Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
AbstractTo determine the relative frequency and change of malignant lymphoma in Korea according to the 4th World Health Organization (WHO) classification and compare with previous reports. Between 2015 and 2016, 7737 new patients with malignant lymphoma were enrolled from 31 institutes, with their clinicopathologic information obtained, and evaluated for the relative frequency of lymphoma subtypes. The relative frequency of non-Hodgkin lymphoma (NHL) was 94.8%, and that of Hodgkin lymphoma (HL) was 5.2%. B cell lymphomas accounted for 83.1% of all NHLs; T/natural killer (NK) cell lymphomas, 16.4%; and immunodeficiency-asso...
Source: Journal of Hematopathology - September 6, 2019 Category: Pathology Source Type: research

SOLAHP: a fledgling organization rapidly taking flight
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 31, 2019 Category: Pathology Source Type: research

Transition from morphologic diagnosis to immunophenotypic diagnosis of acute leukemia —experience of establishing a new flow cytometry laboratory
This study aimed at documenting the leukemia-associated immunophenotype (LAIP) specific for morphologic (FAB) subclasses of acute leukemia (AL). A retrospective case record-based study was carried out including 100 cases of de novo acute leukemia over 1  year to study the association of FCM immunophenotype profile with morphologic FAB classification of acute leukemia. Fourteen cases (14%) were diagnosed as acute leukemia—unclassified by morphology which were accurately classified by FCM into B cell acute lymphoblastic leukemia (ALL) (6), T cell ALL (3), acute myeloid leukemia (AML) (4), and mixed phenotype acute...
Source: Journal of Hematopathology - August 30, 2019 Category: Pathology Source Type: research

Systemic mastocytosis with renal light chain amyloidosis: associated non-mast cell disorder or concurrent disease
AbstractSystemic mastocytosis with an associated hematological neoplasm (SM-AHN) is a rare diagnosis commonly associated with myeloid disorders. Herein, we describe the case of a 53-year-old female diagnosed with systemic mastocytosis (SM) in conjunction with renal light chain amyloidosis (AL) and smoldering myeloma. Although cytokines such as IL-6 may play a role in the proliferation of plasma cells, delays in the diagnosis of SM and paucity of relevant studies cast uncertainty on whether the associated disease is secondary to the mast cells or etiologically independent. To our knowledge, this is the first case of confirm...
Source: Journal of Hematopathology - August 7, 2019 Category: Pathology Source Type: research

Warthin –Finkeldey-like cells in a lymph node from a child with Li-Fraumeni syndrome
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 6, 2019 Category: Pathology Source Type: research

Platelet satellitism: unusual cause of spurious thrombocytopenia
AbstractPlatelet satellitism (PS) is defined as adherence of platelets on the surface of polymorphonuclear leucocytes and imparting a rosette-like appearance especially in ethylenediaminetetraacetic acid (EDTA) whole blood samples. We here present a case of spurious thrombocytopenia resulting from florid platelet adherence on the surface of neutrophils. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - August 1, 2019 Category: Pathology Source Type: research

Post-transplant lymphoproliferative disorder manifesting as lymphomatoid granulomatosis: report of two cases and review of the literature highlighting current challenges in pathologic classification
AbstractClassification of viral- and immunodeficiency-associated lymphoproliferative disorders continues to evolve. Entities in these categories recognized in the 2016 revision of the World Health Organization Classification of Lymphoid Neoplasms show considerable morphologic overlap, and it is unclear whether the current classification conceptualizes the scenarios in which these lesions arise and how they might be best managed. Here, we report two cases of lymphoproliferative disorders meeting histologic criteria for lymphomatoid granulomatosis that arose following solid organ transplant. In reviewing the clinicopathologi...
Source: Journal of Hematopathology - July 27, 2019 Category: Pathology Source Type: research

