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The new agreement of the international RIGA consensus conference on nasal airway function tests.
Authors: Vogt K, Bachmann-Harildstad G, Lintermann A, Nechyporenko A, Peters F, Wernecke KD Abstract The report reflects an agreement based on the consensus conference of the International Standardization Committee on the Objective Assessment of the Nasal Airway in Riga, 2nd Nov. 2016. The aim of the conference was to address the existing nasal airway function tests and to take into account physical, mathematical and technical correctness as a base of international standardization as well as the requirements of the Council Directive 93/42/EEC of 14 June 1993 concerning medical devices. Rhinomanometry, acoustic rhin...
Source: Rhinology - January 22, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

Analysis of taste function in patients before and after cochlear implant surgery.
CONCLUSION: CI candidates exhibited taste and olfactory dysfunction already preoperatively. Furthermore, a significant decrease in taste scores after CI surgery was detected. PMID: 29306957 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 9, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

Case-control study of endoscopic polypectomy in clinic (EPIC) versus endoscopic sinus surgery for chronic rhinosinusitis with polyps.
CONCLUSIONS: In appropriate CRSwNP patients, the EPIC procedure may provide disease specific quality of life improvement similar to that seen with patients who undergo traditional ESS. PMID: 29306958 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 9, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

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CONCLUSIONS: The authors hope inclusion of these core outcomes in future trials will increase the value of research on interventions for CRS in adults. It was felt important to make recommendations regarding how these outcomes should be measured, although additional work is now required to further develop and revalidate existing outcome measures. PMID: 29306959 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 9, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

Decreased electrogustometric taste sensitivity in patients with acquired olfactory dysfunction.
CONCLUSION: Patients with olfactory dysfunction showed decreased taste sensitivity which suggested an interaction between the chemical senses taste, trigeminal function, and olfaction. This provides the basis for including both smell and taste psychophysical assessment in clinical practices. In addition, patients with taste loss appeared to suffer most from chemosensory dysfunction. PMID: 29306960 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 9, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

Outcomes of sphenopalatine and internal maxillary artery ligation inside the pterygopalatine fossa for posterior epistaxis.
CONCLUSIONS: Dual SPA and IMAX ligation is effective in the control of difficult epistaxis cases, even in those patients with prior surgical intervention. PMID: 29292416 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 3, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

How deep is the inflammation in chronic rhinosinusitis? Sinus wall thickness and blood eosinophilia.
Authors: Lin KY, Chen PY, Yeh TH Abstract Various factors have been proposed to be related to refractory chronic rhinosinusitis (CRS). Treatment for refractory CRS is challenging for ear, nose, and throat (ENT) surgeons. The aim of the study was to determine the clinical features associated with the severity of CRS that may necessitate revision surgery by eliminating the bias of the surgeons technique using standardizing surgical procedures. Sinus wall thickness and blood eosinophilia, which may represent the depth of inflammation in CRS, are associated with the need for revision surgery. We found that, when the th...
Source: Rhinology - January 2, 2018 Category: ENT & OMF Tags: Rhinology Source Type: research

Omalizumab treats chronic rhinosinusitis with nasal polyps and asthma together-a real life study.
CONCLUSION: Omalizumab treatment for severe allergic asthma also improves co-existent CRSwNP. Further clinical studies of current and emerging biological agents for severe asthma should include upper airway outcomes. These agents may be effective for severe CRSwNP and comparative studies with surgery are warranted. PMID: 29288573 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - December 31, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Functional anatomy of the nasal bones and adjacent structures. Consequences for nasal surgery.
Authors: Popko M, Verlinde-Schellekens SAMW, Huizing EH, Bleys RLAW Abstract The periosteum of the nasal bones, the periosteal-perichondrial nasal envelope, and the cartilaginous support of the bony vault were studied in serial coronal sections of four human cadaver noses. To differentiate between the various tissue components, the sections were stained according to Mallory-Cason and Verhoeff-Van Gieson stain. The results demonstrated: 1. the presence of clearly distinguishable layers of the periosteum covering the nasal bones; 2. the presence of a continuous periosteal-perichondrial covering of the bony and cartil...
Source: Rhinology - December 30, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

