Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Adjunctive techniques to dacryocystorhinostomy: an evidence ‐based review with recommendations
ConclusionRecommendations for adjunctive techniques to external and endoscopic DCR surgeries can be made based on the current literature. Higher ‐level studies are needed to better optimize perioperative approaches to DCR. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Michael Yim, Peter ‐John Wormald, Manon Doucet, Amarbir Gill, Todd Kingdom, Richard Orlandi, Alison Crum, Douglas Marx, Jeremiah Alt Tags: ORIGINAL ARTICLE Source Type: research

Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia
ConclusionDifferent blood and tissue eosinophilia revealed distinct tissue inflammatory patterns in CRSwNP patients. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Li Pan, Bo Liao, Cui ‐Lian Guo, Jin‐Xin Liu, Heng Wang, Xiao‐Bo Long, Zheng Liu Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of the exhalation delivery system with fluticasone in patients who remain symptomatic on standard nasal steroid sprays
ConclusionEDS ‐FLU comparably improves symptoms, irrespective of whether patients are symptomatic while using conventional nasal steroids before treatment. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Brent A. Senior, Rodney J. Schlosser, John Bosso, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients
ConclusionCRS patients report bitter stimuli as less intense but sweet stimuli as more intense than do control subjects. We speculate that taste responses may reflect the competence of sinonasal innate immunity mediated by taste receptor function, and thus a taste test may have potential for clinical utility in CRS patients. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Cailu Lin, Alyssa M. Civantos, Monique Arnold, Elizabeth M. Stevens, Beverly J. Cowart, Lauren R. Colquitt, Corrine Mansfield, David W. Kennedy, Steven G. Brooks, Alan D. Workman, Mariel T. Blasetti, Michael A. Kohanski, Laurel Doghramji, Jen Tags: ORIGINAL ARTICLE Source Type: research

Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors
ConclusionSCCs are innervated by trigeminal nerve endings in healthy turbinate tissue but not in NPs. SCCs express ACh receptors as well as choline acetyltransferase and, in the setting of a type 2 inflammatory environment, denervated SCCs dramatically expand with nicotinic stimulation. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Jie Deng, Li Hui Tan, Michael A. Kohanski, David W. Kennedy, John V. Bosso, Nithin D. Adappa, James N. Palmer, Jianbo Shi, Noam A. Cohen Tags: ORIGINAL ARTICLE Source Type: research

Pepsin exposure in a non ‐acidic environment upregulates mucin 5AC (MUC5AC) expression via matrix metalloproteinase 9 (MMP9)/nuclear factor κB (NF‐κB) in human airway epithelial cells
ConclusionThese findings suggest that pepsin increased MUC5AC expression in non ‐acidic conditions via the activation of MMP9 and NF‐κB in human airway epithelial cells. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Yoon Seok Choi, Hyung Gyun Na, Chang Hoon Bae, Si ‐Youn Song, Yong‐Dae Kim Tags: ORIGINAL ARTICLE Source Type: research

Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once ‐daily oral antibiotic treatment for chronic rhinosinusitis
This study aimed to investigate the short ‐term effects of antibiotics on the sinus and gut microbiota as well as any relationships these had with drug distribution.MethodsThirty subjects undergoing functional endoscopic sinus surgery for CRS were randomized to one of three groups: (1) doxycycline (100  mg daily for 7 days); (2) roxithromycin (300 mg daily for 7 days); and (3) control (no antibiotics given). Sinonasal and stool samples collected before and after treatment were analyzed using 16S ribosomal RNA (rRNA) gene‐targeted amplicon sequencing and Droplet Digital polymerase chain reactio n (PCR) for bac...
Source: International Forum of Allergy and Rhinology - April 20, 2021 Category: Allergy & Immunology Authors: Joey Siu, Brett Wagner Mackenzie, Lilian Klingler, Kristi Biswas, Yi Wang, Cheung ‐Tak Hung, Soo Hee Jeong, Daniel Barnett, Malcolm Drummond Tingle, Richard George Douglas Tags: ORIGINAL ARTICLE Source Type: research

Psychometric properties of the brief version of the questionnaire of olfactory disorders in patients with chronic rhinosinusitis
ConclusionThe 7 ‐item B‐QOD captures a structurally coherent and reliable single dimension, with minimal information loss and excellent external predictive utility when compared to the QOD‐NS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Jose L. Mattos, Todd E. Bodner, Jess C. Mace, Rodney J. Schlosser, Daniel M. Beswick, Vijay R. Ramakrishnan, Jeremiah A. Alt, Spencer C. Payne, Timothy L. Smith, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Risk factors and characteristics associated with persistent smell loss in coronavirus disease 2019 (COVID ‐19) patients
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Bita Shahrvini, Divya P. Prajapati, Mena Said, Jacklyn Liu, Shanmukha Srinivas, Samuel Jayaraj, Valerie J. Lund, Adam S. DeConde, Matt Lechner, Carol H. Yan Tags: CLINICAL LETTER Source Type: research

