Experiences of attitudes in Sierra Leone from the perspective of people with poliomyelitis and amputations using orthotics and prosthetics.
CONCLUSIONS: In Sierra Leone, people with disabilities face severe discrimination. They need to be included, recognized, and supported to a greater extent by the society, the community, and the family, as well as by the government and international organizations. Traditional beliefs have a negative impact on people with physical disabilities and are an important cause of discrimination in Sierra Leone. Prosthetic and orthotic devices are vital for people with physical disability and offer increased dignity. Prosthetic and orthotic services need to be accessible and affordable. Poverty affects access to education, employmen...
Source: Disability and Rehabilitation - November 10, 2016 Category: Rehabilitation Authors: Andregård E, Magnusson L Tags: Disabil Rehabil Source Type: research

Immunogenicity and Safety of a Liquid Hexavalent Vaccine in Indian Infants.
CONCLUSION: The fully liquid DTaP-IPV-HB-PRP~T vaccine is highly immunogenic in infants in India when administered in a 6, 10, 14 week schedule along with HB and OPV administered at birth, and was well tolerated. PMID: 27889711 [PubMed - as supplied by publisher] (Source: Indian Pediatrics)
Source: Indian Pediatrics - November 5, 2016 Category: Pediatrics Authors: Chhatwal J, Lalwani S, Vidor E Tags: Indian Pediatr Source Type: research

Progress towards poliomyelitis eradication: Afghanistan, January 2015 –August 2016.
Progress towards poliomyelitis eradication: Afghanistan, January 2015–August 2016. Wkly Epidemiol Rec. 2016 Nov 4;91(44):517-22 Authors: PMID: 27811982 [PubMed - in process] (Source: Weekly Epidemiological Record)
Source: Weekly Epidemiological Record - November 4, 2016 Category: Epidemiology Tags: Wkly Epidemiol Rec Source Type: research

Progress Toward Poliomyelitis Eradication - Afghanistan, January 2015 ‒August 2016.
This report describes polio eradication activities and progress in Afghanistan during January 2015‒August 2016 and updates previous reports (5,6). During 2015, a total of 20 WPV1 cases were reported in Afghanistan, compared with 28 cases in 2014; eight cases were reported during January‒August 2016, compared with nine cases reported during the same period in 2015. To achieve interruption of poliovirus transmission in Afghanistan, it is important that the 2016-2017 National Emergency Action Plan(†) for polio eradication be systematically implemented, including 1) improving the quality of SIAs and routine immuniza...
Source: MMWR Morb Mortal Wkl... - November 4, 2016 Category: Epidemiology Authors: Mbaeyi C, Shukla H, Smith P, Tangermann RH, Martinez M, Jorba JC, Hadler S, Ehrhardt D Tags: MMWR Morb Mortal Wkly Rep Source Type: research

The Ebola Crisis and the Corresponding Public Behavior: A System Dynamics Approach
Conclusion and Future Work It is vital to consider how the behavior of communities plays an important role in the spread of Ebola in West Africa. This extends not only to the disease itself but also to the contagion of irrational behaviors. Not only the public, but also high ranking officials, scientists, and even policy makers are at risk for presumptive and consequently dangerous behavior; therefore, it is necessary to combine physical disease spread along with behavioral practices that hinder or spread the disease. As the United Nations head of the Ebola mission (Ismail Ould Cheikh Ahmed) attested, combatting the Ebola ...
Source: PLOS Currents Outbreaks - November 3, 2016 Category: Epidemiology Authors: Nasser Sharareh Source Type: research

Fixator-assisted tibial lengthening over a plate in a patient with sequelae of poliomyelitis
We present a new technique for tibial lengthening with using a monolateral external fixator over a lengthening plate. Lengthening over an intramedullary nail is a commonly used method in patients with short stature or limb-length discrepancy. However, in patients with a narrow and excessively sclerotic intramedullary cavity in the pediatric age group where the skeletal system has not yet fully developed, difficulties have been observed in lengthening methods with nailing. Therefore, in these cases, the use of lengthening techniques over a plate is an alternative treatment option. Nevertheless, in lengthening techniques o...
Source: Medicine - November 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Inequalities in full immunization coverage: trends in low- and middle-income countries.
CONCLUSION: Most low- and middle-income countries are affected by pro-rich and pro-urban inequalities in full immunization coverage that are not apparent when only national mean values of such coverage are reported. PMID: 27821882 [PubMed - in process] (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - November 1, 2016 Category: Global & Universal Authors: Restrepo-Méndez MC, Barros AJ, Wong KL, Johnson HL, Pariyo G, França GV, Wehrmeister FC, Victora CG Tags: Bull World Health Organ Source Type: research

