The volumetric ADC histogram analysis in differentiating stage IA endometrial carcinoma from endometrial polyp
CONCLUSIONS: The volumetric ADC histogram analysis was an effective method in differentiating endometrial carcinoma from an endometrial polyp. The 25th percentile of ADC values has satisfactory performance for detecting malignancy in the endometrium.ADVANCES IN KNOWLEDGE: The ADC histogram metric based on whole lesion is a promising imaging-maker in differentiating endometrial benign and malignant lesions.PMID:38662891 | DOI:10.1093/bjr/tqae081 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - April 25, 2024 Category: Radiology Authors: Yujiao Zhao Cong You Xin Zhou Xiaotian Li Cheng Zhang Yanhong Wu Wen Shen Source Type: research
Genetic Prediction of Micronutrient Levels and the Risk of Colorectal Polyps: A Mendelian Randomization Study
Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 25, 2024 Category: Nutrition Authors: Siyao Lv, Yunyi Ding, Junli Huang, Yixin He, Ruijie Xie, Xiaohong Shi, Wei Ye Source Type: research
Sinonasal Angiomatous Polyp: A Case Report and Review of Literature
We report the case of a 43-year-old woman with a 3 month history of unilateral nasal obstruction with recurrent epistaxis. Nasal endoscopy showed polypoid nasal mass occupying the left nasal cavity. Imaging was suggestive of malignant vascular tumor. The patient underwent surgical excision after embolization. Histopathology concluded to the diagnosis of SAP.PMID:38654494 | DOI:10.1177/01455613241247731 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Bouatay R Bouaziz N Zrig A Hadhri R Harrathi K Koubaa J Source Type: research
Sinonasal Angiomatous Polyp: A Case Report and Review of Literature
We report the case of a 43-year-old woman with a 3 month history of unilateral nasal obstruction with recurrent epistaxis. Nasal endoscopy showed polypoid nasal mass occupying the left nasal cavity. Imaging was suggestive of malignant vascular tumor. The patient underwent surgical excision after embolization. Histopathology concluded to the diagnosis of SAP.PMID:38654494 | DOI:10.1177/01455613241247731 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Bouatay R Bouaziz N Zrig A Hadhri R Harrathi K Koubaa J Source Type: research
Gallbladder Cancer
Gallbladder cancer is the most common biliary tract malignancy, often detected incidentally post-cholecystectomy or at an advanced stage, historically linked to a poor prognosis. Advances in minimally invasive surgery and systemic therapies have improved outcomes. Global incidence varies, with risk factors including gender, age, gallbladder disease history, and polyp size influencing malignancy risks. Management involves cross-sectional imaging, staging laparoscopy in select cases, and radical cholecystectomy with lymphadenectomy and adjuvant therapy, though its use is limited. Trials are ongoing assessing the role of neoa...
Source: Surgical Clinics of North America - April 24, 2024 Category: Surgery Authors: Giacomo C. Waller, Umut Sarpel Source Type: research
Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research
Which is Better in Predicting CT Scores in Patients with Chronic Rhinosinusitis after Medical treatment-Baseline Rhinosinusitis Disability Index (RSDI) or Endoscopic Score?
ConclusionStatistically significant (p < 0.001) association was found between baseline Lund-Kennedy endoscopic scores and Mackay-Lund CT scores post medical treatment. No significant association was found between RSDI scores and Mackay-Lund CT scores. ROC analysis indicated that Lund- Kennedy endoscopy score is a more accurate tool than RSDI score to predict a Mackay-Lund CT scores after medical treatment. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Audit of hemostatic clip use after colorectal polyp resection in an academic endoscopy unit
Conclusions Audits of clip use in an endoscopy practice can reveal surprising findings, including high and variable rates of unnecessary use after cold resection. Audit can potentially reduce unnecessary costs, carbon emissions, and plastic waste. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 23, 2024 Category: Gastroenterology Authors: Stark, Easton M. Lahr, Rachel E. Shultz, Jeremiah Vemulapalli, Krishna C. Guardiola, John J. Rex, Douglas K. Tags: Original article Source Type: research
Imaging findings of children with PTEN-related hamartoma tumor syndrome: a 20-year multicentric pediatric cohort
ConclusionBrain abnormalities, benign non-vascular soft tissue abnormalities, and vascular anomalies are commonly seen in children and adolescents with PTEN-related hamartoma tumor syndrome. However, malignancies involving the thyroid gland are not uncommon. Familiarity with the phenotype of PTEN-related hamartoma tumor syndrome in the pediatric population can improve diagnosis and prompt appropriate clinical surveillance of abnormal findings that warrant further management.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 22, 2024 Category: Radiology Source Type: research
