Cardiovascular diseases in Paralympic athletes
Conclusions PA present an unexpected high prevalence of CV abnormalities (12%), including a non-trivial proportion of diseases at risk for sudden death (2%), such as arrhythmogenic cardiomyopathies and dilated aortic root. This observation suggests that tailored recommendations for preparticipation screening and safe SP in this special athletic population are timely and appropriate. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - August 17, 2016 Category: Sports Medicine Authors: Pelliccia, A., Quattrini, F. M., Squeo, M. R., Caselli, S., Culasso, F., Link, M. S., Spataro, A., Bernardi, M. Tags: Trauma CNS / PNS, Disability, Orthopaedic and trauma surgery, Trauma, Injury Original article Source Type: research

The week in science: 12 –18 August 2016
The week in science: 12–18 August 2016 Nature 536, 7616 (2016). http://www.nature.com/doifinder/10.1038/536254a China launches quantum satellite; Polio re-emerges in Nigeria; and study reveals how a solar flare almost started a war. (Source: Nature)
Source: Nature - August 17, 2016 Category: Research Tags: Seven Days Source Type: research

Eradication and Current Status of Poliomyelitis in Pakistan: Ground Realities.
Authors: Ghafoor S, Sheikh N Abstract Pakistan is among the last three countries along with Afghanistan and Nigeria, where polio virus is still endemic. More or less, with some fluctuations, numbers of reported cases in the past few years have shown a rising trend. Year 2014 pushed the country into the deep sea of difficulties, as number of cases rose to red alert level of 328. Security situation has adversely affected the whole immunization coverage campaign. In a country where 40 polio vaccinators have been killed since 2012, such a big number of cases is not a surprising outcome. Worse perception of parents abou...
Source: Journal of Immunology Research - August 16, 2016 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Edging ever closer to polio eradication
Publication date: September 2016 Source:The Lancet Global Health, Volume 4, Issue 9 Author(s): Robert Booy, Mohamed Tashani (Source: The Lancet Global Health)
Source: The Lancet Global Health - August 16, 2016 Category: Global & Universal Source Type: research

Pakistan as a major obstacle in global end to poliomyelitis program: background and 2016 update
Publication date: Available online 12 August 2016 Source:The Brazilian Journal of Infectious Diseases Author(s): Abdul Waheed Khan, Shahid Ali, Syed Shujait Ali (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - August 13, 2016 Category: Infectious Diseases Source Type: research

Polio back in Nigeria two years after being wiped out in Africa
Just as Africa was due to celebrate the anniversary of its last polio infections, two new cases have set back global efforts to eradicate the virus by 2019 (Source: New Scientist - Health)
Source: New Scientist - Health - August 12, 2016 Category: Consumer Health News Source Type: research

Viruses, Vol. 8, Pages 220: Spinal Cord Ventral Horns and Lymphoid Organ Involvement in Powassan Virus Infection in a Mouse Model
This report provides a detailed description of the neuroanatomical distribution of the lesions produced by POWV infection in C57BL/6 mice. (Source: Viruses)
Source: Viruses - August 12, 2016 Category: Virology Authors: Rodrigo Santos Meghan Hermance Benjamin Gelman Saravanan Thangamani Tags: Article Source Type: research

A randomized trial of the effect of vaccine injection speed on acute pain in infants.
CONCLUSION: Fast injection reduced injection-induced pain in infants receiving DTaP-IPV-Hib but not PCV vaccine. Fast injections are recommended when administering vaccines because of the potential for a reduction in pain, feasibility and practicality. TRIAL REGISTRATION: NCT02504398. PMID: 27527817 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - August 12, 2016 Category: Allergy & Immunology Authors: Taddio A, Wong H, Welkovics B, Ilersich AL, Cole M, Goldbach M, Ipp M Tags: Vaccine Source Type: research

Pakistan as a major obstacle in global end to poliomyelitis program: background and 2016 update.
PMID: 27527564 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - August 12, 2016 Category: Infectious Diseases Authors: Khan AW, Ali S, Ali SS Tags: Braz J Infect Dis Source Type: research

