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Infectious Disease: Parasitic Diseases
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Total 613 results found since Jan 2013.
Malignancy risk in pediatric subjects with undetectable serum IgE
Immunoglobulin E (IgE) is a key mediator in Type I hypersensitivity reactions, and may also be involved in the immune response to parasitic infections. A possible role for IgE in tumor immunosurveillance has been proposed, and IgE deficiency has been associated with an increased risk for various malignancies in adult subjects. However, the association between IgE deficiency and cancer has not been addressed in pediatric populations. We hypothesized that absent serum IgE (
Source: Journal of Allergy and Clinical Immunology - February 1, 2022 Category: Allergy & Immunology Authors: Charlene Dunaway Altamirano, John McDonnell, Katherine Weller, Xiaofeng Wang, Fred Hsieh Source Type: research
Emerging Functions of IL-33 in Homeostasis and Immunity
Annu Rev Immunol. 2022 Jan 5. doi: 10.1146/annurev-immunol-101320-124243. Online ahead of print.ABSTRACTOur understanding of the functions of the IL-1 superfamily cytokine and damage-associated molecular pattern IL-33 continues to evolve with our understanding of homeostasis and immunity. The early findings that IL-33 is a potent driver of type 2 immune responses promoting parasite expulsion, but also inflammatory diseases like allergy and asthma, have been further supported. Yet, as the importance of a type 2 response in tissue repair and homeostasis has emerged, so has the fundamental importance of IL-33 to these process...
Source: Annual Review of Immunology - January 5, 2022 Category: Allergy & Immunology Authors: Gaelen K Dwyer Louise M D'Cruz H ēth R Turnquist Source Type: research
Hookworm infection: Toward development of safe and effective peptide vaccines
Hookworms are hematophagous nematode parasites that have infected a billion people worldwide. Anthelmintic drugs have limited efficacy and do not prevent reinfection. Therefore, prophylactic vaccines are in high demand. Whole parasite vaccines are allergic and unsafe; thus, research into subunit vaccines has been warranted. A comprehensive overview of protein or peptide subunit vaccines’ safety, protective efficacy, and associated immune responses is provided herein. The differences between the immune responses against hookworm infection by patients from epidemic versus nonepidemic areas are discussed in detail.
Source: Journal of Allergy and Clinical Immunology - December 1, 2021 Category: Allergy & Immunology Authors: Ahmed O. Shalash, Waleed M. Hussein, Mariusz Skwarczynski, Istvan Toth Tags: Reviews and feature article Source Type: research
IL-33: A central cytokine in helminth infections
Semin Immunol. 2021 Nov 22:101532. doi: 10.1016/j.smim.2021.101532. Online ahead of print.ABSTRACTIL-33 is an alarmin cytokine which has been implicated in allergy, fibrosis, inflammation, tumorigenesis, metabolism, and homeostasis. However, amongst its strongest roles are in helminth infections, where IL-33 usually (but not always) is central to induction of an effective anti-parasitic immune response. In this review, we will summarise the literature around this fascinating cytokine, its activity on immune and non-immune cells, the unique (and sometimes counterintuitive) responses it induces, and how it can coordinate the...
Source: Seminars in Immunology - November 26, 2021 Category: Allergy & Immunology Authors: Henry J McSorley Danielle J Smyth Source Type: research
A point-of-care cassette test for detection of Strongyloides stercoralis
Acta Trop. 2021 Nov 19:106251. doi: 10.1016/j.actatropica.2021.106251. Online ahead of print.ABSTRACTStrongyloides stercoralis is a parasite that causes strongyloidiasis worldwide. It may lead to a life-long infection in immunocompetent people and hyperinfection in immunosuppressed patients. A point-of-care (POC) rapid test is helpful for patient diagnosis in resource-limited settings and as a detection tool in elimination/control programs. Previously, we reported a rapid IgG4 dipstick test (SsRapid®) for Strongyloides suitable for a laboratory setting. A POC cassette format of the test, which is field-applicable, has sin...
Source: Acta Tropica - November 22, 2021 Category: Infectious Diseases Authors: R Noordin E Osman N Kalantari N S Anuar T Gorgani-Firouzjaee P Sithithaworn N M Juri A Rahumatullah Source Type: research
M036 dobutamine-induced eosinophilia
We present an unusual scenario of eosinophilia in the wake of a routinely used inotrope, dobutamine.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: S. Imam, S. Abbassi, R. Khianey, A. Wolff Source Type: research
M177 polyparasitism in iga deficiency: echinococcus, strongyloides and toxocara as three parasites in one host
Concomitant infections with several parasites are called polyparasitism. Gastrointestinal infections occur with an increased frequency in patients with IgA deficiency and are commonly related to G lamblia. It is postulated that the lack of secretory IgA in these patients allows for attachment and proliferation of the organism on the intestinal epithelium. Polyparasitism has been reported in patients with HIV/AIDS. This is the first case report of polyparasitism in a patient with primary immunodeficiency.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: M. Dimova, S. Mahapatra, L. Caraballo, V. Dimov Source Type: research
M124 eosinophilia in a 64-year-old male with severe persistent asthma
Eosinophilia is a common finding in patients with allergic disease processes and should prompt further evaluation to rule out certain parasitic infections, hematologic and neoplastic disorders, immunologic disorders, and a variety of other disease processes.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: C. Lomas, F. Hoyte Source Type: research
The effect of infectious agents on the prevalence of allergies
CONCLUSIONS: A history of some forms of either infectious or parasitic diseases has a measurable effect on the risk of developing allergies.PMID:34597894 | DOI:10.1016/j.advms.2021.08.002
Source: Advances in Medical Sciences - October 1, 2021 Category: Biomedical Science Authors: Edyta Krzych-Fa łta Oksana Wojas Filip Raciborski Aneta Tomaszewska Piotr Samel-Kowalik Konrad Furma ńczyk Edward Si ński Ma łgorzata Bednarska Daniel Rabczenko Boles ław Samoliński Source Type: research