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CONCLUSIONS: The available evidence suggests that intranasal bevacizumab treatment does not have a significant effect on epistaxis in patients with HHT. There are several limitations that require further investigation to confidently rule out local bevacizumab as an effective therapy in HHT related epistaxis. PMID: 29166422 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Exhaled and nasal nitric oxide in chronic rhinosinusitis patients with nasal polyps in primary care.
CONCLUSION: Subclinical eosinophilic lower airway inflammation is common in CRSwNP in the primary sector, even in the absence of asthma. PMID: 29166423 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The future in Rhinology: from local treatment, to monoclonals and influencing the microbiome.
Authors: Fokkens WJ Abstract Over the last few decades, rhinology has been one of the most dynamic and progressive areas of ENT. We have not experienced such an intense period of development since the introduction of nasal corticosteroids in the 1970s. PMID: 29166424 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Anatomy of the sphenopalatine artery and its implications for transnasal neurosurgery.
CONCLUSIONS: The triangular bony structure is a landmark to find and differentiate the posterior lateral nasal and posterior septal branches of the sphenopalatine artery and to identify the sphenoid sinus. PMID: 29166425 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Rhinology Future Debates, an EUFOREA Report.
Authors: Fokkens WJ, Bachert C, Bernal-Sprekelsen M, Bousquet J, Djandji M, Dorenbaum A, Hakimi-Mehr D, Hendry S, Hopkins C, Leunig A, Mannent L, Mucha D, Onerci M, Pugin B, Toppila-Salmi S, Rowe P, Seys SF, Stimson S, Strzembosz A, Hellings PW Abstract The first Rhinology Future Debates was held in Brussels in December 2016, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases). The purpose of these debates is to bring novel developments in the field of Rhinology to the attention of the medical, paramedical and patient community, in a highly credible and balanced context....
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Prospective evaluation of a nonsurgical device for rhinoplasty.
CONCLUSIONS: Considering the results of this study, we conclude that this perfectly customised external device to enhance surgical rhinoplasty outcomes or correct the shape of the nose without surgery does not seem to be effective and that further investigations in this field are not meaningful. PMID: 29150922 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 20, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Lateral lamella of the cribriform plate, a keystone landmark: proposal for a novel classification system.
CONCLUSIONS: This angle classification is based on the theoretical risk of iatrogenic injuries, but it could be helpful also in clinical practice by providing indirect information on the thickness of the anterior skull base. As the angle decreases, in fact, the portion of the anterior skull base composed by the LLCP, increases. PMID: 29069120 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 28, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Comparison between unilateral PNIF and rhinomanometry in the evaluation of nasal cycle.
CONCLUSIONS: Nasal cycle can be easily assessed by means of PNIF. In fact, AAR and PNIF showed a reasonable correlation in the measurement of nasal cycle, although PNIF offered a lower variability. Reciprocal and in-phase patterns of the nasal cycle were equally distributed in our population. PMID: 29055966 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The fate of the bone graft in cerebrospinal fluid rhinorrhea endoscopic repair for idiopathic intracranial hypertension: a retrospective case series analysis.
CONCLUSIONS: Bone grafts frequently incorporate when used for repair of spontaneous CSF leaks associated with IIH. The rate of incorporation is comparable to bone grafts used for other etiologies of CSF leak, despite the increased pressure on the repair site. Any rigid repair of the leak site should likely be accompanied by treatment of the underlying intracranial hypertension to avoid leak recurrence. PMID: 29055142 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 23, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Moving beyond descriptions of diversity: clinical and research implications of bacterial imbalance in chronic rhinosinusitis.
Authors: Wagner Mackenzie B, Waite DW, Hoggard M, Taylor MW, Biswas K, Douglas RG Abstract Chronic rhinosinusitis (CRS) is a debilitating disease which affects 5-16% of the general population and involves long-term inflammation of the sinonasal cavity. While microbial involvement in the pathogenesis of CRS has long been suspected, the exact role of microbes remains unclear. Recent application of cultivation-independent, molecular methods has provided much new information, taking advantage of developments in both laboratory- and bioinformatics-based analyses. The aim of this mini-review is to present a variety of av...
Source: Rhinology - October 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