Morbidity and mortality following poliomyelitis – a lifelong follow‐up
ConclusionsPoliomyelitis has significant long‐term consequences on morbidity and mortality of both paralytic and non‐paralytic cases. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 1, 2016 Category: Neurology Authors: L. Kay, N. M. Nielsen, B. Wanscher, R. Ibsen, J. Kjellberg, P. Jennum Tags: Original Article Source Type: research

Poliovirus study in the endgame of the polio eradication program.
Abstract Since the start of Global Polio Eradication Initiative in 1988, poliomyelitis cases caused by wild poliovirus (PV) were drastically reduced to only 74 cases in 2 endemic countries in 2015. With established vaccine campaign, current limited PV transmission suggested the endgame of the polio eradication program. In the endgame, we have emerging challenges specific to the endgame; tight budget, switching of the vaccines, and changes in the biorisk management. To overcome these challenges, several projects of PV study attract attention in the eradication program. Some of these emerging challenges/projects of ...
Source: Japanese Journal of Infectious Diseases - October 31, 2016 Category: Infectious Diseases Authors: Arita M Tags: Jpn J Infect Dis Source Type: research

Eradicating infectious disease using weakly transmissible vaccines
Viral vaccines have had remarkable positive impacts on human health as well as the health of domestic animal populations. Despite impressive vaccine successes, however, many infectious diseases cannot yet be efficiently controlled or eradicated through vaccination, often because it is impossible to vaccinate a sufficient proportion of the population. Recent advances in molecular biology suggest that the centuries-old method of individual-based vaccine delivery may be on the cusp of a major revolution. Specifically, genetic engineering brings to life the possibility of a live, transmissible vaccine. Unfortunately, releasing...
Source: Proceedings of the Royal Society B: Biological Sciences - October 26, 2016 Category: Biology Authors: Nuismer, S. L., Althouse, B. M., May, R., Bull, J. J., Stromberg, S. P., Antia, R. Tags: theoretical biology, ecology, health and disease and epidemiology Research articles Source Type: research

Did the national campaign for poliomyelitis vaccination achieve its objectives.
Authors: Al-Sulaiman A, Al-Mazrou Y, Al-Jeffry M, Jamjoom G, Al-Hawas M, Mishkas A, Al-Mazrou A, Makki O, Al-Ahadal M Abstract Full text is available as a scanned copy of the original print version. PMID: 27701506 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - October 7, 2016 Category: Middle East Health Tags: Saudi Med J Source Type: research

Acute flaccid paralysis by non-polio exteroviruses before, during and after eradication of poliomyelitis.
Authors: Arya SC Abstract Full text is available as a scanned copy of the original print version. PMID: 27701505 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - October 7, 2016 Category: Middle East Health Tags: Saudi Med J Source Type: research

Development of inactivated poliovirus vaccine from Sabin strains: A  progress report
Publication date: Available online 5 October 2016 Source:Biologicals Author(s): Hiromasa Okayasu, Carolyn Sein, Ahd Hamidi, Wilfried A.M. Bakker, Roland W. Sutter The Global Polio Eradication Initiative (GPEI) has seen significant progress since it began in 1988, largely due to the worldwide use of oral poliovirus vaccine (OPV). In order to achieve polio eradication the global cessation of OPV is necessary because OPV contains live attenuated poliovirus, which in rare circumstances could re-gain wild poliovirus (WPV) characteristics with potential to establish transmission. The GPEI endgame strategy for the period 2013&nd...
Source: Biologicals - October 6, 2016 Category: Biology Source Type: research

Sailing in Uncharted Waters: Carefully Navigating the Polio Endgame
by Elizabeth Miller, T. Jacob John In a Perspective linked to the research article by Isobel Blake and colleagues, Elizabeth Miller and T. Jacob John discuss the path towards global polio eradication and the challenges, strategies, and necessary precautions around oral polio vaccine cessation. (Source: PLoS Medicine)
Source: PLoS Medicine - October 4, 2016 Category: Internal Medicine Authors: Elizabeth Miller Source Type: research

