Non-classical B Cell Memory of Allergic IgE Responses

Non-classical B Cell Memory of Allergic IgE Responses Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory. General Mechanisms of Humoral Memory in Mice and H...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Yoshihiro Minagawa, Hiroshi Ueno, Kazuhito V. Tabata, Hiroyuki Noji A compact and simple smartphone-based mobile imaging platform realized swift single influenza virus counting of clinical samples. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsProlonged use of cyclosporine may expose to several dose-related adverse events and may contribute to the development of allograft dysfunction but it does not necessarily cause relentless, progressive transplant failure if patients are carefully and consistently monitored during the follow-up.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Didier K, Robbins A, Antonicelli F, Pham BN, Giusti D, Servettaz A Abstract Systemic sclerosis is a rare connective tissue disease characterized by skin and several internal organ fibrosis, systemic vasculopathy and immune abnormalities. Even if fibroblasts and endothelial cells dysfunction, as well as lymphocytes and other immune cells implication are now well described, the exact origin and chronology of the disease pathogenesis remain unclear. Oxidative stress, influenced by genetic and environmental factors, seems to play a key role. Indeed, it seems to be implicated in the early phases of fibrosis dev...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Although an epidemic of opioid-related overdose deaths has continued to increase in the United States for 2 decades, the impact of opioid use disorders (OUDs) on children and families receives minimal attention. The purpose of this commentary was to provid...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This article describes the conception, implementation, and evaluation of a wilderness medicine-based first aid class for the commercial fishing industry. Commercial fishing is a dangerous occupation in the United States. Currently, commercial fishermen oft...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
Long working hours and a lack of sleep have been suggested to negatively affect the safety of workers. Here, we examined the association between long working hours/sleep-related problems and near-misses/injuries in industrial settings using a nationally re...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
PURPOSE: To identify adolescents' substance use and its association to sleep disturbances. METHODS: Databases were searched using terms: "smoking", "tobacco use", "electronic cigarette", "alcohol drinking", "marijuana use" and "substance use" combi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVE: Our objective was to determine whether ADHD medication is associated with a decreased risk of unintentional injuries in children and adolescents in the United States across sexes, age groups and injury types. METHOD: We used de-identifie...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Clinical Implications Bullying is an issue for food-allergic patients. Allergists may benefit from education and resources to recognize and address this problem. Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
BACKGROUND: Sport-related concussion (SRC) has been associated with cognitive impairment, depression, and chronic traumatic encephalopathy. American football is the most popular sport among males in the United States and has one of the highest concussion r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
More News: Allergy | Allergy & Immunology | Anaphylactic Shock | Asthma | Biology | Bone Marrow Transplant | Child Development | Children | Cytology | Dermatitis | Dermatology | Endemics | Environmental Health | Genetics | Graduation | Grants | Immunotherapy | Influenza | Influenza Vaccine | Laboratory Medicine | Lung Transplant | Malaria | Malaria Vaccine | Milk | Mitochondria | Molecular Biology | New York University | Parasitic Diseases | Parasitology | Pathology | Peanuts | Pediatrics | Respiratory Medicine | Science | Sleep Disorders | Sleep Medicine | Smallpox | Smallpox Vaccine | Spain Health | Study | Tonsillitis | Transplants | USA Health | Vaccines | Vegetables | Velcade | Veterinary Vaccinations | Wheat