Ethical predictability of patient safety in Iranian hospitals.
This study aimed to ascertain and compare ethical predictability of patient safety in selected hospitals in Mazandaran Province in Iran. METHODS: A cross-sectional design was applied in the current study. By applying the multistage method for sampling, the statistical population consisted of clinical units of selected public, social security, and private hospitals. Out of the 18 public hospitals, five teaching hospitals, nine private and five social security hospitals, one hospital was randomly selected in Mazandaran Province from each cluster. In total, 938 patients participated in the study. Data entry and analysis w...
Source: International Journal of Risk and Safety in Medicine - July 2, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

A risk balancing act - tourism competition using health leverage in the COVID-19 era.
Authors: Grech V, Grech P, Fabri S Abstract The world is currently in the throes of the COVID-19 pandemic which has halted the tourism sector and created an unprecedented global economic crisis. This paper will outline economics pertaining to COVID-19 lockdown, recovery and the inevitable competition that will occur between countries for tourists who will be scarcer and therefore more valuable. Countries are competing with a variety of incentives in order to lure visitors. However, persistent first waves that extend into July will put off tourists, further reducing tourism revenues and accelerate job losses and ban...
Source: International Journal of Risk and Safety in Medicine - July 2, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Front-line staff's perspective on patient safety culture in an Iranian medical center: A systematic review and meta-analysis.
This study aimed to systematically review the status of patient safety culture from the perspective of clinical personnel at Iranian hospitals through a meta-analysis of studies using the Hospital Survey on Patient Safety Culture (HSOPSC) questionnaire. METHODS: The present systematic review and meta-analysis was conducted in 2018. Data were gathered by searching Google Scholar, Scopus, PubMed, and Web of Science databases up to November 2018. Search keywords were "patient", "safety", "culture", "healthcare", "hospital", "medical center", "HSOPSC tool&quo...
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Medical safety reporting system neccessity and analysis of Turkey 2016 data: A health policy report.
CONCLUSION: In order to reduce medical errors and provide patient safety, every institution must first of all do its own self-assessment. New user-friendly systems can be developed in order to increase medical error notifications and thus institutions can improve their healthcare quality. PMID: 32568117 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Near-miss analysis in a large hospital in southern Brazil: A 5-year retrospective study.
CONCLUSION: The most frequent categories of near-miss incidents were medication processes, other institutional protocols, information control issues, and venous/vascular puncture. The significant number of reported near-miss incidents reflects good adherence to the reporting system. PMID: 32568118 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Presentation of benefits and harms of antidepressants on websites: A cross sectional study.
Authors: Gossell-Williams M PMID: 32568119 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Some reflections on organizational profiles in Italy in the time of COVID-19.
Authors: Bottari C PMID: 32568120 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Physiotherapists' knowledge, usage and attitude towards Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Karachi, Pakistan.
CONCLUSION: This study implicates that physiotherapists should be trained through proper educational sessions such as certification courses on pharmacotherapy (specifically pain medications) in order to become certified to prescribe NSAIDs and other analgesics. PMID: 32568121 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 24, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Controlling nosocomial infection in adult intensive treatment unit: A quality improvement project.
CONCLUSIONS: A multimodal approach is necessary to improve hand hygiene adherence. In-hospital laundry is safer to control nosocomial infections. Quality improvement is a continuous process that guarantees a proper healthcare service as per the quality chasm. PMID: 32538871 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Extension to 'combined SNA and LDA methods to understand adverse medical events': Doctor and nurse perspectives.
CONCLUSIONS: Communication and inattentiveness appeared most frequently in medical adverse events reports regardless of whether doctors or nurses did the reporting. Findings suggest feedback and information sharing processes could be implemented as a step toward alleviating many issues. Institutional management, healthcare managers and government officials should take actions to decrease medical adverse events, many of which may be preventable. PMID: 32538872 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Dogs bark, but the caravan goes on: A discussion on the meta-analysis of antidepressants by Andrea Cipriani et  al.
CONCLUSION: Even the reductionistic phase of the AD story, the mechanism of action, failed to be consistent so it is unclear how the largest meta-analysis of about 21 antidepressants by Andrea Cipriani et al. appeared in The Lancet. PMID: 32538873 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Patient safety issues associated with the use of compounded medicines as alternatives to approved pharmaceutical products in Europe and how best practice can improve outcomes.
CONCLUSIONS: Several case reports/series describing instances of overdose, medication errors and adverse events associated with compounded medications were reviewed. The number of affected patients was relatively small, but many were children and two adult patients experienced permanent sequelae. The number of incidents associated with compounded medicines is unknown, and so these numbers should be interpreted with caution. When licensed medicines are available, the use of compounded medicines can put patients at unnecessary risk which should be avoided. Stricter regulation is necessary to prevent similar cases from occurr...
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Unintended intraoperative awareness: An analysis of perioperative anesthetic adverse events in Thailand (PAAd Thai).
CONCLUSION: Nine intraoperative awareness incidents were observed, however the causes were preventable. The anesthetic component seems to be the most influential to prevent these events. PMID: 32538875 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Inferior alveolar nerve paraestheia and cutaneous sinus on the face associated with periapical infection of lower molar teeth in a 14-year-old girl: A rare and unusual case report.
CONCLUSION: The simultaneous occurrence of infection and paresthesia strongly suggested a definitive relationship. Therefore, there seems to be a correlation between duration, origin, significance of the injury and the prognosis of paresthesia. PMID: 32538876 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 18, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Risk of using hydroxychloroquine as a treatment of COVID-19.
Authors: Alanagreh L, Alzoughool F, Atoum M Abstract The emerging COVID-19 pandemic poses a threat to the global health care system. Given the lack of antiviral therapies or vaccines for the disease, the antimalarial drug hydroxychloroquine (HCQ) obtained much attention as a treatment for COVID-19. However, there are limited and uncertain clinical data to support the beneficial effect of this drug in COVID-19 treatment. HCQ has several side effects and warnings, including blindness, heart failure, and renal toxicity, even with recommended doses. For severe cases of COVID-19 or in patients with preexisting condition...
Source: International Journal of Risk and Safety in Medicine - June 2, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Real world safety of bevacizumab in cancer patients: A systematic literature review of case reports.
CONCLUSION: Bevacizumab is associated with more ADRs in the real world among cancer patients than those reported during clinical trials. PMID: 32444564 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 25, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

