Should rehabilitation goals reflect all aspects of functioning in relation to a biopsychosocial ICF perspective?
Conclusion: The study showed challenges in capturing all aspects of biopsychosocial functioning in rehabilitation goals, particularly Contextual Factors. This study indicates that rehabilitation goals capture capacity rather than performance. Further research could highlight if functioning is captured in the rehabilitation plan, and in this way include both capacity and performance. Implications for rehabilitation Health professionals in a post-acute or long-term rehabilitation setting should pay attention to capacity and performance when rehabilitation goals are set. The rehabilitation plan should contain goals and a desc...
Source: Disability and Rehabilitation - October 7, 2019 Category: Rehabilitation Authors: Riis-Djernæs LM, Jensen CM, Madsen E, Maribo T Tags: Disabil Rehabil Source Type: research

Polio returns to the Philippines
Publication date: 5–11 October 2019Source: The Lancet, Volume 394, Issue 10205Author(s): Jacqui Thornton (Source: The Lancet)
Source: The Lancet - October 5, 2019 Category: General Medicine Source Type: research

Enteroviral infection in neonates
This article provides an overview of what is known about non-polio enteroviruses in neonates including epidemiology, transmission, clinical presentation, diagnosis, and treatment. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - October 1, 2019 Category: Microbiology Source Type: research

Hopkins Syndrome: Post Flaccid Paralysis After an Asthma Exacerbation
We report a rare case of a 22-month-old who developed flaccid paralysis of her right arm shortly after she was hospitalized for an asthma exacerbation. There are many etiologies of acute flaccid paralysis; however, because of the uncommon presentation of a focalized finding, establishing the diagnosis of this patient was difficult in the emergency department setting. Associated with asthma exacerbations, Hopkins syndrome is a paralytic illness that resembles poliomyelitis. This case highlights the challenges of evaluating a child with monoparesis and establishing an association with asthma amyotrophy. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - October 1, 2019 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Occult Femur Fracture
A 60-year-old woman with poliomyelitis presented with knee pain after falling in the street with her left knee flexed. On examination, the left knee was swollen, with passive motion causing severe pain. The lateral radiograph of the left knee revealed a linear interface between 2 soft tissue densities in the suprapatellar pouch with no evidence of fracture (Figure  1). Arthrocentesis revealed 45 mL of bloody joint effusion with fat globules (Figure 2). Based on the findings of the lateral radiograph and arthrocentesis, a diagnosis of lipohemarthrosis was made. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - October 1, 2019 Category: Internal Medicine Authors: Ming-Chen Tsai, Yi-Shin Chen Tags: Medical image Source Type: research

Specific elimination of coxsackievirus B3 infected cells with a protein engineered toxin-antitoxin system
ConclusionThese findings suggest that the MazEF fusion protein has a strong potential to be developed as an anti-virus therapy following CVB3 infection. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 30, 2019 Category: Cytology Source Type: research

Field Performance of Two Methods for Detection of Poliovirus in Wastewater Samples, Mexico 2016 –2017
Abstract To enhance our ability to monitor poliovirus circulation and certify eradication, we evaluated the performance of the bag-mediated filtration system (BMFS) against the two-phase separation (TPS) method for concentrating wastewater samples for poliovirus detection. Sequential samples were collected at two sites in Mexico; one L was collected by grab and  ~ 5 L were collected and filtered in situ with the BMFS. In the laboratory, 500 mL collected by grab were concentrated using TPS and the sample contained in the filter of the BMFS was eluted without secondary concentration. Concentrates were te...
Source: Food and Environmental Virology - September 30, 2019 Category: Virology Source Type: research

Understanding the three As (Awareness, Access, and Acceptability) dimensions of vaccine hesitancy in Odisha, India
ConclusionIn the current scenario of increasing immunization coverage in India, vaccine hesitancy acts as a missing link in action for the policymakers to achieve cent percent target. (Source: Clinical Epidemiology and Global Health)
Source: Clinical Epidemiology and Global Health - September 27, 2019 Category: Epidemiology Source Type: research

Understanding the three A (Awareness, Access, and Acceptability) dimensions of vaccine hesitancy in Odisha, India
ConclusionIn the current scenario of increasing immunization coverage in India, vaccine hesitancy acts as a missing link in action for the policymakers to achieve cent percent target. (Source: Clinical Epidemiology and Global Health)
Source: Clinical Epidemiology and Global Health - September 27, 2019 Category: Epidemiology Source Type: research

