National Trends in the Incidence of Sporadic Malignant Colorectal Polyps in Young Patients (20-49 Years): An 18-Year SEER Database Analysis
Conclusions: Our findings suggest that almost half of the SMPs under 50 years occurred in individuals under age 45, younger than the current screening threshold recommended by the ACP. There has been an upward trend in malignant polyps in the last two decades. This reflects changes in tumor biology, and necessitates further research and support in the USPSTF guidelines to start screening at the age of 45 years.PMID:38674319 | PMC:PMC11052004 | DOI:10.3390/medicina60040673 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mark M Aloysius Tejas Nikumbh Lekha Yadukumar Udit Asija Niraj J Shah Ganesh Aswath Savio John Hemant Goyal Source Type: research
Evaluation and Management of Malignant Colorectal Polyps
Surg Clin North Am. 2024 Jun;104(3):701-709. doi: 10.1016/j.suc.2023.12.007. Epub 2023 Dec 26.ABSTRACTThe detection rate of dysplastic colorectal polyps has significantly increased with improved screening programs. Treatment of dysplastic polyps attempt to limit morbidity of a procedure while also considering the risk of occult lymph node metastasis. Therefore, a variety of methods have been developed to predict the rate of lymph node metastasis to help identify the optimal treatment of patients. These include both the endoscopic and pathologic assessment of the lesion. In order to reduce the morbidity of surgery for patie...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Sarah Becker Jessica Yu Vassiliki Liana Tsikitis Source Type: research
National Trends in the Incidence of Sporadic Malignant Colorectal Polyps in Young Patients (20-49 Years): An 18-Year SEER Database Analysis
Conclusions: Our findings suggest that almost half of the SMPs under 50 years occurred in individuals under age 45, younger than the current screening threshold recommended by the ACP. There has been an upward trend in malignant polyps in the last two decades. This reflects changes in tumor biology, and necessitates further research and support in the USPSTF guidelines to start screening at the age of 45 years.PMID:38674319 | PMC:PMC11052004 | DOI:10.3390/medicina60040673 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mark M Aloysius Tejas Nikumbh Lekha Yadukumar Udit Asija Niraj J Shah Ganesh Aswath Savio John Hemant Goyal Source Type: research
Evaluation and Management of Malignant Colorectal Polyps
Surg Clin North Am. 2024 Jun;104(3):701-709. doi: 10.1016/j.suc.2023.12.007. Epub 2023 Dec 26.ABSTRACTThe detection rate of dysplastic colorectal polyps has significantly increased with improved screening programs. Treatment of dysplastic polyps attempt to limit morbidity of a procedure while also considering the risk of occult lymph node metastasis. Therefore, a variety of methods have been developed to predict the rate of lymph node metastasis to help identify the optimal treatment of patients. These include both the endoscopic and pathologic assessment of the lesion. In order to reduce the morbidity of surgery for patie...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Sarah Becker Jessica Yu Vassiliki Liana Tsikitis Source Type: research
Evaluation and Management of Malignant Colorectal Polyps
Surg Clin North Am. 2024 Jun;104(3):701-709. doi: 10.1016/j.suc.2023.12.007. Epub 2023 Dec 26.ABSTRACTThe detection rate of dysplastic colorectal polyps has significantly increased with improved screening programs. Treatment of dysplastic polyps attempt to limit morbidity of a procedure while also considering the risk of occult lymph node metastasis. Therefore, a variety of methods have been developed to predict the rate of lymph node metastasis to help identify the optimal treatment of patients. These include both the endoscopic and pathologic assessment of the lesion. In order to reduce the morbidity of surgery for patie...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Sarah Becker Jessica Yu Vassiliki Liana Tsikitis Source Type: research
National Trends in the Incidence of Sporadic Malignant Colorectal Polyps in Young Patients (20-49 Years): An 18-Year SEER Database Analysis
Conclusions: Our findings suggest that almost half of the SMPs under 50 years occurred in individuals under age 45, younger than the current screening threshold recommended by the ACP. There has been an upward trend in malignant polyps in the last two decades. This reflects changes in tumor biology, and necessitates further research and support in the USPSTF guidelines to start screening at the age of 45 years.PMID:38674319 | PMC:PMC11052004 | DOI:10.3390/medicina60040673 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mark M Aloysius Tejas Nikumbh Lekha Yadukumar Udit Asija Niraj J Shah Ganesh Aswath Savio John Hemant Goyal Source Type: research
Evaluation and Management of Malignant Colorectal Polyps
Surg Clin North Am. 2024 Jun;104(3):701-709. doi: 10.1016/j.suc.2023.12.007. Epub 2023 Dec 26.ABSTRACTThe detection rate of dysplastic colorectal polyps has significantly increased with improved screening programs. Treatment of dysplastic polyps attempt to limit morbidity of a procedure while also considering the risk of occult lymph node metastasis. Therefore, a variety of methods have been developed to predict the rate of lymph node metastasis to help identify the optimal treatment of patients. These include both the endoscopic and pathologic assessment of the lesion. In order to reduce the morbidity of surgery for patie...
