Non-classical B Cell Memory of Allergic IgE Responses
Non-classical B Cell Memory of Allergic IgE Responses Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen re-exposure by generating new plasma cells and memory B cells. Developing effective immunological memory is essential for protection against pathogens, and is the basis of successful vaccinations. IgE responses have evolved for protection against helminth parasites infections and against toxins, but IgE is also a potent mediator of allergic diseases. There has been a dramatic increase in the incidence of allergic diseases in recent decades and this has provided the impetus to study the nature of IgE antibody responses. As will be discussed in depth in this review, the IgE memory response has unique features that distinguish it from classical B cell memory. General Mechanisms of Humoral Memory in Mice and H...
AIM: To estimate the pooled prevalence and incidence of suicidal ideation, attempts, and deaths in people with sleep apnea. METHOD: We will identify epidemiological studies reporting the prevalence or incidence rate of suicide in people with sleep apne...
Authors: González-Vilas D, Monteagudo B, González-Martín C, Ramírez-Santos A, Campo-Cerecedo F Abstract 53 year old renal transplanted male with secondary amyloidosis to Crohn´sdisease, sent to Dermatology given the presence of multiple red-purple or hyperkeratotic... PMID: 32633255 [PubMed - in process]
Authors: Castro-Diaz DM, Padilla-Fernández B, Correa Corchete MJ Abstract OBJECTIVES: To Evaluate the severity of symptoms in OAB patients and their outcomes expectations, symptoms management and Health-Related Quality of Life (HRQoL). MATERIAL AND METHODS: Epidemiological, multicentre, non-interventional, cross-sectional study, conducted by 294 physicians in Spain in clinical practice. Female adult patients with OAB symptoms, newly diagnosed or during follow-up were included. B-SAQ, OABq-SF and an ad-hoc patient expectation questionnaire were completed. Association between expectations, symptom severity...
CONCLUSIONS: The probabilistic model presented showed a greater persistence in patients treated with mirabegron compared to AM, leading to a positive impactin patients quality of life, as well cost savings to the NHS in Spain. PMID: 32633246 [PubMed - in process]
HI there, anyone can suggest the top fellowships with mostly EMG (no EEG, no pain, no sleep)? Is there a place training mostly in EMG? Goal to be independent in 1 year (for private practice).
Hello! I recently took the MCAT and got my score back: 513 (129/126/127/131) I plan on retaking the MCAT in the beginning of September as that is the earliest I can. I am retaking it because my score is way lower than my average on FL exams (I was averaging around 519 last two weeks), especially in CARS where I got 130-131 on the last 3 practice exams. I know my test day was a fluke because I was sick that week and didn’t sleep the night before my exam (although who knows? Maybe all the... MCAT Retake
From English pubs to the Spanish seaside, mini-lockdowns are cropping up all over the world as countries face fresh clusters of infection.
CBSN political reporter Caitlin Huey-Burns and Washington Post politics reporter Eugene Scott join CBSN's "Red&Blue" to discuss the White House response to the coronavirus pandemic, plans for the Republican National Convention, and Joe Biden's presidential campaign.
Publication date: Available online 7 July 2020Source: SeizureAuthor(s): Yuval Shafrir
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