Progress Toward Poliovirus Containment Implementation - Worldwide, 2018-2019.
s I, Zaffran M, MEng Abstract Among the three wild poliovirus (WPV) types, type 2 (WPV2) was declared eradicated globally by the Global Commission for the Certification of Poliomyelitis Eradication (GCC) in 2015. Subsequently, in 2016, a global withdrawal of Sabin type 2 oral poliovirus vaccine (OPV2) from routine use, through a synchronized switch from the trivalent formulation of oral poliovirus vaccine (tOPV, containing vaccine virus types 1, 2, and 3) to the bivalent form (bOPV, containing types 1 and 3), was implemented. WPV type 3 (WPV3), last detected in 2012 (1), will possibly be declared eradicated in lat...
Source: MMWR Morb Mortal Wkl... - September 27, 2019 Category: Epidemiology Authors: Moffett DB, Llewellyn A, Singh H, Saxentoff E, Partridge J, Iakovenko M, Roesel S, Asghar H, Baig N, Grabovac V, Gurung S, Gumede-Moeletsi N, Barnor J, Theo A, Rey-Benito G, Villalobos A, Boualam L, Swan J, Sutter RW, Pandel E, Wassilak S, Oberste MS, Lew Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Preface
Growing up in rural South India, I witnessed the lifelong effects of polio in my great-uncle and the effects of disability in my grandfather after he suffered a stroke. There were minimal access to health care of any type and no access to medical rehabilitation. (Source: Physical Medicine and Rehabilitation Clinics of North America)
Source: Physical Medicine and Rehabilitation Clinics of North America - September 26, 2019 Category: Rehabilitation Authors: Joseph P. Jacob Source Type: research

Status of coverage of MR vaccination, after supplementary immunization activities in a rural area of South India: a rapid immunization coverage survey.
CONCLUSION: Despite the negative propaganda by social media, the coverage of vaccination by the public healthcare providers was near optimal in phase 1, which shows the strength of the public health system in this rural area of southern India. In accordance with the modern technology, public health policymakers should think about and plan information education and communication activities. PMID: 31529972 [PubMed - in process] (Source: Rural and Remote Health)
Source: Rural and Remote Health - September 20, 2019 Category: Rural Health Tags: Rural Remote Health Source Type: research

Polio vaccination controversy in Pakistan
Publication date: 14–20 September 2019Source: The Lancet, Volume 394, Issue 10202Author(s): Mohammad Ali, Nisar Ahmad, Haji Khan, Shahid Ali, Fazal Akbar, Zahid Hussain (Source: The Lancet)
Source: The Lancet - September 14, 2019 Category: General Medicine Source Type: research

Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process
Delpeyroux RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homologou...
Source: Viruses - September 14, 2019 Category: Virology Authors: Muslin Kain Bessaud Blondel Delpeyroux Tags: Review Source Type: research

Viruses, Vol. 11, Pages 859: Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process
s Delpeyroux RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Recent experimental studies that relied on recombination cellular systems mimicking natural genetic exchanges between enteroviruses provided new insights into the molecular mechanisms of enterovirus recombination and enabled to define a new model of genetic plasticity for enteroviruses. Homolog...
Source: Viruses - September 14, 2019 Category: Virology Authors: Claire Muslin Alice Mac Kain Ma ël Bessaud Bruno Blondel Francis Delpeyroux Tags: Review Source Type: research

Poliovirus and non-polio-enterovirus environmental surveillance in Parma within the "Global Polio Eradication Program" (GPEI).
CONCLUSION: As OPV isn't used in Italy since 2002, recovery of Sabin-like polioviruses indicates the possibility of poliovirus reintroduction, considering also the important exposure to migratory flows. Finally, monitoring the environmental circulation of NPEV, could compensate for the lack of a surveillance system of the infections they cause. PMID: 31517896 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - September 13, 2019 Category: General Medicine Authors: Zoni R, Mezzetta S, Affanni P, Colucci ME, Fiore S, Fontana S, Bracchi M, Capobianco E, Veronesi L Tags: Acta Biomed Source Type: research