A straight choice: avoiding septal re-deviation using titanium plates. A 16 year retrospective patient follow-up evaluation.
CONCLUSIONS: The use of titanium plate for septoplasty has shown to be simple, safe, and easy to learn technique in both secondary and select cases of primary septoplasty. Most importantly the results indicate a long term prevention of the. PMID: 28988259 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The significance of Computed Tomography in invasive paranasal mucormycosis.
CONCLUSION: Bony erosion on paranasal CT is an exceptionally insensitive radiologic sign for establishing or rejecting the diagnosis of Mucor induced AIFR. The mainstay of confirming or rejecting the diagnosis of AIFR is by physical examination, endoscopy and oriented biopsy of suspicious mucosal lesions. PMID: 28988260 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - October 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

P-AzeFlu provides rapid and effective allergic rhinitis control: results of a non-interventional study in Romania.
CONCLUSIONS: MP-AzeFlu provided rapid, effective and sustained AR symptom control in a real-life setting in Romania, irrespective of severity, phenotype or patient age, aligning with ARIA and EU recommendations and supporting the position of MP-AzeFlu as the drug of choice for the treatment of moderate-to-severe AR. PMID: 28942457 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 25, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Orbital floor fracture repair: the endonasal approach.
Authors: Kuhnel T, Jagle H, Hosemann W, Weber R, Vielsmeier V Abstract To avoid the dangers associated with lower eyelid approaches to the orbital floor and to improve visualization, we propose an endoscopic procedure for orbital floor fracture reduction and osteosynthesis using endonasal access via the medial maxillary sinus wall. The technique of endoscopic, endonasal transantral surgery is described, together with a retrospective analysis of 17 patients who had undergone this surgical procedure in the Department of Otorhinolaryngology, University of Regensburg, between July 2013 and June 2016. Fractures without ...
Source: Rhinology - September 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Allergy rhinitis: similarities and differences between children and adults.
CONCLUSIONS: AR in children was more intermittent, severe, with less symptoms but with more comorbidities than in adults. These results suggest AR has similarities but also significant differences between children and adults. PMID: 28887880 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Airflow and symptom outcomes between allergic and non-allergic rhinitis patients from turbinoplasty.
CONCLUSIONS: Both AR and NAR patients gained benefit from surgery to relieve nasal obstruction. AR patients demonstrate greater improvement in GNF score but allergy management may contribute to this. PMID: 28888024 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Comparison of different endoscopic scoring systems in patients with chronic rhinosinusitis: reliability, validity, responsiveness and correlation.
CONCLUSION: MLK and DIP exhibit substantial responsiveness, validity and reliability. MLK and DIP may be well suited for clinical and research use. PMID: 28888025 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