Inconsistency associated with SOX11 immunohistochemistry in mantle cell lymphoma: a meta-analysis
AbstractSOX11 immunohistochemistry (IHC) in mantle cell lymphoma (MCL) is known to show varied results. Our aim was to evaluate the factor responsible for this variation among different studies. A meta-analysis was performed with the original data including the proportion and number of SOX11-positive MCL cases, host and clonality of SOX11 antibodies, clone or catalog number of antibodies, MCL subtypes, number of cases with indolent traits, number of aggressive variants, and cut-off for SOX11 IHC interpretation. A total of 21 published studies were analyzed. The combined proportion of SOX11-positive MCL cases was 0.80 (95% ...
Source: Journal of Hematopathology - July 22, 2019 Category: Pathology Source Type: research

Determining the frequency of iron overload at diagnosis in de novo acute myeloid leukemia patients with multilineage dysplasia or myelodysplasia-related changes: a case control study
AbstractAcute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a new disease category, which was defined as a separate entity in the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. While pre-treatment iron overload in patients with myelodysplastic syndrome has been previously studied, its relationship with AML-MRC has not been studied. We aimed to investigate the relationship between serum iron tests compatible with iron overload and the diagnosis of multilineage dysplasia (MLD) and AML with myelodysplasia-related changes (AML-MRC) in AML patients diagnosed...
Source: Journal of Hematopathology - July 13, 2019 Category: Pathology Source Type: research

Association between serum levels of hepcidin and ferritin in patients with thalassemia major and intermedia, the role of iron chelator
AbstractPatients with beta-thalassemia suffer from iron overload, and hepcidin, as the main regulator of iron hemostasis, can indicate iron overload better than serum ferritin, but changes in serum hepcidin levels are affected by the type of thalassemia (major or intermediate) and by type of treatments. The present study aimed to determine the correlation between serum levels of hepcidin and ferritin in patients with thalassemia major and intermedia under chelation therapy. This cohort study investigated 143 patients with thalassemia (122 patients with thalassemia major and 21 patients with and thalassemia intermedia) who ...
Source: Journal of Hematopathology - July 11, 2019 Category: Pathology Source Type: research

Comprehensive detection of chromosomal translocations in lymphoproliferative disorders by massively parallel sequencing
We describe a method using solution capture for enrichment of known translocation breakpoints and massively parallel sequencing for the detection of balanced translocation in formalin-fixed tissues with a B-cell LPD. We detected a total of 57 rearrangements with a high concordance of 94.2% when compared to FISH. We detected translocations betweenBCL2,BCL6, andMYC and the three Ig loci and non-Ig loci, including novel partners forMYC andBCL6. In addition, massively parallel sequencing allowed a detailed analysis of the structure of the resulting chromosomal fusions. Our comparison shows the feasibility of using massively pa...
Source: Journal of Hematopathology - July 1, 2019 Category: Pathology Source Type: research

Co-occurrence of CALR and MPL somatic mutations in an Indian patient with a Philadelphia-negative myeloproliferative neoplasm
AbstractPhiladelphia-negative myeloproliferative neoplasms (MPNs) are a group of clonal disorders that are characterized by excessive proliferation of abnormal myeloid precursors and mature cells. Somatic driver mutations in theJAK2,CALR, andMPL genes serve as major diagnostic criteria in the classification of the MPNs, namely polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Although initially thought to be mutually exclusive, recent studies have reported the co-existence ofJAK2,MPL, andCALR mutations. In this case report, we describe a case of a Philadelphia-negative myeloproliferat...
Source: Journal of Hematopathology - June 8, 2019 Category: Pathology Source Type: research

Comparison of clinical diagnoses and autopsy findings in 54 cases with lymphoid neoplasms
This study shows the high rate of autopsy-verified lymphoid neoplasms and unrecognised co-morbidities. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 21, 2019 Category: Pathology Source Type: research

Primary plasma cell leukaemia in a 20-year young adult male: a rare presentation
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 20, 2019 Category: Pathology Source Type: research

Advancing diagnostic hematopathology: pigeons or pixels?
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 18, 2019 Category: Pathology Source Type: research

