TWiV 504: Flying foxes and barking pigs
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu) Do we need to worry about Nipah virus? (Tufts Now) Nipah virus infection of bats (EID) Papua New Guinea no longer polio-free (virology blog) WHO polio endgame (polioeradication) Letters read on TWiV 504 W...
Source: This Week in Virology - MP3 Edition - July 29, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

A polio outbreak threatens global eradication plans, and what happened to America ’s first dogs
Wild polio has been hunted to near extinction in a decades-old global eradication program. Now, a vaccine-derived outbreak in the Democratic Republic of the Congo (DRC) is threatening to seriously extend the polio eradication endgame. Deputy News Editor Leslie Roberts joins host Sarah Crespi to talk about the tough choices experts face in the fight against this disease in the DRC. Sarah also talks with Online News Editor David Grimm about when dogs first came to the Americas. New DNA and archaeological evidence suggest these pups did not arise from North American wolves but came over thousands of years after the first pe...
Source: Science Magazine Podcast - July 5, 2018 Category: Science Authors: Science Source Type: podcasts

Ashish Jha tries to see the world as it is.
There ’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc. To make sense of that... (Source: The BMJ Podcast)
Source: The BMJ Podcast - June 8, 2018 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts

TWiV 491: The Ileum and the Odyssey
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary historyof RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cells(Science) Letters readon TWiV 491 Weekly Science Picks Alan - Oligodendroglioma in song Kat...
Source: This Week in Virology - MP3 Edition - April 29, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 459: Polio turns over a new leaf
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public Outreach Fellowship Kymriah approved (PennMed) CAR T cells (NCBI) Cost of Kymriah (NYTimes) Accidental exposure to poliovirus type 2 (Eurosurveill) GAPIII (WHO) Poliovaccine candidate in plants (Nat Commun) Vertical v...
Source: This Week in Virology - MP3 Edition - September 17, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV Special: DA Henderson, smallpox eradicator
Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. Become a  patron of TWiV!This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non ­fiction series from the world's best filmmakers. Get unlimited acce...
Source: This Week in Virology - MP3 Edition - August 23, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 403: It's not easy being vaccine
Hosts:  Vincent Racaniello,  Alan Dove, and  Rich ConditThe TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings  on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a  patron of TWiV!Links for this episodeTribunal orders release of PACE trial data (Valerie Eliot Smith)Our request for PACE trial data (virology blog)GM mosquito release on ballot (NPR)Florida Keys Mosquito Control District  on TWiV #111Cold chain and viru...
Source: This Week in Virology - MP3 Edition - August 21, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 402: The plight of the bumblebee
Hosts:  Vincent Racaniello,  Dickson Despommier,  Alan Dove, and  Rich ConditPolio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a  patron of TWiV!Links for this episodeMarian Horzinek, 80 (ProMedMail)Polio in Nigeria (Atlantic,  Stat,  ProMedMail)Zika virus spreads in Miami (NYTimes)More Zika virus  vaccines (Science)Back to work on Zika, Congress ! (Asbury Park Press)Lack of funding will stymie  Zika vaccines (Wash Examiner)FDA OK...
Source: This Week in Virology - MP3 Edition - August 14, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 365: Blood, feuds, and a foodborne disease
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus. Links for this episode Battle over genome editing (Wired) 10:05 First description of CRISPR in E. coli (J Bacteriol) 14:00 Cas genes identified (Mol Micro) 14:20 CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 Dual RNA-guided DNA endonuclease in bacter...
Source: This Week in Virology - MP3 Edition - November 29, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 360: From Southeastern Michigan
Hosts: Vincent Racaniello and Kathy Spindler Guests: Michael Imperiale, Adam Lauring, and Akira Ohno Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site. Links for this episode World Polio Day Mole Day The rat virus (J Inf Dis) Polyomavirus miRNAs (Curr Op Virol) Costs of GOF pause (mBio) Lethal mutagenesis of influenza virus (J Virol) Mutational robustne...
Source: This Week in Virology - MP3 Edition - October 25, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 353: STING and the antiviral police
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.   Links for this episode 28 years of poliovirus shedding (PLoS Path) NOT a rare poliovirus (Wash Post) Ukraine polio outbreak (ProMedMail) Virus particle transfer of cGAMP (Science one, two) cGAS on TWiV 222 Image credit Letters read on TWiV 353 This episode is sponsored by AS...
Source: This Week in Virology - MP3 Edition - September 6, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 348: Chicken shift
Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.   Links for this episode Virology tenure-track position at NCI (pdf) ASM Agar Art Contest Nigeria on brink of polio eradication (Nature) Dengue in Africa (Tyler Sharp) Permissive vaccines and virulence (PLoS Biol) Marek's disease vaccines and virulence (Ed Yong) Image credit Letters read on TWiV 348 This episode is sponsor...
Source: This Week in Virology - MP3 Edition - August 2, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 329: Pox in the balance
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection. Links for this episode Immune signatures in ME/CFS (Science Adv) Systemic exertion intolerance disease (Lancet) Cell nuclease controls anti-viral responses (Cell Host Micr) Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) Caps off to poxviruses (Cell Host Micr) Drummer Mohr (YouTube) Bo...
Source: This Week in Virology - MP3 Edition - March 22, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 318: Last year in virology
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.   Ten virology stories of 2014 Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283) Directional uncoating of rhinovirus RNA (TWiV 267) Pandemic pathogen controversy (TWiV 287) Viral evolution (TWiV 275) Borna virus inhibition by endogenous DNA (TWiV 303) MERS-CoV in dromedary camels (TWiV special, TWiV 287) Oncolytic...
Source: This Week in Virology - MP3 Edition - January 4, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Polio Vaccine Requirements for Travelers Abroad
Temporary guidance on polio vaccines for travelers abroad aims to prevent the further spread of poliovirus. (Source: Medscape Public Health & Prevention Podcast)
Source: Medscape Public Health & Prevention Podcast - December 15, 2014 Category: Global & Universal Authors: Medscape Source Type: podcasts

