Isolated Langerhans cell histiocytosis in the stomach of adults: four-case series and literature review
We examined four cases (one female, three males) of gastric LCH. The affected patients were between 33 and 70 years of age. Endoscopically, three patients presented with a solitary polyp or elevated lesions, whereas one patient showed no abnormalities. Under a microscope, all cases showed abnormal proliferation of histiocytoid cells infiltrating in a nested or sheet-like fashion. The tumor cells were medium-sized, with a slightly eosinophilic cytoplasm, irregular or renal-shaped nuclei, folded nuclear membranes, visible nuclear grooves, and the infiltration of inflammatory cells in the background. Immunohistochemically, al...
Source: Journal of Hematopathology - April 23, 2024 Category: Pathology Source Type: research
Which is Better in Predicting CT Scores in Patients with Chronic Rhinosinusitis after Medical treatment-Baseline Rhinosinusitis Disability Index (RSDI) or Endoscopic Score?
ConclusionStatistically significant (p < 0.001) association was found between baseline Lund-Kennedy endoscopic scores and Mackay-Lund CT scores post medical treatment. No significant association was found between RSDI scores and Mackay-Lund CT scores. ROC analysis indicated that Lund- Kennedy endoscopy score is a more accurate tool than RSDI score to predict a Mackay-Lund CT scores after medical treatment. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 23, 2024 Category: ENT & OMF Source Type: research
Audit of hemostatic clip use after colorectal polyp resection in an academic endoscopy unit
Conclusions Audits of clip use in an endoscopy practice can reveal surprising findings, including high and variable rates of unnecessary use after cold resection. Audit can potentially reduce unnecessary costs, carbon emissions, and plastic waste. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 23, 2024 Category: Gastroenterology Authors: Stark, Easton M. Lahr, Rachel E. Shultz, Jeremiah Vemulapalli, Krishna C. Guardiola, John J. Rex, Douglas K. Tags: Original article Source Type: research
Imaging findings of children with PTEN-related hamartoma tumor syndrome: a 20-year multicentric pediatric cohort
ConclusionBrain abnormalities, benign non-vascular soft tissue abnormalities, and vascular anomalies are commonly seen in children and adolescents with PTEN-related hamartoma tumor syndrome. However, malignancies involving the thyroid gland are not uncommon. Familiarity with the phenotype of PTEN-related hamartoma tumor syndrome in the pediatric population can improve diagnosis and prompt appropriate clinical surveillance of abnormal findings that warrant further management.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 22, 2024 Category: Radiology Source Type: research
Clinicopathologic and endoscopic characteristics of ten patients with gastric hamartomatous inverted polyp: a single center case series
Gastric hamartomatous inverted polyps (GHIPs) are not well characterized and remain diagnostically challenging due to rarity. Therefore, this study aims to investigate the clinicopathologic and endoscopic char... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Ningning Dong, Fandong Meng, Bing Yue and Junzhen Hou Tags: Research Source Type: research
Response
We appreciate the letter from Pasam et al1 in response to our article2 in Gastrointestinal Endoscopy. The authors included only randomized controlled trials, as opposed to our analysis,2 where we included both observational studies and randomized controlled trials to provide a more comprehensive review. Our analysis did not include the trials by Rex et al3 and Rodríguez Sánchez et al4 because they were published after our search period until January 12, 2023. Because our study inclusion criteria for polyps were size ≥1.5 cm, we also did not include the 2019 study by Yamashina et al. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Dhruvil Radadiya, Madhav Desai, Prateek Sharma Tags: Letter to the Editor Source Type: research
Endoscopic techniques to reduce recurrence after EMR of large nonpedunculated colorectal polyps
We congratulate Radadiya et al1 on their recent study comparing various EMR techniques for large nonpedunculated colorectal polyps by using indirect pairwise comparison. However, their study included observational studies and randomized control trials (RCTs), which limits the ability to draw conclusions. In support of this t opic, we performed a network meta-analysis of RCTs comparing various margin ablation techniques after EMR—snare tip soft coagulation (STSC) and argon plasma coagulation (APC)—with conventional EMR (CEMR) and underwater EMR (UEMR) to treat large nonpedunculated colorectal polyps. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - April 21, 2024 Category: Gastroenterology Authors: Ravi Teja Pasam, Saurabh Chandan, Babu P. Mohan Tags: Letter to the Editor Source Type: research
Evaluating an e-device to monitor the type 2 high unified airway response to dupilumab
Patients with unified airways disease (UAD) who have asthma and concomitant chronic rhinosinusitis with nasal polyps (CRSwNP) are often difficult to manage and have a higher burden of type 2 (T2) inflammation as compared to those with asthma or nasal polyps (NP) alone.1 Few studies have prospectively looked in detail at concomitant upper and lower airway outcomes in patients with T2 high UAD in response to biologics.2 Evaluating the clinical burden of upper and lower airway disease in response to treatment can be challenging using conventional analogue paper diary recordings of peak nasal inspiratory flow (PNIF) and peak e...