Clinicopathologic and endoscopic characteristics of ten patients with gastric hamartomatous inverted polyp: a single center case series
Gastric hamartomatous inverted polyps (GHIPs) are not well characterized and remain diagnostically challenging due to rarity. Therefore, this study aims to investigate the clinicopathologic and endoscopic char... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Ningning Dong, Fandong Meng, Bing Yue and Junzhen Hou Tags: Research Source Type: research
Response
We appreciate the letter from Pasam et al1 in response to our article2 in Gastrointestinal Endoscopy. The authors included only randomized controlled trials, as opposed to our analysis,2 where we included both observational studies and randomized controlled trials to provide a more comprehensive review. Our analysis did not include the trials by Rex et al3 and Rodríguez Sánchez et al4 because they were published after our search period until January 12, 2023. Because our study inclusion criteria for polyps were size ≥1.5 cm, we also did not include the 2019 study by Yamashina et al. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Dhruvil Radadiya, Madhav Desai, Prateek Sharma Tags: Letter to the Editor Source Type: research
Endoscopic techniques to reduce recurrence after EMR of large nonpedunculated colorectal polyps
We congratulate Radadiya et al1 on their recent study comparing various EMR techniques for large nonpedunculated colorectal polyps by using indirect pairwise comparison. However, their study included observational studies and randomized control trials (RCTs), which limits the ability to draw conclusions. In support of this t opic, we performed a network meta-analysis of RCTs comparing various margin ablation techniques after EMR—snare tip soft coagulation (STSC) and argon plasma coagulation (APC)—with conventional EMR (CEMR) and underwater EMR (UEMR) to treat large nonpedunculated colorectal polyps. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Ravi Teja Pasam, Saurabh Chandan, Babu P. Mohan Tags: Letter to the Editor Source Type: research
Evaluating an e-device to monitor the type 2 high unified airway response to dupilumab
Patients with unified airways disease (UAD) who have asthma and concomitant chronic rhinosinusitis with nasal polyps (CRSwNP) are often difficult to manage and have a higher burden of type 2 (T2) inflammation as compared to those with asthma or nasal polyps (NP) alone.1 Few studies have prospectively looked in detail at concomitant upper and lower airway outcomes in patients with T2 high UAD in response to biologics.2 Evaluating the clinical burden of upper and lower airway disease in response to treatment can be challenging using conventional analogue paper diary recordings of peak nasal inspiratory flow (PNIF) and peak e...
Source: Annals of Allergy, Asthma and Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth Tags: Letters Source Type: research
IRF4 Knockdown Inhibits the Chronic Rhinosinusitis Without Nasal Polyps Development by Regulating NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis
Biochem Genet. 2024 Apr 18. doi: 10.1007/s10528-024-10792-8. Online ahead of print.ABSTRACTChronic rhinosinusitis without nasal polyps (CRSsNP) is a CRS phenotype. However, the mechanisms of CRSsNP remains unclear. Differentially expressed genes (DEGs) were obtained from the GSE36830 and GSE198950 datasets through the GEO2R tool. The six hub genes were screened by the protein-protein interaction (PPI) network analysis and Cytoscape software. Then we constructed the mouse models of CRS and verified the expression levels of hub genes by reverse transcription quantitative PCR (RT-qPCR). Hematoxylin-eosin (HE) staining was emp...
Source: Biochemical Genetics - April 18, 2024 Category: Genetics & Stem Cells Authors: Jun Xu Jiahui Li Xiaoya Wang Yunsong An Wenlong Liu Renzhong Luo Changzhi Sun Source Type: research
S. aureus biofilm properties correlate with immune B cell subset frequencies and severity of chronic rhinosinusitis
This study aimed to investigate whether strain-level variation in in vitro-grown S. aureus biofilm properties relates to CRS disease severity, in vitro toxicity, and immune B cell responses in sinonasal tissue from CRS patients and non-CRS controls. S. aureus clinical isolates, tissue samples, and matched clinical datasets were collected from CRS patients with nasal polyps (CRSwNP), CRS without nasal polyps (CRSsNP), and controls. B cell responses in tissue samples were characterised by FACS. S. aureus biofilms were established in vitro, followed by measuring their properties of metabolic activity, biomass, colony-forming ...
Source: Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Gohar Shaghayegh Clare Cooksley George Bouras Beula Subashini Panchatcharam Sholeh Feizi Shari Javadian Mahnaz Ramezanpour Kevin Aaron Fenix Peter-John Wormald Alkis James Psaltis Sarah Vreugde Source Type: research
