Difficult-to-treat chronic rhinosinusitis-when the standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research
Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps
Rhinology. 2024 Mar 13. doi: 10.4193/Rhin23.081. Online ahead of print.ABSTRACTThe latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) >100 kU/L, a blood eosinophil count (BEC, expressed as ·109 cells / L) ≥0.25, or a tissue eosinophil count ≥10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from ≥0.25 (EPOS2020) ...
Source: Rhinology - March 13, 2024 Category: ENT & OMF Authors: R van der Lans J J Otten G F J P M Adriaensen L B L Benoist M E Cornet D R Hoven A B Rinia W J Fokkens S Reitsma Source Type: research
Difficult-to-treat chronic rhinosinusitis-when the standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research
Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps
Rhinology. 2024 Mar 13. doi: 10.4193/Rhin23.081. Online ahead of print.ABSTRACTThe latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) >100 kU/L, a blood eosinophil count (BEC, expressed as ·109 cells / L) ≥0.25, or a tissue eosinophil count ≥10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from ≥0.25 (EPOS2020) ...
Source: Rhinology - March 13, 2024 Category: ENT & OMF Authors: R van der Lans J J Otten G F J P M Adriaensen L B L Benoist M E Cornet D R Hoven A B Rinia W J Fokkens S Reitsma Source Type: research
Difficult-to-treat chronic rhinosinusitis-when the standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research
Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps
Rhinology. 2024 Mar 13. doi: 10.4193/Rhin23.081. Online ahead of print.ABSTRACTThe latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) >100 kU/L, a blood eosinophil count (BEC, expressed as ·109 cells / L) ≥0.25, or a tissue eosinophil count ≥10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from ≥0.25 (EPOS2020) ...
Source: Rhinology - March 13, 2024 Category: ENT & OMF Authors: R van der Lans J J Otten G F J P M Adriaensen L B L Benoist M E Cornet D R Hoven A B Rinia W J Fokkens S Reitsma Source Type: research
Difficult-to-treat chronic rhinosinusitis-when the standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research
Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps
Rhinology. 2024 Mar 13. doi: 10.4193/Rhin23.081. Online ahead of print.ABSTRACTThe latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) >100 kU/L, a blood eosinophil count (BEC, expressed as ·109 cells / L) ≥0.25, or a tissue eosinophil count ≥10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from ≥0.25 (EPOS2020) ...
Source: Rhinology - March 13, 2024 Category: ENT & OMF Authors: R van der Lans J J Otten G F J P M Adriaensen L B L Benoist M E Cornet D R Hoven A B Rinia W J Fokkens S Reitsma Source Type: research
Difficult-to-treat chronic rhinosinusitis-when the standard treatment is not effective and biologics are not available
CONCLUSION: To accurately assess the efficacy of second-line therapies for treatment of difficult-to-treat CRS within an endotype-specific framework, additional controlled clinical trials are needed that take into account the heterogeneity of CRS endotypes.PMID:38472346 | DOI:10.1007/s00106-024-01443-w (Source: HNO)
Source: HNO - March 13, 2024 Category: ENT & OMF Authors: Robert B öscke Source Type: research
Polyphosphate Nanoparticles: Balancing Energy Requirements in Tissue Regeneration Processes
Polyphosphate (polyP) is a physiological polymer composed of orthophosphate units linked by energy-rich bonds. Glucose and polyP serve as energy (ATP) generators. The polyP nanoparticles are converted to a coacervate, followed by enzymatic hydrolysis and free energy conversion to ADP and ATP. This review summarizes the currently available knowledge on the route of polyP nanoparticles during the regeneration of injured human tissue. AbstractNanoparticles of a particular, evolutionarily old inorganic polymer found across the biological kingdoms have attracted increasing interest in recent years not only because of their cruc...
