Carey, Alan D. Workman, James N. Palmer, Nithin D. Adappa, Jason A. Brant Tags: ORIGINAL ARTICLE Source Type: research

Differential perception and tolerance of chronic rhinosinusitis symptoms as a confounder of gender ‐disparate disease burden
BackgroundPrevious studies have consistently shown that females with chronic rhinosinusitis (CRS) have a greater CRS symptom burden than males with CRS. Our objective was to determine whether differential disease perception could explain this phenomenon.MethodsA total of 500 participants (239 males, 261 females) with CRS were recruited. CRS symptom burden was assessed with the 22 ‐item Sino‐Nasal Outcome Test (SNOT‐22). General health‐related quality of life was assessed with the visual analog scale of the 5‐dimensional EuroQol questionnaire (EQ‐5D VAS). Participants were asked to rate their CRS symptom control...
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Authors: Katie M. Phillips, Regan W. Bergmark, Lloyd P. Hoehle, Edina T. Shu, David S. Caradonna, Stacey T. Gray, Ahmad R. Sedaghat Tags: ORIGINAL ARTICLE Source Type: research

Erratum for August 2019 Edition of the Journal “Steroid‐eluting sinus implant for in‐office treatment of recurrent polyposis: a pharmacokinetic study”
International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 17, 2019 Category: Allergy & Immunology Tags: ERRATUM Source Type: research

HLA ‐II genes are associated with outcomes of specific immunotherapy for allergic rhinitis
ConclusionHLA ‐DRB1 and HLA‐DQB1 gene polymorphism are associated with AIT efficacy in HDM‐sensitive Chinese patients with AR, of which DRB1*03:01; DRB1*04:06 and DQB1*03:02:01; DQB1*05:03:01 may be useful biomarkers of AR patient candidacy for effective AIT. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 12, 2019 Category: Allergy & Immunology Authors: Yanming Zhao, Yali Zhao, Yuan Zhang, Luo Zhang Tags: ORIGINAL ARTICLE Source Type: research

Adenosine ‐induced transient hypotension for carotid artery injury during endoscopic skull‐base surgery: case report and review of the literature
ConclusionThis is the first reported use of adenosine to induce transient hypotension for a major vascular injury sustained during endonasal skull ‐base surgery. Based on well‐established safety data from neurosurgical application, adenosine has the potential to be used as a safe and effective adjunctive technique in similar endonasal circumstances and may represent an additional tool in the armamentarium of the skull‐base surgeon. Surge ons should consider having adenosine available when a risk of ICA injury is anticipated. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 10, 2019 Category: Allergy & Immunology Authors: Judd H. Fastenberg, Tomas Garzon ‐Muvdi, Victor Hsue, Erin K. Reilly, Pascal Jabbour, Mindy R. Rabinowitz, Marc R. Rosen, James J. Evans, Gurston N. Nyquist, Christopher J. Farrell Tags: ORIGINAL ARTICLE Source Type: research

Clinical validation of the olfactory detection threshold module of the Snap & Sniff ® olfactory test system
BackgroundQuantitative olfactory testing is essential to determine the validity and nature of a patient's complaint, accurately monitor changes in function over time (including influences of pharmacological, surgical, or immunological interventions), detect malingering, and establish disability compensation. This work describes the clinical validation of an advanced rapid odor detection threshold test that standardizes odorant delivery and eliminates unsanitary sniff bottles, the need for blindfolds, and the possibility of touching an odorant stimulus to the nose.MethodsSnap& Sniff ® single‐staircase phenyl ethyl...
Source: International Forum of Allergy and Rhinology - July 8, 2019 Category: Allergy & Immunology Authors: Richard L. Doty, Crystal Wylie, Mark Potter, Rachel Beston, Brooke Cope, Kelsey Majam Tags: ORIGINAL ARTICLE Source Type: research

Effects of sphenoid surgery on nasal irrigation delivery
In this study we aim to compare the influence of increasing surgical sphenoid openings on the distribution, force, and clearance of nasal irrigations.MethodsA study was performed on fresh ‐frozen adult cadaver heads. The surgical ostium was modified on one side via a simple sphenoidotomy, a sphenoid sinusectomy (type 1), and sphenoid sinusectomy (type 3a). The nasal cavity was irrigated using a 240‐mL squeeze bottle with 0.1% fluoroscein. An endoscope passed through the contralat eral side through the sphenoid septum recorded the irrigation. Videos were recorded and blindly assessed. The distribution was defined as eit...
Source: International Forum of Allergy and Rhinology - July 1, 2019 Category: Allergy & Immunology Authors: Jessica W. Grayson, Marina Cavada, Eugene Wong, Benjamin Lien, Marin Duvnjak, Raewyn Campbell, Larry Kalish, Raymond Sacks, Richard J. Harvey Tags: ORIGINAL ARTICLE Source Type: research