Immunity status against poliomyelitis in young migrants: a seroprevalence study.
CONCLUSION: The low GMTs and the clear tendency to decrease with increasing age of the subjects, especially against to PV1, confirm the framework of attention that polio is receiving at national and international level. PMID: 31517887 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - September 13, 2019 Category: General Medicine Authors: Veronesi L, Colucci ME, Capobianco E, Bracchi MT, Zoni R, Palandri L, Affanni P Tags: Acta Biomed Source Type: research

Viral encephalitis: a practical review on diagnostic approach and treatment.
CONCLUSION: Clinical data, laboratory results, and neuroimaging findings support the diagnosis of encephalitis and the specific viral etiology. To increase the likelihood of etiologic confirmation, it is important to know the best approach to collecting samples and to choose the best identification technique for each virus. The differential diagnosis of viral encephalitis includes other infections and immune-mediated inflammatory central nervous system disorders. PMID: 31513761 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 9, 2019 Category: Pediatrics Authors: Costa BKD, Sato DK Tags: J Pediatr (Rio J) Source Type: research

Poliovirus neutralizing antibody levels among individuals in three regions of Ghana.
Authors: Opare JK, Akweongo P, Afari EA, Odoom JK Abstract Introduction: Ghana was declared polio-free in 2015 after the last polio case in 2008. We determined the poliovirus neutralizing antibody levels among individuals to identify possible immunity gaps. Methods: A cross-sectional, hospital-based study was undertaken in Northern, Ashanti and Greater Accra regions of Ghana. Individuals referred for haematology at the teaching hospitals' laboratories were invited to participate in our study. Neutralizing-antibody titers to poliovirus serotypes 1,2 & 3 were assayed by WHO-standards. Antibody titers of ≥8...
Source: Ghana Medical Journal - September 6, 2019 Category: African Health Tags: Ghana Med J Source Type: research

Borders and Blood Fractions: Gamma Globulin and Canada's Fight against Polio, 1950-55.
Abstract During the early 1950s, Canada's efforts to prevent polio became heavily influenced by developments in the United States. America's foremost polio charity, the National Foundation for Infantile Paralysis, sponsored University of Pittsburgh researcher Dr. William McD. Hammon to evaluate the efficacy of a human blood fraction, gamma globulin (GG), to prevent paralytic polio. When the resulting clinical trial data appeared to show that the blood fraction offered some protection against the disease, Canadians embraced the concept for reasons of historical trust, parental demand, and public health pragmatism. ...
Source: Medical History - September 6, 2019 Category: History of Medicine Authors: Mawdsley SE Tags: Can Bull Med Hist Source Type: research

Viruses, Vol. 11, Pages 821: Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review
rke Tyler In 2014, the United States (US) experienced an unprecedented epidemic of enterovirus D68 (EV-D68)-induced respiratory disease that was temporally associated with the emergence of acute flaccid myelitis (AFM), a paralytic disease occurring predominantly in children, that has a striking resemblance to poliomyelitis. Although a definitive causal link between EV-D68 infection and AFM has not been unequivocally established, rapidly accumulating clinical, immunological, and epidemiological evidence points to EV-D68 as the major causative agent of recent seasonal childhood AFM outbreaks in the US. This review su...
Source: Viruses - September 4, 2019 Category: Virology Authors: Hixon Frost Rudy Messacar Clarke Tyler Tags: Review Source Type: research

Viruses, Vol. 11, Pages 821: Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review
th L. Tyler In 2014, the United States (US) experienced an unprecedented epidemic of enterovirus D68 (EV-D68)-induced respiratory disease that was temporally associated with the emergence of acute flaccid myelitis (AFM), a paralytic disease occurring predominantly in children, that has a striking resemblance to poliomyelitis. Although a definitive causal link between EV-D68 infection and AFM has not been unequivocally established, rapidly accumulating clinical, immunological, and epidemiological evidence points to EV-D68 as the major causative agent of recent seasonal childhood AFM outbreaks in the US. This review summ...
Source: Viruses - September 4, 2019 Category: Virology Authors: Alison M. Hixon Joshua Frost Michael J. Rudy Kevin Messacar Penny Clarke Kenneth L. Tyler Tags: Review Source Type: research

