Demand-side determinants of timely vaccination of oral polio vaccine in social mobilization network areas of CORE Group polio project in Uttar Pradesh, India
Children who receive all doses of scheduled vaccines reduce their susceptibility to vaccine-preventable diseases. In India, full immunization coverage has increased significantly. However, only a small proport... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 16, 2018 Category: Infectious Diseases Authors: Manojkumar Choudhary, Roma Solomon, Jitendra Awale and Rina Dey Tags: Research article Source Type: research

Identification of etiology-specific diarrhea associated with linear growth faltering in Bangladeshi infants.
Abstract Childhood diarrhea in low-resource settings has been variably linked to linear growth shortfalls. However, the association between etiology-specific diarrhea and growth has not been comprehensively evaluated. We tested diarrheal stools collected from the Performance of Rotavirus and Oral Polio Vaccines in Developing Countries study from 2011-2013 in Dhaka, Bangladesh by quantitative polymerase chain reaction for a broad range of enteropathogens to characterize diarrhea etiology and examine the association between etiology-specific diarrhea and linear growth and systemic inflammation. Pathogen-specific bur...
Source: Am J Epidemiol - May 15, 2018 Category: Epidemiology Authors: Schnee AE, Haque R, Taniuchi M, Uddin J, Alam M, Liu J, Rogawski ET, Kirkpatrick B, Houpt ER, Petri WA, Platts-Mills JA Tags: Am J Epidemiol Source Type: research

Reintroducing OPV in Israel on the journey to global polio eradication - Estimation at a low rate of contraindicated population.
CONCLUSION: A statistical model can provide an estimation of the contraindicated population and can be used in the future when devising vaccination campaigns. In contrast to concerns raised by the MOH, our findings show a smaller than anticipated contraindicated population. PMID: 29776752 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - May 15, 2018 Category: Allergy & Immunology Authors: Rosenberg Danziger C, Anis E, Gordon ES, Grotto I, Danon YL Tags: Vaccine Source Type: research

Evaluating scenarios of locations and capacities for vaccine storage in Nigeria.
Abstract Many developing countries still face the prevalence of preventable childhood diseases because their vaccine supply chain systems are inadequate by design or structure to meet the needs of their populations. Currently, Nigeria is evaluating options in the redesign of the country's vaccine supply chain. Using Nigeria as a case study, the objective is to evaluate different regional supply chain scenarios to identify the cost minimizing optimal hub locations and storage capacities for doses of different vaccines to achieve a 100% fill rate. First, we employ a shortest-path optimization routine to determine hu...
Source: Vaccine - May 14, 2018 Category: Allergy & Immunology Authors: Hirsh Bar Gai D, Graybill Z, Voevodsky P, Shittu E Tags: Vaccine Source Type: research

IJERPH, Vol. 15, Pages 968: Immunization Offer Targeting Migrants: Policies and Practices in Italy
ARE Working Group The unprecedented flow of migrants over the last three years places Italy in front of new issues regarding medical care from the rescue phase up to the integration into the national health services, including preventive actions. We used online questionnaires to investigate the Italian national and regional policies for immunization offer targeting asylum seekers, refugees, irregular migrants and unaccompanied minors. Another questionnaire was used to assess how these policies are translated into practice in migrant reception centres and community health services. Questionnaires were filled out at the ...
Source: International Journal of Environmental Research and Public Health - May 12, 2018 Category: Environmental Health Authors: Teresa Dalla Zuanna Martina Del Manso Cristina Giambi Flavia Riccardo Antonino Bella Maria Caporali Maria Dente Silvia Declich The Italian Survey CARE Working Group Tags: Article Source Type: research

Post ‐Polio Syndrome and the Late Effects of Poliomyelitis: Part 2. Treatment, Management and Prognosis
Muscle&Nerve,Volume 0, Issue ja, -Not available-. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 12, 2018 Category: Internal Medicine Authors: Julian K.Lo MD , Lawrence R.Robinson MD Source Type: research

