Achieving the end game: employing “vaccine diplomacy” to eradicate polio in Pakistan
On April 28, 2014, the World Health Organization (WHO) declared polio a “Public Health Emergency of International Concern” (PHIC) under the authority of the International Health Regulations. Although polio has... (Source: BMC Public Health)
Source: BMC Public Health - January 17, 2019 Category: Consumer Health News Authors: Shahella Idrees Shakeel, Matthew Brown, Shakeel Sethi and Tim K. Mackey Tags: Correspondence Source Type: research

Outcome of femoral fractures in poliomyelitis patients
ConclusionsPolio patients with femoral fractures have a guarded prognosis for regaining their pre-injury ambulatory capacity. A higher re-operation rate than that with “normal” osteoporotic fractures is expected. (Source: International Orthopaedics)
Source: International Orthopaedics - January 15, 2019 Category: Orthopaedics Source Type: research

Two Randomized Trials of the Effect of the Russian Strain of Bacillus Calmette-Guérin Alone or With Oral Polio Vaccine on Neonatal Mortality in Infants Weighing
Background: In randomized trials in Guinea-Bissau, the Danish strain of Bacillus Calmette-Guérin (BCG) reduces neonatal mortality, primarily by reducing deaths from pneumonia and sepsis. Because World Health Organization–prequalified BCG-Denmark was not available in India, we conducted 2 randomized trials to test whether BCG-Russia alone or with oral polio vaccine (OPV) has similar effects to BCG-Denmark. Methods: We randomized neonates weighing (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - January 12, 2019 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Timeliness of routine immunization in non-preterm children less than 2 years old using electronic data capture in an ambulatory setting in France in the context of vaccine hesitancy.
CONCLUSION: This large study shows that the proportion of children with delayed vaccination in France was globally high and substantial for Men-C and the first MMR vaccination. Risk of a delayed second and third dose was increased with a delayed first dose, which may reflect vaccine hesitancy. PMID: 30638762 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - January 9, 2019 Category: Pediatrics Authors: Rybak A, Vié le Sage F, Béchet S, Werner A, Thiebault G, Bakhache P, Virey B, Caulin E, Cohen R, Levy C Tags: Arch Pediatr Source Type: research

Factors associated with falls in Japanese polio survivors.
CONCLUSION: Low knee extension muscle strength on the weaker side was associated with falls, but predictive ability using a single internal factor might be poor. It appears that a comprehensive examination, including other factors, is required. Implications for rehabilitation As polio survivors age, their risk of falling increases. To identify polio survivors who are at risk of falls, it is important to determine the factors associated with falls and their influence on fall risk. The results of this study showed that reduced knee extension muscle strength on the weaker side was a risk factor for falls in polio survivors. T...
Source: Disability and Rehabilitation - January 7, 2019 Category: Rehabilitation Authors: Imoto D, Sawada K, Horii M, Hayashi K, Yokota M, Toda F, Saitoh E, Mikami Y, Kubo T Tags: Disabil Rehabil Source Type: research

First case in China of vaccine-associated poliomyelitis after sequential Inactivated and bivalent oral polio vaccination.
Abstract A 16 week newborn vaccinated with bOPV 4 weeks after his first routine IPV vaccination. Nineteen days later, asymmetrical paralysis was developed on his legs, and it was diagnosed to be VAPP. Perianal abscess is suspected to be a risk factor based on some limited results of retrospective studies in China. This is a risk factor similar to the multiple intramuscular injections found by researchers in last century. The two risk factors remind us that, apart from the routine infection route of the fecal to mouth and intestinal tract, skin injury (ulceration) exposure pathway should not be ignored as anoth...
Source: Vaccine - January 7, 2019 Category: Allergy & Immunology Authors: Peng X, Hu X, Salazar MA Tags: Vaccine Source Type: research