Transnasal prelacrimal approach to the inferior intraconal space: a feasibility study
ConclusionIt is feasible to access the inferior intraconal space through the orbital floor via a transnasal prelacrimal approach. The access may be subdivided into inferomedial and inferolateral corridors according to the entry point at the medial or lateral border of the inferior rectus muscle. Neurovascular structures in the inferior intraconal space are visualized directly, which should enhance their preservation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 1, 2019 Category: Allergy & Immunology Authors: Lifeng Li, Nyall R. London, Samuel Silva, Daniel Prevedello, Ricardo L. Carrau Tags: ORIGINAL ARTICLE Source Type: research

Hyams grading as a predictor of metastasis and overall survival in esthesioneuroblastoma: a meta ‐analysis
BackgroundEsthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, represents up to 3% of all sinonasal neoplasms. Hyams histologic grading is a promising tool in predicting metastases and establishing prognoses for this complex tumor.MethodsA systematic literature search was performed in the PubMed, Ovid MEDLINE, and Cochrane databases. ENB patients with Hyams I ‐II or III‐IV were categorized as low‐grade Hyams (LGH) or high‐grade Hyams (HGH), respectively. Binary and continuous random‐effects models were applied to calculate odds ratios (ORs) for the incidences of neck and distal metastases as well a...
Source: International Forum of Allergy and Rhinology - June 28, 2019 Category: Allergy & Immunology Authors: Khodayar Goshtasbi, Arash Abiri, Mehdi Abouzari, Ronald Sahyouni, Beverly Y. Wang, Bobby A. Tajudeen, Frank P. K. Hsu, Gilbert Cadena, Edward C. Kuan Tags: REVIEW ARTICLE Source Type: research

Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation
ConclusionThe olfactory neuroepithelium employs multiple mechanisms to maintain epithelial homeostasis. Our findings provide evidence that in a mouse model of BMI1 deletion, the overall integrity and function of the olfactory neuroepithelium are not compromised, despite increased neuronal turnover, reflecting a remarkable reparative capacity to sustain a critical sensory system. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 28, 2019 Category: Allergy & Immunology Authors: Rhea Choi, Sarah Kurtenbach, Bradley J. Goldstein Tags: ORIGINAL ARTICLE Source Type: research

Central compartment involvement in aspirin ‐exacerbated respiratory disease: the role of allergy and previous sinus surgery
This study was a retrospective analysis of a single ‐institution database for the January 2016 to February 2019 time period. Data regarding endoscopic CC findings, clinical allergy history, and results of allergy testing were collected. Statistical analysis was performed, with significance set atp
Source: International Forum of Allergy and Rhinology - June 27, 2019 Category: Allergy & Immunology Authors: John M. DelGaudio, Joshua M. Levy, Sarah K. Wise Tags: ORIGINAL ARTICLE Source Type: research

Socioeconomic status impacts postoperative productivity loss and health utility changes in refractory chronic rhinosinusitis
BackgroundSocial determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality ‐of‐life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivity loss and health utility after ESS remains unknown.MethodsAdult patients ( ≥18 years of age) with chronic rhinosinusitis (CRS) who underwent ESS were prospectively enrolled into a multi‐institutional cohort study. Productivity losses were calculated using the human capital approach and monetized usi...
Source: International Forum of Allergy and Rhinology - June 27, 2019 Category: Allergy & Immunology Authors: Daniel M. Beswick, Jess C. Mace, Zachary M. Soler, Luke Rudmik, Jeremiah A. Alt, Kristine A. Smith, Kara Y. Detwiller, Vijay R. Ramakrishnan, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

Predictive value of computed tomography in the recurrence of chronic rhinosinusitis with nasal polyps
ConclusionThe E/M ratio is a useful predictor for the recurrence of CRSwNP in the Chinese population. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 25, 2019 Category: Allergy & Immunology Authors: Yifan Meng, Luo Zhang, Hongfei Lou, Chengshuo Wang Tags: ORIGINAL ARTICLE Source Type: research

