Non ‐polio Enterovirus detection with acute flaccid paralysis: A systematic review
This study aims to collate the data on the non‐polio enteroviruses (NPEV) associated with AFP. A systematic review of published case reports, case series, and surveillance studies of AFP from 1960 through 2017 was undertaken. Data were collected including the country of the study, number of specimens positive for NPEV and available clinical data. The majority of studies originated from Asia. In surveillance studies, EV 71 (a serotype of Enterovirus A) was the most commonly detected serotype with AFP, followed by Enterovirus B serotype echovirus 11 and then Enterovirus B serotype echovirus 11. In case studies and case rep...
Source: Journal of Medical Virology - October 12, 2017 Category: Virology Authors: Sneha Suresh, Sarah Forgie, Joan Robinson Tags: RESEARCH ARTICLE Source Type: research

Spatial model for risk prediction and sub-national prioritization to aid poliovirus eradication in Pakistan
Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Pakistan Polio Eradication Program, identifying high risk districts is essential to target interventions and alloca... (Source: BMC Medicine)
Source: BMC Medicine - October 11, 2017 Category: Internal Medicine Authors: Laina D. Mercer, Rana M. Safdar, Jamal Ahmed, Abdirahman Mahamud, M. Muzaffar Khan, Sue Gerber, Aiden O ’Leary, Mike Ryan, Frank Salet, Steve J. Kroiss, Hil Lyons, Alexander Upfill-Brown and Guillaume Chabot-Couture Tags: Research article Source Type: research

Understanding vaccine hesitancy in polio eradication in northern Nigeria.
CONCLUSIONS: Results suggest that strategies to address the micro-political dimension of vaccination - expanding community-level engagement, strengthening the role of local government in public health, and enhancing public participation of women - should be effective in reducing non-compliance, asan important set of strategies complementary to conventional didactic/educational approaches and working through religious and traditional 'influencers'. PMID: 29031691 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - October 11, 2017 Category: Allergy & Immunology Authors: Taylor S, Khan M, Muhammad A, Akpala O, van Strien M, Morry C, Feek W, Ogden E Tags: Vaccine Source Type: research

The risk of type 2 oral polio vaccine use in post-cessation outbreak response
Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associat... (Source: BMC Medicine)
Source: BMC Medicine - October 4, 2017 Category: Internal Medicine Authors: Kevin A. McCarthy, Guillaume Chabot-Couture, Michael Famulare, Hil M. Lyons and Laina D. Mercer Tags: Research article Source Type: research

Polio survivors perceptions of a multi-disciplinary rehabilitation programme.
CONCLUSIONS: Our research identified that participants experienced long term positive benefits from attending a rehabilitation programme. Strategies that users found helpful that explored the effectiveness of interventions to manage polio are not cited within a Cochrane review. If we are to recognise the lived experience and service user empowerment within a model of co- production it is essential that patient preferences are evaluated and used as evidence to justify service provision. Further research is required with polio survivors to explore how best rehabilitation programmes can adopt the principles of co-production. ...
Source: Disability and Rehabilitation - October 3, 2017 Category: Rehabilitation Authors: Atwal A, Duncan H, Queally C, Cedar SH Tags: Disabil Rehabil Source Type: research

Infant immunization coverage in Italy (2000-2016).
DISCUSSION: Further efforts are needed to increase vaccine uptake in Italy, to improve data collection and reporting, as well as to fight the growing phenomenon of the vaccine hesitancy so that PNPV's objectives and targets can be met in the near future. PMID: 28956803 [PubMed - in process] (Source: Annali dell Istituto Superiore di Sanita)
Source: Annali dell Istituto Superiore di Sanita - September 29, 2017 Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research

Predictors of changes in gait performance over four years in persons with late effects of polio.
Authors: Flansbjer UB, Lexell J, Brogårdh C Abstract BACKGROUND: Reduced gait performance is common in persons with late effects of polio. OBJECTIVE: To identify predictors of change in gait performance over four years in persons with late effects of polio. METHODS: Gait performance was assessed annually in 51 ambulatory persons (mean age 64 years, SD 6) by the Timed "Up & Go" (TUG), Comfortable and Fast Gait Speed (CGS, FGS), and 6-Minute Walk Test (6MWT). Isokinetic knee extensor and flexor muscle strength was measured with a Biodex dynamometer. Mixed Linear Models were used to analyze...
Source: NeuroRehabilitation - September 29, 2017 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

