Experience of Autoimmune and autoinflammatory diseases in a Turkish pediatric cohort with primary immunodeficiencies
CONCLUSIONS: It is important to recognize association between autoimmunity, autoinflammation, and PID, which in the future could be useful for increased awareness and early diagnosis for these diseases.PMID:34761650 | DOI:10.15586/aei.v49i6.450 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Dilek Özcan Mahir Serbes Rabia Miray K ışla Ekinci Sibel Balc ı Çetinkaya Ay şe Şenay Şaşihüseyinoğlu At ıl Bişgin Derya Ufuk Alt ıntaş Source Type: research

SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway
CONCLUSION: Ectopical expression of SEMA3A suppressed hyperoxia-induced apoptosis and inflammation in neonatal rats, and ameliorated the histopathological changes through inactivation of ERK/JNK pathway.PMID:34761651 | DOI:10.15586/aei.v49i6.478 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Zhenyu Liang Xiao Zhang Yingxian Liu Qianmei Wu Chuming You Source Type: research

Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology
CONCLUSION: This study revealed the synergistic effects of multiple components, targets, and pathways of GSD for treating KOA. This would enhance the understanding of potential molecular mechanisms of GSD for treating KOA and lay a foundation for further experimental research.PMID:34761652 | DOI:10.15586/aei.v49i6.484 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Pin Deng Huan Liang Kunming Xie Jinglu Han Fasen Huang Huanyu Liu Hanjie Zhu Zhichao Huang Qiong Wu Jingwei Tao Lan Li Zhaojun Chen Source Type: research

A review of aeropalynology research in Nigeria: implication on public health and environmental research collaboration
CONCLUSION: The availability of such data/information is crucial for reducing epidemiological uncertainties, enhancing the diagnosis of allergic conditions, and securing a robust set of mitigation strategies and/or effective treatment of these conditions in Nigeria.PMID:34761653 | DOI:10.15586/aei.v49i6.241 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Linus Bashie Ajikah Olugbenga Shadrak Alebiosu Emuobosa Akpo Orijemie Dough Onah Source Type: research

An unusual case of food protein-induced enterocolitis syndrome due to zucchini
CONCLUSIONS: In this case, the OFC was essential to identify the offending food and to verify that the child had overcome the disease.PMID:34761654 | DOI:10.15586/aei.v49i6.462 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Alberto Garc ía de la Fuente Victoria Fuentes-Aparicio Sonsoles Infante Source Type: research

Perturbation of monocyte subsets in iron-deficient children - a shift to a pro-inflammatory state?
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):42-47. doi: 10.15586/aei.v49i6.91. eCollection 2021.ABSTRACTBACKGROUND: Iron deficiency anemia (IDA) is the most prevalent micronutrient deficiency in preschool children in developing countries including India. IDA is associated with immune perturbation, which is reflected in greater frequency of infections in these children. Recent research has shown three distinct monocyte subsets with distinct functions linked to infectious, inflammatory, and autoimmune diseases. These subsets have not been studied in children with IDA.OBJECTIVE: The aim of the study was to assess the perce...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Nimisha Dhankar Richa Gupta Shyam Lata Jain Shramana Mandal Beauty Sarkar Source Type: research

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases
CONCLUSIONS: In these cohorts of breastfed patients with good adherence to TMD patterns, there was evidence of a low incidence of childhood asthma and the IRD, more pronounced in the highest adherence Group 1. Some non-TMD foods have been linked to the occurrence of childhood asthma and IRD, as their dietary limitations have contributed to decreasing morbidity.PMID:34761656 | DOI:10.15586/aei.v49i6.338 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Fernando M Calatayud-S áez Blanca Calatayud Monica Luque Ana Calatayud J G Gallego Francisco Rivas-Ruiz Source Type: research