What have antidepressants been tested for? A systematic review.
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 25, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Dark present, but look to the future.
Authors: Edwards IR PMID: 32364136 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 6, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Inadequate evaluation of potential side effects of sildenafil in preterm stopped Dutch trial.
Authors: Bijl D, Healy D Abstract Recently a drug trial in the Netherlands in which the efficacy of oral sildenafil was compared to placebo in women bearing children with fetal growth restriction was stopped early because of very harmful side effects to the babies. There were quite some unwanted and unscientific aspects related to this study and the way in which the side effects were communicated to the patients and the community. These have not gained the attention they ought to have. We therefore made an analysis of the basic problems which aims to prevent that the trust in medical research will be weakened. ...
Source: International Journal of Risk and Safety in Medicine - May 6, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19.
Authors: Alzoughool F, Alanagreh L Abstract The ongoing COVID-19 pandemic has infected nearly 400,000 individuals with 17000 deaths since it was first identified in human populations in December 2019, in Wuhan, China. No antiviral therapies or vaccines are available for their treatment or prevention. Passive immunization PI through broadly neutralizing antibodies that bind to the specific antigens of SARS-CoV 2 might be a potential solution to address the immediate health threat of COVID-19 pandemic while vaccines are being developed. The PI approach in treating COVID-19 is discussed herein, including a summary of ...
Source: International Journal of Risk and Safety in Medicine - April 22, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

News Item.
Authors: Edwards IR PMID: 32280066 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - April 15, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Risk and safety: What's the point?
Authors: Ralph Edwards I, Lindquist M PMID: 32176658 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 17, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

In Memoriam.
Authors: Ziganshina LE, Ralph Edwards I PMID: 32176659 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 17, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Presentation of benefits and harms of antidepressants on websites: A cross sectional study.
CONCLUSIONS: None of the websites met our predefined criteria. The information was generally inaccurate and unhelpful and has potential to lead to inappropriate use and overuse of antidepressants and reduce the likelihood that people will seek better options for depression like psychotherapy. PMID: 32144998 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Patient safety climate in a Brazilian general hospital.
CONCLUSION: There is a positive safety climate in health organizations from the perspective of the multiprofessional team. However, the domains Safety Climate, Working Conditions and Stress Perception constitute areas that need improvement, aiming to improve patient safety in the institution. PMID: 32144999 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Determinants of sleep habits in toddlers: Application of planned behavior theory.
CONCLUSION: While recommending more comprehensive studies, the findings of the study emphasize the application of the theory of planned behavior in identifying factors influencing sleep habits and designing child sleep improvement interventions. PMID: 32145000 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Alemtuzumab for relapsing multiple sclerosis in clinical practice: A four-year retrospective one-center study.
CONCLUSION: In clinical practice alemtuzumab showed an acceptable safety profile in selected patients even if all of them suffered at least one adverse effect. Thorough and prolonged follow-up is required to further confirm the safety of this drug. PMID: 32145001 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Pharmaceutical cost analysis of dental diseases: An Indian scenario.
Authors: Talreja P, Kalra R Abstract Medicines are an integral part of the health system and the accessibility hugely depends on affordability and availability of medicines. Oral health is an integral component of overall well-being but is ironically often one of the most neglected areas of healthcare. There is paucity of data on the pharmaceutical cost components of dental disease, so this study aims to address this lacuna on the pricing of medicines. This research study can be considered a partial economic evaluation that focuses on an estimation of costs associated with medicines used in treatment of selected or...
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