Assessment of bioabsorbable implant treatment for nasal valve collapse compared to a sham group: a randomized control trial
This study aimed to evaluate the safety and effectiveness of the treatment in a randomized controlled trial (RCT) with sham control.MethodsIn this prospective, multicenter, single ‐blinded RCT, 137 patients from 10 clinics were randomized into 2 arms: treatment arm (70 patients) and sham control arm (67 patients). Outcome measures were followed through 3 months after the procedure. The primary endpoint was the responder rate (percentage of patients with reduction in clinica l severity by ≥1 category or ≥20% reduction in Nasal Obstruction Symptom Evaluation [NOSE] score).ResultsBefore the procedure, there were no st...
Source: International Forum of Allergy and Rhinology - June 21, 2019 Category: Allergy & Immunology Authors: Pablo Stolovitzky, Brent Senior, Randall A. Ow, Neelesh Mehendale, Nadim Bikhazi, Douglas M. Sidle Tags: ORIGINAL ARTICLE Source Type: research

Role of inferior turbinate reduction in the quality of life of patients undergoing endoscopic sinus surgery for chronic rhinosinusitis
ConclusionBITR in the setting of ESS for CRS is not associated with significant incremental improvement in overall QoL vs ESS alone. However, BITR in polyp and primary surgery patients undergoing ESS appears to offer a significant incremental improvement in nasal congestion/blockage symptoms compared with ESS alone. Future studies are warranted to better corroborate these findings. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 20, 2019 Category: Allergy & Immunology Authors: Ethan Soudry, Jess Mace, Timothy L. Smith, Peter H. Hwang Tags: ORIGINAL ARTICLE Source Type: research

Long ‐term outcomes of endoscopic sinus surgery in the management of adult chronic rhinosinusitis
ConclusionsTen ‐year prospective outcomes of ESS for CRS demonstrate that the initial clinically significant improvements in QOL seen 6 months postoperatively are durable over the long term. Over 75% of patients reported clinically significant long‐term QOL and HUV improvement. HUV returned to normal. Revision surgery rate was 17% and worse postoperative endoscopy scores within 18 months of initial ESS were associated with higher likelihood of revision surgery. Most patients would pursue ESS again and recommend the procedure to other patients considering this treatment option. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 17, 2019 Category: Allergy & Immunology Authors: Timothy L. Smith, Rodney J. Schlosser, Jess C. Mace, Jeremiah A. Alt, Daniel M. Beswick, Adam S. DeConde, Kara Y. Detwiller, Jose L. Mattos, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Association between chronic rhinosinusitis and osteoporosis: a case ‐control study using a national sample cohort
BackgroundThe purpose of this study was to further clarify the relationship between chronic rhinosinusitis (CRS) and osteoporosis in a Korean population.MethodsThe Korean National Health Insurance Service ‒National Sample Cohort, with subjects ≥50 years old, was assessed for the time period 2002‐2013. In total, 68,459 osteoporosis participants were matched with 68,459 control participants at a ratio of 1:1 with respect to age, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of CRS with/without nasal polyp in the osteoporosis and control groups. CRS and...
Source: International Forum of Allergy and Rhinology - June 17, 2019 Category: Allergy & Immunology Authors: Hyo Geun Choi, Gyu Kong Tags: ORIGINAL ARTICLE Source Type: research

Erratum for May 2019 Edition of the Journal “Focusing on Quality of Life in Chronic Rhinosinusitis Patients”
International Forum of Allergy&Rhinology, Volume 9, Issue 6, Page 707-707, June 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 7, 2019 Category: Allergy & Immunology Tags: ERRATUM Source Type: research

Issue Information
International Forum of Allergy&Rhinology, Volume 9, Issue 6, Page 567-569, June 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 7, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Tumor surgery, the microbiome, and anaphylaxis
International Forum of Allergy&Rhinology, Volume 9, Issue 6, Page 571-572, June 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 7, 2019 Category: Allergy & Immunology Authors: Timothy L. Smith Tags: EDITORIAL Source Type: research

Lateral nasal wall extension of the nasoseptal flap for skull ‐base and medial orbital wall defects
ConclusionThe modification of the NSF described here provides excellent coverage for reconstruction of large anterior skull ‐base defects and simultaneous medial orbital wall defects. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 7, 2019 Category: Allergy & Immunology Authors: Justin McCormick, Mark Allen, Joshua J. Kain, Jaime A Pena ‐Garcia, Do‐Yeon Cho, Kristen O. Riley, Bradford A. Woodworth Tags: ORIGINAL ARTICLE Source Type: research