A protocol for investigating the association of vaccination and anti-NMDA receptor encephalitis.
Authors: Wang H Abstract Anti-N-methyl-D-aspartate (Anti-NMDA) receptor encephalitis is an acute autoimmune neurological disorder that can be triggered by virus, H1N1/tetanus/diphtheria/pertussis and polio vaccines or by presence of a tumor. The association between anti-NMDA receptor encephalitis and Japanese encephalitis vaccination was examined and a general protocol of phylogenetic method which details the steps and code and an example of its utility is provided. The approach used here is potentially useful for analyzing the relationship between vaccines and diseases. PMID: 28930529 [PubMed - in process] (So...
Source: Frontiers in Bioscience - Scholar - September 22, 2017 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

Comparison of two 6-minute walk tests to assess walking capacity in polio survivors.
Authors: Brehm MA, Verduijn S, Bon J, Bredt N, Nollet F Abstract OBJECTIVE: To compare walking dynamics and test-retest reliability for 2 frequently applied walk tests in polio survivors: the 6-minute walk test (6MWT) to walk as far as possible; and the 6-minute walking energy cost test (WECT) at comfortable speed. DESIGN: Observational study. PARTICIPANTS: Thirty-three polio survivors, able to walk ≥ 150 m. METHODS: On the same day participants performed a 6MWT and a WECT, which were repeated 1-3 weeks later. For each test, distance walked, heart rate and reduction in speed were assessed. ...
Source: Journal of Rehabilitation Medicine - September 22, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

IJERPH, Vol. 14, Pages 1086: Timeliness of Childhood Primary Immunization and Risk Factors Related with Delays: Evidence from the 2014 Zhejiang Provincial Vaccination Coverage Survey
Conclusions: Although the timeliness of immunization has improved since 2011, necessary steps are still needed to achieve further improvement. Timeliness of immunization should be considered as another important indicator of expanded program on immunization (EPI) performance. Future interventions on vaccination coverage should take into consideration demographic and socio-economic risk factors identified in this study. The importance of adhering to the recommended schedule should be explained to parents. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - September 20, 2017 Category: Environmental Health Authors: Yu Hu Qian Li Yaping Chen Tags: Article Source Type: research

Australian National Enterovirus Reference Laboratory annual report, 2014.
Authors: Roberts J, Hobday L, Ibrahim A, Aitken T, Thorley B Abstract Following the World Health Organization (WHO) recommendation, Australia conducts surveillance for cases of acute flaccid paralysis (AFP) in children less than 15 years of age as the main method to monitor its polio-free status. Cases of AFP in children are notified to the Australian Paediatric Surveillance Unit or the Paediatric Active Enhanced Disease Surveillance System and faecal specimens are referred for virological investigation to the National Enterovirus Reference Laboratory. In 2014, no cases of poliomyelitis were reported from clinical ...
Source: Communicable Diseases Intelligence Quarterly Report - September 15, 2017 Category: Infectious Diseases Tags: Commun Dis Intell Q Rep Source Type: research

Non-polio enteroviruses in faeces of children diagnosed with acute flaccid paralysis in Nigeria
The need to investigate the contribution of non-polio enteroviruses to acute flaccid paralysis (AFP) cannot be over emphasized as we move towards a poliovirus free world. Hence, we aim to identify non-polio en... (Source: Virology Journal)
Source: Virology Journal - September 12, 2017 Category: Virology Authors: T. O. C. Faleye, M. O. Adewumi, M. O. Japhet, O. M. David, A. O. Oluyege, J. A. Adeniji and O. Famurewa Tags: Research Source Type: research