Lack of immune interference between inactivated polio vaccine and inactivated rotavirus vaccine co-administered by intramuscular injection in two animal species.
Abstract A parenteral inactivated rotavirus vaccine (IRV) in development could address three problems with current live oral rotavirus vaccines (ORV): their lower efficacy in low and middle-income countries (LMICs), lingering concerns about their association with intussusception, and their requirement for a separate supply chain with large volume cold storage. Adding a new parenteral IRV to the current schedule of childhood immunizations would be more acceptable if it could be combined with another injectable vaccine such as inactivated polio vaccine (IPV). Current plans for polio eradication call for phasing out ...
Source: Vaccine - January 6, 2019 Category: Allergy & Immunology Authors: Wang Y, Zade J, Moon SS, Weldon W, Pisal SS, Glass RI, Dhere RM, Jiang B Tags: Vaccine Source Type: research

Acute Flaccid Myelitis Associated with Enterovirus D68 in Children, Argentina, 2016.
We describe a cluster of acute flaccid myelitis cases in Argentina in 2016, adding data to the evidence of association between enterovirus D68 and this polio-like illness. PMID: 30602120 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - January 4, 2019 Category: Infectious Diseases Authors: Carballo CM, Erro MG, Sordelli N, Vazquez G, Mistchenko AS, Cejas C, Rodriguez M, Cisterna DM, Freire MC, Contrini MM, Lopez EL Tags: Emerg Infect Dis Source Type: research

Revaccination in Children Undergoing Autologous Hematopoietic Stem Cell Transplantation: Results of a Survey in Germany, Austria and Switzerland
Conclusion Our survey demonstrates a wide variation regarding the timing of live-attenuated vaccines after autologous HSCT or after immunoglobulin administration and regarding immunization against encapsulated bacteria. Many centers do not adhere to current recommendations. Studies should focus on a detailed analysis of the epidemiology of infections with encapsulated bacteria after pediatric autologous HSCT as well as on the immune recovery and the response to revaccination in this setting. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  ...
Source: Klinische Padiatrie - January 2, 2019 Category: Pediatrics Authors: Laws, Hans-J ürgen Simon, Arne Lehrnbecher, Thomas Tags: Original Article Source Type: research

[Immunisation schedule of the Spanish Association of Paediatrics: 2019 recommendations].
te;na M, Montesdeoca Melián A, Ruiz-Contreras J, en representación del Comité Asesor de Vacunas de la Asociación Española de Pediatría (CAV-AEP) Abstract The Advisory Committee on Vaccines of the Spanish Association of Paediatrics annually publishes the immunisation schedule considered optimal for children resident in Spain, according to available evidence on current vaccines. As regards funded immunisations, the 2+1 strategy (2, 4, 11 months) with hexavalent (DTPa-IPV-Hib-HB) and 13-valent pneumococcal vaccines are recommended. Administration of the 6-year booster dose wi...
Source: Anales de Pediatria - January 1, 2019 Category: Pediatrics Authors: Moreno-Pérez D, Álvarez García FJ, Álvarez Aldeán J, Cilleruelo Ortega MJ, Garcés Sánchez M, García Sánchez N, Hernández Merino Á, Méndez Hernández M, Merino Moína M, Montesdeoca Melián A, Ruiz-Contreras J, en representación del Comité As Tags: An Pediatr (Barc) Source Type: research

Using the polio programme to deliver primary health care in Nigeria: implementation research.
Conclusion: Integrating routine primary-care services into polio eradication activities in Nigeria resulted in increased coverage for supplemental oral polio vaccine doses and essential maternal, newborn and child health interventions. PMID: 30618462 [PubMed - in process] (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - January 1, 2019 Category: International Medicine & Public Health Authors: Bawa S, McNab C, Nkwogu L, Braka F, Obinya E, Galway M, Mirelman AJ, Hammanyero KI, Safiyanu G, Chukwuji M, Ongwae K, Mkanda P, Corkum M, Hegg L, Tollefson D, Umar S, Audu S, Gunda H, Chinta M, Baptiste AEJ, Bagana M, Shuaib F Tags: Bull World Health Organ Source Type: research

International Contributions toward the Conquest of Polio.
PMID: 30675080 [PubMed - in process] (Source: The Ulster Medical Journal)
Source: The Ulster Medical Journal - January 1, 2019 Category: General Medicine Authors: Hedley-Whyte J, Milamed DR Tags: Ulster Med J Source Type: research