Let us not underestimate the long-term risk of SPLC after surgical resection of NSCLC
Lung cancer is the most common cause of cancer death worldwide1. Non-small cell lung carcinoma (NSCLC) accounts for around 85% of lung cancer cases. The standard treatment for patients with stage I and II NSCLC is surgery based, with or without postoperative chemotherapy depending on the pathological T and N status. Treatment for stage III NSCLC consists either of concurrent chemoradiation, or surgery with perioperative chemotherapy with or without thoracic radiotherapy2. After surgery, the 5-year survival rates range between 23 and 83%, depending on stage3. (Source: Lung Cancer)
Source: Lung Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Taylor Leroy, Elisabeth Monnet, St éphane Guerzider, Pascale Jacoulet, Bernardino De Bari, Pierre-Emmanuel Falcoz, Marie Gainet-Brun, Jean Lahourcade, Faraj Alfreijat, Hamadi Almotlak, Olivier Adotevi, Didier Pernet, Jean-Charles Polio, Maxime Desmarets, Source Type: research

Resurgence of Vaccine-Preventable Disease: Ethics in the Pediatric Emergency Department
After a decades-long reduction in vaccine-preventable illnesses worldwide, there has been a reappearance of childhood illnesses once thought to be eradicated. This resurgence in illnesses such as polio and measles is a consequence of multifactorial events leading to decreased vaccination rates. A lack of resources in poor and war-torn countries, coupled with increasing global travel, and decisions to delay or defer vaccinations because of inaccurate studies further emphasized by media have combined to result in current state of frequent local and widespread epidemics, specifically the current outbreak of measles. As provid...
Source: Pediatric Emergency Care - September 1, 2019 Category: Emergency Medicine Tags: Review Articles Source Type: research

Wild polio virus eradicated in Nigeria, but battle isn't over yet
Publication date: 31 August 2019Source: New Scientist, Volume 243, Issue 3245Author(s): Debora MacKenzie (Source: New Scientist)
Source: New Scientist - September 1, 2019 Category: Science Source Type: research

[Live Vaccine in Children with DiGeorge/22q11.2 Deletion Syndrome].
CONCLUSION: In our sample, live vaccines were well-tolerated, even in children with moderate T-CD4+ lymphopenia and abnormal lymphocyte proliferative responses to antigens/mitogens. PMID: 31445531 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - August 27, 2019 Category: General Medicine Tags: Acta Med Port Source Type: research

Wild polio has been eradicated in Nigeria but infections will continue
Nigeria has officially wiped out wild polio, but there have already been 15 cases of infection this year, caused by the live virus used in some vaccines (Source: New Scientist - Health)
Source: New Scientist - Health - August 23, 2019 Category: Consumer Health News Source Type: research

DTaP-IPV-HepB-Hib Vaccine (Hexyon ® ): An Updated Review of its Use in Primary and Booster Vaccination
AbstractHexyon® is a fully-liquid, ready-to-use, hexavalent vaccine approved in the EU since 2013 for primary and booster vaccination in infants and toddlers from age 6  weeks against diphtheria, tetanus, pertussis, hepatitis B (HB), poliomyelitis, and invasive diseases caused byHaemophilus influenzae type b (Hib). While the source of HB antigen in Hexyon® is different from other vaccines, the rest of its valences have been extensively used in other approved vaccines. Hexyon® is highly immunogenic for all its component toxoids/antigens when used as primary and booster vaccine in infants and toddlers, irres...
Source: Pediatric Drugs - August 23, 2019 Category: Pediatrics Source Type: research

Progress Toward Poliomyelitis Eradication - Afghanistan, January 2018-May 2019.
This report describes polio eradication activities and progress in Afghanistan during January 2018-May 2019 and updates previous reports (2,3). During May-December 2018, insurgent groups (antigovernment elements) banned house-to-house vaccination in most southern and southeastern provinces, leaving approximately 1 million children inaccessible to oral poliovirus vaccine (OPV) administration. During January-April 2019, vaccination targeting children at designated community sites (site-to-site vaccination) was permitted; however, at the end of April 2019, vaccination campaigns were banned nationally. During 2018, a total of ...
Source: MMWR Morb Mortal Wkl... - August 23, 2019 Category: Epidemiology Authors: Martinez M, Shukla H, Nikulin J, Mbaeyi C, Jorba J, Ehrhardt D Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Viruses, Vol. 11, Pages 775: Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation
This study aimed to detect the introduction and/or circulation of wild poliovirus or vaccine-derived polioviruses (VDPV) in wastewater, covering a significant population of Armenia, Colombia, before trivalent oral polio vaccine (OPV) cessation. Between March and September 2015, 24 wastewater samples were collected from eight study sites in eight communes of Armenia, Colombia. Virus detection and characterization were performed using both cell culture (i.e., RD or L20B cells) and RT-PCR. Polioviruses were isolated in 11 (45.8%) of 24 wastewater samples. All isolates were identified as Sabin strains (type 1 = 9, type 3 = 2) ...
Source: Viruses - August 23, 2019 Category: Virology Authors: Mar ía Mercedes González Magile C. Fonseca Carlos Andr és Rodríguez Alejandra Mar ía Giraldo Jos é Joaquín Vila Jhon Carlos Casta ño Leonardo Padilla Luis Sarmiento Tags: Communication Source Type: research

