Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes

Conclusion: ROS promote CD8+ T cell activation by facilitating autoantigen cross-presentation by DCs. ROS scavengers could potentially represent an important component of therapies aiming to disrupt autoantigen presentation and activation of CD8+ T cells in individuals at-risk for developing T1D. In Type 1 Diabetes (T1D), pancreatic β cells are attacked by a T cell mediated autoimmune response and lose their ability to produce insulin (1–3). While a number of immune cell subsets are involved throughout the development of T1D, cytotoxic CD8+ T cells (CTLs) function as primary effectors of β cell damage. To this end, CTL are the most abundant cell type within T1D patient islet infiltrates (4). In the T1D-prone non-obese diabetic (NOD) mouse, targeted deletion of CTLs or blocking CTL effector function prevents T1D development (5–9). To activate autoreactive naïve CTLs in T1D, dendritic cells (DC) must take up β cell derived autoantigens by phagocytosis and load autoantigen peptides onto MHC Class I molecules. During maturation, the DCs migrate to the pancreatic draining lymph nodes (PLN) where, in conjunction with help signals provided by antigen specific CD4+ T cells, they present the autoantigen peptides to CTLs, via a process termed cross-presentation (10–13). These activated CTLs then emigrate from the PLN and traffic to the islets where they recognize and kill β cells presenting autoantigens (2). In the NOD model, the proces...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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In this study, serum IL6 was measured by ELISA, and the HSD11B1rs12086634(T/G) polymorphism was analyzed using a TaqMan allelic discrimination assay technique. There were statistically significant differences between the two studied groups concerning the serum IL-6 level and HSD11B1rs12086634(T/G) genotype distribution, with increased serum IL6 and increased frequencies of the GG and TG genotypes in patients with PCO. The GG genotype of HSD11B1 rs12086634(T/G) and its associated high level of serum IL-6 may represent genetic risk factors for PCOS.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Zhengzheng Xu, Guangzhe Ge, Bao Guan, Zhentao Lei, Xueyu Hao, Yuanyuan Zhou, Yue Shi, Huan Lu, Jilu Wang, Ding Peng, XiKang Wu, Huiying He, Bao Zhang, Xuesong Li, Liqun Zhou, Weimin Ci
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Pirus Ghadjar, Thomas Wiegel
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Elise De Bleser, Piet Ost
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionsTattooing of axillary LNs is safe and easily performed. Tattooing was helpful in identifying the marked LN in the majority of cases. This technique helps to ensure that metastatic LNs are identified and removed at surgery after NAT.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Individuals who have multiple close relatives with pancreatic cancer should undergo surveillance for pancreatic cancer, according to updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Hematology-Oncology News Source Type: news
ConclusionThe findings from this study have established the need to improve current education and rehabilitation programmes for patients with CHF by addressing those factors significantly influencing their adherence to diet and medication.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: Available online 16 November 2019Source: Social Science &MedicineAuthor(s): Henry J. Whittle, Anna M. Leddy, Jacqueline Shieh, Phyllis C. Tien, Ighovwerha Ofotokun, Adaora A. Adimora, Janet M. Turan, Edward A. Frongillo, Bulent Turan, Sheri D. WeiserAbstractMaterial-need insecurities (including insecurities in basic resources such as income, food, housing, and healthcare) are widespread in the United States (US) and may be important predictors of poor health outcomes. How material-need insecurities besides food insecurity are experienced, however, remains under-researched, including how multiple mater...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 16 November 2019Source: Journal of Contextual Behavioral ScienceAuthor(s): Alan K. Davis, Frederick S. Barrett, Roland R. GriffithsAbstractPrior research has shown that acute subjective psychedelic effects are associated with both spontaneous and intended changes in depression and anxiety. Psychedelics are also theorized to produce increases in psychological flexibility, which could explain decreases in depression and anxiety following a psychedelic experience. Therefore, the present cross-sectional survey study sought to examine whether psychological flexibility mediated the relationship...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 16 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Hermineh Aramin, Pratistha Koirala, Abhishek Shah, Kendall Adams, Natalia Buza, Sapna Desai, Melissa Fairbairn, David Goldenberg, Wenli Gao, Linus Chuang, Ramapriya Vidhun, Vaagn Andikyan
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
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