Long-term outcome after Lambrinudi arthrodesis: How they're doing after three decades.
CONCLUSION:: Lambrinudi arthrodesis is a treatment option with favorable long-term outcome for patients with severe, fixed equinus deformities. PMID: 30798731 [PubMed - in process] (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - January 1, 2019 Category: Orthopaedics Authors: So LWN, Kuong EE, To KM, Leong JCY, Chow W Tags: J Orthop Surg (Hong Kong) Source Type: research

Nerve transfers in Acute Flaccid Myelitis: A beacon of hope
We read with great interest the study by Saltzman et. al. on nerve transfers for acute flaccid myelitis (AFM) [1]. AFM refers to acute flaccid paralysis with focal/ asymmetric limb weakness and characteristic spinal gray matter lesions on imaging. Besides poliomyelitis, an array of viruses may be causative. These include Non-Polio Enteroviruses (NPEV- Enterovirus D-68& A-71, Coxsackie A and B), Arboviruses (West Nile virus, Japanese B encephalitis virus (JEV)), Herpes viruses (Herpes simplex 1 and 2, varicella zoster virus, Ebstein Barr virus) etc. (Source: Pediatric Neurology)
Source: Pediatric Neurology - December 29, 2018 Category: Neurology Authors: Priyanka Madaan, Lokesh Saini Tags: Correspondence Source Type: research

Travel medicine consultation: An opportunity to improve coverage for routine vaccinations.
Authors: Aba YT, Gagneux-Brunon A, Andrillat C, Fouilloux P, Daoud F, Defontaine C, Lucht F, Botelho-Nevers E Abstract BACKGROUND: Travelers may be responsible for the spread of vaccine-preventable diseases upon return. Travel physicians and family physicians may play a role in checking and updating vaccinations before traveling. Our aim was to evaluate the vaccine coverage for mandatory and recommended vaccination in travelers attending a travel medicine clinic (TMC). METHODS: Vaccine coverage was measured using the current French immunization schedule as reference for correct immunization, in travelers provid...
Source: Medecine et Maladies Infectieuses - December 27, 2018 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

IJERPH, Vol. 16, Pages 63: Reply to Comment on Dhiman, R. et al. Correlation of Non-Polio Acute Flaccid Paralysis Rate with Pulse Polio Frequency in India. Int. J. Environ. Res. Public Health 2018, 15, 1755
Puliyel We thank the authors for their interest in our paper [...] (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 27, 2018 Category: Environmental Health Authors: Rachana Dhiman Sandeep C. Prakash V. Sreenivas Jacob Puliyel Tags: Reply Source Type: research

Three Poliovirus Sequences in the Human Genome Associated With Colorectal Cancer
Conclusion: Poliovirus sequences in the human genome may contribute to programmed cell death and lysis of colorectal cancer cells. A recombinant poliovirus, incapable of reverting to neurovirulence, might be given orally at intervals as a colorectal cancer vaccine to prevent colorectal cancer. (Source: Cancer Genomics and Proteomics)
Source: Cancer Genomics and Proteomics - December 26, 2018 Category: Cancer & Oncology Authors: LEHRER, S., RHEINSTEIN, P. H. Tags: Article Source Type: research

IJERPH, Vol. 16, Pages 13: Comment on Dhiman, R. et al. Correlation of Non-Polio Acute Flaccid Paralysis Rate with Pulse Polio Frequency in India. Int. J. Environ. Res. Public Health 2018, 15, 1755
. The authors of the published article ‘Correlation between Non-Polio Acute Flaccid Paralysis Rates with Pulse Polio Frequency in India’ [...] (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 21, 2018 Category: Environmental Health Authors: Siddalingaiah H.S. Tags: Comment Source Type: research

Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP) Recommended Immunization Schedule (2018-19) and Update on Immunization for Children Aged 0 Through 18 Years.
Abstract JUSTIFICATION: There is a need to revise/review recommendations regarding existing vaccines in view of current developments in vaccinology. PROCESS: Advisory Committee on Vaccines and Immunization Practices (ACVIP) of Indian Academy of Pediatrics (IAP) reviewed the new evidence, had two meetings, and representatives of few vaccine manufacturers also presented their data. The recommendations were finalized unanimously. OBJECTIVES: To revise and review the IAP recommendations for 2018-19 and issue recommendations on existing and certain new vaccines. RECOMMENDATIONS: The major changes in the ...
Source: Indian Pediatrics - December 15, 2018 Category: Pediatrics Authors: Balasubramanian S, Shah A, Pemde HK, Chatterjee P, Shivananda S, Guduru VK, Soans S, Shastri D, Kumar R, IAP Advisory Committee on Vaccines and Immunization Practices, 2018-19 Tags: Indian Pediatr Source Type: research

Assessment of vaccination coverage of adolescents aged 16-18 years with an innovative electronic immunization record system.
CONCLUSION: Our study calls attention to the insufficient vaccination of adolescents for pertussis, HBV, meningococcal C disease, and HPV. The absence of a system that routinely provides the vaccination status of this population is a major public health issue in France. The use of an electronic immunization record was innovative, but this tool is not extensively used in the general population and has been evaluated by Santé publique France (the French national public health agency). PMID: 30527973 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)
Source: Medecine et Maladies Infectieuses - December 13, 2018 Category: Infectious Diseases Tags: Med Mal Infect Source Type: research

Profile of polio-compatible cases in Nigeria, 2006 –2016
The tremendous progress made by Nigeria towards polio eradication has recently suffered a setback with the isolation of circulating vaccine-derived poliovirus (cVDPV) type 2 from environmental samples and conf... (Source: BMC Public Health)
Source: BMC Public Health - December 13, 2018 Category: Consumer Health News Authors: Abdullahi Walla Hamisu, Faisal Shuaib, Ticha Muluh Johnson, Kehinde Craig, Braka Fiona, Richard Banda, Sisay G. Tegegne, Ajiboye Oyetunji, Tesfaye B. Erbeto, Peter Nsubuga, Rui Gama Vaz, Ado J. G. Muhamed and Adamu Usman Tags: Research Source Type: research

Lessons learnt from implementing community engagement interventions in mobile hard-to-reach (HTR) projects in Nigeria, 2014 –2015
The year 2014 was a turning point for polio eradication in Nigeria. Confronted with the challenges of increased numbers of polio cases detected in rural, hard-to-reach (HTR), and security-compromised areas of ... (Source: BMC Public Health)
Source: BMC Public Health - December 13, 2018 Category: Consumer Health News Authors: Kulchumi Isa Hammanyero, Samuel Bawa, Fiona Braka, Bassey Enya Bassey, Akinola Fatiregun, Charity Warigon, Yared G. Yehualashet, Sisay Gashu Tegene, Richard Banda, Charles Korir, Tesfaye Bedada Erbeto, Martin Chukwuji, Pascal Mkanda, Usman Saidu Adamu and Tags: Research Source Type: research

Acute flaccid paralysis (AFP) surveillance intensification for polio certification in Kaduna state, Nigeria: lessons learnt, 2015 –2016
Nigeria has made remarkable progress in its current efforts to interrupt wild poliovirus transmission despite the re-emergence of wild poliovirus in 2016. The gains made in Nigeria have been achieved through c... (Source: BMC Public Health)
Source: BMC Public Health - December 13, 2018 Category: Consumer Health News Authors: Gregory C. Umeh, Faisal Shuaib, Audu Musa, Sisay G. Tegegne, Fiona Braka, Pascal Mkanda, Richard Banda, Usman Adamu, Terna I. Nomhwange, Eyiotoyo Arenyeka, Semeeh A. Omoleke, Ticha M. Johnson, Kehinde Craig, Ibrahim Idris, Hadiza Iyal, Ishaku G. Sambo & h Tags: Research Source Type: research

Towards an effective poliovirus laboratory containment strategy in Nigeria
The Global Commission for the Certification of the Eradication of Poliomyelitis will declare the world free of wild poliovirus transmission when no wild virus has been found in at least 3 consecutive years, an... (Source: BMC Public Health)
Source: BMC Public Health - December 13, 2018 Category: Consumer Health News Authors: Johnson Muluh Ticha, Kolawole Olatunji Matthew, Abdullahi Walla Hamisu, Braka Fiona, Pascal Mkanda, Peter Nsubuga, Eberto Tesfaye, Kehinde Craig, Etsano Andrew, Obi Emelife, Faisal Shuaib, Akinkugbe Folasade, Johnson Adeniji, Usman Adamu, Mohammed Dallatu Tags: Research Source Type: research

