Validation and shortcomings of the most common mouse model of chronic rhinosinusitis with nasal polyps
CONCLUSIONS: With the notable exception of local IgE production, the addition of SEB did not induce additional inflammatory or structural change in the sinuses from mice exposed to and challenged with OVA. This model might represent a model for severe upper airway allergy rather than a specific model of human eCRSwNP.PMID:38497676 | DOI:10.4193/Rhin23.331 (Source: Rhinology)
Source: Rhinology - March 18, 2024 Category: ENT & OMF Authors: A S ánchez-Montalvo M Lecocq E Bouillet B Steelant S Gohy A Froidure D Bullens C Pilette V Hox Source Type: research

Clinical outcomes of functional endoscopic sinus surgery in cystic fibrosis patients - a single centre experience
CONCLUSIONS: There was a demonstrated clinical and symptomatic benefit of ESS in CF patients in this study. Stricter guidelines for indications for ESS need to be established with regards to CF patients who will undergo ESS in the future.PMID:38497762 | DOI:10.4193/Rhin23.057 (Source: Rhinology)
Source: Rhinology - March 18, 2024 Category: ENT & OMF Authors: Y Devabalan R Towning J Magill H Saleh C Rennie Source Type: research

Eosinophils are the dominant type2 marker for the current indication of biological treatment in severe uncontrolled chronic rhinosinusitis with nasal polyps
Rhinology. 2024 Mar 13. doi: 10.4193/Rhin23.081. Online ahead of print.ABSTRACTThe latest European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS2020) defines markers for type2 inflammation in the context of indicating biological therapy in severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) as either a total serum immunoglobulin E (total-IgE) >100 kU/L, a blood eosinophil count (BEC, expressed as ·109 cells / L) ≥0.25, or a tissue eosinophil count ≥10 per high power field (HPF) (1). Recently, an EPOS/EUFOREA expert panel advised to lower the threshold for BEC from ≥0.25 (EPOS2020) ...
Source: Rhinology - March 13, 2024 Category: ENT & OMF Authors: R van der Lans J J Otten G F J P M Adriaensen L B L Benoist M E Cornet D R Hoven A B Rinia W J Fokkens S Reitsma Source Type: research

The effect of smell training on COVID-19 induced smell loss
CONCLUSION: we discovered a significant moderate difference in psychophysical smell function between patients with COVID-19-induced smell disorders who performed smell training and those who did not, implying a possible advantage of training. However, no relationship was found between therapeutical adherence of smell training and olfactory function.PMID:38446154 | DOI:10.4193/Rhin23.191 (Source: Rhinology)
Source: Rhinology - March 6, 2024 Category: ENT & OMF Authors: E J A Schepens C J M de Haas E M Postma B van Dijk S Boesveldt I Stegeman D M A Kamalski Source Type: research

Body mass index's effect on CRSwNP extends to pathological endotype and recurrence
CONCLUSIONS: Overweight/obese CRSwNP stands for a unique phenotype and endotype. Conventional parameters predicting recurrence are compromised in overweight/obese CRSwNP, and there is an urgent need for novel biomarkers that predict recurrence for these patients.PMID:38416065 | DOI:10.4193/Rhin23.402 (Source: Rhinology)
Source: Rhinology - February 28, 2024 Category: ENT & OMF Authors: W Chen Y Bai P Fang J Chen X Wang Y Li X Luo Z Xiao R Iyer F Shan T Yuan M Wu X Huang D Fang Q Yang Y Zhang Source Type: research

On the outcome of septoplasty
Rhinology. 2024 Feb 28. doi: 10.4193/Rhin23.472. Online ahead of print.ABSTRACTIn 2019 and 2023, two randomised controlled trials (RCTs) on the effectiveness of septoplasty were published (1,2). Part of the rationale for both studies was that the value of septoplasty had been questioned by policymakers, health insurance carriers and health care providers. The results of both studies showed that patients undergoing septoplasty had a better outcome than patients in the control group. Without questioning these results or the general perception in the rhinology community that septoplasty is of great value to the right patient,...
Source: Rhinology - February 28, 2024 Category: ENT & OMF Authors: O Sunnergren C Alexandersson F Eliasson M Jangard Y Lilja K Sandelin C Ahlstr öm Emanuelsson Source Type: research

Elevated MIF identified by multiple cytokine analyses facilitates macrophage M2 polarization contributing to postoperative recurrence in chronic rhinosinusitis with nasal polyps
CONCLUSIONS: Serum-specific cytokine signatures were associated with postoperative recurrence risk in CRSwNP. Elevated MIF enhanced macrophage M2 polarization and cytokine secretion, contributing to the recurrent mechanisms of CRSwNP.PMID:38416565 | DOI:10.4193/Rhin23.412 (Source: Rhinology)
Source: Rhinology - February 28, 2024 Category: ENT & OMF Authors: S Xie Z Tong J Zhang C Yang W Jiang H Zhang Source Type: research