Uptake and timeliness of rotavirus vaccination in Norway: The first year post-introduction.
CONCLUSIONS: Norway achieved a high national coverage and excellent adherence with the strict age limits for rotavirus vaccine administration during the first year of introduction, indicating robustness of the national immunisation programme. Rotavirus vaccination did not impact coverage or timeliness of other infant vaccines. PMID: 27522178 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - August 10, 2016 Category: Allergy & Immunology Authors: Valcarcel Salamanca B, Hagerup-Jenssen ME, Flem E Tags: Vaccine Source Type: research

Ulcerated Giant Dermatofibroma following Routine Childhood Vaccination in a Young Boy
Conclusion: Neoplastic development in immunization scars following vaccination is a rare occurrence and, hence, makes this case a diagnostic challenge. A high index of suspicion is crucial in atypical presentations of a common skin lesion, as typified by this case. Careful history taking and clinicopathological correlation of clinical findings with gross and microscopic findings along with targeted immunohistological staining is often essential to aid early diagnosis.Case Rep Dermatol 2016;8:210 –217 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 9, 2016 Category: Dermatology Source Type: research

Role of the private sector in vaccination service delivery in India: evidence from private-sector vaccine sales data, 2009-12
Conclusion In India, the public sector offers vaccination services to the majority of the population but the private sector should not be neglected as it could potentially improve overall vaccination coverage. The government could train and incentivize a wider range of private-sector health professionals to help deliver the vaccines, especially in the low income states with the largest birth cohorts. We recommend future studies to identify strengths and limitations of the public and private health sectors in each Indian state. (Source: Health Policy and Planning)
Source: Health Policy and Planning - August 9, 2016 Category: Health Management Authors: Sharma, A., Kaplan, W. A., Chokshi, M., Zodpey, S. P. Tags: Original Articles Source Type: research

Health and social conditions in Norwegian polio survivors: A 20-year follow-up study.
CONCLUSION: The present study indicates that the elderly polio population are experiencing new muscle weakness and increasing health problems, but that the deterioration occurs slowly and with fewer consequences for the subjective experience of general health and well-being, indicating that the patients are adapting to their life situation. However, subgroups of the elderly polio population are in need of special care. PMID: 27494714 [PubMed - as supplied by publisher] (Source: Journal of Rehabilitation Medicine)
Source: Journal of Rehabilitation Medicine - August 8, 2016 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy.
Abstract Early childhood enteric infections have adverse impacts on child growth and can inhibit normal mucosal responses to oral vaccines, two critical components of environmental enteropathy. To evaluate the role of indoleamine 2,3-dioxygenase 1 (IDO1) activity and its relationship with these outcomes, we measured tryptophan and the kynurenine-tryptophan ratio (KTR) in two longitudinal birth cohorts with a high prevalence of stunting. Children in rural Peru and Tanzania (N = 494) contributed 1,251 plasma samples at 3, 7, 15, and 24 months of age and monthly anthropometrics from 0 to 36 months of age. Tryptophan ...
Source: The American Journal of Tropical Medicine and Hygiene - August 8, 2016 Category: Tropical Medicine Authors: Kosek MN, Mduma E, Kosek PS, Lee GO, Svensen E, Pan WK, Olortegui MP, Bream JH, Patil C, Asayag CR, Sanchez GM, Caulfield LE, Gratz J, Yori PP Tags: Am J Trop Med Hyg Source Type: research

