Allergy to beta-lactam antibiotics in children: Looking for a practical approach.
PMID: 32958141 [PubMed - in process] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - September 1, 2020 Category: Allergy & Immunology Authors: Porto JA Tags: Allergol Immunopathol (Madr) Source Type: research

Probiotics function and modulation of the immune system in allergic diseases.
Abstract Allergic diseases have been a global problem over the past few decades. The effect of allergic diseases on healthcare systems and society is generally remarkable and is considered as one of the most common causes of chronic and hospitalized disease. The functional ability of probiotics to modulate the innate/acquired immune system leads to the initiation of mucosal/systemic immune responses. Gut microbiota plays a beneficial role in food digestion, development of the immune system, control/growth of the intestinal epithelial cells and their differentiation. Prescribing probiotics causes a significant chan...
Source: Allergologia et Immunopathologia - August 3, 2020 Category: Allergy & Immunology Authors: Eslami M, Bahar A, Keikha M, Karbalaei M, Kobyliak NM, Yousefi B Tags: Allergol Immunopathol (Madr) Source Type: research

Asthma control affects school absence, achievement and quality of school life: a multicenter study.
Abstract INTRODUCTION AND OBJECTIVES: Asthma may have a detrimental effect on school attendance and achievement. Friend relations, attendance to school activities, quality of life (QOL) of asthmatic children may be negatively affected. The aim of this study was to evaluate factors influencing school functioning for asthmatic school-age children. MATERIALS AND METHODS: From January to May 2019, parents and school-age children who were followed by a diagnosis of asthma for more than one year, from seven pediatric allergy centers, were given a standard questionnaire including questions about child's disease, sch...
Source: Allergologia et Immunopathologia - August 3, 2020 Category: Allergy & Immunology Authors: Toyran M, Yagmur IT, Guvenir H, Haci IA, Bahceci S, Batmaz SB, Topal OY, Celik IK, Karaatmaca B, Misirlioglu ED, Civelek E, Can D, Kocabas CN Tags: Allergol Immunopathol (Madr) Source Type: research

Adverse reactions and influencing factors in children with primary immunodeficiencies receiving intravenous immunglobulin replacement.
CONCLUSIONS: In our study no severe adverse reaction to IVIG was observed, but many mild or moderate side effects occurred. Therefore, IVIG indications must be well identified. Patients, family of the patients and health care workers must be informed for adverse reactions. PMID: 32703652 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 20, 2020 Category: Allergy & Immunology Authors: Ibis IBP, Erdur B, Erdem SB, Karaman S, Gulez N, Genel F Tags: Allergol Immunopathol (Madr) Source Type: research

Effectiveness of allergy testing in milk induced eosinophilic esophagitis. Description and follow-up of patients.
CONCLUSION: Testing-based elimination diets effectively treated all of the patients with milk-induced EoE. The advantage of this diagnostic protocol is that it required a mean of only two foods to be tested, significantly smaller number than in empiric diets. PMID: 32674848 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 13, 2020 Category: Allergy & Immunology Authors: Terrados S, Villafana L, Antolín-Amérigo D, Camarero C, Martínez-Botas J, Sánchez-Ruano L, de la Hoz B Tags: Allergol Immunopathol (Madr) Source Type: research

Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.
CONCLUSIONS: This study showed that among the antibiotics, Co-amoxiclav and Cefixime are more prevalent and a review of prescribing these two antibiotics for the treatment of the children's infections is essential if this finding is confirmed by other Iranian scholars. PMID: 32653225 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 8, 2020 Category: Allergy & Immunology Authors: Mohsenzadeh A, Movahedi M, Saatchi M, Parvaneh N, Shariat M, Aghamohammadi A, Gharagozlou M Tags: Allergol Immunopathol (Madr) Source Type: research