Post-vaccination campaign coverage evaluation of oral cholera vaccine, oral polio vaccine and measles –rubella vaccine among Forcibly Displaced Myanmar Nationals in Bangladesh
. (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - August 23, 2019 Category: Allergy & Immunology Authors: Ashraful Islam Khan Md. Taufiqul Islam Shah Alam Siddique Shakil Ahmed Nurnabi Sheikh Ashraf Uddin Siddik Muhammad Shariful Islam Firdausi Qadri Source Type: research

DTaP-IPV-HepB-Hib Vaccine (Hexyon ®): An Updated Review of its Use in Primary and Booster Vaccination.
DTaP-IPV-HepB-Hib Vaccine (Hexyon®): An Updated Review of its Use in Primary and Booster Vaccination. Paediatr Drugs. 2019 Aug 23;: Authors: Syed YY Abstract Hexyon® is a fully-liquid, ready-to-use, hexavalent vaccine approved in the EU since 2013 for primary and booster vaccination in infants and toddlers from age 6 weeks against diphtheria, tetanus, pertussis, hepatitis B (HB), poliomyelitis, and invasive diseases caused by Haemophilus influenzae type b (Hib). While the source of HB antigen in Hexyon® is different from other vaccines, the rest of its valences have been extensively u...
Source: Paediatric Drugs - August 23, 2019 Category: Pediatrics Authors: Syed YY Tags: Paediatr Drugs Source Type: research

The art of partnerships for vaccines.
Abstract The Developing Countries Vaccine Manufacturers Network (DCVMN) convened vaccine manufacturing experts and leaders from local and global public health organizations for its 19th Annual General Meeting. Lectures and panel discussions centered on international cooperation for better access to vaccines, and partnerships in areas ranging from vaccine research and process development, to clinical studies, regulatory, supply chain and emergency preparedness and response. Global vaccine market trends and changes that will impact vaccine financing and procurement methods were discussed as well as capital sources, ...
Source: Vaccine - August 22, 2019 Category: Allergy & Immunology Authors: Pagliusi S, Che Y, Dong S Tags: Vaccine Source Type: research

New, less-expensive inactivated polio vaccine non-inferior to conventional inactivated vaccine
Hu Y, Wang J, Zeng G, Chu K, Jiang D, Zhu F, et al. Immunogenicity and Safety of a Sabin Strain-Based Inactivated Polio Vaccine: A Phase 3 Clinical Trial. J Infect Dis 2019 pii: jiy736. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - August 20, 2019 Category: Pediatrics Authors: Andrew Kreppel Tags: Current Best Evidence Source Type: research

The future of vaccine development.
Abstract Vaccines are one of the most successful public health interventions in our history resulting in eradication of small pox, near eradication of polio and major reductions in case number and global morbidity and mortality for numerous diseases (Centers for Disease C, 1999) [1]. However, vaccine development has been less successful against complex infectious diseases, where pathogen variability and/or immune evasion mechanisms have combined to pose major obstacles, and have been unsuccessful against non-communicable diseases, including cancer, autoimmunity, allergy, neurodegenerative and metabolic diseases (K...
Source: Vaccine - August 20, 2019 Category: Allergy & Immunology Authors: Koff WC, Schenkelberg T Tags: Vaccine Source Type: research

Quality of life assessment scales in polio survivors: a scoping review
ConclusionThe information provided in this review could be used to guide instrument selection and identify the need to develop a new tool or to adapt a pre-existing scale for measuring quality of life among polio survivors. (Source: Quality of Life Research)
Source: Quality of Life Research - August 17, 2019 Category: Health Management Source Type: research