Inequity in access to childhood immunization in Enugu urban, Southeast Nigeria
This study determined the socioeconomic differentials in immunization coverage for children under 5 years and under 1 year in Enugu urban, Southeast Nigeria. Methods: This was a community-based, descriptive cross-sectional study in Enugu urban of Southeast Nigeria. A modified 30 × 7 cluster sampling design was adopted as the sampling method to select and interview 462 mothers of 685 children under the age of 5 years on their sociodemographic and economic characteristics and immunization status of their children. Principal components analysis in STATA software was used to characterize socioeconomic inequity. Results: I...
Source: Nigerian Journal of Clinical Practice - September 11, 2017 Category: Rural Health Authors: BS Uzochukwu CC Okeke E Envuladu C Mbachu C Okwuosa OE Onwujekwe Source Type: research

Acute Flaccid Myelitis in German Children in 2016-the Return of Polio?
CONCLUSION: The prognosis of this disease cannot be reliably assessed at first, and no specific treatment is currently available. PMID: 28855045 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - September 1, 2017 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Non polio Enterovirus detection with acute flaccid paralysis: A systematic review
This study aims to collate the data on the non‐polio enteroviruses (NPEV) associated with AFP. A systematic review of published case reports, case series and surveillance studies of AFP from 1960 through 2017 was undertaken. Data were collected including the country of the study, number of specimens positive for NPEV and available clinical data. The majority of studies originated from Asia. In surveillance studies, Enterovirus (EV) 71 (a serotype of Enterovirus A) was the most commonly detected serotype with AFP, followed by Enterovirus B serotype echovirus 11 and then Enterovirus B serotype echovirus 11. In case studies...
Source: Journal of Medical Virology - August 31, 2017 Category: Virology Authors: Sneha Suresh, Sarah Forgie, Joan Robinson Tags: Research Article Source Type: research

Global dynamics of a mathematical model for the possible re-emergence of polio.
cute;kely L Abstract Motivated by studies warning about a possible re-emergence of poliomyelitis in Europe, we analyse a compartmental model for the transmission of polio describing the possible effect of unvaccinated people arriving to a region with low vaccination coverage. We calculate the basic reproduction number, and determine the global dynamics of the system: we show that, depending on the parameters, one of the two equilibria is globally asymptotically stable. The main tools applied are Lyapunov functions and persistence theory. We illustrate the analytic results by numerical examples, which also suggest ...
Source: Mathematical Biosciences - August 28, 2017 Category: Statistics Authors: Dénes A, Székely L Tags: Math Biosci Source Type: research

Post-marketing surveillance study to assess the safety and tolerability of an Inactivated Poliomyelitis Vaccine in Indian children
. (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - August 28, 2017 Category: Allergy & Immunology Authors: Hitt Sharma Rajeev Dhere Sameer Parekh Sunil Shewale Source Type: research

Validation of an Immunohistochemistry Assay for Detection of CD155, the Poliovirus Receptor, in Malignant Gliomas.
CONCLUSIONS: - Anti-CD155 antibody D3G7H achieves monospecific detection of CD155 in immunoblots of tumor homogenates and immunohistochemistry of tumor FFPE sections. Our assay has utility in defining appropriate use of PVSRIPO in oncolytic immunotherapy against malignant glioma and other cancer histotypes. PMID: 28829151 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 22, 2017 Category: Laboratory Medicine Authors: Chandramohan V, Bryant JD, Piao H, Keir ST, Lipp ES, Lefaivre M, Perkinson K, Bigner DD, Gromeier M, McLendon RE Tags: Arch Pathol Lab Med Source Type: research

Vaccine epidemiology: Its role in promoting sound immunization programs in Japan.
This report summarizes the recent epidemiological studies on vaccine in Japan as a prologue to the next six papers collected from the symposium. PMID: 28818469 [PubMed - in process] (Source: Vaccine)
Source: Vaccine - August 20, 2017 Category: Allergy & Immunology Authors: Hirota Y, Ozasa K, Nakano T Tags: Vaccine Source Type: research

Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination
Conclusions: Children with pronounced local reactions show higher humoral and cellular immune responses. Acellular vaccines are known to skew toward more Th2 responses. The pronounced local AEs may be associated with more Th2 skewing after the fifth DTaP-IPV vaccination, but other biologic factors may also impact the occurrence of these pronounced local reactions. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Seroprevalence of Anti-polio Antibodies in Children From Polio High-risk Areas of Pakistan: A Cross-Sectional Survey 2015–2016
Background: Pakistan is one of the 3 remaining wild poliovirus endemic countries. We collected sera from children to assess the prevalence of poliovirus antibodies in selected high-risk areas for poliovirus transmission. Methods: Children in 2 age groups (6–11 and 36–48 months) were randomly selected between November 2015 and March 2016 in 6 areas of Pakistan (Sindh Province: Karachi and Kashmore; Khyber Pakhtunkhwa Province: Peshawar, Bannu and Nowshera; Punjab Province: Faisalabad). After obtaining informed consent, basic demographic and vaccination history data were collected, 1 peripheral venipuncture was ...
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Progress Toward Poliomyelitis Eradication - Afghanistan, January 2016-June 2017.
This report describes polio eradication activities, progress, and challenges in Afghanistan during January 2016-June 2017 and updates previous reports (2,3). Thirteen WPV1 cases were confirmed in Afghanistan in 2016, a decrease of seven from the 20 cases reported in 2015. From January to June 2017, five WPV1 cases were reported, compared with six during the same period in 2016. The number of affected districts declined from 23 (including WPV1-positive acute flaccid paralysis [AFP] cases and positive environmental sewage samples) in 2015 to six in 2016. To achieve WPV1 eradication, it is important that Afghanistan's polio p...
Source: MMWR Morb Mortal Wkl... - August 18, 2017 Category: Epidemiology Authors: Martinez M, Shukla H, Nikulin J, Wadood MZ, Hadler S, Mbaeyi C, Tangermann R, Jorba J, Ehrhardt D Tags: MMWR Morb Mortal Wkly Rep Source Type: research

P2-59. The ultrasonographic study of peripheral nerves in lower limbs and quadriceps femoris muscles in polio survivors
The objective of this study is to evaluate ultrasonographically peripheral nerves and muscles in lower limbs of polio survivors. In twenty-four polio survivors (polio) and 24 healthy controls (HC), cross-sectional areas (CSAs) of bilateral sciatic, tibial, common fibular and sural nerves were measured. Thickness of quadriceps femoris muscles (t-QF) was also measured. Then, we compared the results between polio and HC, or among mild, moderate and severe polio limb groups classified according to NRH classification. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Daisuke Watanabe, Akiko Hachisuka, Hiroshi Tsukamoto, Tatsuya Abe, Satoru Saeki, Fumiaki Tanaka, Tetsuo Komori Source Type: research

P349 Assessment of prevalence and risk factors for carpal tunnel syndrome in polio survivors
In this study, we aimed to identify prevalence and risk factors for CTS in polio survivors. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Metin Mercan, Arsida Bajrami, Ibrahim Ac ır, Vildan Yayla Source Type: research

P342 Diagnostic utility of MUNIX method in estimation of motor units loss in post-polio syndrome
The aim of the study was to assess the value of the MUNIX method in terms of reflecting clinical dysfunction in patients with post-polio syndrome and to estimate the relationships between the grade of loss of motor units in post polio syndrome (PPS), and motor unit potential ’s parameters and stage of muscle weakness regarding the stability or newness of weakness. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Malgorzata Gawel, Ewa Zalewska, Elzbieta Szmidt-Salkowska, Marta Lipowska, Anna Lusakowska, Anna Kostera-Pruszczyk Source Type: research

[Comment] Understanding commitment to polio vaccination
The goal of polio eradication is edging ever closer to reality. There is much to celebrate; data from Nigeria suggest limited transmission of wild-type and vaccine-derived polio virus in the northern states despite the perilous security situation, while in Pakistan and Afghanistan inaccessible populations are becoming smaller and efforts to improve managerial and operational capacity have resulted in a substantial reduction of wild-type cases.1 Although these improvements have been welcomed, the Independent Monitoring Board of Polio Eradication described in 2015 the Global Polio Eradication Initiative (GPEI) as having not ...
Source: The Lancet Infectious Diseases - August 14, 2017 Category: Infectious Diseases Authors: Kathleen M O'Reilly Tags: Comment Source Type: research

