IRF4 Knockdown Inhibits the Chronic Rhinosinusitis Without Nasal Polyps Development by Regulating NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis
Biochem Genet. 2024 Apr 18. doi: 10.1007/s10528-024-10792-8. Online ahead of print.ABSTRACTChronic rhinosinusitis without nasal polyps (CRSsNP) is a CRS phenotype. However, the mechanisms of CRSsNP remains unclear. Differentially expressed genes (DEGs) were obtained from the GSE36830 and GSE198950 datasets through the GEO2R tool. The six hub genes were screened by the protein-protein interaction (PPI) network analysis and Cytoscape software. Then we constructed the mouse models of CRS and verified the expression levels of hub genes by reverse transcription quantitative PCR (RT-qPCR). Hematoxylin-eosin (HE) staining was emp...
Source: Biochemical Genetics - April 18, 2024 Category: Genetics & Stem Cells Authors: Jun Xu Jiahui Li Xiaoya Wang Yunsong An Wenlong Liu Renzhong Luo Changzhi Sun Source Type: research
Early detection of gastrointestinal polyps and neoplasia following radiation for childhood-onset cancer
A massive and rapidly increasing burden of care exists for all physicians caring for the 80–90% of childhood cancer survivors. All paediatricians and general practitioners (GPs) seeing these adolescents must attain a sound knowledge of the risks, current and future, faced by these young people. Provision of improved care and appropriate surveillance during adolescence, with information for adult services at time of transition, will also empower patients and their families to advocate for and act upon the essential requirements for long-term surveillance. Not all these risks are yet commonly recognised. Exposure to ab...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Authors: Atlas, G., Zacharin, M. R. Tags: PostScript Source Type: research
Twenty First Century Technological Toolbox Innovation for Transanal Minimally Invasive Surgery (TAMIS)
Surg Technol Int. 2024 Apr 16;44:sti44/1760. Online ahead of print.ABSTRACTTransanal minimally invasive surgery (TAMIS) is an effective procedure that plays an important role in the care of patients with significant rectal neoplasia and polyps including early-stage cancers. However, it is perhaps underutilised and under threat from both advanced flexible endoscopic procedures and proceduralists (who often act as gatekeepers for referral to colorectal surgeons), as well as from robotic surgery proponents. TAMIS advocates can learn and adopt practice insights from both these fields and incorporate available technological inn...
Source: Surgical Technology International - April 17, 2024 Category: Surgery Authors: Alice Moynihan Patrick Boland Ronan A Cahill Source Type: research
The ring rules the chain - inositol pyrophosphates and the regulation of inorganic polyphosphate
Biochem Soc Trans. 2024 Apr 17:BST20230256. doi: 10.1042/BST20230256. Online ahead of print.ABSTRACTThe maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated with monophosphate and diphosphate moieties, and inorganic polyphosphate (polyP), chains of orthophosphate residues linked by phosphoanhydride bonds, are energy-rich biomolecules that play critical roles in phosphate homeostasis. There is a complex interplay between these two phosphate-rich molecules, and the...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Azmi Khan Manisha Mallick Jayashree S Ladke Rashna Bhandari Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 17:BST20230522. doi: 10.1042/BST20230522. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel c...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
Twenty First Century Technological Toolbox Innovation for Transanal Minimally Invasive Surgery (TAMIS)
Surg Technol Int. 2024 Apr 16;44:sti44/1760. Online ahead of print.ABSTRACTTransanal minimally invasive surgery (TAMIS) is an effective procedure that plays an important role in the care of patients with significant rectal neoplasia and polyps including early-stage cancers. However, it is perhaps underutilised and under threat from both advanced flexible endoscopic procedures and proceduralists (who often act as gatekeepers for referral to colorectal surgeons), as well as from robotic surgery proponents. TAMIS advocates can learn and adopt practice insights from both these fields and incorporate available technological inn...