PRIME study: Prescription review to impede medication errors.
CONCLUSIONS: The study was not only successful in highlighting the impact of medication error assessment on patient safety, but it also demonstrated that medication errors can be lowered with the help of clinical pharmacy services. Findings from the study conclude that medication errors can be prevented if healthcare professionals are educated appropriately to avoid recurrence of past mistakes. PMID: 32039861 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Introducing medical students to pharmacovigilance through a basic research skills special study module.
Authors: Gossell-Williams M, Paul T Abstract Pharmacovigilance is an important aspect of clinical practice; however, there is limited evidence that it exists as a theme in medical education curricula. We developed and used a Basic Research Skill Special Study Module to introduce pharmacovigilance to medical students in the early years of their programme. Students completing year one or two of the Faculty of Medical Sciences, Bachelor of Medicine, Bachelor of Surgery programme at The University of the West Indies, Jamaica participated in the four week experience from May 16th to June 12th 2019 to complete structured...
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Proficient until proven unproficient? Exploring attitudes and perceptions of medical specialists on proficiency, proficiency requirements and proficiency tests for electrosurgery.
CONCLUSIONS: When assuring proficiency of users of electrosurgery, the positive attitude towards proficiency requirements and the more negative attitude towards proficiency tests should be taken into account. PMID: 32039863 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