Post ‐Polio Syndrome and the Late Effects of Poliomyelitis: Part 1. Pathogenesis, Biomechanical Considerations, Diagnosis, and Investigations
Muscle&Nerve,Volume 0, Issue ja, -Not available-. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 12, 2018 Category: Internal Medicine Authors: Julian K.Lo MD , Lawrence R.Robinson MD Source Type: research

Post ‐Polio Syndrome and the Late Effects of Poliomyelitis: Part 2. Treatment, Management and Prognosis
Muscle&Nerve,Volume 0, Issue ja, -Not available-. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 12, 2018 Category: Internal Medicine Authors: Julian K.Lo MD , Lawrence R.Robinson MD Source Type: research

Post ‐Polio Syndrome and the Late Effects of Poliomyelitis: Part 1. Pathogenesis, Biomechanical Considerations, Diagnosis, and Investigations
Muscle&Nerve,Volume 0, Issue ja, -Not available-. (Source: Muscle and Nerve)
Source: Muscle and Nerve - May 12, 2018 Category: Internal Medicine Authors: Julian K.Lo MD , Lawrence R.Robinson MD Source Type: research

Progress Toward Polio Eradication - Worldwide, January 2016-March 2018.
This report describes global progress toward polio eradication during January 2016-March 2018, and updates previous reports (2). In 2017, 22 WPV1 cases were reported, a 41% decrease from the 37 WPV1 cases reported in 2016. As of April 24, 2018, eight WPV1 cases have been reported (seven in Afghanistan and one in Pakistan), compared with five cases during the same period in 2017. In Pakistan, continuing WPV1 transmission has been confirmed in multiple areas in 2018 by isolation from wastewater samples. In Nigeria, ongoing endemic WPV1 transmission was confirmed in 2016 (3); although WPV was not detected in 2017 or in 2018 t...
Source: MMWR Morb Mortal Wkl... - May 11, 2018 Category: Epidemiology Authors: Khan F, Datta SD, Quddus A, Vertefeuille JF, Burns CC, Jorba J, Wassilak SGF Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Australian Paediatric Surveillance Unit Annual Report, 2016.
This report summarises the cases reported to the Australian Paediatric Surveillance Unit (APSU) of rare infectious diseases or rare complications of more common infectious diseases in children. During the calendar year 2016, there were approximately 1500 paediatricians reporting to the APSU and the monthly report card return rate was 90%. APSU continued to provide unique national data on the perinatal exposure to HIV, congenital rubella, congenital cytomegalovirus, neonatal and infant herpes simplex virus, and congenital and neonatal varicella. APSU contributed 10 unique cases of Acute Flaccid Paralysis (a surrogate for po...
Source: Communicable Diseases Intelligence Quarterly Report - May 4, 2018 Category: Infectious Diseases Tags: Commun Dis Intell Q Rep Source Type: research

56 - Oral Iron Supplementation During First Year of Life and Diphteria, Tetanus, Pertussis and Polio Vaccination Reduce the Risk of Inflammatory Bowel Disease
(Source: Gastroenterology)
Source: Gastroenterology - May 1, 2018 Category: Gastroenterology Authors: Timo Blomster, Olli-Pekka Koivurova, Ritva Koskela, Karl-Heinz Herzig, Markku Koiranen, Nicholas J. Talley, Jukka Ronkainen Tags: AGA Abstracts Source Type: research

Birth of Airway Surgery and Evolution over the Past Fifty Years
Significant developments in airway surgery occurred following the introduction of mechanical ventilators and intubation with cuffed endotracheal tubes during the poliomyelitis epidemic of the 1950s. The resulting plethora of postintubation injuries provided extensive experience with resection and reconstruction of stenotic tracheal lesions. In the early 1960s, it was thought that no more 2 cm of trachea could be removed. By the late 1960s, this was challenged owing to better knowledge of airway anatomy and blood supply, tension-releasing maneuvers, and improved anesthetic techniques. Currently, about half of the tracheal l...
Source: Thoracic Surgery Clinics - May 1, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Jean Deslauriers Source Type: research