[Articles] Understanding threats to polio vaccine commitment among caregivers in high-priority areas of Afghanistan: a polling study
To enhance OPV commitment, it might be useful to consider a multifactorial approach that highlights building trust in vaccinators, providing facts about transmission, sharing positive messages to overcome key rumours, and strengthening community support for vaccination. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - August 14, 2017 Category: Infectious Diseases Authors: Gillian K SteelFisher, Robert J Blendon, Sherine Guirguis, William Lodge, Hannah Caporello, Vincent Petit, Michael Coleman, Matthew R Williams, Sardar Mohammad Parwiz, Melissa Corkum, Scott Gardner, Eran N Ben-Porath Tags: Articles Source Type: research

Experiences of falls and strategies to manage the consequences of falls in persons with late effects of polio: A qualitative study.
CONCLUSION: Experiences of falls greatly affect persons with late effects of polio in daily life. To reduce falls and fall-related consequences both problem-focused and emotion-focused strategies are used. In order to increase daily functioning, these findings should be included in a multifaceted falls management programme. PMID: 28792586 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - August 11, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

The Jeremiah Metzger Lecture Cancer in the Twenty-First Century: An Inside View from an Outsider.
Authors: Benz EJ Abstract Cancer is not a single disease. The term refers to literally hundreds of illnesses sharing common features: inappropriate proliferation of imperfectly differentiated cell types, invasion of nearby vital structures, and spread to distant sites (metastasis). Invasiveness and metastasis distinguish cancers from benign tumors such as fibroids and meningiomas. Yet, each type is distinct, possessed of defining morphologic, histologic, biochemical, and genomic features that have allowed oncologists to develop a nosology that guides diagnosis and therapy. Cancer is thus a complex collection of dis...
Source: Transactions of the American Clinical and Climatological Association - August 11, 2017 Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research

Chikungunya virus: A new endemic in Pakistan?
Over the last few years, Pakistan has become a major endemic hub of infectious diseases. Although the primary focus of Pakistani health authorities is on the eradication campaign of polio and the resurgent measles endemics [1], arboviral diseases like malaria and dengue continue to be a source of major health concern as well. There has been however a steady decline in arboviral cases over the last few years, especially dengue, with health authorities and Non-Governmental Organizations (NGO) playing a vital role towards curtailment. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - August 11, 2017 Category: International Medicine & Public Health Authors: Om Dawani, Mujtaba Jamal Syed, Abdul Moid Shehzad, Sheheryar Munir Tags: Letter to the Editor Source Type: research

Perceived consequences of ageing with late effects of polio and strategies for managing daily life: a qualitative study
New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness... (Source: BMC Geriatrics)
Source: BMC Geriatrics - August 9, 2017 Category: Geriatrics Authors: Catharina Sj ödahl Hammarlund, Jan Lexell and Christina Brogårdh Tags: Research Article Source Type: research

Feasibility of using global system for mobile communication (GSM)-based tracking for vaccinators to improve oral poliomyelitis vaccine campaign coverage in rural Pakistan.
Abstract Despite multiple rounds of immunization campaigns, it has not been possible to achieve optimum immunization coverage for poliovirus in Pakistan. Supplementary activities to improve coverage of immunization, such as door-to-door campaigns are constrained by several factors including inaccurate hand-drawn maps and a lack of means to objectively monitor field teams in real time, resulting in suboptimal vaccine coverage during campaigns. Global System for Mobile Communications (GSM) - based tracking of mobile subscriber identity modules (SIMs) of vaccinators provides a low-cost solution to identify missed are...
Source: Vaccine - August 9, 2017 Category: Allergy & Immunology Authors: Chandir S, Dharma VK, Siddiqi DA, Khan AJ Tags: Vaccine Source Type: research

A safe and reliable neutralization assay based on pseudovirus to measure neutralizing antibody titer against poliovirus
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - August 8, 2017 Category: Virology Authors: Shaohua Liu, Dongmei Song, Han Bai, Weiwei Lu, Xinxian Dai, Chunsheng Hao, Zhongyang Zhang, Huijie Guo, Yue Zhang, Xiuling Li Tags: Research Article Source Type: research

Inactivation of model viruses and bacteria in human fresh frozen plasma using riboflavin and long wave ultraviolet rays.
CONCLUSION: Results showed that the employed method can inactivate most of the pathogens in fresh frozen plasma. The acceptable activities of selected plasma proteins remained after treatment. PMID: 28775824 [PubMed] (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - August 6, 2017 Category: Microbiology Tags: Iran J Microbiol Source Type: research