Kappa ‐carrageenan sinus rinses reduce inflammation and intracellular Staphylococcus aureus infection in airway epithelial cells
In this study we investigate the antimicrobial and anti ‐inflammatory effects of adding kappa‐carrageenan to a commercially available sinus rinse.MethodsKappa ‐carrageenan was added to Flo CRS and Flo Sinus Care sinus rinses and applied directly to air‐liquid interface cultured primary human nasal epithelial cells (HNECs) from 10 CRS patients. Inflammatory markers were measured using enzyme‐linked immunosorbent assay. Kappa‐carrageenan‒supplemen ted sinus rinses were applied to human bronchial epithelial cells (HBEs) in the presence of differentStaphylococcus aureus strains to observe the effect on intracellu...
Source: International Forum of Allergy and Rhinology - June 4, 2019 Category: Allergy & Immunology Authors: Catherine Bennett, Mahnaz Ramezanpour, Clare Cooksley, Sarah Vreugde, Alkis James Psaltis Tags: ORIGINAL ARTICLE Source Type: research

Clinical predictors of cystic fibrosis chronic rhinosinusitis severity
ConclusionSex, CF ‐related diabetes, sinonasal infection status, allergic rhinitis, and nasal steroid use may all modulate severity of CF‐CRS in adults. Sinusitis exacerbation may be a precursor to pulmonary exacerbation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 4, 2019 Category: Allergy & Immunology Authors: Anna C. Zemke, Seyed Mehdi Nouraie, John Moore, Jordan R. Gaston, Nicholas R. Rowan, Joseph M. Pilewski, Jennifer M. Bomberger, Stella E. Lee Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
International Forum of Allergy&Rhinology, Volume 9, Issue S2, Page S47-S48, June 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 3, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Scientific abstracts for RhinoWorld 2019
AbstractIt has been a decade since the world's rhinologic community gathered in the United States for RhinoWorld. The American Rhinologic Society (ARS), International Rhinologic Society (IRS), and International Society of Inflammation and Allergy of the Nose (ISIAN) have joined together to host this international gathering of clinicians and scientists.Herein, you will find the abstracts that will be presented orally during RhinoWorld on June 5 ‐9, 2019, in Chicago, IL. This IFAR supplement serves as an informational centerpiece for cutting edge discovery and innovation, and commentary and debate, for clinicians and resea...
Source: International Forum of Allergy and Rhinology - June 3, 2019 Category: Allergy & Immunology Authors: Timothy L. Smith Tags: ABSTRACTS Source Type: research

Asymptomatic vs symptomatic septal perforations: a computational fluid dynamics examination
BackgroundA nasal septal perforation (NSP) can lead to frustrating symptoms for some patients while remaining completely asymptomatic for others, without a clear mechanism differentiating them.MethodsWe applied individual computed tomography (CT) ‐based computational fluid dynamics (CFD) to examine the nasal aerodynamics differences between 5 asymptomatic and 15 symptomatic NSP patients. Patients’ symptoms were confirmed through interviews, 22‐item Sino‐Nasal Outcome Test score (asymptomatic, 25 ± 18.8; symptomatic, 53.7 ± 18.2), n asal obstruction symptom evaluation score (asymptomatic, 28.0 &plu...
Source: International Forum of Allergy and Rhinology - May 29, 2019 Category: Allergy & Immunology Authors: Chengyu Li, Guillermo Maza, Alexander A. Farag, Jillian P. Krebs, Bhakthi Deshpande, Bradley A. Otto, Kai Zhao Tags: ORIGINAL ARTICLE Source Type: research

Inverted papilloma with multifocal attachment is associated with increased recurrence
ConclusionPrimary resection and single ‐focus attachment of inverted papilloma are associated with lower recurrence rates at 3‐year follow‐up. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 24, 2019 Category: Allergy & Immunology Authors: Charles C. L. Tong, Neil N. Patel, Ivy W. Maina, Vasiliki Triantafillou, Carol H. Yan, Edward C. Kuan, Michael A. Kohanski, Peter Papagiannopoulos, Alan D. Workman, Noam A. Cohen, David W. Kennedy, Nithin D. Adappa, James N. Palmer Tags: ORIGINAL ARTICLE Source Type: research