Virtual interprofessional chronic cough clinic: An efficient and appealing approach to a complex problem
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Merin Kuruvilla, Jeanne Hatcher, Sandeep Shelly, Adviteeya Narasimhan Dixit, Amanda I. Gillespie, Keriann VanNostrand, Eri Saikawa, Anand Jain, Adam M. Klein Tags: CLINICAL LETTER Source Type: research

Disease involvement in the central compartment in eosinophilic chronic rhinosinusitis
AbstractObjectiveTo evaluate disease presence in the central compartment (CC) in patients with eosinophilic chronic rhinosinusitis (CRS).MethodsPatients with eosinophilic CRS were divided into three endotypes: aspirin ‐exacerbated respiratory disease (AERD), allergic fungal rhinosinusitis (AFRS), and eosinophilic CRS with nasal polyps (eCRSwNP). CT scans were reviewed for CC involvement, defined as the area between the superior nasal septum (SNS) and middle turbinate (MT). CC involvement was measured based on t he degree of opacification (0: no opacification, 1: up to 50% opacification, and 2: >50% opacification)...
Source: International Forum of Allergy and Rhinology - April 17, 2021 Category: Allergy & Immunology Authors: Chadi A. Makary, Jeffrey Falco, Sarah Sussman, Lindsey Ryan, Camilo Reyes, Hassan Ramadan, Stilianos E. Kountakis Tags: ORIGINAL ARTICLE Source Type: research

Prospective assessment of smell and taste impairment in a South ‐American coronavirus disease 2019 (COVID‐19) cohort: Association with the need for hospitalization and reversibility of dysfunction
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 13, 2021 Category: Allergy & Immunology Authors: Claudia Gonz ález, Francisco Gustavo García‐Huidobro, Antonia Elisa Lagos, Rodrigo Aliaga, Eduardo Fuentes‐López, Luis Antonio Díaz, Tamara García‐Salum, Erick Salinas, Adriana Toro, Claudio Andrés Callejas, Arnoldo Riquelme, Rafael Tags: RESEARCH NOTE Source Type: research

CFTR ‐related disorder in an adult with refractory chronic rhinosinusitis: A missed diagnosis and novel mutation
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - April 6, 2021 Category: Allergy & Immunology Authors: Laylaa Ramos Arriaza, Conner J. Massey, Stephen M. Humphries, Daniel M. Beswick, Milene T. Saavedra, Vijay R. Ramakrishnan Tags: CLINICAL LETTER Source Type: research

Systematic review of measures of disease severity in rhinitis
AbstractBackgroundRhinologists often encounter a broad spectrum of allergic rhinitis (AR) and nonallergic rhinitis (NAR) patients, who can be variably classified based upon timing and severity of disease. Our understanding of the varied quality of life (QOL) impact in different classifications of rhinitis is limited. Thus a more comprehensive understanding of the impact of rhinitis upon our patients, as measured by both patient reported outcome measures (PROMs) and clinical physiologic measures, as well as unique factors associated with disease severity is needed.MethodsA systematic search of databases was performed to ide...
Source: International Forum of Allergy and Rhinology - March 30, 2021 Category: Allergy & Immunology Authors: Andraia R. Li, Kathy Zhang, Priyanka D. Reddy, Shaun A. Nguyen, Amar Miglani, Jacob Fried, Mariam I. Nguyen, Rodney J. Schlosser Tags: REVIEW ARTICLE Source Type: research

Usefulness of intraoperative frozen section for diagnosing acute invasive fungal rhinosinusitis: A systematic review and meta ‐analysis
ConclusionPositive frozen sections are reliable and facilitate early intervention in AIFRS. Collecting multiple specimens during surgery will decrease the rate of false ‐negative results. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 26, 2021 Category: Allergy & Immunology Authors: Do Hyun Kim, Sung Won Kim, Se Hwan Hwang Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Cystic fibrosis: On the cusp of cure?
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Brent A. Senior Tags: EDITORIAL Source Type: research

In reply: Aspirin desensitization for aspirin ‐exacerbated respiratory disease in the era of biologics: Clinical perspective
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Joshua M Levy, Merin Kuruvilla Tags: CORRESPONDENCE AND REPLY Source Type: research