Mobilizing political support proved critical to a successful switch from tOPV to bOPV in Kano, Nigeria 2016
Kano is one of the high-risk states for polio transmission in Northern Nigeria. The state reported more cases of wild polioviruses (WPVs) than any other state in the country. The Nigeria Demographic and Health... (Source: BMC Public Health)
Source: BMC Public Health - December 13, 2018 Category: Consumer Health News Authors: Bashir Abba, Sule Abdullahi, Samuel Bawa, Kabir Ibrahim Getso, Imam Wada Bello, Charles Korir, Audu Musa, Fiona Braka, Adamu Ningi, Peter Nsubuga, Richard Banda, Sisay G. Tegegne, Faisal Shuaib, Usman Said Adamu and Sulaiman Haladu Tags: Research Source Type: research

Viruses, Vol. 10, Pages 711: Parechovirus a Detection by a Comprehensive Approach in a Clinical Laboratory
In conclusion, this study established a protocol for enterovirus and HPeV virus identification that combines conventional and molecular methods and would be beneficial for HPeV diagnosis. (Source: Viruses)
Source: Viruses - December 12, 2018 Category: Virology Authors: Bao-Chen Chen Jenn-Tzong Chang Tsi-Shu Huang Jih-Jung Chen Yao-Shen Chen Ming-Wei Jan Tsung-Hsien Chang Tags: Article Source Type: research

Childhood vaccination in Kenya: socioeconomic determinants and disparities among the Somali ethnic community
ConclusionsDisparities persist in pediatric vaccinations in Kenya, with Somali children more likely than non-Somalis to be under-vaccinated. Health inequalities among migrants and ethnic communities in Kenya should be addressed. (Source: International Journal of Public Health)
Source: International Journal of Public Health - December 10, 2018 Category: International Medicine & Public Health Source Type: research

Evaluation of the acute flaccid paralysis (AFP) surveillance system in Mwenezi district, Masvingo, 2018: a descriptive study
Poliomyelitis is an infectious disease caused by the polio virus which affects mostly young children below the age of 15 years. For surveillance children with acute flaccid paralysis (AFP) are tracked. In Zimb... (Source: BMC Research Notes)
Source: BMC Research Notes - December 10, 2018 Category: Research Authors: Morgen Muzondo, Amadeus Shamu, Gerald Shambira, Notion Tafara Gombe, Tsitsi Patience Juru and Mufuta Tshimanga Tags: Research note Source Type: research

WHO keeps polio on the international health emergency list
Publication date: 8–14 December 2018Source: The Lancet, Volume 392, Issue 10163Author(s): John Zarocostas (Source: The Lancet)
Source: The Lancet - December 8, 2018 Category: General Medicine Source Type: research

Daily briefing: The five unmissable science books of 2018
Daily briefing: The five unmissable science books of 2018, Published online: 07 December 2018; doi:10.1038/d41586-018-07703-4Five reads to make you smarter. Plus: why a postdoc might not be the right career move and the hunt for a mysterious polio-like disease in the US. (Source: Nature AOP)
Source: Nature AOP - December 7, 2018 Category: Research Authors: Flora Graham Source Type: research

Vaccine-preventable disease control in the People's Republic of China: 1949-2016.
Abstract BACKGROUND: China's immunization program is one of the oldest and largest in the world. Rates of vaccine-preventable diseases (VPD) are comparable to those in high-income countries. The program's evolution has been characterized by ambitious target setting and innovative strategies that have not been widely described. METHODS: We reviewed national and provincial health department archives; analyzed disease surveillance, vaccination coverage, and serosurvey data from 1950 through 2016; and, conducted in-depth interviews with senior Chinese experts involved early VPD control efforts. RESULTS: Wide...
Source: Vaccine - December 6, 2018 Category: Allergy & Immunology Authors: Yu W, Lee LA, Liu Y, Scherpbier RW, Wen N, Zhang G, Zhu X, Ning G, Wang F, Li Y, Hao L, Zhang X, Wang H Tags: Vaccine Source Type: research