Source: Surgical Technology International - April 17, 2024 Category: Surgery Authors: Alice Moynihan Patrick Boland Ronan A Cahill Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 17:BST20230522. doi: 10.1042/BST20230522. Online ahead of print.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel c...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
The ring rules the chain - inositol pyrophosphates and the regulation of inorganic polyphosphate
Biochem Soc Trans. 2024 Apr 17:BST20230256. doi: 10.1042/BST20230256. Online ahead of print.ABSTRACTThe maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated with monophosphate and diphosphate moieties, and inorganic polyphosphate (polyP), chains of orthophosphate residues linked by phosphoanhydride bonds, are energy-rich biomolecules that play critical roles in phosphate homeostasis. There is a complex interplay between these two phosphate-rich molecules, and the...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Azmi Khan Manisha Mallick Jayashree S Ladke Rashna Bhandari Source Type: research
Inorganic polyphosphate and ion transport across biological membranes
Biochem Soc Trans. 2024 Apr 24;52(2):671-679. doi: 10.1042/BST20230522.ABSTRACTInorganic polyphosphate (polyP) is widely recognized for playing important roles and processes involved in energy and phosphate storage, regulation of gene expression, and calcium signaling. The less well-known role of polyP is as a direct mediator of ion transport across biological membranes. Here, we will briefly summarize current knowledge of the molecular mechanisms of how polyP can be involved in membrane ion transport. We discuss three types of mechanisms that might involve polyP: (1) formation of non-protein channel complex that includes ...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Yaw Akosah Jingyi Yang Evgeny Pavlov Source Type: research
The ring rules the chain - inositol pyrophosphates and the regulation of inorganic polyphosphate
Biochem Soc Trans. 2024 Apr 24;52(2):567-580. doi: 10.1042/BST20230256.ABSTRACTThe maintenance of phosphate homeostasis serves as a foundation for energy metabolism and signal transduction processes in all living organisms. Inositol pyrophosphates (PP-InsPs), composed of an inositol ring decorated with monophosphate and diphosphate moieties, and inorganic polyphosphate (polyP), chains of orthophosphate residues linked by phosphoanhydride bonds, are energy-rich biomolecules that play critical roles in phosphate homeostasis. There is a complex interplay between these two phosphate-rich molecules, and they share an interdepen...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Azmi Khan Manisha Mallick Jayashree S Ladke Rashna Bhandari Source Type: research
Outcome of Post Functional Endoscopic Sinus Surgery Nasal Irrigation with Normal Saline Versus Normal Saline with Budesonide in Patients with Sinonasal Polyposis: A Randomized Control Trial
In conclusion, saline plus budesonide nasal irrigation is a better option when compared to saline only irrigation in terms of efficacy and therapeutic effect in patients undergoing FESS for CRSwNP, hence, it should be advocated in regular clinical practice. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 17, 2024 Category: ENT & OMF Source Type: research
Rectal gastric heterotopia with fundic gland polyps, mimicking a high-risk primary anorectal neoplasm: histological evidence of the effects of gastric acid-suppressing medication in a rectal ‘outlet patch’
Gastric heterotopia can occur in any part of the gastrointestinal tract but is rare in the rectum. This case of rectal gastric heterotopia is novel as the heterotopic mucosa contained fundic gland polyps, and there were histological changes in the gastric glands characteristic of proton pump inhibitor-related changes. These changes included apocrine-like luminal cytoplasmic protrusions in cystically dilated oxyntic gland parietal cells. These are well described in the native stomachs of PPI treated patients, but this is the first report of these changes in heterotopic gastric mucosa to our knowledge. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 17, 2024 Category: Pathology Authors: Ethan Clarke, Khine Thu, Tim Bracey Tags: Short case Source Type: research
The value of CT radiomics combined with deep transfer learning in predicting the nature of gallbladder polypoid lesions
CONCLUSION: The machine learning radiomics combined with deep learning model based on enhanced CT proves valuable in predicting the characteristics of cholesterol and adenomatous gallbladder polyps. This approach provides a more reliable basis for preoperative diagnosis and treatment of these conditions.PMID:38623640 | DOI:10.1177/02841851241245970 (Source: Acta Radiologica)
Source: Acta Radiologica - April 16, 2024 Category: Radiology Authors: Shengnan Yin Ning Ding Yiding Ji Zhenguo Qiao Jianmao Yuan Jing Chi Long Jin Source Type: research
The value of CT radiomics combined with deep transfer learning in predicting the nature of gallbladder polypoid lesions
CONCLUSION: The machine learning radiomics combined with deep learning model based on enhanced CT proves valuable in predicting the characteristics of cholesterol and adenomatous gallbladder polyps. This approach provides a more reliable basis for preoperative diagnosis and treatment of these conditions.PMID:38623640 | DOI:10.1177/02841851241245970 (Source: Acta Radiologica)
Source: Acta Radiologica - April 16, 2024 Category: Radiology Authors: Shengnan Yin Ning Ding Yiding Ji Zhenguo Qiao Jianmao Yuan Jing Chi Long Jin Source Type: research
Endoscopic treatment of scarred polyps with a non-thermal device (Endorotor): A review of the literature
World J Gastroenterol. 2024 Mar 28;30(12):1706-1713. doi: 10.3748/wjg.v30.i12.1706.ABSTRACTEndoscopic resection (ER) of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic devices. ER procedures have evolved over the past few years from endoscopic mucosal resection (EMR) to more advanced techniques, such as endoscopic submucosal dissection and endo-scopic full-thickness resection. Complete resection and disease eradication are the ultimate goals of ER-based techniques, and novel devices ...
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Source Type: research
