Ciliary function and sinonasal mucosal cytology in pediatric patients with chronic rhinosinusitis during a year after functional endoscopic sinus surgery
CONCLUSIONS: Substantial improvement was observed only in a year after surgery, whereas 0 to 3 months after the surgery ciliary function was severely impaired thus predisposing to recurrent sinusitis or other complications.PMID:33904535 | DOI:10.4193/Rhin20.642 (Source: Rhinology)
Source: Rhinology - April 27, 2021 Category: ENT & OMF Authors: S Alekseenko S Karpischenko S Artyushkin S Barashkova I Anikin Source Type: research

Does time from previous surgery predict subsequent treatment failure in Chronic Rhinosinusitis with Nasal Polyps?
CONCLUSIONS: Patients presenting with a symptomatic recurrence within 3 years of surgery have a high risk of treatment failure, defined as the need for further surgery. Time to failure after previous surgery may be used to help select patients who may not benefit from current treatment pathways and may be good candidates for alternative strategies, including biologicals.PMID:33866347 | DOI:10.4193/Rhin21.017 (Source: Rhinology)
Source: Rhinology - April 18, 2021 Category: ENT & OMF Authors: Claire Hopkins Valerie Lund Source Type: research

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.PMID:33847325 | DOI:10.4193/Rhin20.415 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: M Desrosiers L P Mannent N Amin G W Canonica P W Hellings P Gevaert J Mullol S E Lee S Fujieda J K Han C Hopkins W Fokkens R Jankowski S H Cho X Mao M Zhang M S Rice A H Khan S Kamat N Patel N M H Graham M Ruddy C Bachert Source Type: research

Trigeminal impairment in treatment-refractory chronic nasal obstruction
CONCLUSION: Results suggest that reported nasal obstruction in CNO patients without any obvious anatomical obstacle and resistant to medical treatment may be linked to decreased perception of nasal airflow rather than physical obstruction. In this sub-set of CNO patients, trigeminal testing more adequately reflects the reported obstruction than nasal resistance assessment does. In future studies, the relation of the trigeminal status and the subjective sensation of nasal obstruction needs to be addressed with validated patient rated outcome measures (PROMs).PMID:33847326 | DOI:10.4193/Rhin20.510 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: C Migneault-Bouchard F J M Boselie M Hugentobler B N Landis J Frasnelli Source Type: research

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.PMID:33847325 | DOI:10.4193/Rhin20.415 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: M Desrosiers L P Mannent N Amin G W Canonica P W Hellings P Gevaert J Mullol S E Lee S Fujieda J K Han C Hopkins W Fokkens R Jankowski S H Cho X Mao M Zhang M S Rice A H Khan S Kamat N Patel N M H Graham M Ruddy C Bachert Source Type: research

Trigeminal impairment in treatment-refractory chronic nasal obstruction
CONCLUSION: Results suggest that reported nasal obstruction in CNO patients without any obvious anatomical obstacle and resistant to medical treatment may be linked to decreased perception of nasal airflow rather than physical obstruction. In this sub-set of CNO patients, trigeminal testing more adequately reflects the reported obstruction than nasal resistance assessment does. In future studies, the relation of the trigeminal status and the subjective sensation of nasal obstruction needs to be addressed with validated patient rated outcome measures (PROMs).PMID:33847326 | DOI:10.4193/Rhin20.510 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: C Migneault-Bouchard F J M Boselie M Hugentobler B N Landis J Frasnelli Source Type: research

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.PMID:33847325 | DOI:10.4193/Rhin20.415 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: M Desrosiers L P Mannent N Amin G W Canonica P W Hellings P Gevaert J Mullol S E Lee S Fujieda J K Han C Hopkins W Fokkens R Jankowski S H Cho X Mao M Zhang M S Rice A H Khan S Kamat N Patel N M H Graham M Ruddy C Bachert Source Type: research

Trigeminal impairment in treatment-refractory chronic nasal obstruction
CONCLUSION: Results suggest that reported nasal obstruction in CNO patients without any obvious anatomical obstacle and resistant to medical treatment may be linked to decreased perception of nasal airflow rather than physical obstruction. In this sub-set of CNO patients, trigeminal testing more adequately reflects the reported obstruction than nasal resistance assessment does. In future studies, the relation of the trigeminal status and the subjective sensation of nasal obstruction needs to be addressed with validated patient rated outcome measures (PROMs).PMID:33847326 | DOI:10.4193/Rhin20.510 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: C Migneault-Bouchard F J M Boselie M Hugentobler B N Landis J Frasnelli Source Type: research

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.PMID:33847325 | DOI:10.4193/Rhin20.415 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: M Desrosiers L P Mannent N Amin G W Canonica P W Hellings P Gevaert J Mullol S E Lee S Fujieda J K Han C Hopkins W Fokkens R Jankowski S H Cho X Mao M Zhang M S Rice A H Khan S Kamat N Patel N M H Graham M Ruddy C Bachert Source Type: research