Assessment of temperatures in the vaccine cold chain in two provinces in Lao People ’s Democratic Republic: a cross-sectional pilot study
All childhood vaccines, except the oral polio vaccine, should be kept at 2 –8 °C, since the vaccine potency can be damaged by heat or freezing temperature. A temperature monitoring study conducted in 2008–2009 ... (Source: BMC Research Notes)
Source: BMC Research Notes - April 27, 2018 Category: Research Authors: Tomomi Kitamura, Viraneth Bouakhasith, Kongxay Phounphenghack, Chansay Pathammavong, Anonh Xeuatvongsa, Masataro Norizuki, Hironori Okabayashi, Yoshio Mori, Munehito Machida and Masahiko Hachiya Tags: Research note Source Type: research

Assessing the stability of polio eradication after the withdrawal of oral polio vaccine
by Michael Famulare, Christian Selinger, Kevin A. McCarthy, Philip A. Eckhoff, Guillaume Chabot-Couture The oral polio vaccine (OPV) contains live-attenuated polioviruses that induce immunity by causing low virulence infections in vaccine recipients and their close contacts. Widespread immunization with OPV has reduced the annual global burden of paralytic poliomyelitis by a factor of 10,000 or more and has driven wild poliovirus (WPV) to the brink of eradication. However, in instances that have so far been rare, OPV can paralyze vaccine recipients and generate vaccine-derived polio outbreaks. To complete polio eradicatio...
Source: PLoS Biology: Archived Table of Contents - April 27, 2018 Category: Biology Authors: Michael Famulare Source Type: research

The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda
The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs). (Source: Virology Journal)
Source: Virology Journal - April 27, 2018 Category: Virology Authors: Mary Bridget Nanteza, Barnabas Bakamutumaho, Annet Kisakye, Prossy Namuwulya, Henry Bukenya, Edson Katushabe, Josephine Bwogi, Charles Rutebarika Byabamazima, Raffaella Williams and Nicksy Gumede Tags: Research Source Type: research

Genes, Vol. 9, Pages 228: Structure-Function Mutational Analysis and Prediction of the Potential Impact of High Risk Non-Synonymous Single-Nucleotide Polymorphism on Poliovirus 2A Protease Stability Using Comprehensive Informatics Approaches
In this study, the three-dimensional structure of 2A protease was determined and optimized by homology modelling. To predict the molecular basis of the interaction of small molecular agonists, docking simulations were performed on a structurally diverse dataset of poliovirus 2A protease (PV2Apr°) inhibitors. Docking results were employed to identify high risk missense mutations that are highly damaging to the structure, as well as the function, of the protease. Intrinsic disorder regions (IDRs), drug binding sites (DBS), and protein stability changes upon mutations were also identified among them. Our results d...
Source: Genes - April 26, 2018 Category: Genetics & Stem Cells Authors: Amna Younus Saba Munawar Muhammad Faraz Bhatti Aqsa Ikram Faryal Mehwish Awan Ishrat Jabeen Nasar Virk Hussnain Ahmed Janjua Muhammad Arshad Tags: Article Source Type: research

In Vitro Killing of Colorectal Carcinoma Cells by Autologous Activated NK Cells is Boosted by Anti-Epidermal Growth Factor Receptor-induced ADCC Regardless of RAS Mutation Status
In this study, after confirmation that patients’ NK cells were not impaired in their cytotoxic activity, evaluated against long-term tumor cell lines, we evaluated their interactions with autologous mCRC cells. Molecular and phenotypical evaluation of mCRC cells, expanded in vitro from liver metastasis, showed that they expressed high levels of polio virus receptor and Nectin-2, whereas UL16-binding proteins were less expressed in all tumor samples evaluated. Two different patterns of MICA/B and HLA class I expression on the membrane of mCRC were documented; approximately half of mCRC patients expressed high levels o...
Source: Journal of Immunotherapy - April 21, 2018 Category: Allergy & Immunology Tags: Basic Studies Source Type: research