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CONCLUSION: Excellent local control is achievable for patients with NCSCC, especially with radical tumor resection. While cervical lymph node metastasis is rare at the time of diagnosis, regional lymph node recurrence needs to be taken into consideration when planning therapy and follow-up. Multimodal treatment of the neck may be required for patients with advanced stage tumors. PMID: 28888026 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 11, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Paving the future of rhinosinusitis care.
Authors: Hellings PW Abstract Novel insights into the pathophysiology of chronic rhinosinsusitis (CRS) will lead to endo-type driven treatment and reduce oral corticosteroid treatment. PMID: 28865115 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 4, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The comparison of nasal surgery and CPAP on daytime sleepiness in patients with OSAS.
DISCUSSION: These findings suggest that the results of the nasal surgery is more satisfactory for some patients with OSAS than CPAP on daytime sleepiness. PMID: 28865140 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - September 4, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Risk factors for epistaxis in patients followed in general practices in Germany.
CONCLUSIONS: Overall, epistaxis risk is increased by multiple medical and psychiatric disorders. Several antithrombotic and nasal steroid therapies are also associated with this risk.</p&gt. PMID: 28821888 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - August 21, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Allergic inflammation is exacerbated by allergen-induced type 2 innate lymphoid cells in a murine model of allergic rhinitis.
CONCLUSION: These findings show that ILC2s play a proinflammatory role in the murine AR model, and also highlight ILC2s as a new target in the future AR therapy. PMID: 28689218 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 10, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The persistence of intracellular Staphylococcus aureus in the sinuses: a longitudinal study.
CONCLUSIONS: This study demonstrated that S. aureus is found intracellularly within CRSwNP tissue at multiple time points without an increase in the number of eosinophils, lymphocytes and neutrophils. This finding supports our hypothesis that ICSA is able to escape from host detection and resides within the sinonasal mucosa despite intense treatment. PMID: 28687814 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 9, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Postoperative long-term morbidity of extended endoscopic maxillectomy for inverted papilloma.
CONCLUSIONS: Although nasal function outcomes and the results from SNOT-22 questionnaires were favourable, a high rate of neurologic and lacrimal complications was observed. Potential morbidity of the intervention, including the possibility of negative aesthetic sequelae, should be discussed during preoperative counselling. PMID: 28687815 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 9, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Periostin as a marker of mucosal remodelling in chronic rhinosinusitis.
CONCLUSION: Periostin expression was associated with the presence of BMT, fibrosis and tissue eosinophilia and may identify patients undergoing remodelling changes. PMID: 28667737 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - July 3, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Misdiagnosed paranasal gossypiboma: a 10-year experience with 21 cases at a tertiary center.
CONCLUSIONS: A history of endoscopic nasal surgery, especially performed at a primary hospital, is a warning sign for clinicians. Computed tomography can add to the warning by showing a heterogeneous cystic lesion with a thin calcified shell. Clinicians should be aware of these characteristics to avoid misdiagnosing paranasal gossypiboma. PMID: 28647750 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 26, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Chronic rhinosinusitis severity is associated with need for asthma-related systemic corticosteroids.
CONCLUSIONS: CRS symptom severity is associated with past asthma-related oral corticosteroid use. SNOT-22 scores may be used as a versatile tool to screen for past asthma-related oral corticosteroid use in asthmatic CRS patients - i.e. those at greatest risk from their asthma - with either high sensitivity or high specificity. PMID: 28647751 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 26, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Position paper on olfactory dysfunction.
CONCLUSIONS: We hope the current manuscript will encourage clinicians and researchers to adopt a common language, and in so doing, increase the methodological quality, consistency and generalisability of work in this field. PMID: 28623665 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 19, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The effect of endoscopic sinus surgery on quality of life and absenteeism in patients with chronic rhinosinuitis - a multi-centre study.
CONCLUSIONS: This prospective study showed that ESS significantly improved the HRQOL and decreased absenteeism of patients with CRSw/sNP. Shorter duration of disease and Need to blow nose and Blockage/congestion of nose of SNOT-22 were identified as predictive factors for good surgical outcome. PMID: 28624844 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - June 19, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Blocked noses.
Authors: Fokkens WJ Abstract This issue of our Journal contains interesting papers about blocked noses. Nasal obstruction is one of the most common reasons that patients visit their doctors, general practitioners and otorhinolaryngologists alike and has a significant impact on the quality of life of patients. Blockage is an important outcome of disease not only in nasal disease, but also in rhinosinusitis. PMID: 28604844 [PubMed - in process] (Source: Rhinology)
Source: Rhinology - June 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The effect of systemic treatments on periostin expression reflects their interference with the eosinophilic inflammation in chronic rhinosinusitis with nasal polyps.
CONCLUSION: All treatment options distinctly influence periostin expression, reflecting the interference with the local or systemic eosinophilic inflammatory cascade. PMID: 28501884 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 16, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis.
This report provides a concise summary of the outcomes of the brainstorming sessions of the European Rhinology Research Forum 2016. PMID: 28501885 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 16, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Rhinophototherapy in chronic rhinosinusitis: a double blind randomized placebo-controlled trial.
CONCLUSIONS: The present data suggest that rhinophototherapy is not an efficient treatment for chronic rhinosinusitis without nasal polyps. PMID: 28501886 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 16, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Sinonasal symptom-related sleep disorders before and after surgery for nasal polyposis.
CONCLUSION: Nasalization improved sleep quality significantly at 6 weeks and at 7 months after surgery. However, there was a mild increase of complaints related to postnasal discharge and cough at 7 months after surgery. PMID: 28492608 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The risk of osteoporosis in oral steroid treatment for nasal polyposis: a systematic review.
CONCLUSIONS: Registry studies and randomized controlled trials would be needed to assess the risk of osteoporosis in CRSwNP patients and future guidelines should include recommendations regarding preventive treatment and recommendations on doses and durations of oral steroids. PMID: 28492609 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Nasal cytology in children: scraping or swabbing?
Authors: Pipolo C, Bianchini S, Barberi S, Landi M, D'auria S, Fuccillo E, Gaffuri M, Marchisio P, Rosazza C, Saibene AM, Gelardi M, Torretta S Abstract Nasal cytology has become a valuable tool in the assessment of a multitude of nasal pathologies in children. Collection methods differ significantly and even though the use of the nasal curette is regarded as the most reliable in adults, most practitioners use the nasal swab in children. However, no studies have validated the reliability and supposed better tolerability of the latter. We have compared these two sampling methods regarding their tolerability and anal...
Source: Rhinology - May 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