Source: Small - March 13, 2024 Category: Nanotechnology Authors: Werner E.G. M üller,
Meik Neufurth,
Shunfeng Wang,
Heinz C. Schröder,
Xiaohong Wang Tags: Review Source Type: research
Genes, Vol. 15, Pages 355: A POT1 Founder Variant Associated with Early Onset Recurrent Melanoma and Various Solid Malignancies
We report the identification of POT1 p.(I78T), previously ranked with conflicting interpretations of pathogenicity, as a founder pathogenic variant among Ashkenazi Jews (AJs) and describe its unique clinical landscape. A directed database search was conducted for individuals referred for genetic counselling from 2018 to 2023. Demographic, clinical, genetic, and pathological data were collected and analyzed. Eleven carriers, 25 to 67 years old, from ten apparently unrelated families were identified. Carriers had a total of 30 primary malignancies (range 1–6); nine carriers (82%) had recurrent melanoma between ...
Source: Genes - March 13, 2024 Category: Genetics & Stem Cells Authors: Aasem Abu Shtaya Inbal Kedar Lily Bazak Lina Basel-Salmon Sarit Farage Barhom Michal Naftali Marina Eskin-Schwartz Ohad S. Birk Shirley Polager-Modan Nitzan Keidar Gili Reznick Levi Zohar Levi Tamar Yablonski-Peretz Ahmad Mahamid Ori Segol Reut Matar Yifa Tags: Article Source Type: research
Polyphosphate kinase regulates LPS structure and polymyxin resistance during starvation in < i > E < /i > . < i > coli < /i >
by Kanchi Baijal, Iryna Abramchuk, Carmen M. Herrera, Thien-Fah Mah, M. Stephen Trent, Mathieu Lavall ée-Adam, Michael Downey
Polyphosphates (polyP) are chains of inorganic phosphates that can reach over 1,000 residues in length. InEscherichia coli, polyP is produced by the polyP kinase (PPK) and is thought to play a protective role during the response to cellular stress. However, the molecular pathways impacted by PPK activity and polyP accumulation remain poorly characterized. In this work, we used label-free mass spectrometry to study the response of bacteria that cannot produce polyP ( Δppk) during starvation to ide...
Source: PLoS Biology: Archived Table of Contents - March 13, 2024 Category: Biology Authors: Kanchi Baijal Source Type: research
The Prognostic Importance of Cancer Stem Cells in Colorectal Polyps
CONCLUSION: During the examination, the statistical significance of CD133 expression was detected in cases with dysplasia and malignancy. The investigation of CD133 expression in colorectal polyps is crucial in determining the presence of dysplasia and malignancy development, particularly in obtaining prognostic data in colorectal polyps.PMID:38469604 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - March 12, 2024 Category: Surgery Authors: Aynur Safiyeva Nuru Bayramov Mustafa Cihat Avunduk Source Type: research
Upper abdominal pain in a young woman treated by endoscopic submucosal dissection
Rev Esp Enferm Dig. 2024 Mar 12. doi: 10.17235/reed.2024.10375/2024. Online ahead of print.ABSTRACTA previously healthy 39-year-old woman was hospitalized with upper abdominal pain for 1-month duration. A semipedunculated protrusion with smooth surface was found at the gastric angle measuring 2.0 × 2.5-cm by gastroscopy. Endoscopic ultrasound (EUS) showed a hypoechoic mass originated from the mucosal layer. Abdominal computed tomography (CT) revealed a circular pedunculated and slightly low-density mass with mild enhancement in the stomach cavity. Endoscopic submucosal dissection (ESD) was performed. Postoperative histopa...
Source: Revista Espanola de Enfermedades Digestivas - March 12, 2024 Category: Gastroenterology Authors: Qianqian Li Weiwei Chen Lei Chen Zhen Zhu Source Type: research
The Prognostic Importance of Cancer Stem Cells in Colorectal Polyps
CONCLUSION: During the examination, the statistical significance of CD133 expression was detected in cases with dysplasia and malignancy. The investigation of CD133 expression in colorectal polyps is crucial in determining the presence of dysplasia and malignancy development, particularly in obtaining prognostic data in colorectal polyps.PMID:38469604 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - March 12, 2024 Category: Surgery Authors: Aynur Safiyeva Nuru Bayramov Mustafa Cihat Avunduk Source Type: research