Acute flaccid myelitis and enterovirus D68: lessons from the past and present
Conclusion: This review presents the current knowledge on acute flaccid myelitis with respect to the clinical presentation and its differential diagnosis with Guillain-Barr é syndrome and acute transverse myelitis. We also discuss the association with enterovirus D68 and the presumed pathophysiological mechanism of this infection causing anterior horn cell damage. Sharing clinical knowledge and insights from basic research is needed to make progress in diagnosis, trea tment, and prevention of this new polio-like disease.What is Known:•Acute flaccid myelitis (AFM) is a polio-like condition characterized by rapid...
Source: European Journal of Pediatrics - August 15, 2019 Category: Pediatrics Source Type: research

Turning Trash Cans into Iron Lungs: Dr. Robert M. Coffey, the “Genius of Juneau”
Portland surgical pioneer Robert Calvin Coffey named his youngest son Robert Mayo Coffey (1906 to 1972,right). The latter earned his M.D. at the University of Michigan and returned with his wife to his native Oregon. By 1937 the couple and their two young daughters were living in Juneau, Alaska. When neighboring children were quarantined with infantile paralysis, the resourceful Dr. Coffey began converting trash cans into iron lungs (left), just in case any children developed breathing difficulties. Electrical valves on Coffey ’s “pressure and reserve tanks” alternated positive and negative pressures for ...
Source: Anesthesiology - August 13, 2019 Category: Anesthesiology Source Type: research

Growing up with a disability following paralytic poliomyelitis: experiences from persons with late effects of polio.
Conclusion: The challenges of growing up with a disability following paralytic polio led to the development of various psychological strategies for managing daily life. By understanding these experiences and strategies, knowledge may be gained in assisting rehabilitation professionals to better support persons with late effects of polio in adapting to the new situation. Implications for rehabilitation At the onset of late effects of polio, strategies developed earlier in life, such as overachieving, disregarding pain, and weariness, may not function anymore. Understanding the experiences of growing up with poliomyelitis ca...
Source: Disability and Rehabilitation - August 6, 2019 Category: Rehabilitation Authors: Sjödahl Hammarlund C, Lexell J, Brogårdh C Tags: Disabil Rehabil Source Type: research

Progress Toward Poliomyelitis Eradication - Nigeria, January 2018-May 2019.
Abstract The number of wild poliovirus (WPV) cases in Nigeria decreased from 1,122 in 2006 to six WPV type 1 (WPV1) in 2014 (1). During August 2014-July 2016, no WPV cases were detected; during August-September 2016, four cases were reported in Borno State. An insurgency in northeastern Nigeria had resulted in 468,800 children aged
Source: MMWR Morb Mortal Wkl... - July 26, 2019 Category: Epidemiology Authors: Adamu US, Archer WR, Braka F, Damisa E, Siddique A, Baig S, Higgins J, Sume GE, Banda R, Korir CK, Waziri N, Gidado S, Bammeke P, Edukugo A, Nganda GW, Forbi JC, Burns CC, Liu H, Jorba J, Asekun A, Franka R, Wassilak SGF, Bolu O Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Association Between Simian Virus 40 and Human Tumors
Simian virus 40 (SV40) is small DNA tumor virus of monkey origin. This polyomavirus was administered to human populations mainly through contaminated polio vaccines, which were produced in naturally-infected SV40 monkey cells. Previous molecular biology and recent immunological assays have indicated that SV40 is spreading in human populations, independently from early SV40-contaminated vaccines. SV40 DNA sequences have been detected at higher prevalence in specific human cancer specimens, such as brain and bone tumors, malignant pleural mesotheliomas and lymphoproliferative disorders, compared to corresponding normal tissu...
Source: Frontiers in Oncology - July 25, 2019 Category: Cancer & Oncology Source Type: research

Natural Clearance of Prolonged VDPV Infection in a Child With Primary Immunodeficiency Disorder
The emergence of immunodeficiency associated vaccine-derived polioviruses (iVDPV) from the children with primary immunodeficiency disorders poses a threat to the eradication program. Herein we report a patient with severe combined immunodeficiency (SCID), identified as a prolonged serotype 3 VDPV (VDPV3) excreter with thirteen VDPV3 isolates and maximum of 10.33% nucleotide divergence, who abruptly cleared infection after a period of two years. Occurrence of an episode of Norovirus diarrhea associated with increased activated oligoclonal cytotoxic T cells, inverse CD4:CD8 ratio, significantly elevated pro-inflammatory cyto...
Source: Frontiers in Immunology - July 23, 2019 Category: Allergy & Immunology Source Type: research

