Add-on effect of clarithromycin to oral steroids as post- operative therapy for chronic rhinosinusitis with nasal polyps: a randomised controlled trial.
CONCLUSIONS: Adding low-dose clarithromycin to oral corticosteroids as post-ESS therapy was well tolerated and showed benefi- cial subjective and objective outcomes in patients with CRSwNP, especially those without tissue eosinophilia. PMID: 33021606 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 7, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Odor perception depends on airflow, odor solubility and intranasal application site.
Authors: Chen B, Pfister A, Nahrath P, Hummel T Abstract To the Editor: Odorants are sensed by olfactory receptor neurons in the olfac- tory epithelium. Odor molecules pass through the nasal cavity and dissolve in the mucus of the olfactory epithelium which is located on the superior portion of the cavity. There they bind to olfactory receptors on the dendrites of the olfactory recep- tor neurons. PMID: 33006330 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 3, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The Olfactory Cleft Endoscopy Scale: a multi-institutional validation study in chronic rhinosinusitis.
CONCLUSIONS: The OCES is a valid olfactory-specific measure that demonstrates strong validity and provides complimentary infor- mation to traditional sinus endoscopy to aid in our understanding of OD associated with CRS. PMID: 33006331 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 3, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Locally advanced nasal pyramid squamous cell carcinoma: our 15 years' experience in a series of 35 total rhinectomies.
Authors: Bouaoud J, Benmoussa N, Hennocq Q, Hennocq JF, Breuskin I, Gorphe P, Casiraghi O, Classe M, Blanchard P, Janot F, Kolb F, Leymarie N, Temam S, Moya-Plana A Abstract Locally advanced nasal pyramid squamous cell carcinoma (LA-NPSCC) are rare malignancies. Their specific outcomes are unclear. Their management remains challenging with several controversies, in particular regarding the realization of total rhinectomy and the role of elective neck node treatment (1). Between 2005 and 2019 in our department (Gustave Roussy Cancer Campus), n=35 patients with LA-NPSCC were treated with at least total rhinectomy (Su...
Source: Rhinology - October 3, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

EUFOREA treatment algorithm for allergic rhinitis.
Authors: Hellings PW, Scadding G, Bachert C, Bjermer L, Canonica GW, Cardell LO, Carney AS, Constantinidis J, Deneyer L, Diamant Z, Durham S, Gevaert P, Harvey R, Hopkins C, Kjeldsen A, Klimek L, Lund VJ, Price D, Rimmer J, Ryan D, Roberts G, Sahlstrand-Johnson P, Salmi S, Samji M, Scadding G, Smith P, Steinsvik A, Wagenmann M, Seys S, Wahn U, Fokkens WJ Abstract Allergic rhinitis (AR) is the most common chronic inflammatory disease, affecting an estimated 100 million Europeans (1). Despite a substantial burden on individuals, society and health economies (2), AR remains under-diagnosed, under-estimated (in terms o...
Source: Rhinology - September 30, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Predicting difficult-to-treat chronic rhinosinusitis by noninvasive biological markers.
CONCLUSIONS: Patients with difficult-to-treat-CRS were characterized by higher nasal secretion levels of CCL17 and MIP-1β, severe hyposmia and concomitant allergic rhinitis. The classification tree could be useful to identify patients with high risk of poor outcome prior to surgery and offer more personalized interventions. However, since only patients without preoperative steroid treatments were included in this study, the generalization of our predictive model in other patient populations should be conside- red with caution. PMID: 32974623 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 27, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Comparing nasal physiology after superior ethmoidal and traditional endoscopic anterior cranial base approaches.
Authors: Patel V, Viswanathan R, Ruffner R, Peris-Celda M, Pinheiro-Neto CD Abstract To the Editor: Endoscopic endonasal approaches can be effective for treating a wide variety of skull base pathologies with reduced complica- tions compared with open approaches(1). The traditional endo- scopic endonasal anterior cranial base approach (TA) involves total ethmoidectomies, middle and superior turbinectomies, near-total septectomy, sphenoidotomies and wide maxillary an- trostomies. However, these patients may develop chronic nasal crusting postoperatively requiring debridement. PMID: 32926008 [PubMed - as supplied ...
Source: Rhinology - September 16, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Individual importance of olfaction decreases with duration of smell loss.
CONCLUSIONS: The duration of smell loss is negatively correlated with the individual importance of olfaction, suggesting that patients develop coping mechanisms for adjusting to OD. PMID: 32926009 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 16, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Azithromycin for chronic eosinophilic rhinosinusitis with nasal polyp: a placebo-controlled trial.