Update on Vaccine-Derived Polioviruses - Worldwide, January 2015-May 2016.
This report updates previous summaries regarding VDPVs (4). PMID: 27491079 [PubMed - as supplied by publisher] (Source: MMWR Morb Mortal Wkl...)
Source: MMWR Morb Mortal Wkl... - August 6, 2016 Category: Epidemiology Authors: Jorba J, Diop OM, Iber J, Sutter RW, Wassilak SG, Burns CC Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Environmental Isolation of Circulating Vaccine-Derived Poliovirus After Interruption of Wild Poliovirus Transmission - Nigeria, 2016.
Abstract In September 2015, more than 1 year after reporting its last wild poliovirus (WPV) case in July 2014 (1), Nigeria was removed from the list of countries with endemic poliovirus transmission,* leaving Afghanistan and Pakistan as the only remaining countries with endemic WPV. However, on April 29, 2016, a laboratory-confirmed, circulating vaccine-derived poliovirus type 2 (cVDPV2) isolate was reported from an environmental sample collected in March from a sewage effluent site in Maiduguri Municipal Council, Borno State, a security-compromised area in northeastern Nigeria. VDPVs are genetic variants of the v...
Source: MMWR Morb Mortal Wkl... - August 6, 2016 Category: Epidemiology Authors: Etsano A, Damisa E, Shuaib F, Nganda GW, Enemaku O, Usman S, Adeniji A, Jorba J, Iber J, Ohuabunwo C, Nnadi C, Wiesen E Tags: MMWR Morb Mortal Wkly Rep Source Type: research

From polio success to better health?
Publication date: 6 August 2016 Source:New Scientist, Volume 231, Issue 3085 Author(s): Debora MacKenzie Can India benefit from its work against polio, asks Debora MacKenzie (Source: New Scientist)
Source: New Scientist - August 6, 2016 Category: Science Source Type: research

Seroprevalence of Poliovirus Antibodies in the United States Population, 2009 –2010
Polio is eliminated in the United States, with the last indigenous transmission occurring in 1979. However, global eradication of polio has not yet been completed, so importation of poliovirus into the U.S. is... (Source: BMC Public Health)
Source: BMC Public Health - August 5, 2016 Category: Consumer Health News Authors: Gregory S. Wallace, Aaron T. Curns, William C. Weldon and M. Steven Oberste Source Type: research

Police officers gunned down while protecting vaccination workers in Pakistan
The polio vaccination drive in Pakistan has seen numerous obstacles over the years which have all resulted in a failure of complete polio eradication from the country. Parental refusal to administer vaccine, religious misconceptions, security lapses for polio workers and ineffective vaccines have all cumulatively impeded the success of the vaccination drive [1 –3]. Previously, only polio vaccine workers have been targeted by militant groups but in recent years there has been a paradigm shift in the strategy of the militants towards law enforcement agencies. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - August 5, 2016 Category: Global & Universal Authors: Saba Ahmed, Mansoor Ali Merchant Rameez, Huda Fatima, Hadi Usmani Tags: Letter to the Editor Source Type: research

The Pre-Anschluss Vienna School of Medicine - The medical scientists: Karl Landsteiner (1868-1943) and Otto Loewi (1873-1961)
Two famous medical scientists are described whose major advances were made largely from laboratory-based research. Karl Landsteiner, who received the Nobel Prize in 1930, was the discoverer or co-discoverer of the blood groups and the Rhesus factor. He contributed to the understanding of poliomyelitis, syphilis and typhus. He made major contributions to immunology, inter alia by isolating haptens. After World War I, he left Austria and continued his work initially in the Netherlands and then at the Rockefeller Institute in the USA. Otto Loewi, a pharmacologist, received his Nobel Prize (jointly with his life-long friend, S...
Source: Journal of Medical Biography - August 4, 2016 Category: History of Medicine Authors: Shaw, L. B., Shaw, R. A. Tags: Original Articles Source Type: research

Can polio success help India improve its public health?
The legacy of polio eradication gives India a golden opportunity to fix its scandalously poor healthcare system. Will it take it? (Source: New Scientist - Cancer)
Source: New Scientist - Cancer - August 3, 2016 Category: Cancer & Oncology Tags: healthcare India polio Source Type: research

Vaccine hesitancy among general practitioners: evaluation and comparison of their immunisation practice for themselves, their patients and their children
AbstractTo gain knowledge about vaccine hesitancy among general practitioners (GPs), we conducted a survey to compare their vaccination attitudes for themselves, their children and their patients. A questionnaire survey was sent to GPs working in private practice in the Rh ône-Alpes region, France, between October 2013 and January 2014. GPs’ immunisation practices for diphtheria–tetanus–poliomyelitis (DTP), measles–mumps–rubella (MMR), pneumococcal, pertussis, hepatitis B (hepB), human papillomavirus (HPV), seasonal and H1N1 influenza and meningococcal C (m enC) vaccines were considered....
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 3, 2016 Category: Microbiology Source Type: research