Bone marrow fibrosis as prognostic marker in adult patients with acute lymphoblastic leukemia
AbstractThe role of bone marrow (BM) fibrosis on outcomes of children with acute lymphoblastic leukemia (ALL) has been described with inconsistent results. In adults, there is no information regarding its significance. The aim of this study was to describe the prognostic impact of BM fibrosis in this group of patients. We included 88 biopsies of 44 adult patients. Reticulin and Masson trichrome stains were performed. Fibrosis was graded by modified Bauermeister scale and volume of reticulin/collagen fibers, both methods had good correlation. Survival analyses were performed regarding (1) the presence or not of significant ...
Source: Journal of Hematopathology - May 9, 2019 Category: Pathology Source Type: research

Characterization of a cryptic KMT2A/AFF1 gene fusion by mate-pair sequencing (MPseq) in a young adult with newly diagnosed B-lymphoblastic leukemia
We present a newly diagnosed case of B-ALL in a young adult with a crypticKMT2A/AFF1 fusion that was unappreciable by conventional chromosome and fluorescence in situ hybridization (FISH)KMT2A break-apart probe studies. To further characterize this abnormality, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and characterized a cryptic, insertional rearrangement that createdKMT2A/AFF1 gene fusion. This case highlights the superior precision and resolution capabilities of NGS when compared to traditional cytogenetic methodologies, including conventional chromosome and FISH studies. (Source:...
Source: Journal of Hematopathology - May 3, 2019 Category: Pathology Source Type: research

Human endogenous retrovirus, HERV-P and HERV-R in pediatric  leukemia patients
AbstractThe “HERVs” (human endogenous retroviruses) are a family of endogenous retroviruses integrated into the germ cell DNA of primate over than 30 million years ago. HERV expression seems impaired in several diseases, ranging from autoimmune to neoplastic disorders. The purpose of this study was to evalu ate the overall endogenous retroviral transcription profile in bone marrow (BM) samples. A total of 30 pediatric lymphoid and myeloid malignancies patients were tested. Our findings show that HERV-R expression results significantly higher in leukemia patients than donors. This overexpression might b e relate...
Source: Journal of Hematopathology - May 3, 2019 Category: Pathology Source Type: research

Leishmania interaction with an osteoclast
AbstractVisceral leishmaniasis is caused by an intracellular protozoan parasite, Leishmania donovani. Frequently, a bone marrow aspirate can confirm the diagnosis by showing intracellular forms of Leishmania amastigotes in macrophages. Here we present a unusual interaction of Leishmania with an osteoclast in the bone marrow. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - May 1, 2019 Category: Pathology Source Type: research

Evaluation of S1PR1, pSTAT3, S1PR2, and FOXP1 expression in aggressive, mature B cell lymphomas
AbstractAggressive, mature B cell lymphomas include Burkitt lymphoma (BL); high-grade B cell lymphomas (HGBL) (e.g., double-hit B cell lymphomas (HGBL-DH: HGBL with MYC and BCL2 and/or BCL6 translocations)); HGBL, not otherwise specified (HGBL, NOS); and diffuse large B cell lymphoma (DLBCL). Overlapping morphologic and immunohistochemical features of these lymphomas pose diagnostic challenges in some cases, and better understanding of potential diagnostic biomarkers and possible therapeutic targets is needed. Sphingosine 1 phosphate receptors (S1PR1-5) are G protein-coupled receptors that bind S1P and influence migration ...
Source: Journal of Hematopathology - April 27, 2019 Category: Pathology Source Type: research

Biclonal splenic marginal zone lymphoma with T cell-rich background and aggressive transformation to large cell lymphoma
We report a case of biclonal splenic MZL, T cell-rich variant with an abnormal karyotype that progressed to large B cell lymphoma. A 74-year-old female presented with pancytopenia, weight loss, fever, and splenomegaly. Microscopically, the spleen revealed an extensive, vaguely nodular lymphoid proliferation, composed of small lymphocytes, majority of which were reactive T cells. B cells were mostly small and
Source: Journal of Hematopathology - April 5, 2019 Category: Pathology Source Type: research