CONCLUSIONS: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance. PMID: 32926010 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 16, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Factors associated with relevant olfactory recovery after olfactory training: a retrospective study including 601 participants.
CONCLUSIONS: This study demonstrated that OT was more effective than no training in patients with various causes of OD. Additi- onally, baseline olfactory performance and etiology of OD were identified as important factors associated with relevant improve- ments after OT. PMID: 32901616 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 10, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Modelling nasal airflow coefficients: an insight into the nature of airflow.
CONCLUSIONS: A novel method of determining the flow characteristics of the nose, particularly the critical Reynolds number, is presented. The analysis indicates a higher degree of turbulence than is assumed from a simple traditional calculation using a hy- draulic diameter and flow through straight tubes. There are implications for computational fluid dynamics (CFD) modelling where either the entire nasal airflow is assumed to be laminar or a low turbulence model implemented. PMID: 32901617 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 10, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Rhinology on the move despite Covid-19!
Authors: Hellings PW Abstract The October 2020 issue of Rhinology is a very interesting edition as it illustrates how world-wide colleagues pave the way for a better future of patients affected by nose and sinus diseases. After the successful launch of EPOS2020 in Spring 2020, the editorial team of Rhinology is proud to present to you the latest and most exciting data in Rhinology research. Getting insight into the complexity and relevance of proteomics in CRS, epithelial-mesenchymal contribution to CRS, zinc levels in nasal and systemic compartment of CRS, nasal biomarkers of CRSwNP that predict recurrence of dise...
Source: Rhinology - September 10, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Microbial aetiology of acute rhinosinusitis during pregnancy.
CONCLUSIONS: The pathogens of acute rhinosinusitis in pregnant patients are the same as in non-pregnant patients, however, the proportions differ; during pregnancy S. pneumoniae infection is more frequent. PMID: 32830808 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 25, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Nasal chemosensory tests: biomarker between dementia with Lewy bodies and Parkinson disease dementia.
CONCLUSIONS: The current study highlights that DLB patients have very poor olfactory and trigeminal detection threshold perfor- mances, which are significantly lower, compared to PDD patients. These results suggest that olfactory testing, using odorants that stimulate both the olfactory and trigeminal systems, could constitute an interesting biomarker and contribute to the differential diagnosis of PDD and DLB patients. Further researches, notably on olfacto-trigeminal interactions, are warranted in these popula- tions to support our findings. PMID: 32830809 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 25, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Comparison of COVID-19 and common cold chemosensory dysfunction.
In this study, we aimed to objectively assess and compare olfactory and gustatory functions in 10 COVID-19 patients (PCR diagnosed, assessed on average 2 weeks after infection), 10 acute cold (AC) patients (assessed before the COVID-19 outbreak) and 10 healthy controls, matched for age and sex. Smell performance was assessed using the extended "Sniffin' Sticks" test battery (4), while taste function was assessed using "taste strips" (5). Receiver Operating Characteristic (ROC) curves were built to probe olfactory and gustatory scores in terms of their discrimination between COVID-19 and AC patients. Our...
Source: Rhinology - August 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Microbial aetiology of acute rhinosinusitis during pregnancy.
CONCLUSIONS: The pathogens of acute rhinosinusitis in pregnant patients are the same as in non-pregnant patients, however, the proportions differ; during pregnancy S. pneumoniae infection is more frequent. PMID: 32812015 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Microarray analysis of primary epithelial and fibroblast cells in chronic rhinosinusitis without nasal polyps.
CONCLUSIONS: Here we have utilized microarray analysis to search for differentially expressed genes in isolated patient derived epithelial and fibroblast cells. The transcription factor NFE2L3 has been shown to be upregulated in fibroblast cells consistent with increasing evidence that fibroblasts play a key role in tissue specific inflammation within the paranasal sinuses. PMID: 32812016 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Analysis of expression profiling data suggests explanation for difficulties in finding biomarkers for nasal polyps.
CONCLUSION: Our findings indicate that the difficulties in finding specific biomarkers for CRSwNP depend on the complex underly-ing mechanisms, which include multiple pathways and regulators, each of which may be subdivided into multiple components such as ligands, soluble and membrane-bound receptors. This suggests that combinations of biomarkers may be needed for CRSwNP diagnostics. PMID: 32812533 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

How a small virus changed our world and the special role of anosmia.