Hymenoptera venom allergy among children in Italy: time for pediatricians to take action.
Abstract Hymenoptera venom allergy (HVA) is one of the most frequent causes of anaphylaxis following a bee, vespid or ant sting. Real-life data regarding the management of HVA in children are lacking. To address this unmet need, we carried out a survey defining the current management of HVA in children among pediatric allergists in Italy. Educational investments on the improvement of the management of pediatric patients with HVA are urgently needed, and our analysis represents a relevant instrument in targeting a roadmap with this aim. The time for pediatric allergists to take action has come, and a task force fro...
Source: Allergologia et Immunopathologia - July 8, 2020 Category: Allergy & Immunology Authors: Giovannini M, Castagnoli R, Mori F, Arasi S, Barni S, Saretta F, Mastrorilli C, Pecoraro L, Liotti L, Caminiti L, Marseglia GL, Novembre E, from the Rare Allergic Diseases Commission of the Italian Society of Pediatric Allergy and Immunology Tags: Allergol Immunopathol (Madr) Source Type: research

BCG as a game-changer to prevent the infection and severity of COVID-19 pandemic?
Abstract The impact of COVID-19 is changing with country wise and depend on universal immunization policies. COVID-19 badly affects countries that did not have universal immunization policies or having them only for the selective population of countries (highly prominent population) like Italy, USA, UK, Netherland, etc. Universal immunization of BCG can provide great protection against the COVID-19 infection because the BCG vaccine gives broad protection against respiratory infections. BCG vaccine induces expressions of the gene that are involved in the antiviral innate immune response against viral infections wit...
Source: Allergologia et Immunopathologia - July 3, 2020 Category: Allergy & Immunology Authors: Sharma AR, Batra G, Kumar M, Mishra A, Singla R, Singh A, Singh RS, Medhi B Tags: Allergol Immunopathol (Madr) Source Type: research

COVID-19 and air pollution: A dangerous association?
This study compiled the environmental data released by these centers and discussed the impact of the COVID-19 pandemic on environmental pollution. PMID: 32636082 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 1, 2020 Category: Allergy & Immunology Authors: Urrutia-Pereira M, Mello-da-Silva CA, Solé D Tags: Allergol Immunopathol (Madr) Source Type: research

Road toward rapid-molecular point of care test to detect novel SARS-coronavirus 2019 (COVID-19): Review from updated literature.
Abstract Coronavirus disease 2019 (COVID-19) named by the WHO as a result of the global public health emergency. COVID-19 is caused by a new coronavirus named as novel coronavirus (2019-nCOV). From the first case reported in December 2019 it is now a pandemic situation and a major public health emergency. The COVID-19 transmission rate is very high, infecting two to three persons on average with contact to an already infected person. There is a need for the health system, specially in developing countries such as in Pakistan, to combat such a novel disease by rapid, accurate, and high quality diagnostic testing in...
Source: Allergologia et Immunopathologia - July 1, 2020 Category: Allergy & Immunology Authors: Ahmad S, Ali N, Kausar M, Misbah H, Wahid A Tags: Allergol Immunopathol (Madr) Source Type: research

TREE NUTS ALLERGY: Knowledge, gaps and practical implications.
e LÁ PMID: 32616197 [PubMed - in process] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - July 1, 2020 Category: Allergy & Immunology Authors: Echeverría-Zudaire LÁ Tags: Allergol Immunopathol (Madr) Source Type: research

Minimal agreement between basophil activation test and immunoassay in diagnosis of penicillin allergy.
CONCLUSIONS: The agreement between BAT and immunoassay is minimal. Performing both tests provides little increase in the sensitivity of allergy diagnosis work-up for immediate reactions to penicillin. PMID: 32532468 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - June 9, 2020 Category: Allergy & Immunology Authors: Leecyous B, Bakhtiar F, Tang MM, Yadzir ZHM, Abdullah N Tags: Allergol Immunopathol (Madr) Source Type: research