Machine learning helps to hunt down the cause of a paralysing illness
Machine learning helps to hunt down the cause of a paralysing illness, Published online: 06 December 2018; doi:10.1038/d41586-018-07631-3Researchers hope that by probing the immune system, they can determine why children are developing a polio-like disease. (Source: Nature AOP)
Source: Nature AOP - December 6, 2018 Category: Research Authors: Sara Reardon Source Type: research

Cancers, Vol. 10, Pages 492: Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
nin To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been demonstrated to be more efficient than temozolomide, or to increase efficacy of standard therapy (surgery, radiotherapy, temozolomide, steroid dexamethasone). According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18–20 months for adult patients with newly diagnosed glioblastoma. These data explain a failure of positive non-controlled phase II trials to predict positive phase III trials and should result in revision of the landmark Stupp trial as a historical control for ...
Source: Cancers - December 5, 2018 Category: Cancer & Oncology Authors: Aleksei A. Stepanenko Vladimir P. Chekhonin Tags: Review Source Type: research

Development of a respiratory disease model for enterovirus D68 in 4-week-Old mice for evaluation of antiviral therapies
Publication date: Available online 3 December 2018Source: Antiviral ResearchAuthor(s): W. Joseph Evans, Brett L. Hurst, Christopher J. Peterson, Arnaud J. Van Wettere, Craig W. Day, Donald F. Smee, E. Bart TarbetAbstractEnterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used fo...
Source: Antiviral Therapy - December 4, 2018 Category: Virology Source Type: research

Development of a respiratory disease model for enterovirus D68 in 4-week-Old mice for evaluation of antiviral therapies.
Abstract Enterovirus D68 (EV-D68) is a non-polio enterovirus that affects the respiratory system and can cause serious complications, especially in children and older people with weakened immune systems. As an emerging virus, there are no current antiviral therapies or vaccines available. Our goal was to develop a mouse model of human EV-D68 infection that mimicked the disease observed in humans and could be used for evaluation of experimental therapeutics. This is the first report of a respiratory disease model for EV-D68 infection in mice. We adapted the virus by 30 serial passages in AG129 mice, which are defic...
Source: Antiviral Research - December 3, 2018 Category: Virology Authors: Evans WJ, Hurst BL, Peterson CJ, Van Wettere AJ, Day CW, Smee DF, Tarbet EB Tags: Antiviral Res Source Type: research

Optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination: a case report
ConclusionsAlthough the association between immunizations and the onset of central nervous system demyelinating conditions is well documented, this report, to the best of our knowledge, is the first case of optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination. Inclusion of this case report in the medical community will allow for broader understanding of possible conditions that may present shortly after receipt of vaccination. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 30, 2018 Category: General Medicine Source Type: research

Risk of Vaccine-Induced Immune Thrombocytopenia in Children. Nationwide Case Cross-over and Self-Controlled Case Series Studies in France
Conclusion: This study showed an increased occurrence of ITP after MMR and meningococcal C vaccines. It is reassuring for other vaccines. We cannot exclude temporal association with MMR and meningococcal C vaccines due to the peak of ITP incidence at 12 months of age in the general population. However, vaccine-induced ITP is a very rare event, which does not cast doubt on the interest of vaccination.DisclosuresNo relevant conflicts of interest to declare. (Source: Blood)
Source: Blood - November 21, 2018 Category: Hematology Authors: Lafaurie, M., Baricault, B., Lapeyre-Mestre, M., Sailler, L., Sommet, A., Moulis, G. Tags: 311. Disorders of Platelet Number or Function: Advances in the Treatment of ITP Source Type: research

