Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Annu Rev Immunol. 2024 Feb 29. doi: 10.1146/annurev-immunol-083122-043836. Online ahead of print.ABSTRACTLymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to sur...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Ming O Li Jing Zhang Zijian Xu Xian Zhang Peng Li Andrew E Cornish Source Type: research
Immune Activation in Alzheimer Disease
We describe how brain-resident macrophages, the microglia, are able to detect Aβ species and be activated, as well as the consequences of activated microglia in AD pathogenesis. We discuss transcriptional changes of microglia in AD, their unique heterogeneity in humans, and emerging strategies to study human microglia. Finally, we expose, beyond Aβ and microglia, the role of peripheral signals and different cell types in immune activation. Expected final online publication date for the Annual Review of Immunology, Volume 42 is April 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates...
Source: Annual Review of Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Arnaud Mary Renzo Mancuso Michael T Heneka Source Type: research