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):56-59. doi: 10.15586/aei.v49i6.474. eCollection 2021.ABSTRACTFood allergy is rising rapidly among children, and allergy to nuts is one of the most prevalent allergies among them. The category "nuts and seeds" include several plant foods from different botanical families, very different from each other. It is not uncommon to detect co-sensitization to different nuts. However, true co-allergy is less frequent. Up to 80% of patients with positive skin prick tests or specific IgE without true history of reaction who avoid certain nuts, might tolerate them in an Oral Food...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Cristina Blasco Valero Ángela Claver Monzón Natalia Molini Mench ón Antonio Martorell L Aragon és Carlos Garc ía Magán Sara Pereiro Fern ández Celia Pinto Fern ández M ónica Piquer Gibert Ana Prieto Del Prado Laura Valdesoiro Navarrete Marta V á Source Type: research

Does the reaction size of skin prick test associated with the allergic rhinitis symptom severity?
CONCLUSION: Despite previous conflicts to rely on SPT test for starting immunotherapy, we recommend this test especially for patients sensitive to Alternaria, weed pollens, and tree pollens, considering the size of wheal in association with AR symptom severity.PMID:34761658 | DOI:10.15586/aei.v49i6.211 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sedigheh Madani Fariborz Zandieh Maryam Ahmadi Maryam Parvizi Nima Rezaei Source Type: research

Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection
CONCLUSION: Since this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.PMID:34761659 | DOI:10.15586/aei.v49i6.92 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Molood Safarirad Ali Abbaszadeh Ganji Farzad Nazari Reza Yazdani Hassan Abolhassani Ahmad Vosughi Motlagh Source Type: research

Mosquito hypersensitivity may be associated with atopic background in children
Allergol Immunopathol (Madr). 2021 Nov 2;49(6):67-72. doi: 10.15586/aei.v49i6.448. eCollection 2021.ABSTRACTBACKGROUND: Many children encounter unusual or "exaggerated" reactions such as large local, atypical or systemic reactions after mosquito bites.OBJECTIVE: The aim of this study was to document the clinical features of children with mosquito allergy and investigate the possible associations between demographic features and type of reactions in this population.METHODS: Children with large local or unusual reactions after mosquito bites who attended to our outpatient pediatric allergy department were enrolled ...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: S üleyman Tolga Yavuz Onur Akin Ozan Koc Ali G üngör Ahmet Bolat Mustafa G ülec Source Type: research

Bruceine D ameliorates the balance of Th1/Th2 in a mouse model of ovalbumin-induced allergic asthma via inhibiting the NOTCH pathway
In conclusion, BD protected mice against OVA-induced allergic asthma by reducing AHR and restoring the Th1/Th2 balance through the NOTCH signaling pathway. Our findings highlighted the potential of BD as a therapeutic agent for allergic asthma.PMID:34761661 | DOI:10.15586/aei.v49i6.499 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Ying Nie Bangkun Yang Junfeng Hu Lingling Zhang Zhimin Ma Source Type: research

MiR-224 ameliorates inflammation and symptoms in mouse model of allergic rhinitis by targeting CDK9
CONCLUSION: MiR-224 affected the pathogenesis of AR by targeting CDK9. It proves that miR-224 could be a novel potential therapeutic target for AR.PMID:34761662 | DOI:10.15586/aei.v49i6.451 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sang Wang Lei Wang Hua Hu Pin Dong Source Type: research

Experience of Autoimmune and autoinflammatory diseases in a Turkish pediatric cohort with primary immunodeficiencies
CONCLUSIONS: It is important to recognize association between autoimmunity, autoinflammation, and PID, which in the future could be useful for increased awareness and early diagnosis for these diseases.PMID:34761650 | DOI:10.15586/aei.v49i6.450 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Dilek Özcan Mahir Serbes Rabia Miray K ışla Ekinci Sibel Balc ı Çetinkaya Ay şe Şenay Şaşihüseyinoğlu At ıl Bişgin Derya Ufuk Alt ıntaş Source Type: research

SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway
CONCLUSION: Ectopical expression of SEMA3A suppressed hyperoxia-induced apoptosis and inflammation in neonatal rats, and ameliorated the histopathological changes through inactivation of ERK/JNK pathway.PMID:34761651 | DOI:10.15586/aei.v49i6.478 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Zhenyu Liang Xiao Zhang Yingxian Liu Qianmei Wu Chuming You Source Type: research

Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology
CONCLUSION: This study revealed the synergistic effects of multiple components, targets, and pathways of GSD for treating KOA. This would enhance the understanding of potential molecular mechanisms of GSD for treating KOA and lay a foundation for further experimental research.PMID:34761652 | DOI:10.15586/aei.v49i6.484 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Pin Deng Huan Liang Kunming Xie Jinglu Han Fasen Huang Huanyu Liu Hanjie Zhu Zhichao Huang Qiong Wu Jingwei Tao Lan Li Zhaojun Chen Source Type: research

A review of aeropalynology research in Nigeria: implication on public health and environmental research collaboration
CONCLUSION: The availability of such data/information is crucial for reducing epidemiological uncertainties, enhancing the diagnosis of allergic conditions, and securing a robust set of mitigation strategies and/or effective treatment of these conditions in Nigeria.PMID:34761653 | DOI:10.15586/aei.v49i6.241 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Linus Bashie Ajikah Olugbenga Shadrak Alebiosu Emuobosa Akpo Orijemie Dough Onah Source Type: research

An unusual case of food protein-induced enterocolitis syndrome due to zucchini
CONCLUSIONS: In this case, the OFC was essential to identify the offending food and to verify that the child had overcome the disease.PMID:34761654 | DOI:10.15586/aei.v49i6.462 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Alberto Garc ía de la Fuente Victoria Fuentes-Aparicio Sonsoles Infante Source Type: research

Perturbation of monocyte subsets in iron-deficient children - a shift to a pro-inflammatory state?
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):42-47. doi: 10.15586/aei.v49i6.91. eCollection 2021.ABSTRACTBACKGROUND: Iron deficiency anemia (IDA) is the most prevalent micronutrient deficiency in preschool children in developing countries including India. IDA is associated with immune perturbation, which is reflected in greater frequency of infections in these children. Recent research has shown three distinct monocyte subsets with distinct functions linked to infectious, inflammatory, and autoimmune diseases. These subsets have not been studied in children with IDA.OBJECTIVE: The aim of the study was to assess the perce...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Nimisha Dhankar Richa Gupta Shyam Lata Jain Shramana Mandal Beauty Sarkar Source Type: research

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases
CONCLUSIONS: In these cohorts of breastfed patients with good adherence to TMD patterns, there was evidence of a low incidence of childhood asthma and the IRD, more pronounced in the highest adherence Group 1. Some non-TMD foods have been linked to the occurrence of childhood asthma and IRD, as their dietary limitations have contributed to decreasing morbidity.PMID:34761656 | DOI:10.15586/aei.v49i6.338 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Fernando M Calatayud-S áez Blanca Calatayud Monica Luque Ana Calatayud J G Gallego Francisco Rivas-Ruiz Source Type: research

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):56-59. doi: 10.15586/aei.v49i6.474. eCollection 2021.ABSTRACTFood allergy is rising rapidly among children, and allergy to nuts is one of the most prevalent allergies among them. The category "nuts and seeds" include several plant foods from different botanical families, very different from each other. It is not uncommon to detect co-sensitization to different nuts. However, true co-allergy is less frequent. Up to 80% of patients with positive skin prick tests or specific IgE without true history of reaction who avoid certain nuts, might tolerate them in an Oral Food...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Cristina Blasco Valero Ángela Claver Monzón Natalia Molini Mench ón Antonio Martorell L Aragon és Carlos Garc ía Magán Sara Pereiro Fern ández Celia Pinto Fern ández M ónica Piquer Gibert Ana Prieto Del Prado Laura Valdesoiro Navarrete Marta V á Source Type: research

Does the reaction size of skin prick test associated with the allergic rhinitis symptom severity?
CONCLUSION: Despite previous conflicts to rely on SPT test for starting immunotherapy, we recommend this test especially for patients sensitive to Alternaria, weed pollens, and tree pollens, considering the size of wheal in association with AR symptom severity.PMID:34761658 | DOI:10.15586/aei.v49i6.211 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sedigheh Madani Fariborz Zandieh Maryam Ahmadi Maryam Parvizi Nima Rezaei Source Type: research

Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection
CONCLUSION: Since this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.PMID:34761659 | DOI:10.15586/aei.v49i6.92 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Molood Safarirad Ali Abbaszadeh Ganji Farzad Nazari Reza Yazdani Hassan Abolhassani Ahmad Vosughi Motlagh Source Type: research

Mosquito hypersensitivity may be associated with atopic background in children
Allergol Immunopathol (Madr). 2021 Nov 2;49(6):67-72. doi: 10.15586/aei.v49i6.448. eCollection 2021.ABSTRACTBACKGROUND: Many children encounter unusual or "exaggerated" reactions such as large local, atypical or systemic reactions after mosquito bites.OBJECTIVE: The aim of this study was to document the clinical features of children with mosquito allergy and investigate the possible associations between demographic features and type of reactions in this population.METHODS: Children with large local or unusual reactions after mosquito bites who attended to our outpatient pediatric allergy department were enrolled ...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: S üleyman Tolga Yavuz Onur Akin Ozan Koc Ali G üngör Ahmet Bolat Mustafa G ülec Source Type: research

Bruceine D ameliorates the balance of Th1/Th2 in a mouse model of ovalbumin-induced allergic asthma via inhibiting the NOTCH pathway
In conclusion, BD protected mice against OVA-induced allergic asthma by reducing AHR and restoring the Th1/Th2 balance through the NOTCH signaling pathway. Our findings highlighted the potential of BD as a therapeutic agent for allergic asthma.PMID:34761661 | DOI:10.15586/aei.v49i6.499 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Ying Nie Bangkun Yang Junfeng Hu Lingling Zhang Zhimin Ma Source Type: research

MiR-224 ameliorates inflammation and symptoms in mouse model of allergic rhinitis by targeting CDK9
CONCLUSION: MiR-224 affected the pathogenesis of AR by targeting CDK9. It proves that miR-224 could be a novel potential therapeutic target for AR.PMID:34761662 | DOI:10.15586/aei.v49i6.451 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sang Wang Lei Wang Hua Hu Pin Dong Source Type: research

Experience of Autoimmune and autoinflammatory diseases in a Turkish pediatric cohort with primary immunodeficiencies
CONCLUSIONS: It is important to recognize association between autoimmunity, autoinflammation, and PID, which in the future could be useful for increased awareness and early diagnosis for these diseases.PMID:34761650 | DOI:10.15586/aei.v49i6.450 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Dilek Özcan Mahir Serbes Rabia Miray K ışla Ekinci Sibel Balc ı Çetinkaya Ay şe Şenay Şaşihüseyinoğlu At ıl Bişgin Derya Ufuk Alt ıntaş Source Type: research

SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway
CONCLUSION: Ectopical expression of SEMA3A suppressed hyperoxia-induced apoptosis and inflammation in neonatal rats, and ameliorated the histopathological changes through inactivation of ERK/JNK pathway.PMID:34761651 | DOI:10.15586/aei.v49i6.478 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Zhenyu Liang Xiao Zhang Yingxian Liu Qianmei Wu Chuming You Source Type: research

Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology
CONCLUSION: This study revealed the synergistic effects of multiple components, targets, and pathways of GSD for treating KOA. This would enhance the understanding of potential molecular mechanisms of GSD for treating KOA and lay a foundation for further experimental research.PMID:34761652 | DOI:10.15586/aei.v49i6.484 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Pin Deng Huan Liang Kunming Xie Jinglu Han Fasen Huang Huanyu Liu Hanjie Zhu Zhichao Huang Qiong Wu Jingwei Tao Lan Li Zhaojun Chen Source Type: research

A review of aeropalynology research in Nigeria: implication on public health and environmental research collaboration
CONCLUSION: The availability of such data/information is crucial for reducing epidemiological uncertainties, enhancing the diagnosis of allergic conditions, and securing a robust set of mitigation strategies and/or effective treatment of these conditions in Nigeria.PMID:34761653 | DOI:10.15586/aei.v49i6.241 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Linus Bashie Ajikah Olugbenga Shadrak Alebiosu Emuobosa Akpo Orijemie Dough Onah Source Type: research

