A Clinicopathological Study of Aural Polyps: A Retrospective Analysis in a Tertiary Care Hospital
Conclusion A thorough detailed examination and mastoid exploration with radiological and histopathological evaluation is mandatory for better defining the definitive treatment. Utmost care and meticulousness are advised for the surgeons while dealing with aural polyps to avoid any complications. [...] Thieme Revinter Publicações Ltda. Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, BrazilArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: International Archives of Otorhinolaryngology)
Source: International Archives of Otorhinolaryngology - April 12, 2024 Category: ENT & OMF Authors: Prasad, K. C. Indu Varsha, Gopinath Mohammadi, Kouser Gupta, Arjun Jose, Diana Ann Tags: Original Research Source Type: research
Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes
This study examined effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of SPS patients. We also compared with organoids representing the hereditary gastrointestinal syndromes, Familial Adenomatous Polyposis (FAP) and Lynch syndrome (LS). Eighteen total organoid colon cultures were generated from uninvolved colon and polyps in SPS, FAP, LS, and non-syndromic screening colonoscopy patients.BRAF andKRAS mutation status was determined for each culture. Erlotinib (EGFR inhibitor) and sulindac (COX inhibitor) were applied individually and in combination. A 44-target gene cust...
Source: Familial Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research
Oral corticosteroid prescribing practice for chronic rhinosinusitis with nasal polyps among otorhinolaryngologists in Scotland: a nationwide survey
J Laryngol Otol. 2024 Apr 11:1-18. doi: 10.1017/S0022215124000446. Online ahead of print.NO ABSTRACTPMID:38602175 | DOI:10.1017/S0022215124000446 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 11, 2024 Category: ENT & OMF Authors: Rasads Misirovs Gary Hoey Brian Lipworth Richard Green Source Type: research
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps
Biomaterials. 2024 Apr 6;308:122567. doi: 10.1016/j.biomaterials.2024.122567. Online ahead of print.ABSTRACTFrequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue impede penetration of αCD124. Herein, two novel protamine nanoconstructs: allyl glycidyl ether conjugated protamin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jiamin Wu Natalie Jones Po-Han Chao Vanessa Chan Lukas Hohenwarter Angeline Wu Marta Bergamo Cristina Rodr íguez-Rodríguez Katayoun Saatchi Alex Liang Urs O H äfeli Zheng Tan Sarah Hedtrich Lucas J Andrew Shyh-Dar Li Source Type: research
Oral corticosteroid prescribing practice for chronic rhinosinusitis with nasal polyps among otorhinolaryngologists in Scotland: a nationwide survey
J Laryngol Otol. 2024 Apr 11:1-18. doi: 10.1017/S0022215124000446. Online ahead of print.NO ABSTRACTPMID:38602175 | DOI:10.1017/S0022215124000446 (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 11, 2024 Category: ENT & OMF Authors: Rasads Misirovs Gary Hoey Brian Lipworth Richard Green Source Type: research
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps
Biomaterials. 2024 Apr 6;308:122567. doi: 10.1016/j.biomaterials.2024.122567. Online ahead of print.ABSTRACTFrequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue impede penetration of αCD124. Herein, two novel protamine nanoconstructs: allyl glycidyl ether conjugated protamin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jiamin Wu Natalie Jones Po-Han Chao Vanessa Chan Lukas Hohenwarter Angeline Wu Marta Bergamo Cristina Rodr íguez-Rodríguez Katayoun Saatchi Alex Liang Urs O H äfeli Zheng Tan Sarah Hedtrich Lucas J Andrew Shyh-Dar Li Source Type: research
Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps
Biomaterials. 2024 Apr 6;308:122567. doi: 10.1016/j.biomaterials.2024.122567. Online ahead of print.ABSTRACTFrequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue impede penetration of αCD124. Herein, two novel protamine nanoconstructs: allyl glycidyl ether conjugated protamin...
Source: Biomaterials - April 11, 2024 Category: Materials Science Authors: Jiamin Wu Natalie Jones Po-Han Chao Vanessa Chan Lukas Hohenwarter Angeline Wu Marta Bergamo Cristina Rodr íguez-Rodríguez Katayoun Saatchi Alex Liang Urs O H äfeli Zheng Tan Sarah Hedtrich Lucas J Andrew Shyh-Dar Li Source Type: research
Importance of aspirin challenges in patients with NSAID-exacerbated respiratory disease
CONCLUSION: ASA challenges have high sensitivity and specificity. In clinical ASA challenge studies, there is a high concordance between a positive history of NSAID hypersensitivity obtained by rhinologists and the measured data of ASA challenge in patients with CRSwNP and comorbid asthma. Therefore, ASA challenge is primarily indicated in patients with an unclear history of NSAID hypersensitivity.PMID:38597968 | DOI:10.1007/s00106-024-01460-9 (Source: HNO)
Source: HNO - April 10, 2024 Category: ENT & OMF Authors: Ulrike F örster-Ruhrmann Heidi Olze Source Type: research
Identification of neutrophils and eosinophils in upper airway mucosa with immunofluorescence multiplex image cytometry
AbstractCharacterization of inflammation in chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP) is an ongoing research process. To overcome limitations of current cytologic techniques, we investigated whether immunofluorescence multiplex image cytometry could quantify intact neutrophils, eosinophils, and other immune cells in solid upper airway mucosa. We used a four-channel immunofluorescence-microscopy technique for the simultaneous detection of the leukocyte marker CD45, the neutrophil marker myeloperoxidase, two eosinophil markers, i.e., major basic protein and eosinophil peroxidase, and DAPI (4 ′,...
Source: Histochemistry and Cell Biology - April 10, 2024 Category: Biomedical Science Source Type: research
Unrestricted vs 3-day low-residue diet for colonoscopy preparation. Results of a feasibility randomized trial
CONCLUSIONS: It is feasible to test the impact of an unrestricted diet for adequate bowel preparation. Comparable cleansing results were achieved, but the unrestricted diet showed better tolerability.PMID:38591600 | DOI:10.17235/reed.2024.10417/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - April 9, 2024 Category: Gastroenterology Authors: Salvador Machlab Mashlab Eva Mart ínez-Bauer Pilar L ópez Mar ía Del Mar Pujals Fernando Fern ández-Bañares Anna Selva Xavier Calvet Rafel Campo Source Type: research
Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis
Conclusions: We demonstrated the efficacy and safety of thermal ablation after EMR for decreasing recurrence of adenoma.PMID:38592137 | PMC:PMC10932371 | DOI:10.3390/jcm13051298 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Hossein Haghbin Nuruddinkhodja Zakirkhodjaev Rawish Fatima Faisal Kamal Muhammad Aziz Source Type: research
Unrestricted vs 3-day low-residue diet for colonoscopy preparation. Results of a feasibility randomized trial
CONCLUSIONS: It is feasible to test the impact of an unrestricted diet for adequate bowel preparation. Comparable cleansing results were achieved, but the unrestricted diet showed better tolerability.PMID:38591600 | DOI:10.17235/reed.2024.10417/2024 (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - April 9, 2024 Category: Gastroenterology Authors: Salvador Machlab Mashlab Eva Mart ínez-Bauer Pilar L ópez Mar ía Del Mar Pujals Fernando Fern ández-Bañares Anna Selva Xavier Calvet Rafel Campo Source Type: research