Estimation of surgeons ’ ergonomic dynamics with a structured light system during endoscopic surgery
ConclusionSignificant musculoskeletal symptoms were reported after an endoscopic operation by both the resident and the practicing otolaryngologists. All surgeons obtained a high RULA score, meaning that urgent changes are required in the task. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 15, 2019 Category: Allergy & Immunology Authors: David Lobo, Pedro Anuarbe, Jos é Miguel López‐Higuera, Jaime Viera, Nathalia Castillo, Roberto Megía Tags: ORIGINAL ARTICLE Source Type: research

Topical therapies for management of chronic rhinosinusitis: steroid implants
ConclusionThe novel steroid ‐eluting implants appear to be beneficial for CRS patients immediately post‐operatively as well as for nasal polyps patients. Interestingly, these implants could be used as a substitute for the beneficial effect of systemic steroid use for CRS patients. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Joseph K. Han, Robert C. Kern Tags: REVIEW ARTICLE Source Type: research

Future topical medications in chronic rhinosinusitis
ConclusionThe ease of access of the sinonasal mucosa positions CRS as a disease with high potential for local topical treatment. The ultimate adoption of topical agents will require continued expansion of our understanding of novel local targets in CRS as well as improved methods to deliver and retain the drug of interest at the site of activity. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Michelle Menon Miyake, Benjamin S. Bleier Tags: REVIEW ARTICLE Source Type: research

Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?
ConclusionEDS ‐FLU is an important adjunct therapy for sinonasal inflammatory disease. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Edward C. Kuan, Alexander J. Kovacs, Alan D. Workman, John V. Bosso, Nithin D. Adappa Tags: REVIEW ARTICLE Source Type: research

Topical antibiotic therapy in chronic rhinosinusitis: an update
ConclusionThere is additional evidence to support continuing investigation of topical antibiotic therapies. Further, larger RCTs are required to establish the efficacy of topical antibiotic therapies. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Daniel A. Carlton, D. David Beahm, Alexander G. Chiu Tags: REVIEW ARTICLE Source Type: research

Topical corticosteroid irrigations in chronic rhinosinusitis
ConclusionMany factors are associated with efficacious and adequate treatment of primary CRS. The pathology must be correctly diagnosed and be inflammatory in nature. The treatment paradigm should include wide and complete endoscopic sinus surgery for the adequate delivery of topical therapy. Topical therapy should be delivered in large ‐volume, low‐pressure devices with adequate dosing. Although there is some systemic absorption, multiple studies have demonstrated that long‐term, daily use of topical corticosteroids does not increase intraocular pressure, suppress the hypothalamic‐pituitary‐adrenal axis, or incr...
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Jessica W. Grayson, Richard J. Harvey Tags: REVIEW ARTICLE Source Type: research

Nasal saline irrigation: a clinical update
ConclusionThe most recent consensus statements and Cochrane Review recommend the use of NSI for CRS based on a preponderance of lower level evidence. A conclusion regarding the optimal method of delivery and solution composition cannot be drawn based on the current literature. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Eric F. Succar, Justin H. Turner, Rakesh K. Chandra Tags: REVIEW ARTICLE Source Type: research

Issue Information
International Forum of Allergy&Rhinology, Volume 9, Issue S1, Page S1-S2, May 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Editorial by Dr. Woodworth
International Forum of Allergy&Rhinology, Volume 9, Issue S1, Page S3-S3, May 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 14, 2019 Category: Allergy & Immunology Authors: Bradford A. Woodworth Tags: EDITORIAL Source Type: research

Use of a crossing suture to correct caudal septal deviations
BackgroundSeptoplasty usefully treats patients with nasal obstructions caused by septal deviations. However, correction of a caudal septal deviation remains surgically challenging; no standard procedure is available, although various procedures have been introduced. In this work we propose a simple, safe, and time ‐saving technique for patients with caudal septal deviations.MethodsThe medical records of 50 patients with caudal septal deviations who underwent septoplasty using a crossing ‐suture technique from October 2016 to October 2018 were retrospectively reviewed. Postoperative nasal obstruction status and patient ...
Source: International Forum of Allergy and Rhinology - May 11, 2019 Category: Allergy & Immunology Authors: Yeon ‐Hee Joo, Hyun‐Jin Cho, Yung Jin Jeon, Sang‐Wook Kim Tags: ORIGINAL ARTICLE Source Type: research