Trigeminal impairment in treatment-refractory chronic nasal obstruction
CONCLUSION: Results suggest that reported nasal obstruction in CNO patients without any obvious anatomical obstacle and resistant to medical treatment may be linked to decreased perception of nasal airflow rather than physical obstruction. In this sub-set of CNO patients, trigeminal testing more adequately reflects the reported obstruction than nasal resistance assessment does. In future studies, the relation of the trigeminal status and the subjective sensation of nasal obstruction needs to be addressed with validated patient rated outcome measures (PROMs).PMID:33847326 | DOI:10.4193/Rhin20.510 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: C Migneault-Bouchard F J M Boselie M Hugentobler B N Landis J Frasnelli Source Type: research

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.PMID:33847325 | DOI:10.4193/Rhin20.415 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: M Desrosiers L P Mannent N Amin G W Canonica P W Hellings P Gevaert J Mullol S E Lee S Fujieda J K Han C Hopkins W Fokkens R Jankowski S H Cho X Mao M Zhang M S Rice A H Khan S Kamat N Patel N M H Graham M Ruddy C Bachert Source Type: research

Trigeminal impairment in treatment-refractory chronic nasal obstruction
CONCLUSION: Results suggest that reported nasal obstruction in CNO patients without any obvious anatomical obstacle and resistant to medical treatment may be linked to decreased perception of nasal airflow rather than physical obstruction. In this sub-set of CNO patients, trigeminal testing more adequately reflects the reported obstruction than nasal resistance assessment does. In future studies, the relation of the trigeminal status and the subjective sensation of nasal obstruction needs to be addressed with validated patient rated outcome measures (PROMs).PMID:33847326 | DOI:10.4193/Rhin20.510 (Source: Rhinology)
Source: Rhinology - April 13, 2021 Category: ENT & OMF Authors: C Migneault-Bouchard F J M Boselie M Hugentobler B N Landis J Frasnelli Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 1;59(2):113. doi: 10.4193/Rhin21.802.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: W J Fokkens Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 1;59(2):113. doi: 10.4193/Rhin21.802.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: W J Fokkens Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 1;59(2):113. doi: 10.4193/Rhin21.802.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: W J Fokkens Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 1;59(2):113. doi: 10.4193/Rhin21.802.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: W J Fokkens Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 5. doi: 10.4193/Rhin21.802. Online ahead of print.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: Wytske J Fokkens Source Type: research

Predictive factors for identifying macrolide responder in treating chronic rhinosinusitis
This study aimed to assess factors which predict LDM responders.METHODOLOGY: A prospective cohort study was performed. Patients with CRS received roxithromycin (150 mg) once daily for 12 weeks. Nasal secretions and serology were collected. Nine predictors for LDM response were assessed: nasal secretion IgE, nasal secretion IL-5, serum IgE, serum eosinophils, serum neutrophils, nasal polyps, asthma, allergy, and aspirin hypersensitivity, using receiver-operating curve analysis and multivariable logistic regression. Macrolide responders were those with sino-nasal outcome test-22 improvement, symptoms visual analogue scale de...
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: K Seresirikachorn S J Kerr S Aeumjaturapat S Chusakul J Kanjanaumporn J Wongpiyabovorn K Snidvongs Source Type: research

A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
CONCLUSIONS: Both the IFT and ESS scores correlate to each other, and their results are comparable. Whether the IFT or ESS scoring was performed by the patient or doctor had no significant impact.PMID:33821857 | DOI:10.4193/Rhin20.540 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: O J Jorgensen J Steineger G Bachmann-Harildstad S Dheyauldeen Source Type: research

Smell is the sense of memory and desire
Rhinology. 2021 Apr 5. doi: 10.4193/Rhin21.802. Online ahead of print.NO ABSTRACTPMID:33821858 | DOI:10.4193/Rhin21.802 (Source: Rhinology)
Source: Rhinology - April 6, 2021 Category: ENT & OMF Authors: Wytske J Fokkens Source Type: research

Nonpharmacological interventions to reduce respiratory viral transmission: an evidence-based review with recommendations
CONCLUSIONS: Mask use and hand hygiene are strong recommendations for prevention of viral transmission. Donning gloves, gowns, and eye protection are a recommendation in healthcare settings. Saline nasal washing and gargling are options in selected populations. Although an aggregate level of evidence is not provided, the authors recommend social distancing.PMID:33760909 | DOI:10.4193/Rhin20.563 (Source: Rhinology)
Source: Rhinology - March 24, 2021 Category: ENT & OMF Authors: E Yuen J Fried C Salvador D A Gudis R J Schlosser S A Nguyen E A Brennan N R Rowan Source Type: research