Etiology of diarrheal hospitalizations following rotavirus vaccine implementation and association of enteric pathogens with malnutrition among under-five children in India
AbstractMalnourished children are at higher risk of mortality and morbidity following diarrheal illness and certain enteropathogens have been associated with malnutrition in children. Very few studies have comprehensively looked at the etiology of diarrhea in malnourished children and most have used conventional diagnostic methods with suboptimal sensitivity. We used a highly sensitive molecular approach against a broad range of pathogens causing diarrhea and examined their association with malnutrition. In addition, we looked at the pathogen diversity of pediatric diarrhea, three years after the nationwide rotavirus vacci...
Source: Gut Pathogens - April 10, 2024 Category: Microbiology Source Type: research
Genetic evolution and phylogenetic analysis of porcine epidemic diarrhea virus strains circulating in and outside China with reference to a wild type virulent genotype CHYJ130330 reported from Guangdong Province, China
AbstractDuring the last decade, porcine epidemic diarrhea virus has detrimental consequences on swine industry, due to severe outbreaks especially in the suckling piglets. In March 2013, an outbreak was reported on a commercial swine farm in Guangdong Province, Southern China. A wild-type PEDV strain named as CHYJ130330 was identified, complete genome was sequenced and deposited in GenBank (accession no. KJ020932). The molecular epidemiological including evolutionary characteristics and pathogenicity assessment were explored during this study with particular interest and focus to develop this candidate strain for new vacci...
Source: Gut Pathogens - April 8, 2024 Category: Microbiology Source Type: research
Case report: Aberrant fecal microbiota composition of an infant diagnosed with prolonged intestinal botulism
ConclusionThis study brings novel insights into the infant fecal composition associated with intestinal botulism and provides a basis for a more systematic analysis of the gut microbiota of infants diagnosed with botulism. A better understanding of the gut microbial ecology associated with infant botulism may support the development of prophylactic strategies against this life-threatening disease in small babies. (Source: Gut Pathogens)
Source: Gut Pathogens - April 5, 2024 Category: Microbiology Source Type: research
The influence of plant extracts on viability of ST3 and ST7 subtypes of Blastocystis sp.
AbstractBlastocystis sp. is one of the most frequently detected protozoa during stool specimen examination. In the last decade, the studies about the pathogenic potential ofBlastocystis sp. have intensified. Additionally, treatment approaches against this parasite are still disputable. The study aimed to investigate the in vitro activity of the substances of natural origin against two subtypes (ST) ofBlastocystis sp. —ST3 and ST7. Garlic and turmeric extracts exhibited the highest inhibitory effect in relation to the ST3 viability. While horseradish and turmeric were found to be the most effective extracts to the ST7 v...
Source: Gut Pathogens - April 3, 2024 Category: Microbiology Source Type: research
Neutrophil percentage-to-albumin ratio is a new diagnostic marker for spontaneous bacterial peritonitis: a prospective multicenter study
ConclusionsNPAR could be a new, affordable, noninvasive test for diagnosing SBP. (Source: Gut Pathogens)
Source: Gut Pathogens - April 1, 2024 Category: Microbiology Source Type: research
High prevalence of carbapenem resistance and clonal expansion of blaNDM gene in Klebsiella pneumoniae isolates in an Iranian referral pediatric hospital
ConclusionOur study reveals a concerning prevalence of carbapenem resistance inK. pneumoniae isolates. Specifically, the detection of theblaNDM gene in 20% of CRKP isolates, with a significant proportion (82%) observed in isolated CRKP from the ICUs and emergency departments, underscores the potential clonal expansion of these resistant strains within these critical hospital wards. (Source: Gut Pathogens)
Source: Gut Pathogens - March 28, 2024 Category: Microbiology Source Type: research
Constituents of stable commensal microbiota imply diverse colonic epithelial cell reactivity in patients with ulcerative colitis
ConclusionThis study reveals that a substantial part of the gut microbiota remains stable throughout progression of UC. Functional experiments suggest that members of core microbiota –Escherichia coli andPhocaeicola vulgatus – potentially differentially regulate the expression of tight junction gene in the colonic epithelium of UC patients and healthy individuals. (Source: Gut Pathogens)
