A polio outbreak threatens global eradication plans, and what happened to America ’s first dogs
Wild polio has been hunted to near extinction in a decades-old global eradication program. Now, a vaccine-derived outbreak in the Democratic Republic of the Congo (DRC) is threatening to seriously extend the polio eradication endgame. Deputy News Editor Leslie Roberts joins host Sarah Crespi to talk about the tough choices experts face in the fight against this disease in the DRC. Sarah also talks with Online News Editor David Grimm about when dogs first came to the Americas. New DNA and archaeological evidence suggest these pups did not arise from North American wolves but came over thousands of years after the first peop...
Source: Science Magazine Podcast - July 5, 2018 Category: Science Authors: Science Tags: Science Source Type: podcasts
Ashish Jha tries to see the world as it is.
There ’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc.
To make sense of that... (Source: The BMJ Podcast)
Source: The BMJ Podcast - June 8, 2018 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Ashish Jha tries to see the world as it is.
There ’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc.
To make sense of that a little, we grabbed Ashish Jha - Director of the Harvard Global Health Institute to shed some light into how decisions about global health are made, and why he tries to see the world as it actually is - not how he wishes it would be.
Reading list :
Mortality in Puerto R...
Source: The BMJ Podcast - June 8, 2018 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Ashish Jha tries to see the world as it is.
There ’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc.
To make sense of that... (Source: The BMJ Podcast)
Source: The BMJ Podcast - June 8, 2018 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Ashish Jha tries to see the world as it is.
There’s a lot going on in the world at the moment - Ebola’s back, Puerto Rico is without power and the official estimations of death following the hurricane are being challenged. The WHO’s just met to decide what to do about it all, as well as sorting out universal healthcare, access to medicines, eradicating polio, etc etc.
To make sense of that a little, we grabbed Ashish Jha - Director of the Harvard Global Health Institute to shed some light into how decisions about global health are made, and why he tries to see the world as it actually is - not how he wishes it would be.
Reading list:
Mortality in Puerto Ric...
Source: The BMJ Podcast - June 8, 2018 Category: General Medicine Authors: BMJ Group Source Type: podcasts
TWiV 491: The Ileum and the Odyssey
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary historyof RNA viruses (Nature) The amphioxus song Norovirus tropism for tuft cells(Science) Letters readon TWiV 491 Weekly Science Picks Alan - Oligodendroglioma in song Kathy- Everything-repellent coating...
Source: This Week in Virology - MP3 Edition - April 29, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 459: Polio turns over a new leaf
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public Outreach Fellowship Kymriah approved (PennMed) CAR T cells (NCBI) Cost of Kymriah (NYTimes) Accidental exposure to poliovirus type 2 (Eurosurveill) GAPIII (WHO) Poliovaccine candidate in plants (Nat Commun) Vertical vaccine farm (TWi...
Source: This Week in Virology - MP3 Edition - September 17, 2017 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV Special: DA Henderson, smallpox eradicator
Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. Become a patron of TWiV!This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, ...
Source: This Week in Virology - MP3 Edition - August 23, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 403: It's not easy being vaccine
Hosts: Vincent Racaniello, Alan Dove, and Rich ConditThe TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine. Become a patron of TWiV!Links for this episodeTribunal orders release of PACE trial data (Valerie Eliot Smith)Our request for PACE trial data (virology blog)GM mosquito release on ballot (NPR)Florida Keys Mosquito Control District on TWiV #111Cold chain and virus free plant based polio vaccine (Plant Biotechnol J)Disappointing flu vaccine ef...
Source: This Week in Virology - MP3 Edition - August 21, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 402: The plight of the bumblebee
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich ConditPolio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. Become a patron of TWiV!Links for this episodeMarian Horzinek, 80 (ProMedMail)Polio in Nigeria (Atlantic, Stat, ProMedMail)Zika virus spreads in Miami (NYTimes)More Zika virus vaccines (Science)Back to work on Zika, Congress ! (Asbury Park Press)Lack of funding will stymie Zika vaccines (Wash Examiner)FDA OK on genetically modified mosquitoes (FDA)CMV attracts aphid v...
Source: This Week in Virology - MP3 Edition - August 14, 2016 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 365: Blood, feuds, and a foodborne disease
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
Links for this episode
Battle over genome editing (Wired) 10:05
First description of CRISPR in E. coli (J Bacteriol) 14:00
Cas genes identified (Mol Micro) 14:20
CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55
Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50
Genome engineering using CRISPR/Cas (S...
Source: This Week in Virology - MP3 Edition - November 29, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 360: From Southeastern Michigan
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Michael Imperiale, Adam Lauring, and Akira Ohno
Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.
Links for this episode
World Polio Day
Mole Day
The rat virus (J Inf Dis)
Polyomavirus miRNAs (Curr Op Virol)
Costs of GOF pause (mBio)
Lethal mutagenesis of influenza virus (J Virol)
Mutational robustness in RNA virus evolution (Nat Rev Micro)
Membrane ...
Source: This Week in Virology - MP3 Edition - October 25, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 353: STING and the antiviral police
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.
Links for this episode
28 years of poliovirus shedding (PLoS Path)
NOT a rare poliovirus (Wash Post)
Ukraine polio outbreak (ProMedMail)
Virus particle transfer of cGAMP (Science one, two)
cGAS on TWiV 222
Image credit
Letters read on TWiV 353
This episode is sponsored by AS...
Source: This Week in Virology - MP3 Edition - September 6, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 348: Chicken shift
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.
Links for this episode
Virology tenure-track position at NCI (pdf)
ASM Agar Art Contest
Nigeria on brink of polio eradication (Nature)
Dengue in Africa (Tyler Sharp)
Permissive vaccines and virulence (PLoS Biol)
Marek's disease vaccines and virulence (Ed Yong)
Image credit
Letters read on TWiV 348
This episode is sponsored by ASM GAP
Weekly Science Picks
Rich - Swan-Ganz catheter (Wiki, v...
Source: This Week in Virology - MP3 Edition - August 2, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