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.
Abstract Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility to infection, indicating that KREMEN1 is a rate-limiting factor for CV-A10 infection. Furthermore, the extracellul...
Source: Cell Host and Microbe - April 18, 2018 Category: Microbiology Authors: Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR Tags: Cell Host Microbe Source Type: research

6.5-O8High coverage of the polio immunization program in refugees resettling in Denmark
Background: (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - April 17, 2018 Category: General Medicine Source Type: research

Surveillance to Track Progress Toward Polio Eradication - Worldwide, 2016-2017.
Abstract Global efforts to eradicate polio began in 1988, and four of the six World Health Organization (WHO) regions currently have achieved poliofree certification. Within the remaining two regions with endemic poliomyelitis (African and Eastern Mediterranean), Afghanistan, Nigeria, and Pakistan have never interrupted transmission of wild poliovirus (WPV). The primary means of detecting poliovirus transmission is surveillance for acute flaccid paralysis (AFP) among children aged
Source: MMWR Morb Mortal Wkl... - April 13, 2018 Category: Epidemiology Authors: Gardner TJ, Diop OM, Jorba J, Chavan S, Ahmed J, Anand A Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Evaluation of the use of various rat strains for immunogenic potency tests of Sabin-derived inactivated polio vaccines
Publication date: March 2018 Source:Biologicals, Volume 52 Author(s): Yuichi Someya, Yasushi Ami, Reiko Takai-Todaka, Akira Fujimoto, Kei Haga, Kosuke Murakami, Yoshiki Fujii, Haruko Shirato, Tomoichiro Oka, Takashi Shimoike, Kazuhiko Katayama, Takaji Wakita Slc:Wistar rats have been the only strain used in Japan for purpose of evaluating a national reference vaccine for the Sabin-derived inactivated polio vaccine (sIPV) and the immunogenicity of sIPV-containing products. However, following the discovery that the Slc:Wistar strain was genetically related to the Fischer 344 strain, other “real” Wistar strains, ...
Source: Biologicals - April 13, 2018 Category: Biology Source Type: research

Population sensitivity of acute flaccid paralysis and environmental surveillance for serotype 1 poliovirus in Pakistan: an observational study
To support poliomyelitis eradication in Pakistan, environmental surveillance (ES) of wastewater has been expanded alongside surveillance for acute flaccid paralysis (AFP). ES is a relatively new method of surv... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 13, 2018 Category: Infectious Diseases Authors: Kathleen M. O ’Reilly, Robert Verity, Elias Durry, Humayun Asghar, Salmaan Sharif, Sohail Z. Zaidi, M. Zubair M. Wadood, Ousmane M. Diop, Hiro Okayasu, Rana M. Safdar and Nicholas C. Grassly Tags: Research article Source Type: research

Planning for globally coordinated cessation of bivalent oral poliovirus vaccine: risks of non-synchronous cessation and unauthorized oral poliovirus vaccine use
Oral polio vaccine (OPV) containing attenuated serotype 2 polioviruses was globally withdrawn in 2016, and bivalent OPV (bOPV) containing attenuated serotype 1 and 3 polioviruses needs to be withdrawn after th... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 10, 2018 Category: Infectious Diseases Authors: Radboud J. Duintjer Tebbens, Lee M. Hampton and Kimberly M. Thompson Tags: Research article Source Type: research

Ensuring childhood vaccination among slums dwellers under the National Immunization Program in India - Challenges and opportunities
Conclusion Thus, in addition to inclusion of more and more vaccines in the National Immunization Program, there is a definite need to focus on people living in high risk areas in order to improve coverage and healthcare indicators. (Source: Preventive Medicine)
Source: Preventive Medicine - April 10, 2018 Category: International Medicine & Public Health Source Type: research