Population Immunity against Serotype-2 Poliomyelitis Leading up to the Global Withdrawal of the Oral Poliovirus Vaccine: Spatio-temporal Modelling of Surveillance Data
by Margarita Pons-Salort, Natalie A. Molodecky, Kathleen M. O ’Reilly, Mufti Zubair Wadood, Rana M. Safdar, Andrew Etsano, Rui Gama Vaz, Hamid Jafari, Nicholas C. Grassly, Isobel M. Blake BackgroundGlobal withdrawal of serotype-2 oral poliovirus vaccine (OPV2) took place in April 2016. This marked a milestone in global polio eradication and was a public health intervention of unprecedented scale, affecting 155 countries. Achieving high levels of serotype-2 population immunity before OPV2 withdrawal was critical to avoid subsequent outbreaks of serotype-2 vaccine-derived polioviruses (VDPV2s). Methods and FindingsIn A...
Source: PLoS Medicine - October 4, 2016 Category: Internal Medicine Authors: Margarita Pons-Salort Source Type: research

[Back to the Future. Vaccine trials against Ebola in the history of resistance to immunization].
This article offers a retrospective view on the resistances to vaccination throughout its history, from smallpox inoculation to anti-polio vaccine. Resistances have been linked to the political contexts and the rejection of an oppressive power, either local or foreign, as well as mistakes and scientific uncertainties. The analysis of the historical factors of resistance leads to reverse the question: what convinces people to accept a vaccine trial, despite the obscurities of the immunization processes inside the body? The article hypothesizes that Guineans and West Africans face a dilemma similar to their counterparts in t...
Source: Bulletin de la Societe de Pathologie Exotique - October 2, 2016 Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research

Reporting of Acute Flaccid Paralysis in Children under 15 years of age: Improving Surveillance, January 2009 - December 2014.
Abstract Acute Flaccid Paralysis (AFP) surveillance, including case investigation and specimen collection is a gold standard method for poliomyelitis surveillance. The expected annual non-polio AFP rate
Source: Ir Med J - October 1, 2016 Category: Journals (General) Authors: Flanagan P, O'Lorcain P, Cotter S, Connell J, Lynch B, Cunney R, O'Flanagan D Tags: Ir Med J Source Type: research

Polio Eradication in India: The Lessons Learned
(Source: PEDIATRICS)
Source: PEDIATRICS - September 30, 2016 Category: Pediatrics Authors: Thacker, N., Vashishtha, V. M., Thacker, D. Tags: Infectious Disease, Vaccine/Immunization, Public Health Monthly Feature Source Type: research

VIRO-TypeNed, systematic molecular surveillance of enteroviruses in the Netherlands between 2010 and 2014
VIRO-TypeNed is a collaborative molecular surveillance platform facilitated through a web-based database. Genetic data in combination with epidemiological, clinical and patient data are shared between clinical and public health laboratories, as part of the surveillance underpinning poliovirus eradication. We analysed the combination of data submitted from 2010 to 2014 to understand circulation patterns of non-polio enteroviruses (NPEV) of public health relevance. Two epidemiological patterns were observed based on VIRO-TypeNed data and classical surveillance data dating back to 1996: (i) endemic cyclic, characterised by pr...
Source: Eurosurveillance - September 29, 2016 Category: Infectious Diseases Source Type: research

Predictive potential of IL-28B genetic testing for interferon based hepatitis C virus therapy in Pakistan: Current scenario and future perspective.
Authors: Afzal MS Abstract In Pakistan which ranked second in terms of hepatitis C virus (HCV) infection, it is highly needed to have an established diagnostic test for antiviral therapy response prediction. Interleukin 28B (IL-28B) genetic testing is widely used throughout the world for interferon based therapy prediction for HCV patients and is quite helpful not only for health care workers but also for the patients. There is a strong relationship between single nucleotide polymorphisms at or near the IL-28B gene and the sustained virological response with pegylated interferon plus ribavirin treatment for chronic...
Source: World Journal of Hepatology - September 24, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Expression and purification of polioviral proteins in E.  coli, and production of antisera as reagents for immunological assays
Publication date: December 2016 Source:Protein Expression and Purification, Volume 128 Author(s): Madala Uma, P.P. Rao, K. Nagalekshmi, N.R. Hegde Poliomyelitis, caused by poliovirus, is on the verge of eradication, and the world is preparing to shift from live to inactivated polio vaccine. In view of the requirement of non-infectious reagents, especially protein antigens, for surveillance during the final phase of poliovirus eradication, we have attempted to generate reagents that may be of use for the development of diagnostic tests. Polioviral proteins VP0, VP3, VP1, and 3AB were expressed in Escherichia coli using the...
Source: Protein Expression and Purification - September 24, 2016 Category: Biochemistry Source Type: research