Improvement of the sensitivity of the detection of Gal d 6-specific IgE via biotinylation in vivo.
CONCLUSIONS: rGal d 6-Bio improved the sensitivity for the detection of allergen-specific IgE. PMID: 32532469 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - June 9, 2020 Category: Allergy & Immunology Authors: Huang L, Bao H, Li S, Zhang J, Li L, Zhang B, Yu Y, Liu Y, Li H Tags: Allergol Immunopathol (Madr) Source Type: research

Does delayed urticaria induced by drug allergy exist?
Abstract With the help of a routine clinical case about delayed urticaria induced by drug, we have analyzed the scientific societies reports published during the last 5 years on this topic. We highlighted the differences between the EAACI consensus and documents on drug allergy, commenting their positions and some of their definitions on delayed urticaria. However, the question of disagreement between definitions of delayed urticaria can generate confusion. It would be beneficial to have more and "official" clearness about this topic because of its important clinical application to our patients. PMI...
Source: Allergologia et Immunopathologia - June 3, 2020 Category: Allergy & Immunology Authors: Del Vescovo E, Gelsomino M, Bersani G, Miceli Sopo S Tags: Allergol Immunopathol (Madr) Source Type: research

The status of FOXP3 gene methylation in pediatric systemic lupus erythematosus.
CONCLUSIONS: The FOXP3 gene methylation in children with SLE was significantly higher than healthy subjects, which could possibly affect the level of gene expression. Therefore, one of the causes of increased immune response in SLE can be the lower expression of FOXP3 by hypermethylation of this gene. PMID: 32475613 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 29, 2020 Category: Allergy & Immunology Authors: Hanaei S, Sanati G, Zoghi S, Gharibzadeh S, Ziaee V, Rezaei N Tags: Allergol Immunopathol (Madr) Source Type: research

The use of in vivo and in vitro tests in children with beta lactam allergy.
CONCLUSION: Allergy work-up should be performed in patients with immediate reactions to BLA. A skin test can demonstrate BLA hypersensitivity in most patients. Thus, skin tests should be performed prior to the drug provocation test. PMID: 32473813 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 27, 2020 Category: Allergy & Immunology Authors: Akcal O, Ozen S, Taskirdi I, Haci IA, Kanik ET, Karkiner CS, Can D Tags: Allergol Immunopathol (Madr) Source Type: research

Omalizumab treatment in adolescents with chronic spontaneous urticaria: Efficacy and safety.
CONCLUSIONS: Omalizumab is considered as an effective and safe treatment for CSU in adolescents. Relapses mostly occur within the first year after the cessation of treatment. PMID: 32467066 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 25, 2020 Category: Allergy & Immunology Authors: Kahveci M, Soyer O, Buyuktiryaki B, Sekerel BE, Sahiner UM Tags: Allergol Immunopathol (Madr) Source Type: research

Venom allergy and knowledge about anaphylaxis among beekeepers and their families.
CONCLUSION: It is essential that implementation of focused training programs about anaphylaxis symptoms and signs as well as practical instructions of when and how to use an epinephrine auto-injector will decrease preventable morbidities and mortalities due to bee-stings in this selected high-risk population of beekeepers and their family members, as well as other fieldworkers under risk. PMID: 32460992 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 24, 2020 Category: Allergy & Immunology Authors: Hızlı Demirkale Z, Yücel E, Sipahi Çimen S, Süleyman A, Özdemir C, Kara A, Tamay Z Tags: Allergol Immunopathol (Madr) Source Type: research

Contact haptens in emollients marketed in two European countries (Poland and Spain).
CONCLUSIONS: This study shows that a vast majority of products taken into consideration contain at least one potential contact hapten. These findings indicate a need for patient education about potentially allergenic ingredients and stronger cooperation between academia and cosmetic manufacturers. PMID: 32460993 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 24, 2020 Category: Allergy & Immunology Authors: Kunkiel K, Sojewska M, Feleszko W Tags: Allergol Immunopathol (Madr) Source Type: research

