Inhaled corticosteroid treatment's impact on asthma exacerbations: Influence  of human genetics on microbiome composition

We read with great interest the study by Perez-Garcia et  al1 on the human genetics that influence microbiome composition involved in asthma exacerbations despite inhaled corticosteroid (ICS) treatment. In this retrospective cohort study using data from the Genomic and Metagenomics of Asthma Severity (GEMAS) study, Perez-Garcia et al1 hypothesized a rel ationship between the genetic variants, microbiome associated with asthma exacerbation, and possible biologic pathway. To augment their findings, we would like to offer several suggestions on covariates that could be adopted and included in their study.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research