Synchronizing a Switch From Trivalent to Bivalent Oral Polio Vaccine
This Viewpoint discusses the global effort to synchronize transition from trivalent to bivalent oral polio vaccine as a crucial component of the effort to eradicate polio. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - August 1, 2016 Category: Pediatrics Source Type: research

The Importance of Social Networking in a National Polio Vaccine Campaign
(Source: PEDIATRICS)
Source: PEDIATRICS - August 1, 2016 Category: Pediatrics Authors: Rubin, L., Landsman, K. Tags: Infectious Disease, Vaccine/Immunization, Media, Social Media Pediatrics Perspectives Source Type: research

Polio eradication: no time for complacency
(Source: International Health)
Source: International Health - August 1, 2016 Category: Global & Universal Authors: Durrheim, D. N., Adams, A. Tags: Editorial Source Type: research

Tetanus disease and deaths in men reveal need for vaccination.
Abstract With efforts focused on the elimination of maternal and neonatal tetanus, less attention has been given to tetanus incidence and mortality among men. Since 2007 voluntary medical male circumcision has been scaled-up in 14 sub-Saharan African countries as an effective intervention to reduce the risk of human immunodeficiency virus (HIV) acquisition among men. As part of a review of adverse events from these programmes, we identified 13 cases of tetanus from five countries reported to the World Health Organization (WHO) up to March 2016. Eight patients died and only one patient had a known history of tetanu...
Source: Bulletin of the World Health Organization - August 1, 2016 Category: Global & Universal Authors: Dalal S, Samuelson J, Reed J, Yakubu A, Ncube B, Baggaley R Tags: Bull World Health Organ Source Type: research

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles
Conclusion Intradermal immunogenicity of IPV1 was not affected by injection depth. CpG and CT were potent adjuvants for both intradermal and intramuscular immunization, allowing effective vaccination upon a minimally-invasive single intradermal microinjection by HMN. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 30, 2016 Category: Drugs & Pharmacology Source Type: research

Assessing sex-differences and the effect of timing of vaccination on immunogenicity, reactogenicity and efficacy of vaccines in young children: study protocol for an individual participant data meta-analysis of randomised controlled trials
Introduction Disease incidence differs between males and females for some infectious or inflammatory diseases. Sex-differences in immune responses to some vaccines have also been observed, mostly to viral vaccines in adults. Little evidence is available on whether sex-differences occur in response to immunisation in infancy even though this is the age group in which most vaccines are administered. Factors other than sex, such as timing or coadministration of other vaccines, can also influence the immune response to vaccination. Methods and analysis Individual participant data meta-analysis of randomised controlled trials ...
Source: BMJ Open - July 29, 2016 Category: Journals (General) Authors: Voysey, M., Pollard, A. J., Perera, R., Fanshawe, T. R. Tags: Open access, Infectious diseases, Paediatrics Protocol Source Type: research

Currents issues in cardiorespiratory care of patients with post-polio syndrome
Conclusion Only when evaluated and treated promptly, somE patients can obtain the full benefits of the use of respiratory muscles aids as far as quality of life is concerned. RESUMO S índrome pós-polio (SPP) é uma condição que afeta sobreviventes da poliomielite aguda (PAA), anos após a recuperação de um ataque agudo inicial do vírus. Na maioria das vezes, os sobreviventes da polio começam a apresentar nova paresia gradual nos músculos que foram previamente afetados pe la infecção. A incidência real de doenças cardiovasc...
Source: Arquivos de Neuro-Psiquiatria - July 28, 2016 Category: Neurology Source Type: research

Polio, terror and the immunological worldview
10.1080/17441692.2016.1211164 Robert Peckham (Source: Global Public Health)
Source: Global Public Health - July 23, 2016 Category: Global & Universal Authors: Robert Peckham Source Type: research

Polio, terror and the immunological worldview
. (Source: Global Public Health)
Source: Global Public Health - July 23, 2016 Category: Global & Universal Authors: Robert Peckham Source Type: research