Immunological evaluation of sequential poliovirus vaccination among Saudi and non-Saudi children living in Jeddah
Poliomyelitis is a life-threatening acute paralytic disease caused by Poliovirus (PV). In the present study, the immunostatus of polio-vaccinated children and young adults (1 to 21 years old) living in Jeddah, Saudi Arabia was investigated to ascertain their extent of protection against the virus. Children were categorized in three groups: (A) Immunocompetent: Group I: Vaccinated by IPV at f... (Source: African Journal of Microbiology Research)
Source: African Journal of Microbiology Research - August 4, 2017 Category: Microbiology Source Type: research

How Drone Strikes and a Fake Vaccination Program Have Inhibited Polio Eradication in Pakistan: An Analysis of National Level Data.
This article investigates whether the United States' counterinsurgency operations have inhibited polio eradication efforts in northwestern Pakistan, the world's last major reservoir of polio. Anecdotal evidence suggests that militants disrupt polio vaccination programs because of suspicions that campaigns are a cover for gathering intelligence on Central Intelligence Agency (CIA) drone targets. This paper analyzes national-level quantitative data to test this argument. Between 2004 and 2012, the number of polio cases in Pakistan closely mirrored the number of drone strikes. But from 2013 onward, polio cases increased while...
Source: International Journal of Health Services - August 4, 2017 Category: Health Management Tags: Int J Health Serv Source Type: research

Filovirus Research: How it Began.
Authors: Slenczka W Abstract The first reported filovirus outbreak occurred in August 1967, when laboratory workers in Marburg and Frankfurt, Germany, and Belgrade, Yugoslavia (now Serbia) became infected with an unknown highly pathogenic agent. The disease was characterized by high fever, malaise, rash, hemorrhagic and tetanic manifestations, and high lethality, amounting to 25%. The disease was introduced to Europe by grivets (Chlorocebus aethiops), which were used for biomedical research and vaccine production. The causative agent, Marburg virus, was isolated and identified by scientists of the University of Mar...
Source: Current Topics in Microbiology and Immunology - August 4, 2017 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research

Benevolent personification of the MoH increases compliance with an emergency polio vaccination.
CONCLUSION: Parents who experienced the Israeli MoH as a benevolent protagonist were more likely to comply with the mass vaccination campaign. Findings highlight the role of leadership in public health campaigns during emergencies. PMID: 28760615 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 28, 2017 Category: Allergy & Immunology Authors: Shahar G, Noyman-Veksler G, Itamar S, Greenberg D, Grotto I Tags: Vaccine Source Type: research

Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds
Conclusions: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275 Received: 09 February 2016 Revised: 06 June 2016 Accepted: 12 July 2016 Published: 26 July 2017 Address correspondence to P. Grandjean, HSPH-EOME, 401 Park Dr., 3E L3-045, Boston, MA 02215 USA. Telephone: 617-384-8907. Email: pgrandjean@health.sdu.dk The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figure...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Serum Vaccine Antibody Concentrations in Adolescents Exposed to Perfluorinated Compounds
Conclusions: These results are in accord with previous findings of PFAS immunotoxicity at current exposure levels. https://doi.org/10.1289/EHP275 Received: 09 February 2016 Revised: 06 June 2016 Accepted: 12 July 2016 Published: 26 July 2017 Address correspondence to P. Grandjean, HSPH-EOME, 401 Park Dr., 3E L3-045, Boston, MA 02215 USA. Telephone: 617-384-8907. Email: pgrandjean@health.sdu.dk The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figure...
Source: EHP Research - July 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Global health: Towards polio eradication
eda Polio has almost been eradicated. A field study demonstrates that a combination of focused science and epidemiology, and community-based integrated health approaches, are required to finish the job. (Source: Nature)
Source: Nature - July 26, 2017 Category: Research Authors: Jaime Sep ú lveda Tags: News & Views Source Type: research

