The mitochondrial multi-omic response to exercise training across rat tissues
Cell Metab. 2024 Apr 15:S1550-4131(23)00472-2. doi: 10.1016/j.cmet.2023.12.021. Online ahead of print.ABSTRACTMitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colo...
Source: Cell Metabolism - May 3, 2024 Category: Cytology Authors: David Amar Nicole R Gay David Jimenez-Morales Pierre M Jean Beltran Megan E Ramaker Archana Natarajan Raja Bingqing Zhao Yifei Sun Shruti Marwaha David A Gaul Steven G Hershman Alexis Ferrasse Ashley Xia Ian Lanza Facundo M Fern ández Stephen B Montgomer Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
Post-marketing safety concerns with elagolix: a disproportionality analysis of the FDA adverse event reporting system
CONCLUSION: Our study provides a comprehensive picture of the safety of elagolix in the post-marketing setting, while also identifying potential new AE signals. These findings emphasize the importance of continued monitoring of the potential risks of elagolix.PMID:38700323 | DOI:10.1080/14740338.2024.2351451 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - May 3, 2024 Category: Drugs & Pharmacology Authors: En Chang Yong-Fang Shi Jin-Feng Liu Wei Wei Source Type: research
Evaluation of some proinflammatory cytokines and biochemical parameters in pre and postmenopausal breast cancer women
Cytokine. 2024 May 2;179:156632. doi: 10.1016/j.cyto.2024.156632. Online ahead of print.ABSTRACTThe study was planned to evaluate the differences in certain proinflammatory cytokines(IL-6, TNF-α) with CRP and biochemical parameters (E2, D3, LDH, GGT, TSB, Ca, Ph, uric acid), between women with pre- and postmenopausal breast cancer and seemingly healthy women in Iraqi women as controls; at medical city in teaching Oncology hospital,70 breast cancer patients women their ages ranged (47.51 ± 1.18) and 20 healthy women with age (44.45 ± 2.66) begun from September (2020) to February (2021). The aims of this study to investig...
Source: Cytokine - May 3, 2024 Category: Molecular Biology Authors: Maryam Mohammed Bakheet Hiba Mohssin Ali Tabarak Jalil Talab Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
Comparative evaluation of volumetry estimation from plain and contrast enhanced computed tomography liver images
CONCLUSIONS: The obtained results from plain CT images will undoubtedly provide valuable diagnostic assistance and surgery planning even for the subset of patients for whom CECT acquisition is not advisable.PMID:38700703 | DOI:10.1515/bmt-2022-0349 (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - May 3, 2024 Category: Biomedical Engineering Authors: Lakshmipriya Balagourouchetty Pragatheeswaran K Jayanthi Biju Pottakkat Govindarajalou Ramkumar Source Type: research
The safety of modified, all-oral shorter tuberculosis regimens in Armenia
CONCLUSION: The shorter regimens proved to be safe and effective for treatment of rifampicin-resistant tuberculosis, but proper follow-up of adverse events is necessary.PMID:38701164 | DOI:10.3233/JRS-230039 (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 3, 2024 Category: Drugs & Pharmacology Authors: Hakob Atshemyan Naira Khachatryan Anush Khachatryan Narine Mirzoyan Source Type: research
Structural and functional characteristics of pectins from three cultivars of apple (Malus pumila Mill.) pomaces
This study aimed to investigate the chemical composition, structural properties, and biological properties of pectin polysaccharides (AP-FS, AP-QG, and AP-HG) isolated from different varieties of apple pomace. Based on the methylation and nuclear magnetic resonance analyses, the structure of AP-FS was determined to be composed of an α-1,4-linked homogalacturonan backbone that exhibited high levels of O-6 methylation. All pectins exhibit potent inhibitory activity against human colon cancer and human liver cancer cells, along with immunostimulatory effects. Among them, AP-FS exhibited the highest activity level. Finally, w...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Huan Guo Hang Li Wenyi Ran Wenyue Yu Yue Xiao Renyou Gan Hong Gao Source Type: research
Chronic lead poisoning-induced budgerigar liver damage, gut microbiota dysbiosis, and metabolic disorder
Ecotoxicol Environ Saf. 2024 May 2;278:116388. doi: 10.1016/j.ecoenv.2024.116388. Online ahead of print.ABSTRACTBirds are sensitive to heavy metal pollution, and lead (Pb) contamination can negatively affect their liver and gut. Therefore, we used budgerigars to examine liver and gut toxicosis caused by Pb exposure in bird, and the possible toxic mechanisms. The findings showed Pb exposure increased liver weight and decreased body weight. Moreover, histopathological and immunofluorescence assay results demonstrated obvious liver damage and cell apoptosis increased in Pb- treated budgerigars. Quantitative polymerase chain r...