Allergy to beta-lactam antibiotics in children: Risk factors for a positive diagnostic work-up.
as JR Abstract BACKGROUND: Allergy to beta-lactam (βL) antibiotics is highly reported in children, but rarely confirmed. Risk factors for a positive diagnostic work-up are scarce. The primary aim was to characterize the cases of children with confirmed βL allergy, investigating potential risk factors. Secondary aims were to assess the prevalence of allergy to βL in this population and to confirm the safety of less extensive diagnostic protocols for milder reactions. METHODS: We reviewed the clinical data from all children evaluated in our Department for suspected βL allergy, over a six-yea...
Source: Allergologia et Immunopathologia - May 24, 2020 Category: Allergy & Immunology Authors: Dias de Castro E, Carolino F, Carneiro-Leão L, Barbosa J, Ribeiro L, Cernadas JR Tags: Allergol Immunopathol (Madr) Source Type: research

Comparison of methemoglobin levels in food protein-induced enterocolitis syndrome and other gastrointestinal diseases in neonates.
CONCLUSION: High MHb levels may help diagnose severe acute FPIES in neonates, but careful evaluation is needed. PMID: 32451130 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 22, 2020 Category: Allergy & Immunology Authors: Makita E, Kuroda S, Sato H, Itabashi K, Kawano A, Matsuura M, Sugiyama Y, Sugawara D, Maruyama A, Ichihashi K Tags: Allergol Immunopathol (Madr) Source Type: research

Seasonal allergic rhinitis and the role of apitherapy.
CONCLUSIONS: The large discrepancies and number of different recommendations demonstrate that apitherapy is not a consistent type of medicine. The recommendations regarding seasonal allergic rhinitis in the vast majority of apitherapy books cannot be considered adequate when compared to the scientific findings. PMID: 32451131 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 22, 2020 Category: Allergy & Immunology Authors: Münstedt K, Männle H Tags: Allergol Immunopathol (Madr) Source Type: research

Antihistamines in children and adolescents: A practical update.
Abstract Histamine is a chemical mediator, released predominantly by tissue mast cells, circulating basophils, and neurons, which are activated in response to various immunological and non-immunological stimuli. Histamine has to bind to specific receptors to exert its physiological and pathophysiological functions. Endogenous histamine is the main mediator of the immediate allergic response, which moreover, performs other multiple functions, including regulation of gastric secretion, neurotransmission in the central nervous system, and immunomodulatory activity. The involvement of histamine in various disorders an...
Source: Allergologia et Immunopathologia - May 21, 2020 Category: Allergy & Immunology Authors: Parisi GF, Leonardi S, Ciprandi G, Corsico A, Licari A, Miraglia Del Giudice M, Peroni D, Salpietro C, Marseglia GL Tags: Allergol Immunopathol (Madr) Source Type: research

Dust mite-derived Enterobacterial fimbriae H protein enforces the allergen specific immunotherapy in asthma mice.
CONCLUSION: Used as an adjuvant, FimH enforces the effect of ASIT in asthmatic mice via augmenting Tregs. PMID: 32446781 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 20, 2020 Category: Allergy & Immunology Authors: Yang X, Wang H, Zhao D, Wang J, Liu X, Yuan X, Zhang M, Li G, Ran P, Yang P, Liu Z Tags: Allergol Immunopathol (Madr) Source Type: research

Autoimmune and inflammatory manifestations in pediatric patients with primary immunodeficiencies and their importance as a warning sign.
CONCLUSION: Autoimmune/inflammatory manifestations are associated with high morbidity in patients with PIDs and may precede the diagnosis of PID in childhood. Therefore, physicians must be aware of underlying possible immune deficiency and patients with known PIDs should be evaluated for autoimmune and inflammatory complications. PMID: 32446782 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 20, 2020 Category: Allergy & Immunology Authors: Kaplan MY, Ozen S, Akcal O, Gulez N, Genel F Tags: Allergol Immunopathol (Madr) Source Type: research