The effect of topical treatments for CRS on the sinonasal epithelial barrier.
CONCLUSIONS: Our findings confirm that isotonic and hypertonic saline solutions do not compromise epithelial barrier function in vitro but underscore the importance of examining safety and efficacy of over-the-counter wash solutions. PMID: 28492611 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

A prospective, randomized clinical study comparing drug eluting stent therapy and intranasal corticoid steroid therapy in the treatment of patients with chronic rhinosinusitis.
CONCLUSION: We found that patients benefitted from DES and the corticosteroid nasal spray. We could not find any significant difference between the treatments, except the greater increase in the total nasal cavity volumes favouring the nasal spray group. Because of the very good results for the nasal spray and the much higher material and operating room costs associated with DES, we cannot recommend the use of DES over nasal spray as a monotherapeutic treatment for CRS. PMID: 28492612 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - May 13, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Prospective open-label evaluation of long-term low-dose doxycycline for difficult-to-treat chronic rhinosinusitis with nasal polyps.
CONCLUSION: These findings suggest that doxycycline may have a beneficial role for CRSwNP patients, especially for patients without asthma, NERD or high levels of serum IgE before treatment. PMID: 28434014 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - April 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Low lymphatic vessel density associates with chronic rhinosinusitis with nasal polyps.
CONCLUSION: In the nasal cavity, the low absolute and relative density of vessels and of lymphatic vessels was associated with CRSwNP and ACP tissues compared to control inferior turbinate. This was observed also in the inflammatory hotspot area. In the maxillary sinus, lower absolute and relative density of lymphatic vessels associated with the CRSwNP phenotype. High lymphatic vessel density in polyp tissue associated with the need for revision CRS-surgery. As a conclusion, low density of lymphatic vessels distinguished patients with CRSwNP not only in the hotspot area of polyp tissue, but also in maxillary sinus mucosa. ...
Source: Rhinology - April 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Chronic rhinosinusitis and mood disturbance.
CONCLUSIONS: Depression and anxiety are significantly more common in patients with CRS compared to healthy controls, especially in those with CRSsNPs. This added mental health morbidity needs consideration when managing these patients in primary and secondary care settings. PMID: 28434016 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - April 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research