Co-administration of paediatric vaccines in Shanghai, China
The World Health Organization (WHO) recommends countries to include 11 antigens on a publicly-funded, paediatric Expanded Program on Immunization (EPI): Bacillus Calmette-Gu érin, hepatitis B, polio, diphtheria-tetanus-pertussis (DTP), Haemophilus influenzae type b (Hib), pneumococcus, rotavirus, measles, and rubella.1 Some of these diseases are still a significant source of morbidity and mortality in China, for example, there are 19,000 deaths from Hib disease each ye ar.2 China's EPI includes all of these vaccines, except for the Hib vaccine, the pneumococcal conjugate vaccine (PCV), and rotavirus, and the process...
Source: Public Health - September 24, 2016 Category: Global & Universal Authors: A.L. Wagner, X. Sun, Z. Huang, M.L. Boulton Tags: Short Communication Source Type: research

Polio Patients in Northern Italy, a 50 Year Follow-up.
CONCLUSION: Female gender, fatigue and wheelchair dependency were significantly more common in PPS while pain was common in both groups. PMID: 27651845 [PubMed] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - September 23, 2016 Category: Neurology Tags: Open Neurol J Source Type: research

Taliban militants kill doctor working to eradicate polio
(Source: BMJ News)
Source: BMJ News - September 20, 2016 Category: Journals (General) Source Type: research

[Newsdesk] Infectious disease surveillance update
On Aug 11, 2016, more than 2 years since the last reported case of polio in Nigeria, the government reported cases of two children from Borno state in northern Nigeria who were paralysed with the disease. Genetic sequencing of the virus determined that the new cases are linked to the wild strain circulating in Borno in 2011, suggesting that low-level transmission of the virus has been ongoing without detection. This suggestion is unsurprising against the backdrop of a long-term and worsening humanitarian crisis in the region, making large areas hard to reach for vaccination teams. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - September 20, 2016 Category: Infectious Diseases Authors: Ruth Zwizwai Tags: Newsdesk Source Type: research

Recurrent pneumonia and vaccine associated paralytic polio in a child with X-linked agammaglobulinemia
This report suggests the importance of evaluating patients with vaccine associated paralytic polio (VAPP) for immunodeficiency diseases. We describe a child with VAPP and recurrent pneumonias who had underlying X-linked agammaglobulinemia. (Source: Pediatric Infectious Disease)
Source: Pediatric Infectious Disease - September 18, 2016 Category: Pediatrics Source Type: research

Polio Eradication Initiative (PEI) contribution in strengthening public health laboratories systems in the African region.
CONCLUSION: The Polio Eradication Initiative (PEI) is a good example of contribution in strengthening public health laboratories systems in the African region. It has established strong Polio Laboratory network that contributed to the strengthening of capacities and its expansion to surveillance of other viral priority diseases such as measles, yellow fever, Influenza, MERS-CoV and Ebola. This could serve as lesson and good example of laboratory based surveillance to improving diseases prevention, detection and control in our middle and low income countries as WHO and partners are heading to polio eradication in the world....
Source: Vaccine - September 16, 2016 Category: Allergy & Immunology Authors: Gumede N, Coulibaly SO, Yahaya AA, Ndihokubwayo JB, Nsubuga P, Okeibunor J, Dosseh A, Salla M, Mihigo R, Mkanda P, Byabamazima C Tags: Vaccine Source Type: research