Quality ‐of‐life impact after in‐office treatment of nasal valve obstruction with a radiofrequency device: 2‐year results from a multicenter, prospective clinical trial
BackgroundInsufficiency of the nasal valve is increasingly being recognized as a cause of nasal airway obstruction. The condition is associated with many symptoms, including nasal congestion, sleep disturbance, snoring, and an overall decline in quality of life (QoL). An in ‐office, minimally invasive radiofrequency treatment of the nasal valve has been associated with improved symptoms of nasal obstruction and patients’ QoL for a 6‐month period in a noncontrolled, prospective, single‐arm study. The purpose of this study was to determine whether the results ach ieved with radiofrequency treatment at 6 months wo...
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Moshe Ephrat, Ofer Jacobowitz, Mark Driver Tags: ORIGINAL ARTICLE Source Type: research

Patient ‐reported sleep outcomes lack association with mucosal eosinophilia or neutrophilia in patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery
BackgroundChronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction following functional endoscopic sinus surgery (FESS).MethodsA total of 104 patients with medically refractory CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP), completed the Pittsburgh Sleep Quality Index (PSQI) before and after FESS. Anterior ethmoid mucosa was collected during FESS and de...
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Nyssa Fox Farrell, Jess C. Mace, David A. Sauer, Andrew J. Thomas, Mathew Geltzeiler, Kara Y. Detwiller, Jeremiah A. Alt, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS) –nucleotide‐binding, oligomerization domain–like receptor family, pyrin domain containing 3 (NLRP3)–caspase‐1–interleukin 1β (IL‐1β) pathway
ConclusionThese findings suggest that exposure to BC and pollen can exaggerate oxidative stress and significantly increase the expression of IL ‐1β in hNECs, and that this may involve a pathway integrating ROS–NLRP3–Caspase‐1–IL‐1β signaling. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Ying Li, Yuhui Ouyang, Jian Jiao, Zhaojun Xu, Luo Zhang Tags: ORIGINAL ARTICLE Source Type: research

Azithromycin in high ‐risk, refractory chronic rhinosinusitus after endoscopic sinus surgery and corticosteroid irrigations: a double‐blind, randomized, placebo‐controlled trial
ConclusionLow ‐dose azithromycin is a therapeutic option with few side effects. Its use can show favorable clinical outcomes in this difficult‐to‐treat population, especially if patients are AERD‐negative. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Anastasios Maniakas, Marc ‐Henri Asmar, Axel Eluid Renteria, Smriti Nayan, Saud Alromaih, Leandra Mfuna Endam, John Sam Sampalis, Martin Desrosiers Tags: ORIGINAL ARTICLE Source Type: research

Serum eosinophil cationic protein: a prognostic factor for early postoperative recurrence of nasal polyps
ConclusionSerum ECP appears to be a feasible predictor for early postoperative recurrence of nasal polyps. CRSwNP patients with preoperative serum ECP levels of ≥21.8 µg/L had an approximately 55‐fold increased risk of early recurrence. CRSwNP patients with higher preoperative serum ECP levels should be closely monitored within the first year after surgery. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 23, 2021 Category: Allergy & Immunology Authors: Pin ‐Ching Lu, Ta‐Jen Lee, Chi‐Che Huang, Po‐Huang Chang, Yi‐Wei Chen, Chia‐Hsiang Fu Tags: ORIGINAL ARTICLE Source Type: research

Distributed monitoring of sinonasal symptoms using a mobile device application —a pilot study
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 22, 2021 Category: Allergy & Immunology Authors: Chris Marcellino, Erin K. O'Brien, Garret Choby, Janalee K. Stokken Tags: CLINICAL LETTER Source Type: research

The efficacy of silastic sheet nasal splints in endoscopic nasal septal repair surgery: a prospective, randomized, single ‐blinded controlled trial
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 20, 2021 Category: Allergy & Immunology Authors: Fahad Alasousi, Judy Fan, Athenea Pascual, Juan Carlos Hernaiz ‐Leonardo, Amin R. Javer Tags: RESEARCH NOTE Source Type: research

Gender and authorship trends in rhinology, allergy, and skull ‐base literature from 2008 to 2018
ConclusionThis study represents the first assessment of gender differences in the rhinology literature. Areas where female representation can improve include senior authorship, increased involvement in skull base publications, and increased funding. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Ashleigh A. Halderman, Anupriya Rao, Stuti Desai ‐Markowski, Alex Yang, Amber U. Luong, Erin O'Brien, Stacey T. Gray, Devyani Lal, Sandra Y. Lin, Richard Orlandi, Sarah K. Wise Tags: ORIGINAL ARTICLE Source Type: research