Short communication: Could the genexpert system be a new tool for poliovirus detection in the sewage water?
Authors: Bãicuş A Abstract Environmental enterovirus surveillance plays a key role in the detection and identification of importation of circulating vaccine-derived polioviruses into polio-free areas. In 2015, 2 cases of paralytic poliomyelitis caused by circulating vaccine-derived poliovirus type 1 (cVDPV1), from south-western Ukraine, bordering Romania, were confirmed. Romania was considered a country at risk and the environmental enterovirus surveillance was enhanced. In this context we tried to find a diagnosis algorithm for the rapid detection of poliovirus (PV) in the sewage water, using a combination...
Source: Roumanian Archives of Microbiology and Immunology - April 7, 2018 Category: Microbiology Tags: Roum Arch Microbiol Immunol Source Type: research

How often do children receive their vaccinations late, and why?
CONCLUSION: Adherence to vaccination is fairly common in this part of the country. However, vaccination delays are still present and should be addressed to improve health care. PMID: 29619485 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 7, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research

Polio transition: overlooked challenges
Publication date: 7–13 April 2018 Source:The Lancet, Volume 391, Issue 10128 Author(s): Oliver Razum, Maike Voss (Source: The Lancet)
Source: The Lancet - April 7, 2018 Category: General Medicine Source Type: research

On reducing the risk of vaccine-associated paralytic poliomyelitis in the global transition from oral to inactivated poliovirus vaccine
Publication date: Available online 5 April 2018 Source:The Lancet Author(s): Xiangdong Peng, Xiaojiang Hu, Miguel A Salazar (Source: The Lancet)
Source: The Lancet - April 7, 2018 Category: General Medicine Source Type: research

[Correspondence] Polio transition: overlooked challenges
The reduction in the number of poliomyelitis cases by more than 99% is an extraordinary success of the global community. In their Comment, Michel Zaffran and colleagues (Jan 6, p 11)1 assume that eradication will be achieved soon and focus on strategies to ensure that poliovirus will not be reintroduced into a polio-free world.2 (Source: LANCET)
Source: LANCET - April 6, 2018 Category: General Medicine Authors: Oliver Razum, Maike Voss Tags: Correspondence Source Type: research

Good practices and challenges in addressing poliomyelitis and measles in the European Union
ConclusionsPoliomyelitis and measles should be brought fully onto the policy agendas of all EU/EEA Member States, and adequate resources provided to address them. Each country must abide by the relevant commitments that they have already made. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - April 6, 2018 Category: General Medicine Source Type: research

Birth of Airway Surgery and Evolution over the Past Fifty Years
Significant developments in airway surgery occurred following the introduction of mechanical ventilators and intubation with cuffed endotracheal tubes during the poliomyelitis epidemic of the 1950s. The resulting plethora of postintubation injuries provided extensive experience with resection and reconstruction of stenotic tracheal lesions. In the early 1960s, it was thought that no more 2 cm of trachea could be removed. By the late 1960s, this was challenged owing to better knowledge of airway anatomy and blood supply, tension-releasing maneuvers, and improved anesthetic techniques. Currently, about half of the tracheal l...
Source: Thoracic Surgery Clinics - April 5, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Jean Deslauriers Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Total Hip Arthroplasty for Patients with Residual Poliomyelitis at a Mean Eight Years of Follow-up.
Abstract In patients with poliomyelitis, degenerative arthritis of the hip may be encountered in the paralytic or normal contralateral limb because of leg length discrepancy, pelvic obliquity, or severe deformities of the affected hip. Although total hip arthroplasty (THA) is one of the most common orthopedic procedures, there are few reports of THA in adult patients with residual poliomyelitis. From March 2001 to January 2011, 5 patients with residual poliomyelitis (6 hips) underwent THA using uncemented implants at our hospital. We retrospectively evaluated the Japanese Orthopaedic Association (JOA) hip score, c...
Source: Acta Med Okayama - April 1, 2018 Category: Universities & Medical Training Authors: Sonekatsu M, Sonohata M, Kitajima M, Kawano S, Mawatari M Tags: Acta Med Okayama Source Type: research