Therapeutic targets and microenvironment in sequential biopsies of classical Hodgkin lymphoma at diagnosis and relapse
AbstractClassical Hodgkin lymphoma is dominated by the non-neoplastic microenvironment, while the neoplastic Hodgkin-Reed-Sternberg cells compose only a minority of cells in the lymphoma tissue. Both the Hodgkin-Reed-Sternberg cells due to their expression of CD30 and PD-L1 and the microenvironment with abundant T cells and expression of PD1 are specifically targeted by new treatment concepts. We aimed to understand the dynamics of therapeutic targets in patients treated with conventional chemotherapy. We analyzed sequential biopsy specimens obtained at diagnosis and at relapse from the same patient for morphology, immunop...
Source: Journal of Hematopathology - March 11, 2019 Category: Pathology Source Type: research

Keeping tabs on the mabs: a hematopathologist ’s dilemma
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 22, 2019 Category: Pathology Source Type: research

Characterization of a t(1;2)(p36;p21) involving the PRDM16 gene region by mate-pair sequencing (MPseq) in a patient with newly diagnosed acute myeloid leukemia with myelodysplasia-related changes
We describe the first case to our knowledge of t(1;2)(p36;p21) observed in AML-MRC. In addition, a next-generation sequencing strategy, mate-pair sequencing (MPseq) was performed and revealed the promoter 2 region ofTHADA (2p21) was juxtaposed upstream fromPRDM16 which may be responsible forPRDM16 overexpression that has been reported in hematologic neoplasms harboring the t(1;2)(p36;p21). (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 21, 2019 Category: Pathology Source Type: research

Reviewers for Journal of Hematopathology in 2018
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 20, 2019 Category: Pathology Source Type: research

Incorporation of digital gene expression profiling for cell-of-origin determination (Lymph2Cx testing) into the routine work-up of diffuse large B cell lymphoma
AbstractDiffuse large B cell lymphomas (DLBCL) represent a clinically heterogeneous group of lymphomas that are classified together based on similarities in morphology and immunophenotype. Gene expression profiling further classifies DLBCL into distinct molecular subgroups based on cell-of-origin (COO), including germinal center B cell type, activated B cell type, and unclassified type. COO assignment of DLBCL has important biological and prognostic significance, as well as emerging therapeutic implications. Herein, we describe the first clinical validation of a digital gene expression-profiling assay (Lymph2Cx) to perform...
Source: Journal of Hematopathology - February 14, 2019 Category: Pathology Source Type: research

Plasma cell leukemia masquerading as lymphoplasmacytic lymphoma: a diagnostic challenge
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - February 7, 2019 Category: Pathology Source Type: research

Leukemic presentation of high-grade B cell lymphoma with MYC and BCL2 rearrangement —a series of two cases and review of literature
AbstractHigh-grade B cell lymphoma (HGBL) is a recently introduced category of aggressive mature B cell lymphoma which is clinically and biologically distinct from diffuse large B cell lymphoma (DLBCL), NOS, and Burkitt Lymphoma. HGBL consists of two categories; the first category includes HGBL withMYC andBCL2 and/orBCL6 rearrangement which is so-called double or triple hit lymphoma. The second category includes HGBL, NOS which lacks genetic double or triple hit; however, its morphology is intermediate between DLBCL and Burkitt lymphoma or appear blastoid. Clinically, patients present with advanced disease, bone marrow inv...
Source: Journal of Hematopathology - January 31, 2019 Category: Pathology Source Type: research

Mediastinal germ cell tumor with associated myeloid sarcoma: An exceptional co-occurrence
AbstractThe association of mediastinal germ cell tumor (GCT) and hematological malignancy is a well-documented but extremely rare phenomenon. This syndrome is characterized by the occurrence of nonseminomatous mediastinal germ cell tumor and an associated hematological neoplasm that usually involve the megakaryocytic lineage. The hematopoietic malignancies can involve the mediastinum or present as infiltration of bone marrow or lymphoid organs. In majority of cases, the hematological malignancy was detected in the bone marrow simultaneously or within 6  months after the detection of mediastinal germ cell tumor. There ...
Source: Journal of Hematopathology - January 28, 2019 Category: Pathology Source Type: research