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Sarah Becker Jessica Yu Vassiliki Liana Tsikitis Source Type: research
National Trends in the Incidence of Sporadic Malignant Colorectal Polyps in Young Patients (20-49 Years): An 18-Year SEER Database Analysis
Conclusions: Our findings suggest that almost half of the SMPs under 50 years occurred in individuals under age 45, younger than the current screening threshold recommended by the ACP. There has been an upward trend in malignant polyps in the last two decades. This reflects changes in tumor biology, and necessitates further research and support in the USPSTF guidelines to start screening at the age of 45 years.PMID:38674319 | PMC:PMC11052004 | DOI:10.3390/medicina60040673 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mark M Aloysius Tejas Nikumbh Lekha Yadukumar Udit Asija Niraj J Shah Ganesh Aswath Savio John Hemant Goyal Source Type: research
Altered mucosal bacteria and metabolomics in patients with Peutz –Jeghers syndrome
ConclusionThis is the first report on the mucosa-associated microbiota and metabolite profile of subjects with PJS, which may be meaningful to provide a structural basis for further research on intestinal microecology in PJS. (Source: Gut Pathogens)
Source: Gut Pathogens - April 27, 2024 Category: Microbiology Source Type: research
Butyrate inhibits type 2 inflammation in eosinophilic chronic rhinosinusitis
Biochem Biophys Res Commun. 2024 Apr 18;714:149967. doi: 10.1016/j.bbrc.2024.149967. Online ahead of print.ABSTRACTButyrate and other Short-chain fatty acids (SCFAs) are microbial metabolites from Bacteroides and Clostridium species that may suppress type 2 inflammation. However, the mechanisms of SCFAs in the nasal sinuses are not fully understood. We aimed to clarify the in vitro and in vivo roles of SCFAs in eosinophilic chronic rhinosinusitis (ECRS) pathophysiology. We investigated whether SCFAs induced changes in type 2 cytokines, IgE, and apoptosis and the roles of GPR41, GPR43, and histone deacetylase. Analysis of t...
Source: Biochemical and Biophysical Research communications - April 26, 2024 Category: Biochemistry Authors: Masatomo Toyama Hideaki Kouzaki Takeshi Shimizu Hitoshi Hirakawa Mikio Suzuki Source Type: research
Butyrate inhibits type 2 inflammation in eosinophilic chronic rhinosinusitis
Biochem Biophys Res Commun. 2024 Apr 18;714:149967. doi: 10.1016/j.bbrc.2024.149967. Online ahead of print.ABSTRACTButyrate and other Short-chain fatty acids (SCFAs) are microbial metabolites from Bacteroides and Clostridium species that may suppress type 2 inflammation. However, the mechanisms of SCFAs in the nasal sinuses are not fully understood. We aimed to clarify the in vitro and in vivo roles of SCFAs in eosinophilic chronic rhinosinusitis (ECRS) pathophysiology. We investigated whether SCFAs induced changes in type 2 cytokines, IgE, and apoptosis and the roles of GPR41, GPR43, and histone deacetylase. Analysis of t...