Extension of French vaccination mandates: from the recommendation of the Steering Committee of the Citizen Consultation on Vaccination to the law.
lon F Abstract On 4 December 2017, French parliamentarians passed a law extending the vaccination mandates for children up to 2 years of age from three vaccinations (against diphtheria, tetanus and poliomyelitis) to 11 by adding vaccinations against pertussis, Haemophilus influenza b (Hib), hepatitis B, pneumococcal diseases, meningococcal C diseases, measles, mumps and rubella. This vote follows a recommendation made by the Steering Committee of the Citizen Consultation on Vaccination that took place in 2016. The law applies to all children born after 1 January 2018. Parents who do not fulfil the mandate will not...
Source: Euro Surveill - April 1, 2018 Category: Infectious Diseases Authors: Lévy-Bruhl D, Desenclos JC, Quelet S, Bourdillon F Tags: Euro Surveill Source Type: research

Whole body vibration on people with sequelae of polio.
CONCLUSIONS: WBV appears to be a safe exercise for this population. Long-term use in polio survivors needs to be researched, particularly in reducing barriers to participation to promote the physical aspects of health. PMID: 29596010 [PubMed - as supplied by publisher] (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - March 29, 2018 Category: Physiotherapy Authors: Da Silva CP, Szot CL, deSa N Tags: Physiother Theory Pract Source Type: research

Factors associated with routine immunization coverage of children under one year old in Lao People's Democratic Republic.
In this study, factors related to the immunization system and characteristics of provinces and districts in Lao PDR were examined to evaluate the association with routine immunization coverage. METHODS: Coverage rates for Bacillus Calmette-Guerin (BCG), Diphtheria-Tetanus-Pertussis-Hepatitis B (DTP-HepB), DTP-HepB-Hib (Haemophilus influenzae type B), polio (OPV), and measles (MCV1) vaccines from 2002 to 2014 collected through regular reporting system, were used to identify the immunization coverage trends in Lao PDR. Correlation analysis was performed using immunization coverage, characteristics of provinces or distri...
Source: Vaccine - March 29, 2018 Category: Allergy & Immunology Authors: Phoummalaysith B, Yamamoto E, Xeuatvongsa A, Louangpradith V, Keohavong B, Saw YM, Hamajima N Tags: Vaccine Source Type: research

White Book on Physical and Rehabilitation Medicine (PRM) in Europe. Chapter 4. History of the specialty: where PRM comes from.
Abstract In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with the history of the PRM medical specialty. The specialty evolved in different European countries, and sometimes also into the single countries, from different medical streams that finally joined. These included among others: balneology, gymnastic, use of physical agents (water, heat, cold, massage, joint manipulations, physical exercise, etc.). Another important role has been played by the increasing number of people experiencing or likely to experience disability due to improvement of medicine a...
Source: European Journal of Physical and Rehabilitation Medicine - March 24, 2018 Category: Rehabilitation Authors: European Physical and Rehabilitation Medicine Bodies Alliance Tags: Eur J Phys Rehabil Med Source Type: research

A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vaccine in 3 and 4-year-old healthy children in the UK.
CONCLUSION: Non-inferiority of dTap-IPVB to dTap-IPVR was demonstrated. Both vaccines had a clinically acceptable safety and reactogenicity profile when co-administered with MMRV to children 3-4 years old. TRIAL REGISTRATION: NCT01245049 (ClinicalTrials.gov). PMID: 29576304 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - March 22, 2018 Category: Allergy & Immunology Authors: Marlow R, Kuriyakose S, Mesaros N, Han HH, Tomlinson R, Faust SN, Snape MD, Pollard AJ, Finn A Tags: Vaccine Source Type: research

Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation
In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Among the first 100 patients enrolled in this study, only seven adult SOT candidates had proven polio vaccination at childhood. Three of these seven patients (43%) had no protective antibody titers to one or mor...
Source: The Brazilian Journal of Infectious Diseases - March 20, 2018 Category: Infectious Diseases Source Type: research