An unusual case of food protein-induced enterocolitis syndrome due to zucchini
CONCLUSIONS: In this case, the OFC was essential to identify the offending food and to verify that the child had overcome the disease.PMID:34761654 | DOI:10.15586/aei.v49i6.462 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Alberto Garc ía de la Fuente Victoria Fuentes-Aparicio Sonsoles Infante Source Type: research

Perturbation of monocyte subsets in iron-deficient children - a shift to a pro-inflammatory state?
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):42-47. doi: 10.15586/aei.v49i6.91. eCollection 2021.ABSTRACTBACKGROUND: Iron deficiency anemia (IDA) is the most prevalent micronutrient deficiency in preschool children in developing countries including India. IDA is associated with immune perturbation, which is reflected in greater frequency of infections in these children. Recent research has shown three distinct monocyte subsets with distinct functions linked to infectious, inflammatory, and autoimmune diseases. These subsets have not been studied in children with IDA.OBJECTIVE: The aim of the study was to assess the perce...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Nimisha Dhankar Richa Gupta Shyam Lata Jain Shramana Mandal Beauty Sarkar Source Type: research

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases
CONCLUSIONS: In these cohorts of breastfed patients with good adherence to TMD patterns, there was evidence of a low incidence of childhood asthma and the IRD, more pronounced in the highest adherence Group 1. Some non-TMD foods have been linked to the occurrence of childhood asthma and IRD, as their dietary limitations have contributed to decreasing morbidity.PMID:34761656 | DOI:10.15586/aei.v49i6.338 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Fernando M Calatayud-S áez Blanca Calatayud Monica Luque Ana Calatayud J G Gallego Francisco Rivas-Ruiz Source Type: research

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):56-59. doi: 10.15586/aei.v49i6.474. eCollection 2021.ABSTRACTFood allergy is rising rapidly among children, and allergy to nuts is one of the most prevalent allergies among them. The category "nuts and seeds" include several plant foods from different botanical families, very different from each other. It is not uncommon to detect co-sensitization to different nuts. However, true co-allergy is less frequent. Up to 80% of patients with positive skin prick tests or specific IgE without true history of reaction who avoid certain nuts, might tolerate them in an Oral Food...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Cristina Blasco Valero Ángela Claver Monzón Natalia Molini Mench ón Antonio Martorell L Aragon és Carlos Garc ía Magán Sara Pereiro Fern ández Celia Pinto Fern ández M ónica Piquer Gibert Ana Prieto Del Prado Laura Valdesoiro Navarrete Marta V á Source Type: research

Does the reaction size of skin prick test associated with the allergic rhinitis symptom severity?
CONCLUSION: Despite previous conflicts to rely on SPT test for starting immunotherapy, we recommend this test especially for patients sensitive to Alternaria, weed pollens, and tree pollens, considering the size of wheal in association with AR symptom severity.PMID:34761658 | DOI:10.15586/aei.v49i6.211 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sedigheh Madani Fariborz Zandieh Maryam Ahmadi Maryam Parvizi Nima Rezaei Source Type: research

Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection
CONCLUSION: Since this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.PMID:34761659 | DOI:10.15586/aei.v49i6.92 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Molood Safarirad Ali Abbaszadeh Ganji Farzad Nazari Reza Yazdani Hassan Abolhassani Ahmad Vosughi Motlagh Source Type: research

Mosquito hypersensitivity may be associated with atopic background in children
Allergol Immunopathol (Madr). 2021 Nov 2;49(6):67-72. doi: 10.15586/aei.v49i6.448. eCollection 2021.ABSTRACTBACKGROUND: Many children encounter unusual or "exaggerated" reactions such as large local, atypical or systemic reactions after mosquito bites.OBJECTIVE: The aim of this study was to document the clinical features of children with mosquito allergy and investigate the possible associations between demographic features and type of reactions in this population.METHODS: Children with large local or unusual reactions after mosquito bites who attended to our outpatient pediatric allergy department were enrolled ...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: S üleyman Tolga Yavuz Onur Akin Ozan Koc Ali G üngör Ahmet Bolat Mustafa G ülec Source Type: research