Responsiveness and convergent validity of the chronic rhinosinusitis patient ‐reported outcome (CRS‐PRO) measure in CRS patients undergoing endoscopic sinus surgery
This study establishes the factor structure, responsiveness, and convergent validity of the CRS‐PRO following endoscopic sinus su rgery (ESS).MethodsNorthwestern CRS Subject Registry patients had pre ‐ESS, 3‐month (n = 111; CRS without nasal polyps [CRSsNP] = 60, CRS with nasal polyps [CRSwNP] = 51), and 6‐month (n = 86; CRSsNP = 47, CRSwNP = 39) post‐ESS assessments where patients completed the CRS‐PRO, 22‐item Sino‐Nasal Outcome Test (SNOT‐22), and four Patient‐Reported Outco mes Measurement (PROM) Information System (PROMIS) short forms (general health measures). Patients had pre‐ESS objective test...
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Katherine A. Lin, Caroline P.E. Price, Julia H. Huang, Saied Ghadersohi, David Cella, Robert C. Kern, David B. Conley, Stephanie Shintani ‐Smith, Kevin C. Welch, Bruce K. Tan Tags: ORIGINAL ARTICLE Source Type: research

Trigeminal features in COVID ‐19 patients with smell impairment
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Fabio Ferreli, Matteo Di Bari, Francesca Gaino, Alberto Albanese, Letterio S. Politi, Giuseppe Spriano, Giuseppe Mercante Tags: RESEARCH NOTE Source Type: research

Smell impairment in patients with allergic rhinitis
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Francesco Maria Passali, Giulio Cesare Passali, Desiderio Passali, Giorgio Ciprandi Tags: CLINICAL LETTER Source Type: research

Systemic corticosteroids in coronavirus disease 2019 (COVID ‐19)‐related smell dysfunction: an international view
SummaryThe frequent association between coronavirus disease 2019 (COVID ‐19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID‐19–related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID‐19–related olfactory dysfunction is high; and (3) corticosteroids have well‐known potential adverse effects. We encourage rando...
Source: International Forum of Allergy and Rhinology - March 17, 2021 Category: Allergy & Immunology Authors: Caroline Huart, Carl M. Philpott, Aytug Altundag, Alexander W. Fjaeldstad, Johannes Frasnelli, Simon Gane, Julien W. Hsieh, Eric H. Holbrook, Iordanis Konstantinidis, Basile N. Landis, Alberto Macchi, Christian A. Mueller, Simona Negoias, Jay Tags: VIEWPOINT Source Type: research

Perioperative management and perceived risks of sinus surgery in patients with aspirin ‐exacerbated respiratory disease
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 16, 2021 Category: Allergy & Immunology Authors: Hannah Wangberg, Samantha R. Spierling Bagsic, Joshua M. Levy, Andrew White Tags: CLINICAL LETTER Source Type: research

International consensus statement on allergy and rhinology: rhinosinusitis 2021
ConclusionThis ICAR ‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 15, 2021 Category: Allergy & Immunology Authors: Richard R. Orlandi, Todd T. Kingdom, Timothy L. Smith, Benjamin Bleier, Adam DeConde, Amber U. Luong, David M. Poetker, Zachary Soler, Kevin C. Welch, Sarah K. Wise, Nithin Adappa, Jeremiah A. Alt, Wilma Terezinha Anselmo ‐Lima, Claus Bache Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 15, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Fulminant mucormycosis complicating coronavirus disease 2019 (COVID ‐19)
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 13, 2021 Category: Allergy & Immunology Authors: Mahboobeh Karimi ‐Galougahi, Shima Arastou, Sara Haseli Tags: CLINICAL LETTER Source Type: research

Association between migraine and vasomotor rhinitis
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 13, 2021 Category: Allergy & Immunology Authors: Yan Liu, Zhimin Xing, Xin Ma, Lisheng Yu Tags: RESEARCH NOTE Source Type: research

“Volcanic eruptions” and “mucosal avalanches”—real‐time documentation of cellular reactions in allergic rhinitis visualized in vivo by confocal laser endomicroscopy
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 10, 2021 Category: Allergy & Immunology Authors: Nina Wenda, Christoph Striedter, Ralf Kiesslich, Jan Gosepath Tags: RESEARCH NOTE Source Type: research