The future control of rotavirus disease: Can live oral vaccines alone solve the rotavirus problem?
Abstract Live oral rotavirus (RV) vaccines used worldwide are most effective in reducing diarrheal hospitalizations from RV in high income countries and least effective in low income countries where RV remains a prime cause of death in children. Research has failed to fully explain the reason for this difference of efficacy for RV vaccines, an observation made with other live oral vaccines for polio, cholera and typhoid fever. Use of parenteral vaccines have been successful in overcoming this problem for both polio and typhoid and parenteral RV vaccines are now in development. This approach should be pursued for r...
Source: Vaccine - March 19, 2018 Category: Allergy & Immunology Authors: Glass RI, Jiang B, Parashar U Tags: Vaccine Source Type: research

Vaccine-Derived Poliovirus Outbreaks and Events - Three Provinces, Democratic Republic of the Congo, 2017.
Abstract The last confirmed wild poliovirus (WPV) case in Democratic Republic of the Congo (DRC) had paralysis onset in December 2011 (1). DRC has had cases of vaccine-derived polioviruses (VDPVs) documented since 2004 (Table 1) (1-6). After an outbreak of 30 circulating VDPV type 2 (cVDPV2) cases during 2011-2012, only five VDPV2 cases were reported during 2013-2016 (Table 1) (1-6). VDPVs can emerge from oral poliovirus vaccine (OPV types 1, 2, or 3; Sabin) polioviruses that have genetically mutated resulting in reversion to neurovirulence. This process occurs during extensive person-to-person transmission in pop...
Source: MMWR Morb Mortal Wkl... - March 16, 2018 Category: Epidemiology Authors: Alleman MM, Chitale R, Burns CC, Iber J, Dybdahl-Sissoko N, Chen Q, Van Koko DR, Ewetola R, Riziki Y, Kavunga-Membo H, Dah C, Andriamihantanirina R Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Enhancing viral vaccine production using engineered knockout vero cell lines - A second look.
Abstract The global adoption of vaccines to combat disease is hampered by the high cost of vaccine manufacturing. The work described herein follows two previous publications (van der Sanden et al., 2016; Wu et al., 2017) that report a strategy to enhance poliovirus and rotavirus vaccine production through genetic modification of the Vero cell lines used in large-scale vaccine manufacturing. CRISPR/Cas9 gene editing tools were used to knockout Vero target genes previously shown to play a role in polio- and rotavirus production. Subsequently, small-scale models of current industry manufacturing systems were develope...
Source: Vaccine - March 16, 2018 Category: Allergy & Immunology Authors: Hoeksema F, Karpilow J, Luitjens A, Lagerwerf F, Havenga M, Groothuizen M, Gillissen G, Lemckert AAC, Jiang B, Tripp RA, Yallop C Tags: Vaccine Source Type: research

19-Polio-like syndrome – Electrophysiological findings
Although viral poliomyelitis has been eradicated in the Czech Republic for over 50  years, lesions of peripheral mononeurons with acute onset, frequently accompanied by fever, have still been known to occur. Despite the fact that there are no sensory distrubances, and the paresis tend to have typical distribution, they are often accompanied by pain. In addition, muscle atrophy i s a regular occurence. These acute motoneuron disorders and their possible combination with motor roots disorder are called “polio-like syndromes.” (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - March 13, 2018 Category: Neuroscience Authors: E. Ehler Source Type: research

Vernet syndrome resulting from varicella zoster virus infection —a very rare clinical presentation of a common viral infection
AbstractVernet syndrome is a unilateral palsy of glossopharyngeal, vagus, and accessory nerves. Varicella zoster virus (VZV) infection has rarely been described as a possible cause. A 76-year-old man presented with 1-week-long symptoms of dysphonia, dysphagia, and weakness of the right shoulder elevation, accompanied by a mild right temporal parietal headache with radiation to the ipsilateral ear. Physical examination showed signs compatible with a right XI, X, and XI cranial nerves involvement and also several vesicular lesions in the right ear ’s concha. He had a personal history of poliomyelitis and chickenpox. La...
Source: Journal of NeuroVirology - March 12, 2018 Category: Neurology Source Type: research