Authors: Fokkens WJ Abstract In January 2020 we encountered the first news on a novel coronavirus (SARS-CoV-2) infecting the population of the Chinese city Wuhan and resulting for some patients in a potentially deadly pneumonia. Currently, coronavirus disease 2019 (COVID-19) is spreading rapidly around the globe. For many years we have been warned that we would face a new pandemic, most likely with a zoonotic virus. For COVID-19 it was shown that transmission can occur via droplets and aerosols that can remain in the air for some hours and also via contaminated surfaces. Extra risks have been suggested to exists fo...
Source: Rhinology - August 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Risk factors for postoperative CSF leakage after endonasal endoscopic skull base surgery: a meta-analysis and systematic review.
CONCLUSIONS: This comprehensive quantitative assessment of postoperative CSF leakage showed that obesity, perioperative radiotherapy, and high intraoperative CSF flow rate raised the risk of CSF leakage; however, a pedicled vascularized flap can ef- fectively reduce the risk of postoperative CSF leakage. PMID: 32785296 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 14, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Reduction of postural nasal resistance following oropharyngeal surgery in patients with moderate-severe obstructive sleep apnea.
CONCLUSIONS: Oropharyngeal surgery improves nasal obstruction during sleep and lowers the supine TNR measured in poste- rior rhinomanometry in patients with moderate-severe OSA. Oropharyngeal surgery is a possible treatment for postural nasal obstruction in patients with moderate-severe OSA. PMID: 32779643 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 13, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The Amsterdam Classification of Completeness of Endoscopic Sinus Surgery (ACCESS): a new CT-based scoring system grading the extent of surgery.
CONCLUSIONS: the ACCESS score is an easy-to-use valid tool to assess extent of sinus surgery with an excellent interrater agree- ment. Further validation in a random group of CRS cases is required. PMID: 32720936 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 29, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Systemic medication requirement in post-surgical patients with eosinophilic chronic rhinosinusitis.
CONCLUSION: Pre-operative blood eosinophil count >0.45 x109/L was associated with failure of local therapy following contem- porary management of eCRS. The quantitative value of serum eosinophilia may be a useful predictor of disease progression and those patients in need of systemic therapies, such as biologic agents. PMID: 32720937 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 29, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Role of lncRNA-ENST00000412010 in regulating nasopharyngeal cancer cell survival.
CONCLUSIONS: These findings suggested that lncRNA-ENST00000412010 plays a role in modulating NPC survival and tumorigenesis through regulating molecules associated with cell cycle and protein phosphatase. PMID: 32720938 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 29, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Endotypes of chronic rhinosinusitis with nasal polyps with and without NSAID - intolerance.
CONCLUSION: We identified IL-13 as a possible specific biomarker in nasal secretions of patients with NERD, which allows us to differentiate between CRSwNP with vs. without NERD. The characterization of inflammatory endotypes in CRSwNP enables the introduction of the best available therapy in the context of precision medicine. PMID: 32692786 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 22, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Leukotriene receptor antagonist addition to intranasal steroid: systematic review and meta-analysis.
CONCLUSIONS: The effects of the INCS+LTRA combination are not different from INCS in monotherapy in the improvement of both nasal symptoms and patient's QOL. The combination may, however, be better on improving ocular symptoms. PMID: 32692787 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 22, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The clinical outcomes of medical therapies in chronic rhinosinusitis is independent of microbiomic outcomes: a double-blinded, randomised placebo-controlled trial.
CONCLUSION: Clinical improvement was significant with oral and topical steroid but not empirical antibiotic. Although there were some associated microbiome changes with the various treatments, we could not ascertain the consistency of these and whether they do have a clinical significance at all. PMID: 32692788 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 22, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Predominance of an altered sense of smell or taste among long-lasting symptoms in patients with mildly symptomatic COVID-19.
Authors: Boscolo-Rizzo P, Polesel J, Spinato G, Fabbris C, Menegaldo A, Borsetto D, Hopkins C PMID: 32683438 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 21, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Outcomes of microdebrider-assisted versus radiofrequency-assisted inferior turbinate reduction surgery: a systematic review and meta-analysis of interventional randomised studies.
CONCLUSIONS: The microdebrider-assisted technique results in a better outcome, particularly in long-term follow-up, when compa- red with radiofrequency. PMID: 32679584 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 18, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Compressive stress induces collective migration through cytoskeletal remodelling in nasal polyp epithelium.