When the diagnosis is difficult to digest: severe vitamin B 12 deficiency secondary to pernicious anemia mimicking life-threatening thrombotic thrombocytopenic purpura
AbstractThrombotic thrombocytopenic purpura (TTP) is an uncommon yet life-threatening condition, usually marked by a classic pentad of microangiopathic hemolytic anemia (MAHA), thrombocytopenia, acute kidney injury (AKI), neurological disturbances, and fevers. Prompt recognition and treatment is essential to reduce morbidity and mortality. The rarity and variability of presentations, however, makes this a difficult diagnosis to make reliably, and in many cases, treatment is initiated empirically before the appropriate diagnostic testing is completed. After TTP and other common causes of thrombotic microangiopathy (TMA) hav...
Source: Journal of Hematopathology - January 11, 2019 Category: Pathology Source Type: research

Autoimmune hemolytic anemia: an uncommon cause of elevated fetal hemoglobin
(Source: Journal of Hematopathology)
Source: Journal of Hematopathology - January 8, 2019 Category: Pathology Source Type: research

CD38 negative anaplastic plasma cell myeloma with (14;16) translocation: a diagnostic dilemma for highly aggressive neoplasm: case report
AbstractAnaplastic plasma cell myeloma (PCM) is an aggressive morphological variant of myeloma characterized by involvement of extramedullary sites and extremely poor prognosis. Moreover, anaplastic PCM is frequently associated with high frequency of 17p(p53) deletions, 1q21(CKS1B) amplifications and immunoglobulin A (IgA) isotype. It usually manifests as an adverse progression of previously treated conventional plasma cell myeloma. However, the anaplastic morphology can be encountered in newly diagnosed cases and might pose a major diagnostic challenge. Herein, we present a rare case of anaplastic plasma cell myeloma with...
Source: Journal of Hematopathology - January 2, 2019 Category: Pathology Source Type: research

Nodal mesenteric marginal zone lymphoma with amyloid deposits, calcification, and ossification
AbstractMarginal zone lymphomas (MZLs) are rarely associated with amyloid deposits, calcification, and ossification. Herein, we describe a case of a MZL with a primary nodal mesenteric presentation, associated with amyloid deposits, calcification, and ossification, highlighting its clinicopathological features, based on our findings, but also on a brief review of the literature. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - December 18, 2018 Category: Pathology Source Type: research

Distribution of lymphomas in Mexico: a multicenter descriptive study
AbstractEpidemiology of lymphoma is not well described in Mexico. We determined the frequencies and subtypes of the main non-Hodgkin ’s and Hodgkin’s lymphomas in the Mexican population. Files for tissue samples for lymphomas stored in five different hospitals in Mexico City were retrieved for re-analysis and further immunostaining. The most common mature B cell, T cell/NK cell, Hodgkin’s, and precursor lymphoid neoplasms w ere identified according to the 2008 WHO classification of tumors. All stains were performed in the same laboratory and interpreted by three pathologists. Five thousand seven hundred s...
Source: Journal of Hematopathology - December 7, 2018 Category: Pathology Source Type: research

Nonconventional morphology in plasma cell leukemia
We present such a case that emphasizes the importance of integrating flow cytometric immunophenotyping to confirm the diagnosis. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - November 13, 2018 Category: Pathology Source Type: research

Synchronous discordant Epstein-Barr virus (EBV) –positive nodal T/NK-cell lymphoma and EBV-positive diffuse large B cell lymphoma in a patient with a history of EBV-positive Burkitt lymphoma
We report a case of discordant Epstein-Barr virus –associated lymphoma consisting of nodal T/NK-cell lymphoma and diffuse large B cell lymphoma in a patient with a history of EBV-positive Burkitt lymphoma post treatment. Simultaneous biopsies of the left and right femoral lymph nodes showed a synchronous nodal T/NK-cell lymphoma (left) and diffus e large B cell lymphoma (right). The nodal T/NK-cell lymphoma was morphologically and immunohistochemical distinct from the diffuse large B cell. Both the T/NK-cell component and the B cell component showed bright nuclear positivity with in situ hybridization for EBER. Molec...
Source: Journal of Hematopathology - November 3, 2018 Category: Pathology Source Type: research