Guillain –Barre syndrome following oral polio vaccination
(Source: Journal of NeuroVirology)
Source: Journal of NeuroVirology - July 22, 2016 Category: Neurology Source Type: research

Efficacy, Safety, and Pharmacokinetics of a New 10  % Liquid Intravenous Immunoglobulin Containing High Titer Neutralizing Antibody to RSV and Other Respiratory Viruses in Subjects with Primary Immunodeficiency Disease
Conclusions There were zero serious bacterial infections, thus meeting the primary endpoint for this trial. The secondary endpoints including days missed from work due to infection, unscheduled visits to the physician, and days of hospitalization due to infection compared favorably to published reports of other IVIG products. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - July 21, 2016 Category: Allergy & Immunology Source Type: research

Current Disease and Epidemiologic Problems: What ’s Hot?
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): CH Calisher Included among the many current world problems are viral diseases of considerable significance and threat. This talk could not possible cover them all but will discuss the emergence of Middle East respiratory syndrome in Saudi Arabia and nearby countries, ebolavirus hemorrhagic fever in West Africa, chikungunya in the Western Hemisphere, and the re-emergence of poliomyelitis. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - July 21, 2016 Category: Research Source Type: research

Safety and immunogenicity of inactivated poliovirus vaccine when given with measles –rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia
Publication date: August 2016 Source:The Lancet Global Health, Volume 4, Issue 8 Author(s): Ed Clarke, Yauba Saidu, Jane U Adetifa, Ikechukwu Adigweme, Mariama Badjie Hydara, Adedapo O Bashorun, Ngozi Moneke-Anyanwoke, Ama Umesi, Elishia Roberts, Pa Modou Cham, Michael E Okoye, Kevin E Brown, Matthias Niedrig, Panchali Roy Chowdhury, Ralf Clemens, Ananda S Bandyopadhyay, Jenny Mueller, David J Jeffries, Beate Kampmann Background The introduction of the inactivated poliovirus vaccine (IPV) represents a crucial step in the polio eradication endgame. This trial examined the safety and immunogenicity of IP...
Source: The Lancet Global Health - July 21, 2016 Category: Global & Universal Source Type: research

Coverage estimates and patterns of inactivated poliovirus vaccine (IPV) use prior to and during the polio eradication endgame, Jinan City, China, 2010 –2015
10.1080/21645515.2016.1208327 Caiyun Chang (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - July 20, 2016 Category: Allergy & Immunology Authors: Caiyun Chang Ji Zhang Jingwen Zhou Ruoming Cao Kaijun Song Chong Liu Xianhui Zhang Xingyi Geng Xiaoxue Liu Chuanbin Li Source Type: research

Modeling and Managing the Risks of Measles and Rubella: A Global Perspective, Part I
Over the past 50 years, the use of vaccines led to significant decreases in the global burdens of measles and rubella, motivated at least in part by the successive development of global control and elimination targets. The Global Vaccine Action Plan (GVAP) includes specific targets for regional elimination of measles and rubella in five of six regions of the World Health Organization by 2020. Achieving the GVAP measles and rubella goals will require significant immunization efforts and associated financial investments and political commitments. Planning and budgeting for these efforts can benefit from learning some importa...
Source: Risk Analysis - July 17, 2016 Category: Global & Universal Authors: Kimberly M. Thompson, Stephen L. Cochi Tags: Special Series Source Type: research

Aerobic Exercise Training in Post-Polio Syndrome: Process Evaluation of a Randomized Controlled Trial
Conclusion Our results suggest that severely fatigued individuals with PPS cannot adhere to a high intensity aerobic exercise program on a cycle ergometer. Despite exercise intensities around the AT, lower extremity muscle function nor cardiorespiratory fitness improved. Improving the aerobic capacity in PPS is difficult through exercise primarily focusing on the lower extremities, and may require a more individualized approach, including the use of other large muscle groups instead. Trial Registration Netherlands National Trial Register NTR1371 (Source: PLoS One)
Source: PLoS One - July 15, 2016 Category: Biomedical Science Authors: Eric L. Voorn Source Type: research