Recurrent pneumonia and vaccine associated paralytic polio in a child with X linked agammaglobulinemia
This report suggests the importance of evaluating patients with vaccine associated paralytic polio (VAPP) for immunodeficiency diseases. We describe a child with VAPP and recurrent pneumonias who had underlying X linked agammaglobulinemia. (Source: Pediatric Infectious Disease)
Source: Pediatric Infectious Disease - September 13, 2016 Category: Pediatrics Source Type: research

NIV for OHS without severe OSAS: is it worth it?
Home non-invasive ventilation (NIV) has been used to manage chronic respiratory failure since the polio epidemics of the 1940s; however, the support for many of the indications remains based on small non-randomised or uncontrolled studies. Obesity hypoventilation syndrome (OHS) is an increasingly common cause of chronic respiratory failure and indication for home mechanical ventilation; unsurprisingly as the diagnosis remains frequently missed, significant variation exists across Europe.1 2 The majority of patients with OHS have significant obstructive sleep apnoea (OSA) and recent data have demonstrated the benefits of NI...
Source: Thorax - September 13, 2016 Category: Respiratory Medicine Authors: Murphy, P. B., Janssens, J.-P. Tags: Editorial Source Type: research

[Comment] Unravelling mucosal immunity to poliovirus
From an immunological perspective, the battle to eradicate polio is one of blood and guts. Induction of circulating poliovirus antibodies in blood is essential to block the spread of viruses to the CNS and thereby protect against paralytic disease. However, as eradication draws closer, the induction of immunity in the gut mucosa is becoming an ever-greater concern. Mucosal immunity is key to halting the spread of poliovirus from person to person, and thereby condemning the virus to extinction. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - September 13, 2016 Category: Infectious Diseases Authors: Edward P K Parker, Nicholas C Grassly Tags: Comment Source Type: research

W. Ritchie Russell, A.B. Baker, and Fred Plum: Pioneers of ventilatory management in poliomyelitis
Historically, neurologists were not involved in the day-to-day management of critically ill patients with bulbar poliomyelitis, but some were. The major contributions of 3 neurologists—W. Ritchie Russell, A.B. Baker, and Fred Plum—in the respiratory management of poliomyelitis have not been recognized. Russell's work was instrumental in identifying multiple types of poliomyelitis defined by their respiratory needs, and he advised treatment that varied from simple postural drainage to use of respirators. He participated in the development of the Radcliffe respiratory pump. Baker recognized the essential involvem...
Source: Neurology - September 12, 2016 Category: Neurology Authors: Wijdicks, E. F. M. Tags: History of Neurology, Clinical neurology history, Critical care HISTORICAL NEUROLOGY Source Type: research

Two recent pediatric cases of severe polio-like paralysis caused by enterovirus D68 infection in Spain
We present two cases identified in the last three months in Spain. First patient was a previously healthy two-year-old girl that, few days after suffering from bronchitis with fever, presented distal weakness that rapidly progressed to complete flaccid paralysis. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - September 10, 2016 Category: Neurology Authors: M. Gomez-Garcia de la Banda, N. Julia, A. Felipe, A. Sanchez-Monta ñez, J. Balcells, M. Pujol, P. Soler, C. Rodrigo, B. Floriano, J. Lopez, A. Macaya, F. Munell Source Type: research

Cessation of Trivalent Oral Poliovirus Vaccine and Introduction of Inactivated Poliovirus Vaccine - Worldwide, 2016.
Abstract Since the 1988 World Health Assembly resolution to eradicate poliomyelitis, transmission of the three types of wild poliovirus (WPV) has been sharply reduced (1). WPV type 2 (WPV2) has not been detected since 1999 and was declared eradicated in September 2015. Because WPV type 3 has not been detected since November 2012, WPV type 1 (WPV1) is likely the only WPV that remains in circulation (1). This marked progress has been achieved through widespread use of oral poliovirus vaccines (OPVs), most commonly trivalent OPV (tOPV), which contains types 1, 2, and 3 live, attenuated polioviruses and has been a mai...
Source: MMWR Morb Mortal Wkl... - September 9, 2016 Category: Epidemiology Authors: Hampton LM, Farrell M, Ramirez-Gonzalez A, Menning L, Shendale S, Lewis I, Rubin J, Garon J, Harris J, Hyde T, Wassilak S, Patel M, Nandy R, Chang-Blanc D, Immunization Systems Management Group of the Global Polio Eradication Initiative Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Performance of acute flaccid paralysis (AFP) surveillance and incidence of poliomyelitis, 2016.
Authors: PMID: 27623615 [PubMed - indexed for MEDLINE] (Source: Weekly Epidemiological Record)
Source: Weekly Epidemiological Record - September 9, 2016 Category: Epidemiology Tags: Wkly Epidemiol Rec Source Type: research