Illness perceptions and quality of life in families with child with atopic dermatitis.
Abstract OBJECTIVE: To assess the Quality of Life (QoL) of children with Atopic Dermatitis (AD) and their families and the impact of the mothers' illness perceptions on the family QoL. MATERIALS AND METHODS: Seventy-five children with AD (54 infants and 21 children) and their mothers participated in the study. The following questionnaires were administrated: 1. Brief Illness Perception Questionnaire (Brief IPQ); 2. Infant's Dermatitis Quality of Life Index (IDQOL); 3. Children's Dermatology Life Quality Index (CDLQI); 4. Dermatitis Family Impact Questionnaire (DFIQ) and 5. The Severity Scoring of Atopic Derma...
Source: Allergologia et Immunopathologia - May 20, 2020 Category: Allergy & Immunology Authors: Siafaka V, Zioga A, Evrenoglou T, Mavridis D, Tsabouri S Tags: Allergol Immunopathol (Madr) Source Type: research

Immunogenicity of a new allergoid from Felis domesticus.
CONCLUSIONS: This preclinical study carried out with the present assay has established that the allergoid of cat dander extract, as designed for its optimal use in allergen immunotherapy, produces a higher specific IgG than the native extract, in addition to showing significantly higher specific IgG1 levels, evidencing a greater effectiveness in immunization. PMID: 32446784 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 20, 2020 Category: Allergy & Immunology Authors: González JPS, Hernández EB, Abellán AC, Peñalver-Mellado M Tags: Allergol Immunopathol (Madr) Source Type: research

Lung disease in patients with common variable immunodeficiency.
CONCLUSIONS: GLILD is the major cause of lung disease in CVID. Computed tomography is useful for diagnosis but not necessary in follow-up, in which functional tests should have better correlation with clinical evolution, reducing radiation exposure. Biopsy should be indicated when the clinical diagnosis is unclear. Treatment should be considered whenever there is clear evidence of disease progression. PMID: 32446785 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 20, 2020 Category: Allergy & Immunology Authors: López AL, Paolini MV, Fernández Romero DS Tags: Allergol Immunopathol (Madr) Source Type: research

Food allergen sensitization patterns in a large allergic population in Mexico.
CONCLUSION: Our study reported the presence of a differential regional IgE sensitization pattern as compared with the internationally reported one, highlighting the importance of local staple foods. PMID: 32444115 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 19, 2020 Category: Allergy & Immunology Authors: Ruiz Segura LT, Figueroa Pérez E, Nowak-Wegrzyn A, Siepmann T, Larenas-Linnemann D Tags: Allergol Immunopathol (Madr) Source Type: research

Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study.
CONCLUSIONS: Our findings suggest that maternal SHS exposure during pregnancy might be associated with an increased risk of ever asthma and current asthma in young children whose mothers have never smoked. PMID: 32439145 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 18, 2020 Category: Allergy & Immunology Authors: Tanaka K, Arakawa M, Miyake Y Tags: Allergol Immunopathol (Madr) Source Type: research

Prevalence of asthma, allergic rhinitis and pollinosis in a city of Brazil: A monitoring study.
Abstract BACKGROUND: Allergic respiratory diseases such as asthma and allergic rhinitis have increased considerably in the last decades. OBJECTIVE: The present study estimates prevalence trends of asthma, allergic rhinitis and pollinosis in the population of a city of Southern Brazil, without restriction of age, from 2011 to 2018, using the ISAAC standardized questionnaire. METHODS: Data was collected from March to June of 2011 and during the same months in 2018, in order to verify trends in the prevalence of these allergic conditions. The total sample consisted of 3132 individuals of both sexes living i...
Source: Allergologia et Immunopathologia - May 18, 2020 Category: Allergy & Immunology Authors: Oliveira TB, Persigo ALK, Ferrazza CC, Ferreira ENN, Veiga ABG Tags: Allergol Immunopathol (Madr) Source Type: research

Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults.
allar I, Colás C Abstract INTRODUCTION: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation. OBJECTIVE: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital. METHOD: Descriptive, retrospective and cross-sectional study. We randomly selected 40 children and 40 adults diagnosed with EoE between 2009 and 2016. The patient characteristics were analysed by means of epidemiologica...
Source: Allergologia et Immunopathologia - May 15, 2020 Category: Allergy & Immunology Authors: Agulló-García A, Cubero JL, Lezaun A, Boné J, Guallar I, Colás C Tags: Allergol Immunopathol (Madr) Source Type: research

Tyrophagus putrescentiae group 4 allergen allergenicity and epitope prediction.
CONCLUSIONS: Similar to group 4 allergens of other species of mite, allergenicity of Tyr p 4 is weak. The expression, characterization and epitope prediction of recombinant Tyr p 4 protein provide a foundation for further study of this allergen in the diagnosis and ASIT of storage mite allergy. PMID: 32418775 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 14, 2020 Category: Allergy & Immunology Authors: Teng FX, Huang HF, Ge DZ, Yu LL, Xu C, Cui YB Tags: Allergol Immunopathol (Madr) Source Type: research

Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran.
CONCLUSION: Ten warning sign scoring system is of less value to consider a patient suspected of having primary immune deficiency. There is a meaningful delay in diagnosis of primary immune deficiencies especially in antibody deficiency defects which seeks further upgrading of knowledge in physicians. PMID: 32404246 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 11, 2020 Category: Allergy & Immunology Authors: Bahrami A, Sayyahfar S, Soltani Z, Khodadost M, Moazzami B, Rezaei N Tags: Allergol Immunopathol (Madr) Source Type: research

Adverse reaction with hexavalent vaccine: An unusual case.
;lez-Muñoz M, Quirce S PMID: 32402623 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 10, 2020 Category: Allergy & Immunology Authors: Tomás-Pérez M, Gómez-Traseira C, González-Muñoz M, Quirce S Tags: Allergol Immunopathol (Madr) Source Type: research

Factors associated with wheezing among Lebanese children: Results of a cross-sectional study.
CONCLUSION: The findings of the study suggest that certain environmental factors, such as pesticides, humidity at home and reflux disease, might be associated with wheezing episodes in children. Those factors can be prevented through raising awareness by health care professionals. PMID: 32402625 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 10, 2020 Category: Allergy & Immunology Authors: Malaeb D, Hallit S, Sacre H, Hallit R, Salameh P Tags: Allergol Immunopathol (Madr) Source Type: research

Predictors of a positive oral food challenge to cow's milk in children sensitized to cow's milk.
This study aimed to determine the value of specific IgEs, ratios of specific IgEs for cow's milk and its components to total IgE, and wheal size on SPT for predicting a positive OFC for CMA. MATERIAL AND METHODS: We retrospectively studied 72 patients [median age, four years; age range 0.75-15 years] sensitized to cow's milk who underwent OFCs to milk. predictive variables between patients with positive and negative OFCs were compared. Receiver operator characteristic (ROC) curves were uses to assess variables' discriminatory capacity and Youden's index to determine the best cut-offs for predicting CMA. RESULTS: ...
Source: Allergologia et Immunopathologia - May 10, 2020 Category: Allergy & Immunology Authors: Ayats-Vidal R, Valdesoiro-Navarrete L, García-González M, Asensio-De la Cruz O, Larramona-Carrera H, Bosque-García M Tags: Allergol Immunopathol (Madr) Source Type: research