Source: Annals of Allergy, Asthma and Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth Tags: Letters Source Type: research
IRF4 Knockdown Inhibits the Chronic Rhinosinusitis Without Nasal Polyps Development by Regulating NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis
Biochem Genet. 2024 Apr 18. doi: 10.1007/s10528-024-10792-8. Online ahead of print.ABSTRACTChronic rhinosinusitis without nasal polyps (CRSsNP) is a CRS phenotype. However, the mechanisms of CRSsNP remains unclear. Differentially expressed genes (DEGs) were obtained from the GSE36830 and GSE198950 datasets through the GEO2R tool. The six hub genes were screened by the protein-protein interaction (PPI) network analysis and Cytoscape software. Then we constructed the mouse models of CRS and verified the expression levels of hub genes by reverse transcription quantitative PCR (RT-qPCR). Hematoxylin-eosin (HE) staining was emp...
Source: Biochemical Genetics - April 18, 2024 Category: Genetics & Stem Cells Authors: Jun Xu Jiahui Li Xiaoya Wang Yunsong An Wenlong Liu Renzhong Luo Changzhi Sun Source Type: research
S. aureus biofilm properties correlate with immune B cell subset frequencies and severity of chronic rhinosinusitis
This study aimed to investigate whether strain-level variation in in vitro-grown S. aureus biofilm properties relates to CRS disease severity, in vitro toxicity, and immune B cell responses in sinonasal tissue from CRS patients and non-CRS controls. S. aureus clinical isolates, tissue samples, and matched clinical datasets were collected from CRS patients with nasal polyps (CRSwNP), CRS without nasal polyps (CRSsNP), and controls. B cell responses in tissue samples were characterised by FACS. S. aureus biofilms were established in vitro, followed by measuring their properties of metabolic activity, biomass, colony-forming ...
Source: Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Gohar Shaghayegh Clare Cooksley George Bouras Beula Subashini Panchatcharam Sholeh Feizi Shari Javadian Mahnaz Ramezanpour Kevin Aaron Fenix Peter-John Wormald Alkis James Psaltis Sarah Vreugde Source Type: research
Early detection of gastrointestinal polyps and neoplasia following radiation for childhood-onset cancer
A massive and rapidly increasing burden of care exists for all physicians caring for the 80–90% of childhood cancer survivors. All paediatricians and general practitioners (GPs) seeing these adolescents must attain a sound knowledge of the risks, current and future, faced by these young people. Provision of improved care and appropriate surveillance during adolescence, with information for adult services at time of transition, will also empower patients and their families to advocate for and act upon the essential requirements for long-term surveillance. Not all these risks are yet commonly recognised. Exposure to ab...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Atlas, G., Zacharin, M. R. Tags: PostScript Source Type: research
Twenty First Century Technological Toolbox Innovation for Transanal Minimally Invasive Surgery (TAMIS)
Surg Technol Int. 2024 Apr 16;44:sti44/1760. Online ahead of print.ABSTRACTTransanal minimally invasive surgery (TAMIS) is an effective procedure that plays an important role in the care of patients with significant rectal neoplasia and polyps including early-stage cancers. However, it is perhaps underutilised and under threat from both advanced flexible endoscopic procedures and proceduralists (who often act as gatekeepers for referral to colorectal surgeons), as well as from robotic surgery proponents. TAMIS advocates can learn and adopt practice insights from both these fields and incorporate available technological inn...
Source: Surgical Technology International - April 17, 2024 Category: Surgery Authors: Alice Moynihan Patrick Boland Ronan A Cahill Source Type: research
The ring rules the chain - inositol pyrophosphates and the regulation of inorganic polyphosphate
Biochem Soc Trans. 2024 Apr 17:BST20230256. doi: 10.1042/BST20230256. Online ahead of print.ABSTRACTThe maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated with monophosphate and diphosphate moieties, and inorganic polyphosphate (polyP), chains of orthophosphate residues linked by phosphoanhydride bonds, are energy-rich biomolecules that play critical roles in phosphate homeostasis. There is a complex interplay between these two phosphate-rich molecules, and the...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Azmi Khan Manisha Mallick Jayashree S Ladke Rashna Bhandari Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 17:BST20230522. doi: 10.1042/BST20230522. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel c...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
Twenty First Century Technological Toolbox Innovation for Transanal Minimally Invasive Surgery (TAMIS)
Surg Technol Int. 2024 Apr 16;44:sti44/1760. Online ahead of print.ABSTRACTTransanal minimally invasive surgery (TAMIS) is an effective procedure that plays an important role in the care of patients with significant rectal neoplasia and polyps including early-stage cancers. However, it is perhaps underutilised and under threat from both advanced flexible endoscopic procedures and proceduralists (who often act as gatekeepers for referral to colorectal surgeons), as well as from robotic surgery proponents. TAMIS advocates can learn and adopt practice insights from both these fields and incorporate available technological inn...
Source: Surgical Technology International - April 17, 2024 Category: Surgery Authors: Alice Moynihan Patrick Boland Ronan A Cahill Source Type: research