Impact of Pre-Transplant Rituximab on Efficacy of Revaccination of Lymphoma Patients after Autologous Hematopoietic Stem Cell Transplantation
Background: Guidelines recommend reimmunization starting 12 months after autologous hematopoietic stem cell transplant (AHCT). However, lymphoma patients routinely receive rituximab, an anti-CD20 monoclonal antibody that depletes CD20+ B-cells and may impair response to vaccination. We have shown that rituximab use may prevent on time vaccination in patients who undergo an allogeneic stem cell transplant (BBMT 2018 S427-S428). We therefore aimed to evaluate the impact of rituximab on responses to revaccination after AHCT and included patients with B-cell Non-Hodgkin Lymphoma (B-NHL) and T-cell NHL (T-NHL) and Hodgkin Lymph...
Source: Blood - November 21, 2018 Category: Hematology Authors: Preston, E. V., Palazzo, M. A., Seier, K., Devlin, S. M., Giralt, S., Scordo, M., Dahi, P. B., Matasar, M. J., Moskowitz, C. H., Sauter, C. S., Shah, G. L., Perales, M.-A. Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster III Source Type: research

Prevalence and factors associated with incomplete immunization of children (12 –23 months) in Kwabre East District, Ashanti Region, Ghana
ConclusionsImmunization coverage is high in the Kwabre East district but very few children received the second measles dose. None of the maternal and child factors assessed is associated with immunisation coverage. Further research is needed to identify the determinants of immunisation coverage and the reasons for the low uptake of second measles dose in the study area. (Source: Archives of Public Health)
Source: Archives of Public Health - November 19, 2018 Category: International Medicine & Public Health Source Type: research

The Contribution of Poliomyelitis to President Roosevelt ’s Heart Failure. A Lesson on the Importance of Vaccinations for Cardiovascular Prevention
(Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - November 19, 2018 Category: Cardiology Source Type: research

Fighting a polio outbreak in Papua New Guinea
Publication date: 17–23 November 2018Source: The Lancet, Volume 392, Issue 10160Author(s): Jo Chandler (Source: The Lancet)
Source: The Lancet - November 17, 2018 Category: General Medicine Source Type: research

Global Routine Vaccination Coverage - 2017.
This report updates previous reports (2,3) and presents global, regional, and national vaccination coverage estimates and trends as of 2017. It also describes the number of infants surviving to age 1 year (surviving infants) who did not receive the third dose of diphtheria and tetanus toxoids and pertussis-containing vaccine (DTP3), a key indicator of immunization program performance (4,5), with a focus on the countries with the highest number of children who did not receive DTP3 in 2017. Based on the World Health Organization (WHO) and United Nations Children's Fund (UNICEF) estimates, global DTP3 coverage increased from ...
Source: MMWR Morb Mortal Wkl... - November 16, 2018 Category: Epidemiology Authors: VanderEnde K, Gacic-Dobo M, Diallo MS, Conklin LM, Wallace AS Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Enterovirus D68 – The New Polio?
Hayley Cassidy, Randy Poelman, Marjolein Knoester, Coretta C. Van Leer-Buter, Hubert G. M. Niesters (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 13, 2018 Category: Microbiology Source Type: research

Paediatric immunisation and chemoprophylaxis in a Ugandan sickle cell disease clinic
AimWe aimed to assess the receipt of recommended care for young children with sickle cell disease (SCD) in a central SCD clinic in Kampala Uganda, focusing on standard vaccination and antibacterial and antimalarial prophylaxis.MethodsA cross ‐sectional assessment of immunisation status and timeliness and prescribed antibacterial and antimalarial prophylaxis was performed in a sample with SCD aged ≤71 months in Mulago Hospital SCD Clinic. Government‐issued immunisation cards and clinic‐issued visit records for prescribed prophyla xis were reviewed.ResultsVaccinations were documented by immunisation cards in 104 pat...
Source: Journal of Paediatrics and Child Health - November 9, 2018 Category: Pediatrics Authors: Chung ‐Jen Chen, Sabrina Bakeera‐Kitaka, Ezekiel Mupere, Philip Kasirye, Deogratias Munube, Richard Idro, Heather Hume, Betsy Pfeffer, Philip LaRussa, Nancy S Green Tags: Original Article Source Type: research