Atopy patch test in children with cow's milk and hen's egg allergy: Do clinical symptoms matter?
CONCLUSION: Our study showed that APT provided reliable diagnostic accuracy in atopic dermatitis patients. However, APT had low sensitivity in patients with gastrointestinal symptoms. PMID: 32402621 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 8, 2020 Category: Allergy & Immunology Authors: Sirin Kose S, Asilsoy S, Tezcan D, Atakul G, Al S, Atay O, Kangalli Boyacioglu O, Uzuner N, Anal O, Karaman O Tags: Allergol Immunopathol (Madr) Source Type: research

LTP allergy/sensitization in a pediatric population.
Abstract Plant lipid transfer proteins (LTPs) are widespread plant food allergens, highly resistant to food processing and to the gastrointestinal environment, which have been described as the most common food allergens in the Mediterranean area. LTP allergy is widely described in adults, but it represents an emerging allergen also in the pediatric population. Little is known about the real prevalence and the clinical features of this allergy in children and it still often remains underdiagnosed in these patients. An early identification and a deeper knowledge of this allergy in childhood can avoid severe systemic...
Source: Allergologia et Immunopathologia - May 8, 2020 Category: Allergy & Immunology Authors: Aruanno A, Urbani S, Frati F, Nucera E Tags: Allergol Immunopathol (Madr) Source Type: research

Atopic dermatitis incidence and risk factors in young adults in Castellon (Spain): A prospective cohort study.
CONCLUSIONS: AD incidence in our cohort was high and several risks factors were related to AD. PMID: 32402624 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 8, 2020 Category: Allergy & Immunology Authors: Arnedo-Pena A, Puig-Barberà J, Artero-Civera A, Romeu-Garcia MA, Meseguer-Ferrer N, Fenollosa-Amposta C, Vizcaino-Batllés A, Silvestre-Silvester E, Pac-Sa MR, Segura-Navas L, Dubón MA, Fabregat-Puerto J, Bellido-Blasco JB Tags: Allergol Immunopathol (Madr) Source Type: research

Asthma diagnosis and lung testing: Where is the boundary of asthma?
PMID: 32370876 [PubMed - in process] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - May 1, 2020 Category: Allergy & Immunology Authors: Moral L Tags: Allergol Immunopathol (Madr) Source Type: research

Disagreement between guidelines regarding the third step of asthma drug therapy for school-age children.
Abstract With the help of a routine clinical case, we highlighted the difference between two of the best asthma guidelines available at the time regarding therapeutic suggestions for the so-called "third step" for school-age asthmatic children. We have analyzed the scientific evidence that each of the two guidelines brings to support their position. Finally, we have motivatedly solved the clinical scenario. However, the question of disagreement between two guidelines remains unresolved. This can lead to unjustified differences in the management of schoolchildren with persistent asthma. PMID: 3237102...
Source: Allergologia et Immunopathologia - May 1, 2020 Category: Allergy & Immunology Authors: Miceli Sopo S, Bersani G, Del Vescovo E, Gelsomino M Tags: Allergol Immunopathol (Madr) Source Type: research

The MEFV gene and its association with familial Mediterranean fever, severe atopy, and recurrent respiratory tract infections.
CONCLUSIONS: While being a periodic fever syndrome, familial Mediterranean fever also presents as a multisystemic disease with heterogeneous clinical symptoms. Severe atopic diseases and recurrent respiratory tract infections are characteristic features of this disease. PMID: 32359823 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 28, 2020 Category: Allergy & Immunology Authors: Celiksoy MH, Dogan C, Erturk B, Keskin E, Ada BS Tags: Allergol Immunopathol (Madr) Source Type: research

Network pharmacology-based study of the protective mechanism of conciliatory anti-allergic decoction on asthma.
CONCLUSION: The anti-asthma mechanism of CAD possibly stemmed from the active ingredients targeting asthma-related targets, which are involved in the asthma pathway and signaling pathways to exhibit therapeutic effects. PMID: 32359824 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 28, 2020 Category: Allergy & Immunology Authors: Xuan X, Sun Z, Yu C, Chen J, Chen M, Wang Q, Li L Tags: Allergol Immunopathol (Madr) Source Type: research

Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency.
CONCLUSIONS: Screening for APDS in patients with recurrent respiratory tract infections with undefined antibody deficiency or combined immune deficiency with or without bronchiectasis is required. These patients need great attention to benefit from the available treatment. Further studies on the Egyptian population are recommended to increase the knowledge about the prevalence and phenotypic characterization of this disease in Egypt. PMID: 32349894 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 26, 2020 Category: Allergy & Immunology Authors: Ahmed AA, El Shahaway AA, Hussien SA Tags: Allergol Immunopathol (Madr) Source Type: research

Anti-allergic function of α-Tocopherol is mediated by suppression of PI3K-PKB activity in mast cells in mouse model of allergic rhinitis.
CONCLUSIONS: Our results demonstrated that α-TCP-mediated suppression of PI3K-PKB activity in mast cells is a potential mechanism of anti-allergic function of α-TCP. PMID: 32334909 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 22, 2020 Category: Allergy & Immunology Authors: Wu G, Zhu H, Wu X, Liu L, Ma X, Yuan Y, Fu X, Zhang L, Lv Y, Li D, Liu J, Lu J, Yu Y, Li M Tags: Allergol Immunopathol (Madr) Source Type: research

Role of nasal saline irrigation in the treatment of allergic rhinitis in children and adults: A systematic analysis.
CONCLUSIONS: Saline irrigation can significantly improve symptoms of AR in children and adults. Saline irrigation can serve as a safe adjunctive treatment to medication of AR in adults. Saline irrigation can be an alternative therapy for children and pregnant women with AR. Efficacy of hypertonic saline may be better than that of isotonic saline in treating AR of children. PMID: 32331798 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 21, 2020 Category: Allergy & Immunology Authors: Wang Y, Jin L, Liu SX, Fan K, Qin ML, Yu SQ Tags: Allergol Immunopathol (Madr) Source Type: research

Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy.
CONCLUSION: The cross-reactivity rate was quite low for oat and Job's tears compared to that of barley; therefore, avoidance of all cereal grains may be unnecessary in patients with severe wheat allergy. PMID: 32327208 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 20, 2020 Category: Allergy & Immunology Authors: Srisuwatchari W, Piboonpocanun S, Wangthan U, Jirapongsananuruk O, Visitsunthorn N, Pacharn P Tags: Allergol Immunopathol (Madr) Source Type: research

Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape.
ez JA Abstract INTRODUCTION AND OBJECTIVES: Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary. MATERIALS AND METHODS: A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. TFVL loops were classified into one of three categories depending of their geometric shape (symmetric, convex, and concave). Respiratory rate (Rr), presence of API+, and the number of exacerbations during th...
Source: Allergologia et Immunopathologia - April 17, 2020 Category: Allergy & Immunology Authors: Keklikian E, Cornes P, Cela CJ, Sanchez Solis M, García Marcos L, Castro-Rodriguez JA Tags: Allergol Immunopathol (Madr) Source Type: research

Reference values of leukocyte and lymphocytes populations in umbilical cord and capillary blood in healthy Mexican newborns.
DISCUSSION: Our data contribute to newborn Mexican reference values for all these populations of leukocytes. We found that the dispersal range differs between the two types of blood, suggesting a different fate in the immune response. Immunophenotyping of the blood cell population to identify these cells is an essential tool in the diagnosis and follow-up of neonates with immunodeficiencies and other immune disorders. PMID: 32312563 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - April 17, 2020 Category: Allergy & Immunology Authors: Scheffer-Mendoza S, Espinosa-Padilla SE, López-Herrera G, Mujica-Guzmán F, López-Padilla MG, Berrón-Ruiz L Tags: Allergol Immunopathol (Madr) Source Type: research