Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism Blunt Thoughts on Calculating the Revealed Value of Human Life A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition Towards Adjustment of the Gut Microbiome to Slow Aging Gene Therapy Enhances Object Recognition Memory in Young and Old Mice Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Gut Microbiome Differs in Characteristic Ways in Patients with Precancerous Colon Polyps
The gut microbiome changes with age, the relative abundance of microbial populations shifting in ways that appear connected to chronic inflammation and dysfunction of the intestinal epithelium and intestinal barrier function. Cancer of the colon is an important cause of human mortality, and there is some hope that finding ways to prevent or reverse gut microbiome aging, such as via fecal microbiota transplant from young individuals, will go some way to minimizing colon cancer incidence. Colorectal cancer is the second leading cause of cancer-related death in the U.S., and rates of colorectal cancer are rising amon...
Source: Fight Aging! - June 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Bonus Features – May 7, 2023 – Less than 1% of all medical claims include an ICD-10 Z code, 78% of consumers say virtual health is important when considering health plans, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News CMS has opened the Hardship Exception application period for eligible hospitals and critical access hospitals (CAHs) that participated in the Medicare Promoting Interoperability Program in 2022. Hospitals may be exempt from...
Source: EMR and HIPAA - May 7, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Alan Bugos Alexander Group Amazon Amazon Web Services CAHs Carenet Health CarePort Connect CGI CharmHealth CMS Consensus Cloud Solutions Controlled Medications CrunchBase DAS Health DEA eClinicalWorks eCW Source Type: blogs

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
 September 08, 2022 Edition-----In the US we are seeing the outcomes of Climate Change really of and running with droughts and fires etc. Biden amped up the partisan divide with a fiery anti-Republican speech!In Russia the last leader of Soviet Russia died.In the UK we have a new PM while in Europe the energy crisis is just getting worse.In OZ we have survived the Jobs and Skills Summit with 36 prearranged outcomes. Stage management +++ in action. The GP crisis is not being addressed fully and worries regarding the Global Economy - esp. China - worsen.-----Major Issues.-----https://www.afr.com/work-and-careers/educati...
Source: Australian Health Information Technology - September 8, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Weekly Overseas Health IT Links – 23rd July2022.
In this study, researchers sought to determine whether differences in occult hypoxemia treatment existed between people of different races.Occult hypoxemia was defined as arterial blood oxygen saturation of less than 88 percent despite a pulse oximetry reading of 92 percent or more.-----https://healthitsecurity.com/news/security-awareness-and-training-crucial-to-preventing-healthcare-phishing-attacksSecurity Awareness and Training Crucial to Preventing Healthcare Phishing AttacksSecurity awareness and training greatly decreased the likelihood of an employee falling for a healthcare phishing attack, KnowBe4 researchers foun...
Source: Australian Health Information Technology - July 23, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

AI Adoption in Healthcare Requires Better Approaches to Patient Data
The following is a guest article by Vanessa Braunstein, Healthcare Product Marketing Lead at NVIDIA. Building great AI models in healthcare and life sciences requires lots of data that is diverse, well-labeled, and spans across different patient types. However, as AI gains traction, there are still a number of bottlenecks that slow down the process of developing robust AI models such as patient privacy, access to data, and lack of clinical expertise to annotate data for training. In order to overcome these barriers, data scientists and developers have developed new solutions such as federated learning paradigms, AI models ...
Source: EMR and HIPAA - June 28, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Federated Learning GDPR Health Data Ethics Health Data Privacy Healthcare AI Healthcare AI Ethics Healthcare Neural Source Type: blogs

Catheter-Deliverable Biomaterial Sealants: Interview with Natalie Artzi, Co-founder of BioDevek
BioDevek, a medtech company based in Cambridge, Massachusetts, has developed a biomaterial adhesive that acts to seal internal wounds and incisions. The material is designed to be sprayed through a catheter, and the primary application for the technology so far is to act as a sealant following colonic polyp resection. At present, following polyp resection, surgeons can use polyp clips to seal the resection site, which can hamper wound healing, or use no sealant at all, leading to an open wound that comes with a risk of bleeding or other complications. This can lead to additional surgeries to correct the issue and is inc...
Source: Medgadget - November 30, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Materials Plastic Surgery BioDevek Source Type: blogs