Serum Neutralization Assay for the Determination of Antibody Levels Against Non-Polio Enterovirus Strains in Central and Western Greece
Viral Immunology , Vol. 0, No. 0. (Source: Viral Immunology)
Source: Viral Immunology - July 13, 2016 Category: Allergy & Immunology Authors: Antonis FikatasTilemachos G. DimitriouZaharoula KyriakopoulouOurania TsachouridouConstantina GartzonikaStamatina Levidiotou-StefanouGrigoris D. AmoutziasPanayotis Markoulatos Source Type: research

The physiological cost index of walking with a powered knee-ankle-foot orthosis in subjects with poliomyelitis: A pilot study
Conclusion: Using a powered knee–ankle–foot orthosis did not significantly improve any of the primary outcome measures during walking for poliomyelitis subjects. Clinical relevance This powered knee–ankle–foot orthosis design did not improve the physiological cost index of walking for people with poliomyelitis when compared to walking with a knee–ankle–foot orthosis with drop lock knee joints. This may have been due to the short training period used or the bulky design and additional weight of the powered orthosis. Further research is therefore warranted. (Source: Prosthetics and Orthotics International)
Source: Prosthetics and Orthotics International - July 12, 2016 Category: Orthopaedics Authors: Arazpour, M., Ahmadi Bani, M., Samadian, M., Mousavi, M. E., Hutchins, S. W., Bahramizadeh, M., Curran, S., Mardani, M. A. Tags: Original Research Reports Source Type: research

Interventions for improving coverage of childhood immunisation in low- and middle-income countries.
CONCLUSIONS: Providing parents and other community members with information on immunisation, health education at facilities in combination with redesigned immunisation reminder cards, regular immunisation outreach with and without household incentives, home visits, and integration of immunisation with other services may improve childhood immunisation coverage in LMIC. Most of the evidence was of low certainty, which implies a high likelihood that the true effect of the interventions will be substantially different. There is thus a need for further well-conducted RCTs to assess the effects of interventions for improving chi...
Source: Cochrane Database of Systematic Reviews - July 10, 2016 Category: Journals (General) Authors: Oyo-Ita A, Wiysonge CS, Oringanje C, Nwachukwu CE, Oduwole O, Meremikwu MM Tags: Cochrane Database Syst Rev Source Type: research

[Department of Error] Department of Error
Parker EPK, Grassly NC. Polio vaccination: preparing for a change of routine. Lancet 2016; 388: 107–08—In this Comment, the second sentence in the seventh paragraph should have read “Of the infants in this study who had not seroconverted to serotype 2 before receiving mOPV2, seroconversion 1 week after challenge was recorded in 127 (71%) of 179 who had received bOPV alone and 20 (53%) of 38 who had received bOPV alongside one dose of IPV.” This correction has been made to the online version as of July 7, 2016, and the printed Comment is correct. (Source: LANCET)
Source: LANCET - July 8, 2016 Category: Journals (General) Tags: Department of Error Source Type: research

Contribution of polio eradication initiative to strengthening routine immunization: Lessons learnt in the WHO African region.
CONCLUSIONS: PEI has been associated with increased spending on immunization and the related improvements, especially in the areas of micro planning, service delivery, program management and capacity building. Continued efforts are needed to mobilize international and domestic support to strengthen and sustain high-quality immunization services in African countries. Strengthening RI will in turn sustain the gains made to eradicate poliovirus in the region. PMID: 27396492 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 7, 2016 Category: Allergy & Immunology Authors: Anya BM, Moturi E, Aschalew T, Carole Tevi-Benissan M, Akanmori BD, Poy AN, Mbulu KL, Okeibunor J, Mihigo R, Zawaira F Tags: Vaccine Source Type: research

The contribution of the polio eradication initiative to narrowing the gaps in the health workforce in the African Region.
DISCUSSION: GPEI investment achieved far beyond its primary goal, and contributed to narrowing the gaps in the health workforce in countries of the African Region, as demonstrated by the best practice documentation exercise. We recommend that expertise and experience of polio funded staff should be leveraged to strengthen, expand and support other public health programmes. PMID: 27395564 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 6, 2016 Category: Allergy & Immunology Authors: Kamso J, Mvika ES, Martin OC, Okeibunor J, Mkanda P, Mihigo R Tags: Vaccine Source Type: research