Incomplete childhood immunization with new and old vaccines and associated factors: BRISA birth cohort, S ão Luís, Maranhão State, Northeast Brazil.
This study estimated the percentages of incomplete immunization with new vaccines and old vaccines and associated factors in children 13 to 35 months of age belonging to a birth cohort in São Luís, the capital of Maranhão State, Brazil. The sample was probabilistic, with 3,076 children born in 2010. Information on vaccination was obtained from the Child's Health Card. The new vaccines, namely those introduced in 2010, were meningococcal C and 10-valent pneumococcal, and the old vaccines, or those already on the childhood immunization schedule, were BCG, hepatitis B, human rotavirus, polio, tetravalent ...
Source: Cadernos de Saude Publica - March 12, 2018 Category: International Medicine & Public Health Authors: Silva FS, Barbosa YC, Batalha MA, Ribeiro MRC, Simões VMF, Branco MDRFC, Thomaz ÉBAF, Queiroz RCS, Araújo WRM, Silva AAMD Tags: Cad Saude Publica Source Type: research

The multiple lives of DEAD-box RNA helicase DP103/DDX20/Gemin3.
Abstract Gemin3, also known as DDX20 or DP103, is a DEAD-box RNA helicase which is involved in more than one cellular process. Though RNA unwinding has been determined in vitro, it is surprisingly not required for all of its activities in cellular metabolism. Gemin3 is an essential gene, present in Amoeba and Metazoa. The highly conserved N-terminus hosts the helicase core, formed of the helicase- and DEAD-domains, which, based on crystal structure determination, have key roles in RNA binding. The C-terminus of Gemin3 is highly divergent between species and serves as the interaction site for several accessory fact...
Source: Biochemical Society Transactions - March 9, 2018 Category: Biochemistry Authors: Curmi F, Cauchi RJ Tags: Biochem Soc Trans Source Type: research

Ultrasound Guided Carpal Tunnel Release Using Dynamic Expansion of the Transverse Safe Zone in a Patient with Post-Polio Syndrome: A Case Report
Publication date: Available online 6 March 2018 Source:PM&R Author(s): Troy Henning, Daniel Lueders, Kate Chang, Lynda Yang The prevalence of carpal tunnel syndrome(CTS) in patients that suffer from post-polio syndrome occurs at a rate of 22%.[1] Irrespective of those with CTS, 74% of post-polio patients weight bear through their arms for ambulation or transfers.[1] As open carpal tunnel release is performed along the weight bearing region of the wrist, their functional independence may be altered while recovering. This case demonstrates that ultrasound guided carpal tunnel release(USCTR) was successfully performe...
Source: PMandR - March 6, 2018 Category: Rehabilitation Source Type: research

Polio eradication - just one final sprint to the finish.
ash;S PMID: 29513430 [PubMed - in process] (Source: Tidsskrift for den Norske Laegeforening)
Source: Tidsskrift for den Norske Laegeforening - March 6, 2018 Category: General Medicine Authors: Sivertsen ØS Tags: Tidsskr Nor Laegeforen Source Type: research

Ultrasound Guided Carpal Tunnel Release Using Dynamic Expansion of the Transverse Safe Zone in a Patient with Post-Polio Syndrome: A Case Report
The prevalence of carpal tunnel syndrome(CTS) in patients that suffer from post-polio syndrome occurs at a rate of 22%.[1] Irrespective of those with CTS, 74% of post-polio patients weight bear through their arms for ambulation or transfers.[1] As open carpal tunnel release is performed along the weight bearing region of the wrist, their functional independence may be altered while recovering. This case demonstrates that ultrasound guided carpal tunnel release(USCTR) was successfully performed in a patient with post-polio syndrome allowing him to immediately weight bear through his hands after the procedure so he could rec...
Source: PM and R - March 5, 2018 Category: Rehabilitation Authors: Troy Henning, Daniel Lueders, Kate Chang, Lynda Yang Source Type: research