Bruceine D ameliorates the balance of Th1/Th2 in a mouse model of ovalbumin-induced allergic asthma via inhibiting the NOTCH pathway
In conclusion, BD protected mice against OVA-induced allergic asthma by reducing AHR and restoring the Th1/Th2 balance through the NOTCH signaling pathway. Our findings highlighted the potential of BD as a therapeutic agent for allergic asthma.PMID:34761661 | DOI:10.15586/aei.v49i6.499 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Ying Nie Bangkun Yang Junfeng Hu Lingling Zhang Zhimin Ma Source Type: research

MiR-224 ameliorates inflammation and symptoms in mouse model of allergic rhinitis by targeting CDK9
CONCLUSION: MiR-224 affected the pathogenesis of AR by targeting CDK9. It proves that miR-224 could be a novel potential therapeutic target for AR.PMID:34761662 | DOI:10.15586/aei.v49i6.451 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sang Wang Lei Wang Hua Hu Pin Dong Source Type: research

Experience of Autoimmune and autoinflammatory diseases in a Turkish pediatric cohort with primary immunodeficiencies
CONCLUSIONS: It is important to recognize association between autoimmunity, autoinflammation, and PID, which in the future could be useful for increased awareness and early diagnosis for these diseases.PMID:34761650 | DOI:10.15586/aei.v49i6.450 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Dilek Özcan Mahir Serbes Rabia Miray K ışla Ekinci Sibel Balc ı Çetinkaya Ay şe Şenay Şaşihüseyinoğlu At ıl Bişgin Derya Ufuk Alt ıntaş Source Type: research

SEMA3A protects against hyperoxia-induced lung injury in a bronchopulmonary dysplasia model of newborn rat by inhibiting ERK pathway
CONCLUSION: Ectopical expression of SEMA3A suppressed hyperoxia-induced apoptosis and inflammation in neonatal rats, and ameliorated the histopathological changes through inactivation of ERK/JNK pathway.PMID:34761651 | DOI:10.15586/aei.v49i6.478 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Zhenyu Liang Xiao Zhang Yingxian Liu Qianmei Wu Chuming You Source Type: research

Study on the molecular mechanism of Guizhi Jia Shaoyao decoction for the treatment of knee osteoarthritis by utilizing network pharmacology and molecular docking technology
CONCLUSION: This study revealed the synergistic effects of multiple components, targets, and pathways of GSD for treating KOA. This would enhance the understanding of potential molecular mechanisms of GSD for treating KOA and lay a foundation for further experimental research.PMID:34761652 | DOI:10.15586/aei.v49i6.484 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Pin Deng Huan Liang Kunming Xie Jinglu Han Fasen Huang Huanyu Liu Hanjie Zhu Zhichao Huang Qiong Wu Jingwei Tao Lan Li Zhaojun Chen Source Type: research

A review of aeropalynology research in Nigeria: implication on public health and environmental research collaboration
CONCLUSION: The availability of such data/information is crucial for reducing epidemiological uncertainties, enhancing the diagnosis of allergic conditions, and securing a robust set of mitigation strategies and/or effective treatment of these conditions in Nigeria.PMID:34761653 | DOI:10.15586/aei.v49i6.241 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Linus Bashie Ajikah Olugbenga Shadrak Alebiosu Emuobosa Akpo Orijemie Dough Onah Source Type: research

An unusual case of food protein-induced enterocolitis syndrome due to zucchini
CONCLUSIONS: In this case, the OFC was essential to identify the offending food and to verify that the child had overcome the disease.PMID:34761654 | DOI:10.15586/aei.v49i6.462 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Alberto Garc ía de la Fuente Victoria Fuentes-Aparicio Sonsoles Infante Source Type: research