Primary spinal T cell/histiocyte-rich large B cell lymphoma (THRLBCL) —a rare diagnosis at a rare site
We describe a case of THRLBCL with an uncommon isolated spinal involvement. A 37-year-old male came to the neurosurgery outpatient department with weakness of both upper and lower limbs. Histopathology and immunohistochemistry revealed features consistent with THRLBCL. The patient was treated with D5-D6 laminectomy followed by six cycles of chemotherapy (CHOP; cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone) and was disease free for 5  years until he had relapse of disease at the same location in 2016 for which he is receiving palliative radiation therapy. Isolated spinal involvement as the first or only ...
Source: Journal of Hematopathology - October 28, 2018 Category: Pathology Source Type: research

Post-transplant CD4+ non-cytotoxic γδ T cell lymphoma with lymph node involvement
AbstractGamma delta T cells represent a minor subset of the normal lymphocyte component of the human immune system, largely inhabiting mucosal surfaces. Gamma delta T cell lymphomas ( γδ TCLs) are thought to be derived from these cells and are rare, extremely aggressive lymphomas that typically exhibit a cytotoxic phenotype and often present in extranodal sites, most commonly as cutaneous or hepatosplenic subtypes. The immunophenotype usually lacks both CD4 and CD8 expression, but occasional cases express CD8. CD4 expression in γδ TCLs is exceedingly rare. The few reported cases tend to show a non-c...
Source: Journal of Hematopathology - September 8, 2018 Category: Pathology Source Type: research

A unique case of mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 sarcoma with epitheliotropism mimicking intestinal T cell lymphoma
We present an unusual case of myeloid sarcoma of T/myelomonocytic biphenotypic nature andBCR-ABL1 translocation demonstrating an epitheliotropism in the gastrointestinal tract and mass-forming lesions in the lungs without bone marrow involvement. A 69-year-old gentleman presented with non-bloody diarrhea and abdominal pain complicated by weight loss. CT scan showed diffuse mural thickening in the jejunum, distal ileum, transverse colon, and splenic flexure and bilateral pulmonary nodules. Biopsies of the ileum and colon were performed. An initial diagnosis of T cell lymphoma was made based on intestinal infiltration with C...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

Disseminated BCG-osis with haemophagocytosis, tubercular bacteraemia, and unusual haematological findings with its haematology analyser-based expression
AbstractInfantile disseminated BCG-osis is an uncommon complication of BCG vaccination and the presence of haemophagocytic lymphohistiocytosis (HLH) further complicates the clinical course due to its fatal outcome. Here, we describe a rare case of disseminated BCG-osis with HLH in a 3-month-old male child and the unusual morphological findings in the peripheral blood with its haematology analyser-based expression. The child presented with fever, failure to thrive, hepatosplenomegaly, erythematous skin rashes, and left axillary lymphadenopathy with history of BCG vaccination at birth. He was the first born of second-degree ...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

High-risk acute promyelocytic leukemia with unusual T/myeloid immunophenotype successfully treated with ATRA and arsenic trioxide-based regimen
We describe two patients with acute promyelocytic leukemia (APL) with an unusual immunophenotype with co-expression of myeloperoxidase (MPO) with cytoplasmic CD3 (cCD3) representing myeloid and T-lineage differentiation. Both harboredFLT3-ITD mutations. One additionally had a deletion in thePML gene affecting the primer binding site, thus limiting measurable residual disease (MRD) analysis during follow-up. Both patients achieved durable remission with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)-based therapy, thus mitigating the need for repetitive conventional chemotherapy cycles and allogeneic stem cell tr...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

Adult T cell leukemia/lymphoma complicated by proliferation of large B cells: a diagnostic dilemma
AbstractPeripheral T cell lymphomas are clinically and pathologically complex and generally associated with overall poor prognosis and aggressive clinical course. In recent years, there is a greater recognition of abnormal B cell expansion as a component of T cell lymphomas especially those derived from follicular helper T cells. Most of these B cells are EBV positive and show a wide range of morphology which includes large mononuclear cells and Hodgkin-like cells. The number of the abnormal B cells can also vary. It is possible to misdiagnose this entity as a B cell lymphoma, Hodgkin lymphoma, composite lymphoma, or react...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