Targetable pathogenic mechanisms in nasal polyposis
AbstractChronic rhinosinusitis with nasal polyps (CRSwNP) represents a challenging disease entity with significant rates of recurrence following appropriate medical and surgical therapy. Recent approval of targeted biologics in CRSwNP compels deeper understanding of underlying disease pathophysiology. Both of the approved biologics for CRSwNP modulate the type 2 inflammatory pathway, and the majority of drugs in the clinical trials pathway are similarly targeted. However, there remain multiple other pathogenic mechanisms relevant to CRSwNP for which targeted therapeutics already exist in other inflammatory diseases that ha...
Source: International Forum of Allergy and Rhinology - March 8, 2021 Category: Allergy & Immunology Authors: Alexander L. Schneider, Robert P. Schleimer, Bruce K. Tan Tags: REVIEW ARTICLE Source Type: research

Hypernasality after the endoscopic modified Lothrop procedure for refractory frontal sinusitis
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 28, 2021 Category: Allergy & Immunology Authors: Li ‐Chun Hsieh, Guo‐She Lee, Kuo‐Sheng Lee, Chin‐Wen Chang, Ying‐Piao Wang Tags: RESEARCH NOTE Source Type: research

Olfactory cleft mucus inflammatory proteins in CRS: a case ‐control study
BackgroundMultiple hypotheses are evolving that suggest several, potentially overlapping etiologies for olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). Understanding inflammatory cytokine profiles of the olfactory cleft (OC) and their association with olfactory function is foundational for future clinical care and research.MethodsThis cross ‐sectional, case‐control study evaluates associations among OC mucus inflammatory proteins, psychophysical olfactory testing, and computed tomography (CT) analysis of the OC and sinuses. Normative reference intervals were determined for each protein and odds ratios (ORs)...
Source: International Forum of Allergy and Rhinology - February 25, 2021 Category: Allergy & Immunology Authors: Timothy L. Smith, Rodney J. Schlosser, Zachary M. Soler, Jess C. Mace, Jose L. Mattos, Vijay R. Ramakrishnan, Daniel M. Beswick, Jeremiah A. Alt, Jennifer K. Mulligan Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Asthma increases long ‐term revision rates of endoscopic sinus surgery in chronic rhinosinusitis with and without nasal polyposis
The objective of this study was to evaluate revision rates of ESS in CRS‐A and identify risk factors associated with in creased likelihood for revision surgery compared to those with CRS without asthma (CRS‐alone).MethodsThe Utah Population Database was queried for patients age>18 years with CRS who underwent at least 1 ESS between 1996 and 2018. Demographic information and history of ESS were collected and compared between CRS ‐A and CRS‐alone using chi‐square tests for categorical variables andt tests for continuous variables. Risk factors for revision surgery were analyzed using Cox proportional hazard mode...
Source: International Forum of Allergy and Rhinology - February 25, 2021 Category: Allergy & Immunology Authors: Amarbir S. Gill, Kristine A. Smith, Huong Meeks, Gretchen M. Oakley, Karen Curtin, Laurie LeClair, Heather Howe, Richard R. Orlandi, Jeremiah A. Alt Tags: ORIGINAL ARTICLE Source Type: research

Conjunctivodacryocystorhinostomy (CDCR) success rates and complications in endoscopic vs non ‐endoscopic approaches: a systematic review
ConclusionBased on the data available in the literature, CDCR is considered an effective procedure for treating epiphora due to proximal obstruction. Controlled and qualitative studies are needed to clarify the significance of the endoscope's contribution to CDCR. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Netanel Eisenbach, Ohad Karni, Eyal Sela, Achia Nemet, Amiel Dror, Einat Levy, Yanir Kassif, Relli Ovadya, Ohad Ronen, Tal Marshak Tags: REVIEW ARTICLE Source Type: research

Topical nasal treatment efficacy on adult obstructive sleep apnea severity: a systematic review and meta ‐analysis
ConclusionTNTs may improve minimum oxygen saturation, ODI, RDI, and subjective/quality ‐of‐life measures. Allergic patients may have more improvement in OSA measures compared with nonallergic patients. Future studies are indicated to accurately determine the efficacy of TNTs. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Dang ‐Khoa Nguyen, Jonathan Liang, Megan Durr Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

The clinical implications of microbiome research
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Richard Douglas Tags: EDITORIAL Source Type: research

Association of spontaneous cerebrospinal fluid rhinorrhea with transverse venous sinus stenosis: a retrospective matched case ‐control study
(Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Halil Onder Tags: CORRESPONDENCE AND REPLY Source Type: research