Perturbation of monocyte subsets in iron-deficient children - a shift to a pro-inflammatory state?
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):42-47. doi: 10.15586/aei.v49i6.91. eCollection 2021.ABSTRACTBACKGROUND: Iron deficiency anemia (IDA) is the most prevalent micronutrient deficiency in preschool children in developing countries including India. IDA is associated with immune perturbation, which is reflected in greater frequency of infections in these children. Recent research has shown three distinct monocyte subsets with distinct functions linked to infectious, inflammatory, and autoimmune diseases. These subsets have not been studied in children with IDA.OBJECTIVE: The aim of the study was to assess the perce...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Nimisha Dhankar Richa Gupta Shyam Lata Jain Shramana Mandal Beauty Sarkar Source Type: research

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases
CONCLUSIONS: In these cohorts of breastfed patients with good adherence to TMD patterns, there was evidence of a low incidence of childhood asthma and the IRD, more pronounced in the highest adherence Group 1. Some non-TMD foods have been linked to the occurrence of childhood asthma and IRD, as their dietary limitations have contributed to decreasing morbidity.PMID:34761656 | DOI:10.15586/aei.v49i6.338 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Fernando M Calatayud-S áez Blanca Calatayud Monica Luque Ana Calatayud J G Gallego Francisco Rivas-Ruiz Source Type: research

Practical protocol of the food allergy committee of the seicap on open oral food challenges to nuts
Allergol Immunopathol (Madr). 2021 Nov 1;49(6):56-59. doi: 10.15586/aei.v49i6.474. eCollection 2021.ABSTRACTFood allergy is rising rapidly among children, and allergy to nuts is one of the most prevalent allergies among them. The category "nuts and seeds" include several plant foods from different botanical families, very different from each other. It is not uncommon to detect co-sensitization to different nuts. However, true co-allergy is less frequent. Up to 80% of patients with positive skin prick tests or specific IgE without true history of reaction who avoid certain nuts, might tolerate them in an Oral Food...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Cristina Blasco Valero Ángela Claver Monzón Natalia Molini Mench ón Antonio Martorell L Aragon és Carlos Garc ía Magán Sara Pereiro Fern ández Celia Pinto Fern ández M ónica Piquer Gibert Ana Prieto Del Prado Laura Valdesoiro Navarrete Marta V á Source Type: research

Does the reaction size of skin prick test associated with the allergic rhinitis symptom severity?
CONCLUSION: Despite previous conflicts to rely on SPT test for starting immunotherapy, we recommend this test especially for patients sensitive to Alternaria, weed pollens, and tree pollens, considering the size of wheal in association with AR symptom severity.PMID:34761658 | DOI:10.15586/aei.v49i6.211 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Sedigheh Madani Fariborz Zandieh Maryam Ahmadi Maryam Parvizi Nima Rezaei Source Type: research

Transient increased immunoglobulin levels in a hyper-IgM syndrome patient with COVID-19 infection
CONCLUSION: Since this transient increase in the levels of immunoglobulins was solely observed during the COVID-19 infection, and no other infectious episodes were diagnosed in the patient, clarifying the exact cause would help to understand in a better manner the implications and specification of humoral immunity in patients with primary antibody deficiencies.PMID:34761659 | DOI:10.15586/aei.v49i6.92 (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: Molood Safarirad Ali Abbaszadeh Ganji Farzad Nazari Reza Yazdani Hassan Abolhassani Ahmad Vosughi Motlagh Source Type: research

Mosquito hypersensitivity may be associated with atopic background in children
Allergol Immunopathol (Madr). 2021 Nov 2;49(6):67-72. doi: 10.15586/aei.v49i6.448. eCollection 2021.ABSTRACTBACKGROUND: Many children encounter unusual or "exaggerated" reactions such as large local, atypical or systemic reactions after mosquito bites.OBJECTIVE: The aim of this study was to document the clinical features of children with mosquito allergy and investigate the possible associations between demographic features and type of reactions in this population.METHODS: Children with large local or unusual reactions after mosquito bites who attended to our outpatient pediatric allergy department were enrolled ...
Source: Allergologia et Immunopathologia - November 11, 2021 Category: Allergy & Immunology Authors: S üleyman Tolga Yavuz Onur Akin Ozan Koc Ali G üngör Ahmet Bolat Mustafa G ülec Source Type: research