Progress Toward Poliomyelitis Eradication - Pakistan, January 2017-September 2018.
This report documents Pakistan's activities and progress toward polio eradication during January 2017-September 2018 and updates previous reports (1,2). In 2017, Pakistan reported eight WPV1 cases, a 60% decrease from 20 cases in 2016. As of September 18, 2018, four cases had been reported, compared with five cases at that time in 2017. Nonetheless, in 2018, WPV1 continues to be isolated regularly from environmental surveillance sites, primarily in the core reservoir areas of Karachi, Quetta, and Peshawar, signifying persistent transmission. Strategies to increase childhood immunity have included an intense schedule of sup...
Source: MMWR Morb Mortal Wkl... - November 9, 2018 Category: Epidemiology Authors: Hsu C, Mahamud A, Safdar M, Nikulin J, Jorba J, Bullard K, Agbor J, Kader M, Sharif S, Ahmed J, Ehrhardt D Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Closer to a polio-free Eastern Mediterranean Region (Editorial).
Authors: Alwan A, Maher C Abstract After a long hard struggle, the start of this decade saw the fight to eradicate polio from the Eastern Mediterranean Region appearing to bear fruit. In 2011 and 2012, only two countries in the Region were reporting wild poliovirus - Pakistan and Afghanistan, two of the last endemic countries in the world. By the end of 2012, when only 95 cases were reported in total from the Region, it seemed that finally stopping the transmission of poliovirus was just around the corner. The number of cases and countries were at the lowest-ever recorded levels. PMID: 30387108 [PubMed] (Source...
Source: Eastern Mediterranean Health Journal - November 8, 2018 Category: Middle East Health Tags: East Mediterr Health J Source Type: research

Coverage and timeliness of vaccination and the validity of routine estimates: Insights from a vaccine registry in Kenya.
CONCLUSIONS: Standard coverage surveys in 12-23 month old children overestimate protection by ignoring timeliness, and survivor and recall biases. Where delayed vaccination is common, up-to-date coverage will give biased estimates of population immunity. Surveys and administrative methods also underestimate FIC prevalence. Better measurement of coverage and more sophisticated analyses are required to control vaccine preventable diseases. PMID: 30416017 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - November 8, 2018 Category: Allergy & Immunology Authors: Adetifa IMO, Karia B, Mutuku A, Bwanaali T, Makumi A, Wafula J, Chome M, Mwatsuma P, Bauni E, Hammitt LL, Mataza C, Tabu C, Kamau T, Williams TN, Scott JAG Tags: Vaccine Source Type: research

Epidemiology of the silent polio outbreak in Rahat, Israel, based on modeling of environmental surveillance data [Environmental Sciences]
Israel experienced an outbreak of wild poliovirus type 1 (WPV1) in 2013–2014, detected through environmental surveillance of the sewage system. No cases of acute flaccid paralysis were reported, and the epidemic subsided after a bivalent oral polio vaccination (bOPV) campaign. As we approach global eradication, polio will increasingly be detected... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 6, 2018 Category: Science Authors: Andrew F. Brouwer, Joseph N. S. Eisenberg, Connor D. Pomeroy, Lester M. Shulman, Musa Hindiyeh, Yossi Manor, Itamar Grotto, James S. Koopman, Marisa C. Eisenberg Tags: PNAS Plus Source Type: research

The push to eradicate poliomyelitis in the Eastern Mediterranean Region (Editorial).
Authors: Maher C Abstract The Eastern Mediterranean Region, and the world, has never been closer to eradicating poliomyelitis. Wild poliovirus transmission is at the lowest levels in history and is limited to a few zones in the two remaining polio-endemic countries - Afghanistan and Pakistan. As at 30 October 2017, only 13 cases of poliomyelitis due to wild poliovirus type 1 (WPV 1) had been reported in the Region in 2017: 8 from Afghanistan and 5 from Pakistan. These two countries collectively reported 33 cases in 2016, 74 in 2015, and 334 in 2014. PMID: 30378657 [PubMed - in process] (Source: Eastern Mediterr...
Source: Eastern Mediterranean Health Journal - November 2, 2018 Category: Middle East Health Tags: East Mediterr Health J Source Type: research

US doctors criticise CDC ’s response to “mystery” polio-like disease in children
(Source: BMJ News)
Source: BMJ News - November 1, 2018 Category: General Medicine Source Type: research