Poliomyelitis outbreak in Papua New Guinea: health system and health security implications for PNG and Australia.
Authors: Hall JJ, Ambang T, Asante A, Mapira P, Craig A, Schuele E, Pervaz Iqbal M PMID: 31318056 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - July 19, 2019 Category: General Medicine Tags: Med J Aust Source Type: research

Twitter Conversations and English News Media Reports on Poliomyelitis in Five Different Countries, January 2014 to April 2015.
DISCUSSION: Contrary to our hypothesis, our evidence suggests Twitter content differs significantly from English mass media content. Evidence from our study helps inform media monitoring and communications surveillance during global public health crises, such as infectious disease outbreaks, as well as reactions to health promotion campaigns. PMID: 31314733 [PubMed - in process] (Source: The Permanente journal)
Source: The Permanente journal - July 19, 2019 Category: General Medicine Tags: Perm J Source Type: research

Enteroviral meningitis reduces CSF concentration of A β42, but does not affect markers of parenchymal damage
AbstractBiomarkers classically studied in Alzheimer ’s disease have been analyzed in numerous central nervous system infections in adults, but there are scarce data on these biomarkers in children. Enteroviruses appear to be the most common cause of aseptic meningitis throughout the world. The aim of the study was to investigate neuroinflammatory p roperties of non-polio enteroviruses by measuring CSF concentrations of biomarkers that are involved in neuropathological pathways of neurodegenerative disorders. We measured Aβ42, t-tau, and S100B concentrations in 42 children with enteroviral meningitis (EM) compare...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 18, 2019 Category: Microbiology Source Type: research

Fred Snite, Jr., Headlined as the “Iron Lung Boy” Who Attended a Wedding
Long before he was paralyzed by poliomyelitis, Frederick Bernard Snite, Jr. (1910 to 1954) shared childhood adventures with Joseph Murray (left) and Mary Grass. Much later, as a 26-yr-old tourist to China in 1936, “Fred” was stricken with infantile paralysis. Fortunately, his financier father could marshal resources to save Fred Jr. with an assortment of “iron lung” and other ventilatory assistance devices. After visiting the Shrine of Miracles in 1939 in Lourdes, France, for spiritual inspiration, Fr ed Jr. witnessed the wedding of Joseph and Mary, his two childhood friends, by using the swiveling ...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease
Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the aetiology of PPS remains elusive, mechanisms of progression are poorly understood and the condition is notoriously under-researched. While motor dysfunction is a hallmark feature of the condition, generalised fatigue, sleep disturbance, decreased endurance, neuropsychological deficits, sensory symptoms and chronic pain are also often reported and have considerable quality of life implications in PPS. The non-motor aspects of PPS are particularly challenging to evaluate, ...
Source: Frontiers in Neurology - July 16, 2019 Category: Neurology Source Type: research

A 5-year study of human parechoviruses in children living in bad sanitation conditions and non-polio acute flaccid paralysis children from Greece
We describe the presence of HPeVs in Greece, and we enforce that their diagnosis should be considered in children with neurological outcome such as non-polio AFP. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 16, 2019 Category: Microbiology Source Type: research

Vaccination uptake and income inequalities within a mass vaccination campaign
ConclusionsPublic health professionals promoting vaccine programs need to make specially-designed efforts both in localities with high average income and in localities with a high level of income diversity/inequality. Such practice will better utilize funds, resources, and manpower dedicated to increasing vaccination uptake across varying populations and communities. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - July 15, 2019 Category: International Medicine & Public Health Source Type: research

Movement Analysis in Orthopedics and Trauma Surgery - Measurement Systems and Clinical Applications.
CONCLUSION: The instrumented movement analysis is an additional tool that aids clinical practitioners of O/U in the dynamic assessment of pathologic movement and loading patterns. In conjunction with common radiologic imaging it aids in the planning of type and extent of corrective surgical interventions. In the field of orthopaedics and trauma surgery movement analysis can help as an additional diagnostic tool to develop therapeutic strategies and evaluate clinical outcomes. PMID: 31291674 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Orthopadie und Unfallchirurgie)
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - July 12, 2019 Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research