Immunophenotypic and cytogenetic evolution patterns of the neoplastic plasma cells in multiple myeloma relapsed after stem cell transplant
AbstractMultiple myeloma (MM) is a neoplasm characterized by proliferation of clonal plasma cells (PCs) and a combination of clinical manifestations. Flow cytometry is an important method for diagnosing and monitoring of MM. Cytogenetic profiling of neoplastic PCs provides important prognostic information. Although stem cell transplantation (SCT) has significantly improved the overall survival of patients with MM, most SCT recipients relapse. We have studied the immunophenotypic and cytogenetic dissimilarities in the neoplastic PCs before SCT and after relapse in patients with initial complete remission, and investigated a...
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

Unusual morphology of multiple myeloma
AbstractMultiple myeloma can have plasma cells with unusual morphology and a high index of suspicion is required to diagnose multiple myeloma with atypical morphology. (Source: Journal of Hematopathology)
Source: Journal of Hematopathology - September 1, 2018 Category: Pathology Source Type: research

Immunophenotypic and cytogenetic evolution patterns of the neoplastic plasma cells in multiple myeloma relapsed after stem cell transplant
AbstractMultiple myeloma (MM) is a neoplasm characterized by proliferation of clonal plasma cells (PCs) and a combination of clinical manifestations. Flow cytometry is an important method for diagnosing and monitoring of MM. Cytogenetic profiling of neoplastic PCs provides important prognostic information. Although stem cell transplantation (SCT) has significantly improved the overall survival of patients with MM, most SCT recipients relapse. We have studied the immunophenotypic and cytogenetic dissimilarities in the neoplastic PCs before SCT and after relapse in patients with initial complete remission, and investigated a...
Source: Journal of Hematopathology - August 15, 2018 Category: Pathology Source Type: research

High-risk acute promyelocytic leukemia with unusual T/myeloid immunophenotype successfully treated with ATRA and arsenic trioxide-based regimen
We describe two patients with acute promyelocytic leukemia (APL) with an unusual immunophenotype with co-expression of myeloperoxidase (MPO) with cytoplasmic CD3 (cCD3) representing myeloid and T-lineage differentiation. Both harboredFLT3-ITD mutations. One additionally had a deletion in thePML gene affecting the primer binding site, thus limiting measurable residual disease (MRD) analysis during follow-up. Both patients achieved durable remission with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)-based therapy, thus mitigating the need for repetitive conventional chemotherapy cycles and allogeneic stem cell tr...
Source: Journal of Hematopathology - August 9, 2018 Category: Pathology Source Type: research

A unique case of mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 sarcoma with epitheliotropism mimicking intestinal T cell lymphoma
We present an unusual case of myeloid sarcoma of T/myelomonocytic biphenotypic nature andBCR-ABL1 translocation demonstrating an epitheliotropism in the gastrointestinal tract and mass-forming lesions in the lungs without bone marrow involvement. A 69-year-old gentleman presented with non-bloody diarrhea and abdominal pain complicated by weight loss. CT scan showed diffuse mural thickening in the jejunum, distal ileum, transverse colon, and splenic flexure and bilateral pulmonary nodules. Biopsies of the ileum and colon were performed. An initial diagnosis of T cell lymphoma was made based on intestinal infiltration with C...
Source: Journal of Hematopathology - July 30, 2018 Category: Pathology Source Type: research

Adult T cell leukemia/lymphoma complicated by proliferation of large B cells: a diagnostic dilemma
AbstractPeripheral T cell lymphomas are clinically and pathologically complex and generally associated with overall poor prognosis and aggressive clinical course. In recent years, there is a greater recognition of abnormal B cell expansion as a component of T cell lymphomas especially those derived from follicular helper T cells. Most of these B cells are EBV positive and show a wide range of morphology which includes large mononuclear cells and Hodgkin-like cells. The number of the abnormal B cells can also vary. It is possible to misdiagnose this entity as a B cell lymphoma, Hodgkin lymphoma, composite lymphoma, or react...
Source: Journal of Hematopathology - July 18, 2018 Category: Pathology Source Type: research