Source: Ecotoxicology and Environmental Safety - May 3, 2024 Category: Environmental Health Authors: Chongyang Yu Na Xu Xiaoyu Tao Gang Liu Source Type: research
The Value of Follow-Up Liver Stiffness Changes Measured by Virtual Touch Quantification Elastography for Predicting Recurrence of Gastroesophageal Varices after Endoscopic Injection Sclerotherapy on Cirrhotic Patients
CONCLUSIONS: Longitudinal assessment of LS values in post-EIS patients can provide valuable information for predicting the recurrence of GEVs.PMID:38698910 | PMC:PMC11065494 | DOI:10.1155/2024/6802870 (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - May 3, 2024 Category: Gastroenterology Authors: Yayang Duan Jinfei Zhang Min Fan Derun Kong Chaoxue Zhang Source Type: research
Lipid Nanoparticles as a Platform for miRNA and siRNA Delivery in Hepatocellular Carcinoma
Curr Drug Deliv. 2024 May 2. doi: 10.2174/0115672018292331240404070236. Online ahead of print.ABSTRACTLiver cancer is the sixth most common cancer and the fourth leading cause of death worldwide. Hepatocellular carcinoma (HCC) comprises 75-80% of liver cancer cases. Therapeutic strategies for HCC are available and have been shown to prolong survival but not treat HCC. Gene expression and regulation are responsible for the pathogenesis and progression of HCC. Altering these genetic networks can impact cellular behaviors and in turn cure HCC. Single-stranded and double-stranded non-coding ribonucleic acid known as microRNA a...
Source: Current Drug Delivery - May 3, 2024 Category: Drugs & Pharmacology Authors: Gaidaa Dogheim Sampath Chinnam Mohamed T Amralla Source Type: research
Comparison of Hospital Volume and Risk-Standardized Mortality Rate as a Proxy for Hospital Quality in Complex Oncologic Hepatopancreatobiliary Surgery
CONCLUSIONS: HVC and HPC have the lowest overall and risk-standardized 90-day mortality after oncologic hepatopancreatobiliary procedures, but RSMR may outperform volume as a measure of hospital quality.PMID:38700800 | DOI:10.1245/s10434-024-15361-2 (Source: Ann Oncol)
Source: Ann Oncol - May 3, 2024 Category: Cancer & Oncology Authors: William T Julian Mohamedraed Elshami John B Ammori Jeffrey M Hardacre Lee M Ocuin Source Type: research
Inhibition of Liver Cancer Cell Viability by Triazole through Up-regulation of p38 Phosphorylation and Targeting the Activation of p-ERK1/2 and Akt Protein Expression
Dokl Biochem Biophys. 2024 May 3. doi: 10.1134/S1607672923600525. Online ahead of print.ABSTRACTThe present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using the MTT test and expression of several proteins was assessed by western blotting assay. The Matrigel-coated Transwell assay was employed to examine the infiltration of cells. The data from MTT assay showed that MHCC97H and H4TG liver cancer cell viability was inhibited by triazole in a concentration-dependent manner. After treatment with 0.5, 1.0, 2.0, 4, 8, and 16 µM doses of triazole, the...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: None Shanfeng Li Long Zhou Feng Zhao Haisong Wang Meng Sun Source Type: research
Therapeutic Potential of Silymarin in Mitigating Paclitaxel-Induced Hepatotoxicity and Nephrotoxicity: Insights into Oxidative Stress, Inflammation, and Apoptosis in Rats
CONCLUSION: Our findings indicate the potential of SIL to alleviate PAX-induced liver and kidney damage in rats by reducing oxidative stress, inflammation, and apoptotic processes.PMID:38700358 | DOI:10.4274/balkanmedj.galenos.2024.2024-1-60 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Seda Yakut Tu ğçe Atcalı C üneyt Çaglayan Aykut Ulucan Fatih Mehmet Kandemir Adem Kara Turgut Anuk Source Type: research
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