Computational fluid dynamic analysis of aggressive turbinate reductions: is it a culprit of empty nose syndrome?
BackgroundEmpty nose syndrome (ENS) remains highly controversial, with aggressive inferior turbinate reduction (ITR) or mucociliary dysfunction frequently implicated. However, the appropriate degree of ITR is highly debatable.MethodsWe applied individual computed tomography (CT) ‐based computational fluid dynamics (CFD) to 5 patients receiving relatively aggressive ITR but with no ENS symptoms, and compared them to 27 symptomatic ENS patients who all had histories of aggressive ITRs, and 42 healthy controls. Patients’ surgical outcomes were confirmed with 22‐item Sino ‐Nasal Outcome Test (SNOT‐22) (ITR: 6.40 ...
Source: International Forum of Allergy and Rhinology - May 11, 2019 Category: Allergy & Immunology Authors: Jennifer Malik, Chengyu Li, Guillermo Maza, Alexander A. Farag, Jillian P. Krebs, Sam McGhee, Gabriela Zappitelli, Bhakthi Deshpande, Bradley A. Otto, Kai Zhao Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
International Forum of Allergy&Rhinology, Volume 9, Issue 5, Page 439-441, May 2019. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 30, 2019 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Focusing on quality of life in chronic rhinosinusitis patients
International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Justin H. Turner Tags: EDITORIAL Source Type: research

Postoperative epistaxis and sphenoid sinus ostial stenosis after posterior septal branch injury during sphenoidotomy
ConclusionPSB injury occurred in 17.2% of ESS ‐related sphenoidotomies and 5.8% of TSA‐related sphenoidotomies. After PSB injury, postoperative epistaxis from the PSB was rare (3.1%). After ESS‐related sphenoidotomies, sphenoid stenosis was rare (3.7%), and was more likely to occur with smaller sphenoid dimensions, but not with PSB injury or other factors. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Joanna Kam, Abid Ahmad, Amy Williams, Edward L. Peterson, John R. Craig Tags: ORIGINAL ARTICLE Source Type: research

Validation of a rhinologic virtual surgical simulator for performing a Draf 3 endoscopic frontal sinusotomy
ConclusionVD showed nearly matching results with the actual cadaver dissection. With further validation, our rhinologic VSE may be used for presurgical planning and rehearsal before the actual Draf 3 procedure is performed in the operating room. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Tae ‐Bin Won, Sung‐Woo Cho, Myung‐Whun Sung, Sun Ha Paek, Sonny Chan, Kenneth Salisbury, Nikolas H. Blevins, Yona Vaisbuch, Peter Hwang Tags: ORIGINAL ARTICLE Source Type: research

Focusing on quality of life in chronic rhinosinusitis patients
International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Justin H. Turner Tags: EDITORIAL Source Type: research

Postoperative epistaxis and sphenoid sinus ostial stenosis after posterior septal branch injury during sphenoidotomy
ConclusionPSB injury occurred in 17.2% of ESS ‐related sphenoidotomies and 5.8% of TSA‐related sphenoidotomies. After PSB injury, postoperative epistaxis from the PSB was rare (3.1%). After ESS‐related sphenoidotomies, sphenoid stenosis was rare (3.7%), and was more likely to occur with smaller sphenoid dimensions, but not with PSB injury or other factors. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Joanna Kam, Abid Ahmad, Amy Williams, Edward L. Peterson, John R. Craig Tags: ORIGINAL ARTICLE Source Type: research

Validation of a rhinologic virtual surgical simulator for performing a Draf 3 endoscopic frontal sinusotomy
ConclusionVD showed nearly matching results with the actual cadaver dissection. With further validation, our rhinologic VSE may be used for presurgical planning and rehearsal before the actual Draf 3 procedure is performed in the operating room. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 23, 2019 Category: Allergy & Immunology Authors: Tae ‐Bin Won, Sung‐Woo Cho, Myung‐Whun Sung, Sun Ha Paek, Sonny Chan, Kenneth Salisbury, Nikolas H. Blevins, Yona Vaisbuch, Peter Hwang Tags: ORIGINAL ARTICLE Source Type: research

International consensus statement on endoscopic skull ‐base surgery: executive summary
ConclusionThe ICAR:SB Executive Summary recaps the evidenced ‐based recommendations concerning the advantages, limitations and challenges of ESBS in the management of diverse skull‐base pathologies. Although multifactorial in nature, the overall level of evidence in ESBS is modest. This represents an opportunity to address these knowledge gaps moving forw ard. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 8, 2019 Category: Allergy & Immunology Authors: Eric W. Wang, Paul A. Gardner, Adam M. Zanation Tags: ORIGINAL ARTICLE Source Type: research