The effect of educational intervention on the knowledge and attitude of intensive care nurses in the prevention of pressure ulcers.
CONCLUSIONS: Since educational intervention improved the knowledge and attitude of nurses in preventing pressure ulcers, it is required to conduct appropriate educational interventions to improve their knowledge and attitude. PMID: 32039864 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Affordability versus innovation: Is compulsory licensing the solution?
Authors: Pandey E, Paul SB Abstract  In an era which marks an exceptional phase of growth in science and technology, the acute disparities in access to healthcare still persist. So where on one hand scientific advancement in medicine aims at increasing life expectancy, on the other hand there are millions who are denied access to existing medicines. Patents on medicines also pose a significant barrier to access new drugs, especially in low and middle income countries which already suffer from poor health financing mechanisms. The patent laws were built on the assumption of incentivizing the innovators by rewar...
Source: International Journal of Risk and Safety in Medicine - October 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Impact of increased focus on pharmacovigilance on knowledge and attitude towards adverse drug reaction reporting among medical students in India.
CONCLUSION: In spite of collaborative and synchronized efforts by various agencies there is a need to further improve the PV milieu in India by confidence building exercises, imparting training on PV programme, updating of the current knowledge on PV and also sustaining motivation. PMID: 31594254 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Global trigger tool in child psychiatry: A treatment safety evaluation in adolescents with an acute psychotic episode.
CONCLUSION: We recommend three triggers, "Abrupt medication stop", "Prescribing of extrapyramidal symptoms corrector", and "Hospital readmission within 30 days", with reasonable positive predictive value for incorporation into routine systems for patient safety monitoring in adolescents with an acute psychotic episode. Antipsychotic-induced extrapyramidal symptoms were more prevalent in older adolescents and patients with fewer lifetime hospital admissions. These patients need to be carefully monitored to ensure patient safety. PMID: 31594255 [PubMed - as supplied by publisher] (Source: In...
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Long-term use of antipsychotics and antidepressants is not evidence-based.
CONCLUSIONS: If we accept the evidence-based premises that antipsychotics and antidepressants do not have clinically relevant effects and that the patients dislike them, the data suggest massive overuse of the drugs, to a remarkably similar degree. We need to focus on helping patients withdraw slowly and safely from the drugs they are on instead of telling them that they need to stay on them. PMID: 31594256 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Mitigating risk in Norwegian psychiatric care: Identifying triggers of adverse events through Global Trigger Tool for psychiatric care.
CONCLUSIONS: There is a clear relationship between the presence of triggers in a patient record and the likelihood of adverse events. Particularly relevant for psychiatric patients is 'suffering' as a trigger and this may also be relevant to somatic care and has implications for inclusion in the GTT-P. PMID: 31561389 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Drop-out rates in placebo-controlled trials of antidepressant drugs: A systematic review and meta-analysis based on clinical study reports.
CONCLUSIONS: By using CSRs, we were able to demonstrate for the first time that more patients dropped out on active drug than on placebo. As it can be argued that the drop-out rate reflects the patients' overall assessment of the balance between benefits and harms, our review adds to the growing concern that SSRIs and SNRIs might not have the desired effect. Our review also highlights the importance of using CSRs for undertaking reviews of drugs. PMID: 31561390 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Prevalence and types of potentially inappropriate prescriptions among older and  middle-aged community-dwelling Albanian patients.
CONCLUSIONS: Prevalence of PIP is higher in elderly patients and slightly different according to the tool used for detection. However, PIP are also common in the middle-aged population. PMID: 31561391 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Benefits and harms of antipsychotic drugs in  drug-naïve patients with psychosis: A systematic review.
CONCLUSIONS: The use of antipsychotics cannot be justified based on the evidence we currently have. Withdrawal effects in the placebo groups make existing placebo-controlled trials unreliable. PMID: 31561392 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Editorial.
Authors: Ralph Edwards I, Lindquist M PMID: 31524183 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 18, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Combined SNA and LDA methods to understand adverse medical events.
CONCLUSIONS: Communication and inattentiveness were the most common problems reported in medical adverse events regardless of healthcare professional reporting or harm levels. Findings suggested that an information-sharing and feedback mechanism should be implemented to eliminate preventable medical adverse events. Healthcare institutions managers and government officials should take targeted actions to decrease these preventable medical adverse events through quality improvement efforts. PMID: 31476171 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 4, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals.
CONCLUSIONS: Healthcare professionals are nervous about or reluctant to engage with novel problems on a treatment. This is not widely appreciated and the reasons for this concern are not understood. PMID: 31450514 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 29, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Patent implications in the pharmaceutical industry: Are static high prices leading to dynamic innovations?
Authors: Pandey E, Paul SB Abstract Agreement on Trade Related aspects of Intellectual Property Rights (TRIPS) was laid on the premises of rewarding monopolistic patent rights to the innovator. Stronger patent protection was advocated to promote technology transfer from developed nations to the rest of the world. To boost domestic innovative potential and to maintain trade ties, most developing countries signed the TRIPS agreement. Impact of patent laws in the pharmaceutical industry was crucial as it posed threat to access health. This paper aims to analyze the impact of pharmaceutical product patent laws incorpor...
Source: International Journal of Risk and Safety in Medicine - August 29, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Effect of lithium on suicide and mortality in mood disorders: A systematic review.
CONCLUSION: According to our study, lithium reduces total mortality in mood disorders but not suicide. Because of small numbers and unreliable data, the findings should be interpreted with caution. PMID: 31381531 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 6, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Why health policies should be transnational: A case for East Asia Pacific countries.
We present transnational health policy recommendations for the EAP region based on both our use of robust methodology and the resulting comparative clusters. PMID: 31282430 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - July 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Knowledge, attitudes and practice preference regarding drug prescriptions of resident dental doctors: A quantitative study.
CONCLUSION: The results of this study indicate that resident dental doctors' knowledge, attitudes and behavior about the drug prescription need to be improved. More studies are needed to determine whether this issue affects the quality of patient care and the effectiveness and safety of treatments. PMID: 31256074 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - July 2, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Adverse pregnancy outcomes between the anti-malarial drugs: Is there a difference between the drugs recommended by World Health Organization? Results of a mixed treatment comparison analysis of randomized clinical trials and cohort studies.
CONCLUSION: WHO recommended anti-malarials in pregnancy have similar risk profiles with regard to abortion, stillbirth and neonatal deaths. PMID: 30714973 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 5, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.
CONCLUSION: The randomised trials currently available cannot be used to investigate persistent harms of antidepressants. PMID: 30714974 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 5, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

The preoperative risk factors of postoperative self-extubation in elderly patients.
CONCLUSIONS: Elderly patients with a history of dementia and low preoperative hemoglobin are at a risk of postoperative self-extubation, especially after an abdominal operation. These predictors can contribute to the more effective prevention of perioperative self-extubation. PMID: 30175984 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 4, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research