Cessation of use of trivalent oral polio vaccine and introduction of inactivated poliovirus vaccine worldwide, 2016.
Authors: PMID: 27623614 [PubMed - indexed for MEDLINE] (Source: Weekly Epidemiological Record)
Source: Weekly Epidemiological Record - September 9, 2016 Category: Epidemiology Tags: Wkly Epidemiol Rec Source Type: research

Comprehensive review of challenges associated with management of lower limb fractures in poliomyelitis patients
This article gives a comprehensive review of the challenges faced in fixation of fractures in polio affected limbs and possible solutions to overcome them. Knowledge of treating these fractures is important to a trauma surgeon as such scenarios are not uncommon in daily practice. (Source: Journal of Clinical Orthopaedics and Trauma)
Source: Journal of Clinical Orthopaedics and Trauma - September 7, 2016 Category: Orthopaedics Source Type: research

Vaccines and multiple sclerosis: a systematic review
This study offers a literature review on the role of vaccines regarding the risk of developing multiple sclerosis (MS) and MS relapse. The method used in this study is a systematic literature review on the database PubMed. The study found no change in risk of developing multiple sclerosis (MS) after vaccination against hepatitis B virus, human papillomavirus, seasonal influenza, measles –mumps–rubella, variola, tetanus, Bacillus Calmette-Guérin (BCG), polio, or diphtheria. No change in risk of relapse was found for influenza. Further research is needed for the potential therapeutic use of the BCG vaccine...
Source: Journal of Neurology - September 7, 2016 Category: Neurology Source Type: research

Assessment of Motor Units in Neuromuscular Disease
AbstractThe motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it innervates. Although the true number of motor units is unknown, the number of motor units appears to vary greatly between different muscles and between different individuals. Assessment of the number and function of motor units is needed in diseases of the anterior horn cell and other motor nerve disorders. Amyotrophic lateral sclerosis is the most important disease of anterior horn cells. The need for an effective biomarker for assessing disease progression and for use in clinical trials in amyotrophic lateral sclerosis has st...
Source: Neurotherapeutics - September 6, 2016 Category: Neurology Source Type: research

Testing the measurement invariance of the University of Washington Self-Efficacy Scale short form across four diagnostic subgroups
ConclusionsThe current study suggests that the 6-item short form of the UW-SES has the same meaning across the four diagnostic subgroups. Thus, the 6-item short form is validated for people with MD, MS, PPS, and SCI. (Source: Quality of Life Research)
Source: Quality of Life Research - September 4, 2016 Category: Health Management Source Type: research

Absence of poliovirus in apparently healthy school children in Bauchi state, Nigeria
Conclusions: Findings from this investigation indicate the absence of polioviruses in the children studied. This is an indication of good polio immunization coverage in these communities. However, more intensive and periodic surveillance is required to confirm the presence or exclude the absence of polioviruses in these communities and other parts of Nigeria. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - August 31, 2016 Category: Infectious Diseases Source Type: research

Determinants of Falls and Fear of Falling in Ambulatory Persons  With Late Effects of Polio
Conclusions Reduced gait performance, knee muscle strength, and dynamic balance are to a varying degree determinants of falls and FOF in ambulatory persons with late effects of polio. Future studies need to evaluate whether rehabilitation programs targeting these factors can reduce falls and FOF in this population. (Source: PMandR)
Source: PMandR - August 30, 2016 Category: Rehabilitation Source Type: research