Source: Gut Pathogens - March 23, 2024 Category: Microbiology Source Type: research
Correction to: 16 S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population
(Source: Gut Pathogens)
Source: Gut Pathogens - March 19, 2024 Category: Microbiology Source Type: research
Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment
ConclusionThese results – which are supported by previous urinary studies of tuberculosis – highlight the importance of gut metabolism and of identifying corresponding microbial metabolites as novel points for the foundation of improved management of TBM patients. (Source: Gut Pathogens)
Source: Gut Pathogens - March 12, 2024 Category: Microbiology Source Type: research
A case –control study of the association between the gut microbiota and colorectal cancer: exploring the roles of diet, stress, and race
ConclusionsOur findings suggest that microbiome-CRC associations may differ by racial group. Additional large, racially diverse population-based studies are needed to determine if previously identified associations between characteristics of the gut microbiome and CRC are generalizable to Black women and other racial, ethnic, and gender groups. (Source: Gut Pathogens)
Source: Gut Pathogens - March 11, 2024 Category: Microbiology Source Type: research
Identification of enterotype and its predictive value for patients with colorectal cancer
ConclusionThis study provides the first evidence to indicate that changes in the microbial composition of enterotypes are associated with disease status, thereby highlighting the diagnostic potential of enterotypes in the treatment of adenoma and CRC. (Source: Gut Pathogens)
Source: Gut Pathogens - February 27, 2024 Category: Microbiology Source Type: research
TRS-PCR profiles correlate with polymorphisms of the genomic o454-nlpD region, virulence factors repertoire, and phylogenetic groups among uropathogenic Escherichia coli strains isolated from patients from Lodz region, Poland
In this study, we investigated the presence and distribution of theo454-nlpD genomic polymorphism in our collection of 124 uropathogenicE. coli strains, examining the correlation ofo454-nlpD region types with the virulence factors studied. Our findings revealed a positive association between certain virulence factors in UPEC strains and the presence of pattern III in theo454-nlpD region. Additionally, all these strains were classified under phylogenetic group B2. We also showed that the highly pathogenic group ofE. coli identified by examining the polymorphism of theo454-nlpD region coincides with the highly pathogenic gro...
Source: Gut Pathogens - February 23, 2024 Category: Microbiology Source Type: research
Timing and clinical risk factors for early acquisition of gut pathogen colonization with multidrug resistant organisms in the intensive care unit
AbstractBackgroundMicrobiome restitution therapies are being developed to prevent gut pathogen colonization among patients in the intensive care unit (ICU) and in other select populations. If preventive therapies are to be effective, they must be administered prior to pathogen acquisition. The timing and risk factors for early acquisition of gut pathogen colonization (within 72 h) are currently unknown and could be helpful to guide ICU trial design.MethodsThis was a prospective cohort study. Patients in the ICU had deep rectal swabs performed within 4 h of ICU admission and exactly 72 h later. Early gut pathogen colon...
Source: Gut Pathogens - February 21, 2024 Category: Microbiology Source Type: research
16S rRNA sequencing analysis of the oral and fecal microbiota in colorectal cancer positives versus colorectal cancer negatives in Iranian population
ConclusionThrough meticulous selection of saliva and stool microbes based on Mean Decrease GINI values and employing logistic regression for saliva and support vector machine models for stool, we successfully developed a microbiota test with heightened sensitivity and specificity for early CRC detection. (Source: Gut Pathogens)
Source: Gut Pathogens - February 20, 2024 Category: Microbiology Source Type: research
Intestinal metabolites predict treatment resistance of patients with depression and anxiety
ConclusionFecal N- ε-acetyllysine levels before treatment may be a predictive biomarker of treatment-refractory depression and anxiety.Odoribacter may play a role in the homeostasis of intestinal L-lysine levels. More attention should be paid to the importance of L-lysine metabolism in those with depression and anxiety. (Source: Gut Pathogens)
Source: Gut Pathogens - February 9, 2024 Category: Microbiology Source Type: research