Detection of Polioviruses in Sewage Using Cell Culture and Molecular Methods.
Authors: Figas A, Wieczorek M, Litwińska B, Gut W Abstract The work presented here demonstrates the utility of a two-step algorithm for environmental poliovirus surveillance based on: preselection of sewage samples tested for the presence of enteroviral genetic material-RT-PCR assay and detection of infectious viruses by cell culture technique (L20B for polioviruses and RD for polio and other non-polio enteroviruses). RD and L20B cell lines were tested to determine their sensitivity for isolation of viruses from environmental samples (sewage). Finally, we wanted to determine if sewage concentration affects the res...
Source: Polish Journal of Microbiology - July 25, 2017 Category: Microbiology Tags: Pol J Microbiol Source Type: research

Molecular Characterization of Enteroviruses Isolated from Acute Flaccid Paralysis Cases in Poland, 1999-2014.
This study represents an overview of EVs isolated through AFP surveillance in Poland between 1999 and 2014. The presence of enteroviruses was studied in stool samples that were collected from 747 AFP cases and their asymptomatic contacts. Fifty five (6.12%) cases of AFP were associated with enterovirus isolation. Out of the 55 positive cases, 40 were associated with detection of enterovirus in patient, and 15 with detection of EV in healthy contact, without positive detection in paralytic patient. Polioviruses were isolated from 35 AFP cases. The results of this study showed that about 43.6% of positive AFP cases were foun...
Source: Polish Journal of Microbiology - July 25, 2017 Category: Microbiology Tags: Pol J Microbiol Source Type: research

Enteroviral T-cell encephalitis related to immunosuppressive therapy including rituximab
Enteroviruses are a common cause of aseptic meningitis and mild infections in childhood. However, in immunocompromised patients they may cause severe neurologic conditions such as encephalitis or polio-like paralysis. (Source: Neurology)
Source: Neurology - July 24, 2017 Category: Neurology Authors: Garzo-Caldas, N., Ruiz-Sainz, E., Vila-Bedmar, S., Llamas-Velasco, S., Hernandez-Lain, A., Ruiz-Morales, J., Folgueira-Lopez, D., Villarejo-Galende, A. Tags: Encephalitis, Viral infections CLINICAL/SCIENTIFIC NOTES Source Type: research

Gait patterns in association with underlying impairments in polio survivors with calf muscle weakness
(Source: Gait and Posture)
Source: Gait and Posture - July 23, 2017 Category: Orthopaedics Authors: Hilde E. Ploeger, Sicco A. Bus, Frans Nollet, Merel-Anne Brehm Tags: Full length article Source Type: research

History of club-foot treatment; part II: tenotomy in the nineteenth century
AbstractClubfoot is one of the most common congenital orthopaedic anomalies and was described by Hippocrates in the year 400  BC. From manipulation in antiquity to splint and plaster in the Renaissance the treatment had improved before tenotomy. Tenotomy was tested during the 19th century and will be explained in this manuscript; the introduction of subcutaneous tenotomy of the Achilles tendon had focused the attention o f surgeons on the surgical treatment of clubfeet. While this operation was very successful in the correction of equinus deformities due to poliomyelitis, cerebral palsy, and old injuries, it was not a...
Source: International Orthopaedics - July 22, 2017 Category: Orthopaedics Source Type: research

Restless legs syndrome is highly prevalent in patients with post-polio syndrome
Few studies have quantified the prevalence of restless legs syndrome (RLS) in patients with post-polio syndrome (PPS). Our objective was to assess the prevalence and severity of RLS in patients with PPS and to examine the demographic characteristics of this population. (Source: Sleep Medicine)
Source: Sleep Medicine - July 22, 2017 Category: Sleep Medicine Authors: Luis Fabiano Marin, Luciane B.C. Carvalho, Lucila B.F. Prado, Acary S.B. Oliveira, Gilmar F. Prado Source Type: research

Measuring Physical and Cognitive Fatigue in People With Post-Polio Syndrome: Development of the Neurological Fatigue Index for Post-Polio Syndrome (NFI-PP)
Conclusions A patient-derived Neurological Fatigue Index for PPS, with physical and cognitive subscales and a total score, has demonstrated good reliability, appropriate concurrent validity, and satisfies the Rasch measurement model. A raw-score to interval scale transformation is available for parametric applications and the calculation of change scores. Level of Evidence To be determined. (Source: PMandR)
Source: PMandR - July 18, 2017 Category: Rehabilitation Source Type: research