November 2021: Fleshy Lumps on the Scalp
Nausea and body aches. Probably COVID. Unvaccinated. Definitely COVID. After all, what else are we seeing?The 20-something young man was eating and talking on his phone. He passed the look test. His vitals were pristine, but he regaled me with myriad symptoms he had had for months. He hadn't taken any medicine. I was at a loss for what drove him to come to the emergency department. He thought for a minute and said, "I want to know why I have all these."He pointed to a spot on his head, which drew my attention to a fleshy lump. Then he moved his hair around, causing others to appear. "You can feel lots more,&...
Source: Lions and Tigers and Bears - November 1, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Gastroenterology Embraces Artificial Intelligence
AI and machine learning have the potential to redefine the management of several GI disorders.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.Colonoscopy is one of the true success stories in modern medicine.Studies have demonstrated that colonoscopy screening detects the cancer at a much earlier stage, reducing the risk of invasive tumors and metastatic disease, andreducing mortality. However, while colorectal cancer is highly preventable, it is thethird leading cause of cancer-related deathsin the U.S. A...
Source: Life as a Healthcare CIO - October 13, 2021 Category: Information Technology Source Type: blogs

Reimagining the FDA ’s Role in Digital Medicine
In addition to evaluating the safety of software as a medical device (SaMD), the agency needs to devote more resources to evaluating its efficacy and quality.John Halamka, M.D., president, Mayo Clinic Platform, and Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, wrote this article.The FDA ’s approach to software as a medical device (SaMD) has been evolving. Consider a few examples.In 2018, IDx-DR, a software system used to improve screening for retinopathy, a common complication of diabetes that affects the eye, became the first AI-based medical device to receiveUS Food and Drug...
Source: Life as a Healthcare CIO - September 30, 2021 Category: Information Technology Source Type: blogs

GI Genius Polyp Detection System: Interview with Giovanni Di Napoli, President, Gastrointestinal at Medtronic
We recently reported on the de novo FDA clearance received by Medtronic for its GI Genius AI polyp detection system. The product is hugely flexible as it works with any video colonoscope and provides AI powered assistance for clinicians in identifying colorectal polyps during colonoscopies. Medtronic reports that the system has significantly improved polyp detection rates, which should translate to better colorectal cancer patient outcomes through prompt diagnosis and early treatment. As a clinician performs a colonoscopy the system analyzes the video data and highlights suspected polyps using a green box on the vid...
Source: Medgadget - May 13, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive GI Source Type: blogs

FDA Clears First AI Polyp Detection System for Colonoscopies
Medtronic won FDA de novo clearance for its GI Genius endoscopy technology that can spot suspicious lesions during routine colonoscopy exams. The system works with any video colonoscope and can even process pre-recorded colonoscopies. Even highly experienced gastroenterologists can miss a polyp while navigating through the colon. Computer vision technology can carefully process the entirety of every video frame to spot any irregularities associated with polyps. According to Medtronic, “the GI Genius module has demonstrated a 14% absolute increase in ADR [adenoma detection rate] compared to colonoscopy alone fo...
Source: Medgadget - April 15, 2021 Category: Medical Devices Authors: Medgadget Editors Tags: GI Source Type: blogs

Racial disparities and early-onset colorectal cancer: A call to action
Colorectal cancer (CRC) is the second leading cause of death from cancer in both men and women in the US. Thanks in large part to increased screening of those over age 50 in last decade, overall CRC rates have been falling among the general population. However, the incidence of CRC among younger individuals in the US is rising at an alarming rate. Over the past 20 years, the rate of CRC has increased by 2.2% per year in people under age 50. Hidden within these statistics are the significant disparities in CRC incidence and outcomes that exist for African Americans. Compared to whites, African Americans have a 20% higher in...
Source: Harvard Health Blog - March 17, 2021 Category: Consumer Health News Authors: Andrew Chan, MD, MPH Tags: Cancer Digestive Disorders Health care disparities Source Type: blogs