Fractional-Dose Inactivated Poliovirus Vaccine Immunization Campaign - Telangana State, India, June 2016.
Abstract Wild poliovirus type 2 was declared eradicated in September 2015 (1). In April 2016, India, switched from use of trivalent oral poliovirus vaccine (tOPV; containing types 1, 2, and 3 polio vaccine viruses), to bivalent OPV (bOPV; containing types 1 and 3), as part of a globally synchronized initiative to withdraw Sabin poliovirus type 2 vaccine. Concurrently, inactivated poliovirus vaccine (IPV) was introduced into India's routine immunization program to maintain an immunity base that would mitigate the number of paralytic cases in the event of epidemic transmission of poliovirus type 2 (2,3). After cessa...
Source: MMWR Morb Mortal Wkl... - August 27, 2016 Category: Epidemiology Authors: Bahl S, Verma H, Bhatnagar P, Haldar P, Satapathy A, Kumar KN, Horton J, Estivariz CF, Anand A, Sutter R Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Determinants of childhood immunisation coverage in urban poor settlements of Delhi, India: a cross-sectional study
Conclusions Immunisation coverage in this urban poor area was much lower than that of regional surveys reporting overall urban data. Socioeconomic status of the household, female illiteracy, health awareness and gender inequality were important determinants of coverage in this population. Hence, in addition to enhancing the infrastructure for providing mother and child services, efforts are also needed to address these issues in order to improve immunisation coverage in deprived urban communities. Trial registration number CTRI/2011/091/000095. (Source: BMJ Open)
Source: BMJ Open - August 26, 2016 Category: Journals (General) Authors: Devasenapathy, N., Ghosh Jerath, S., Sharma, S., Allen, E., Shankar, A. H., Zodpey, S. Tags: Open access, Paediatrics, Public health Research Source Type: research

Processes for Producing and Purifying Nucleic Acid-Containing Compositions
This technology consists of improved processes for producing and purifying nucleic acid-containing compositions, such as non-naturally occurring viruses, for example, recombinant polioviruses that can be used as oncolytic agents. Some of the improved processes relate to producing viral DNA templates and for chromatographic purification of nucleic acid-containing compositions, in which the nucleic acid is quantified in chromatography fractions with the rapid detection of one or more nucleic acid sequences (e.g., using real time RT-qPCR detection). In addition, the invention includes improved processes for production and pur...
Source: NIH OTT Licensing Opportunities - August 25, 2016 Category: Research Authors: ajoyprabhu3 Source Type: research

Minimising invasiveness in diagnostics: developing a rapid urine ‐based monoclonal antibody dipstick test for malaria
ConclusionMAb UCP4W7 seems promising for diagnosing Plasmodium infection. Urine is a reliable biomarker source for developing non‐invasive malaria diagnostic tests. SDS‐PAGE and MAb‐based WBA appear explorable in assays for detecting different levels of Plasmodium parasitaemia. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - August 22, 2016 Category: Tropical Medicine Authors: Uri S. Markakpo, Kwabena M. Bosompem, Mawuli Dzodzomenyo, Anthony Danso ‐Appiah, Edward E. Essuman, William K. Anyan, Mitsuko Suzuki, Judith K. Stephens, Isaac Anim‐Baidoo, Richard H. Asmah, Michael F. Ofori, Parnor Madjitey, Jonas B. Danquah, Naa Adj Tags: Original Article Source Type: research

Polio returns
Publication date: 20 August 2016 Source:New Scientist, Volume 231, Issue 3087 (Source: New Scientist)
Source: New Scientist - August 20, 2016 Category: Science Source Type: research

High-resolution CT predictors of hypersensitivity pneumonitis.
CONCLUSION: Our results provide evidence that HRCT can accurately distinguish HP from other DPLDs. PMID: 27537713 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - August 19, 2016 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Erratum to: Modeling the spread of polio in an IPV-vaccinated population: lessons learned from the 2013 silent outbreak in southern Israel
(Source: BMC Medicine)
Source: BMC Medicine - August 19, 2016 Category: Internal Medicine Authors: Rami Yaari, Ehud Kaliner, Itamar Grotto, Guy Katriel, Jacob Moran-Gilad, Danit Sofer, Ella Mendelson, Elizabeth Miller and Amit Huppert Source Type: research

Determinants of falls and fear of falling in ambulatory persons with late effects of polio
Conclusions Reduced gait performance, knee muscle strength and dynamic balance are to a varying degree determinants of falls and FOF in ambulatory persons with late effects of polio. Future studies need to evaluate if rehabilitation programs targeting these factors can reduce falls and FOF in this population. (Source: PMandR)
Source: PMandR - August 19, 2016 Category: Rehabilitation Source Type: research