CONCLUSION: Taken together, these findings demonstrate that compressive stress on nasal polyp epithelium is capable of inducing collective migration and induce increased expression of genes related to airway inflammation, innate immunity, and polyp remo- delling, even in the absence of inflammatory mediators. PMID: 32666957 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 17, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Extended approach or usage of nasoseptal flap is a risk factor for olfactory dysfunction after endoscopic anterior skullbase surgery: results from 928 patients in a single tertiary center.
CONCLUSIONS: We conclude that NSF was the key factor that led to olfactory impairment after endoscopic skull-base surgery. PMID: 32662778 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 15, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Occupational exposure and the risk of new-onset chronic rhinosinusitis - a prospective study 2013-2018.
CONCLUSION: In this random population cohort from Norway, exposure to several common occupational agents, such as hair-care products, super glue and wood dust, was associated with the onset of CRS. It is important that physicians who see patients with CRS inquire about workplace exposure. PMID: 32645120 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 11, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients.
CONCLUSIONS: Based on this meta-analysis, we recommend self-isolation and testing, where possible, for patients complaining smell or taste impairment during COVID-19 pandemic in order to prevent spread of disease and propose the inclusion of loss of smell and taste as recognized symptoms of SARS-CoV-2 in the World Health Organization and other relevant regulatory body's lists. PMID: 32626853 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 8, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The role of Narrow Band Imaging (NBI) in the diagnosis of sinonasal diseases.
CONCLUSIONS: This is the first study to propose a systematic NBI description and a classification of the vasculature of healthy and pathological mucosa in the sinonasal tract. Our preliminary results show that this technique can help in the workup of several rhinologic conditions and especially in distinguishing benign from malignant tumors. PMID: 32628224 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 8, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Co-morbid anxiety and depression impacts on the correlation between symptom and radiological severity in patients with chronic rhinosinusitis.
CONCLUSION: When CRS patients who do not have anxiety and depression are analysed in isolation, or when these conditions are controlled in a multivariable regression, there is a significant correlation between radiological findings and symptom score. This correlation is absent in patients with co-morbid anxiety and depression. Anxiety and depression should be considered in patients in whom there is a mismatch in symptom and radiological disease severity as it is associated with symptom amplification. PMID: 32609104 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 2, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

FID Score: an effective tool in Hereditary Haemorrhagic Telangiectasia - related epistaxis.
CONCLUSIONS: The FID score is a quick, easy and precise tool for evaluating HHT-related epistaxis and could be a possible alternative to the ESS. The FID score meets the need for an intuitive and smart grading system that is easy to manage in clinicians' hands. PMID: 32584331 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 27, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Zinc-depletion associates with tissue eosinophilia and collagen depletion in chronic rhinosinusitis.
CONCLUSIONS: These results suggest mucosal zinc depletion associates with tissue eosinophilia and collagen depletion in CRSwNP and induces pro-inflammatory cytokine expression and reduction of collagen synthesis in vitro. PMID: 32542237 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 18, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Acute smell and taste loss in outpatients: all infected with SARS-CoV-2?
Authors: Renaud M, Leon A, Trau G, Fath L, Ciftci S, Bensimon Y, Venkatasamy A, Debry C Abstract During SARS-CoV-2 pandemic, our region (Alsace, East of France) became a Covid-19 cluster quite early in Europe. Loss of smell and taste was quickly flagged by the Ears-Nose and Throat scientific community as a potential warning signs of SARS-CoV-2 infection (1). Many patients and medical/paramedical workers with mild to moderate form of SARS-CoV-2 infection complained about their loss of sense of smell and taste to our ENT department. The aim of our study was to compare the characteristics of loss of smell and taste be...
Source: Rhinology - June 18, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The effect of olfactory training on olfactory bulb volumes in patients with idiopathic olfactory loss.
Authors: Mahmut MK, Musch M, Han P, Abolmaali N, Hummel T Abstract Olfactory loss impacts around 20% of the population and is associated with the reduction of pleasure from eating and drinking, sex and depression (1). Encouragingly, research findings have consistently demonstrated that olfactory training (OT) can improve olfactory function in people with olfactory loss due to various aetiologies (2). The most commonly used method for OT involves smelling four different odours (lemon, eucalyptus, rose and cloves), twice daily, for 12 weeks. PMID: 32533766 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 15, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

How I do it: Surgical management of maxillary sinus hemangiomas via prelacrimal approach.