Source: Biochemical and Biophysical Research communications - April 26, 2024 Category: Biochemistry Authors: Masatomo Toyama Hideaki Kouzaki Takeshi Shimizu Hitoshi Hirakawa Mikio Suzuki Source Type: research
IJERPH, Vol. 21, Pages 552: Clinical Outcomes from the Alaska Native Tribal Health Consortium Colorectal Cancer Control Program: 2009 & ndash;2015
IJERPH, Vol. 21, Pages 552: Clinical Outcomes from the Alaska Native Tribal Health Consortium Colorectal Cancer Control Program: 2009–2015
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph21050552
Authors:
Nash
Verhage
Flanagan
Haverkamp
Roik
Zimpelman
Redwood
The Alaska Native Tribal Health Consortium (ANTHC) participated in the United States Centers for Disease Control and Prevention Colorectal Cancer Control Program (CRCCP) from 2009 to 2015. We conducted a descriptive evaluation of ANTHC CRCCP demographics, quality measures, and clinical outcomes,...
Source: International Journal of Environmental Research and Public Health - April 26, 2024 Category: Environmental Health Authors: Nash Verhage Flanagan Haverkamp Roik Zimpelman Redwood Tags: Article Source Type: research
UViT-Seg: An Efficient ViT and U-Net-Based Framework for Accurate Colorectal Polyp Segmentation in Colonoscopy and WCE Images
AbstractColorectal cancer (CRC) stands out as one of the most prevalent global cancers. The accurate localization of colorectal polyps in endoscopy images is pivotal for timely detection and removal, contributing significantly to CRC prevention. The manual analysis of images generated by gastrointestinal screening technologies poses a tedious task for doctors. Therefore, computer vision-assisted cancer detection could serve as an efficient tool for polyp segmentation. Numerous efforts have been dedicated to automating polyp localization, with the majority of studies relying on convolutional neural networks (CNNs) to learn ...
Source: Journal of Digital Imaging - April 26, 2024 Category: Radiology Source Type: research
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024
Endoscopy DOI: 10.1055/a-2304-3219
1 ESGE recommends cold snare polypectomy (CSP), to include a clear margin of normal tissue (1–2 mm) surrounding the polyp, for the removal of diminutive polyps (≤ 5 mm).Strong recommendation, high quality of evidence.
2 ESGE recommends against the use of cold biopsy forceps excision because of its high rate of incomplete resection.Strong recommendation, moderate quality of evidence.
3 ESGE recommends CSP, to include a clear margin of normal tissue (1–2 mm) surrounding the polyp, for the removal of small polyps (6–9 mm).Strong recommendation, high qua...
Source: Endoscopy - April 26, 2024 Category: Gastroenterology Authors: Ferlitsch, Monika Hassan, Cesare Bisschops, Raf Bhandari, Pradeep Dinis-Ribeiro, M ário Risio, Mauro Paspatis, Gregorios A. Moss, Alan Lib ânio, Diogo Lorenzo-Z úñiga, Vincente Voiosu, Andrei M. Rutter, Matthew D. Pellis é, Maria Moons, Leon M. G. Pr Tags: Guideline Source Type: research
The volumetric ADC histogram analysis in differentiating stage IA endometrial carcinoma from endometrial polyp
CONCLUSIONS: The volumetric ADC histogram analysis was an effective method in differentiating endometrial carcinoma from an endometrial polyp. The 25th percentile of ADC values has satisfactory performance for detecting malignancy in the endometrium.ADVANCES IN KNOWLEDGE: The ADC histogram metric based on whole lesion is a promising imaging-maker in differentiating endometrial benign and malignant lesions.PMID:38662891 | DOI:10.1093/bjr/tqae081 (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - April 25, 2024 Category: Radiology Authors: Yujiao Zhao Cong You Xin Zhou Xiaotian Li Cheng Zhang Yanhong Wu Wen Shen Source Type: research