TWiV 305: Rhymes with shinola
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States. This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is...
Source: This Week in Virology - MP3 Edition - October 5, 2014 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Ruling Out Poliovirus in Cases of Acute Flaccid Paralysis
Most current practitioners have never seen a case of polio. Would you recognize the signs and symptoms? (Source: Medscape Infectious Disease Podcast)
Source: Medscape Infectious Disease Podcast - August 4, 2014 Category: Infectious Diseases Authors: Medscape Source Type: podcasts

TWiV 281: The Salk legacy with Peter L. Salk
Host: Vincent Racaniello Guest: Peter L. Salk Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary. Links for this episode Jonas Salk Legacy Foundation The Cutter Incident by Paul Offit Splendid Solution by Jeffrey Kluger (review) Coming soon: Video of this episode Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - April 21, 2014 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 274: Data dump
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces. Links for this episode MERS-CoV in dromedary camels (EID) Virologist Al Kapikian dies Polio-like illness in CA (ProMedMail) Acute flaccid paralysis AFP in India (EID) Enterovirus 68 (MMWR) EV 68 CNS infection (Arch Path Lab Med) Polio-free does not mean paralysis-free (The Hindu) Viruses in 14th century coprolite (AEM) Coprolite...
Source: This Week in Virology - MP3 Edition - March 2, 2014 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 256: How mice say nodavirus
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals. Links for this episode: World Polio Day Mole Day John Holland's publications RNAi is antiviral in mammals (Science) Antiviral RNA interference in mammals (Science) RNAi, antiviral after all (Science) Is RNA interference antiviral in mammals? (Cell Host Microbe) Nodamura virus (Nature) Ebolavirus proteins suppress R...
Source: This Week in Virology - MP3 Edition - October 27, 2013 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 227: Lacks security and bad poultry
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus. Links for this episode: Containment plan for poliovirus (pdf, WHO) Post-eradication of polio Ocular tropism of respiratory viruses (MMBR) Rally for medical research HeLa genome sequence withdrawn (ScienceInsider) Immortal life sequel (Rebecca Skloot) HeLa genome sequence publish...
Source: This Week in Virology - MP3 Edition - April 7, 2013 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 213: Not bad for a hobby
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012. Twelve virology stories from 2012: H5N1 (TWiV 190, 182, 177, 173, 168) Polymorphisms that control susceptibility (TWiV 175, 180) New virus receptors (TWiV 166, 210) XMRV: Last nail in the coffin (TWiV special) Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog) Biomedical research crisis (TWiV 208, 184, 189, 194) Polydna...
Source: This Week in Virology - MP3 Edition - December 31, 2012 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 212: Apocalypse TWiV 122112 212
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more. Links for this episode: TWiV 116: Cocaine, colonies, and chickens Glofish Recombinant Hendra vaccine Gene therapy for color blindness (Nature) FDR, polio, and Guillain-Barré Transcript of TWiV 197: Philip Marcus (pdf) TWiV 10: Bats, elephants, and AIDS TWiM 6: Phage therapy TWiP 47: For whom the trich tolls Vir...
Source: This Week in Virology - MP3 Edition - December 24, 2012 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 201: Rabid about viruses
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more. Links for this episode: Mattias Schnell Novel rhabdovirus from Africa (Plos Path) Milwaukee protocol (Wikipedia) How lethal is rabies virus? (virology blog) Issues with polio eradication (J Gen Virol) Vaccine-derived polioviruses (J Inf Dis) Global pandemics with Hidde Ploegh (Vimeo) Polio vs Bin Laden (Alan Dove) Letters read on TWiV 201 Weekly Science Picks ...
Source: This Week in Virology - MP3 Edition - September 30, 2012 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Eradicating Polio: The Dollars and Sense
Dr. Kimberly Thompson, Associate Professor and Director of the Kids Risk Project at the Harvard School of Public Health, explains how humankind CAN eliminate polio. (Source: MedGenMed Weekly Editorials from Medscape.com)
Source: MedGenMed Weekly Editorials from Medscape.com - October 15, 2007 Category: Journals (General) Authors: Kimberly M. Thompson, ScD Source Type: podcasts

Getting Rid of Polio... for Good
When the global polio eradication campaign was launched in 1988, polio virus caused more than 350,000 cases of paralytic disease annually in more than 125 countries. By 2003, only 784 cases of poliomyelitis were reported in a total of six countries (Aylward et al. 2005). The final steps in the eradication of polio, however, pose a challenge. The week's podcast looks at the challenges being faced in the final steps to eradicate this disease.  Read the report online. (Source: The Sounds of Science from the National Academies)
Source: The Sounds of Science from the National Academies - August 10, 2007 Category: Science Authors: The National Academies Source Type: podcasts