Authors: Tran LV, Le LT, Wormald PJ Abstract Hemangiomas are tumours originating from the vascular endothelium and can be found throughout the body. These are relatively common in the head and neck regions but very rarely seen in sinonasal region. In the nose and sinuses tumours typically are seen on the septum or lateral nasal wall (1-4). These tumours can be quite vascular and bleed during attempted resection. Incomplete resection does result in residual disease or recurrence so the best approach to achieve complete resection is important. PMID: 32533767 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 15, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Time scale for resolution of olfactory dysfunction in COVID-19.
Authors: Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR Abstract By now, the 2019 novel coronavirus disease (COVID-19), caused by the SARS-CoV-2 virus, is widely recognized around the world as a pandemic that has infected millions and claimed the lives of hundreds of thousands (1). Despite months of mitigation strategies, COVID-19 continues to spread and ascertainment of new knowledge about the disease process continues to be a priority of the medical community. Originally described by characteristic symptoms of fever, cough and/or shortness of breath that can rapidly progress to acut...
Source: Rhinology - June 15, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Chronic rhinosinusitis disease control as a metric for guiding treatment.
Authors: Sedaghat A, Hopkins C Abstract The assessment of Chronic Rhinosinusitis, like any other disease, may involve multiple possible disease manifestations, including subjective patient-reported outcomes, objective disease (e.g. endoscopy or radiographic), and physician-driven (e.g. need for systemic medications). Disease control is often used as a global metric of disease burden and represents the extent to which disease manifestations are within an acceptable range. Achieving control is an important treatment goal. PMID: 32500868 [PubMed - in process] (Source: Rhinology)
Source: Rhinology - June 7, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Trigeminal endonasal perception - an outcome predictor for septoplasty.
CONCLUSION: The preoperative evaluation of the trigeminal sensitivity could improve patients' selection for septoplasty with a higher rate of satisfaction. Endonasal trigeminal sensitivity is directly linked with subjective outcome. Therefore, patients with low trigeminal sensitivity should undergo septoplasty only after thorough counselling. PMID: 32500869 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 7, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Scoping review of chronic rhinosinusitis proteomics.
CONCLUSIONS: Alterations in the healthy sinonasal proteome may lead to the increased immunological, metabolic and tissue remodeling processes observed in CRS. However, it is difficult to draw significant conclusions from the GSEA due to the heterogeneity present in the limited literature available. These findings allow us to direct further research to better understand CRS pathogenesis and its endotypes. PMID: 32500870 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 7, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Faster olfactory adaptation in patients with olfactory deficits: an analysis of results from odor threshold testing.
CONCLUSION: People with poor olfaction seem to adapt faster to olfactory stimuli. The trajectory of turning points in odor threshold test may serve as an indicator of olfactory adaptation and function of olfactory receptors. Olfactory adaptation may provide a new tool in the assessment of subtle olfactory loss. PMID: 32478337 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 2, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

High-mobility group box 1 protein induces epithelialmesenchymal transition in upper airway epithelial cells.
CONCLUSION: HMGB1 secretion in nasal epithelium may be a major pathogenic factor in upper respiratory EMT, contributing to nasal polyps. PMID: 32478338 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 2, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Executive summary of EPOS 2020 including integrated care pathways.
Authors: Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitzma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J Abstract The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012(1-3). The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses ar...
Source: Rhinology - June 1, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

The use of throat packs in ear, nose and throat, oral and dental surgery: a systematic review.
CONCLUSION: The study was limited by methodological flaws of included trials, overall relatively low numbers of patients and difficulty in contacting authors to clarify information and obtain raw data. However, this systematic review found no evidence to support the use of throat packs. This supports the proposal that there is no indication for the routine use of throat packs in ENT, maxillofacial and dental procedures. PMID: 32452470 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 28, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Prediction of malignant sinonasal inverted papilloma transformation by preoperative computed tomography and magnetic resonance imaging.
CONCLUSIONS: Of the independent risk factors and related combination identified, the nomogram model based on bone destruction on CT, CCP mutation on MRI, and washout-type TIC of DCE-MRI had the best predictive value for malignant transformation of SNIP. PMID: 32441707 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 23, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research

Using 3D printed sinonasal models to visualize and optimize personalized sinonasal sinus irrigation strategies.
CONCLUSION: With more affordable 3D printing, this technology may potentially improve patient care and patient education, allowing clinicians and patients to develop a personalized irrigation strategy and have visual confirmation. PMID: 32441708 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 23, 2020 Category: ENT & OMF Tags: Rhinology Source Type: research