The Epidemic of Infantile Paralysis
All reports agree in characterizing the outbreak of poliomyelitis now making such sad havoc in New York City and elsewhere as a highly serious emergency both for the affected locality and for the entire country. The type of disease is evidently severe, and the mortality already has passed far beyond the figures reached in the great New York epidemic in 1907. The time of year is distinctly unfavorable, summer being usually the period of greatest prevalence. Once the disease has started there is generally an increase in the number of cases until checked in some unknown way by the advent of cool weather. In the Vermont epidem...
Source: JAMA - July 5, 2016 Category: Journals (General) Source Type: research

Polyneuritische Variante einer rein neuritischen Lepra mit massiver Beteiligung der peripheren Nerven und Verschonung der von Polio betroffenen Extremität: Ein seltenes Fallbeispiel
(Source: JDDG)
Source: JDDG - July 4, 2016 Category: Dermatology Authors: Swetalina Pradhan, Tanmay Padhi, B.B Panda, Bibhu Prasad Nayak Tags: Clinical Letter Source Type: research

Safety and immunogenicity of inactivated poliovirus vaccine when given with measles–rubella combined vaccine and yellow fever vaccine and when given via different administration routes: a phase 4, randomised, non-inferiority trial in The Gambia
Publication date: Available online 27 June 2016 Source:The Lancet Global Health Author(s): Ed Clarke, Yauba Saidu, Jane U Adetifa, Ikechukwu Adigweme, Mariama Badjie Hydara, Adedapo O Bashorun, Ngozi Moneke-Anyanwoke, Ama Umesi, Elishia Roberts, Pa Modou Cham, Michael E Okoye, Kevin E Brown, Matthias Niedrig, Panchali Roy Chowdhury, Ralf Clemens, Ananda S Bandyopadhyay, Jenny Mueller, David J Jeffries, Beate Kampmann Background The introduction of the inactivated poliovirus vaccine (IPV) represents a crucial step in the polio eradication endgame. This trial examined the safety and immunogenicity of IPV...
Source: The Lancet Global Health - July 4, 2016 Category: Global & Universal Source Type: research

Polio Eradication Initiative contribution in strengthening immunization and integrated disease surveillance data management in WHO African region, 2014.
CONCLUSION: Polio data management has helped to improve the overall VPD, IDSR and routine data management as well as emergency response in the Region. As we approach the polio end game, the African Region would benefit in using the already set infrastructure for other public health initiative in the Region. PMID: 27389171 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 4, 2016 Category: Allergy & Immunology Authors: Poy A, Minkoulou E, Shaba K, Yahaya A, Gaturuku P, Dadja L, Okeibunor J, Mihigo R, Mkanda P Tags: Vaccine Source Type: research

Polio Eradication Initiative: Contribution to improved communicable diseases surveillance in WHO African region.
CONCLUSION: As we approach polio eradication, polio-eradication initiative staff, financial resources, and infrastructure can be used as one strategy to build IDSR in Africa. As we are now focusing on measles and rubella elimination by the year 2020, other disease-specific programs having similar goals of eradicating and eliminating diseases like malaria, might consider investing in general infectious disease surveillance following the polio example. PMID: 27389170 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 4, 2016 Category: Allergy & Immunology Authors: Mwenge W, Mbulu LK, Okeibunor J, Nsubuga P, Salla M, Mihigo R, Mkanda P Tags: Vaccine Source Type: research

New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy.
Authors: Schulze K, Ebensen T, Riese P, Prochnow B, Lehr CM, Guzmán CA Abstract The young twenty-first century has already brought several medical advances, such as a functional artificial human liver created from stem cells, improved antiviral (e.g., against HIV) and cancer (e.g., against breast cancer) therapies, interventions controlling cardiovascular diseases, and development of new and optimized vaccines (e.g., HPV vaccine). However, despite this substantial progress and the achievements of the last century, humans still suffer considerably from diseases, especially from infectious diseases. Thus, almo...
Source: Current Topics in Microbiology and Immunology - July 3, 2016 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research