Real world safety of bevacizumab in cancer patients: A systematic literature review of case reports.
CONCLUSION: Bevacizumab is associated with more ADRs in the real world among cancer patients than those reported during clinical trials. PMID: 32444564 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 25, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

What have antidepressants been tested for? A systematic review.
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 25, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Dark present, but look to the future.
Authors: Edwards IR PMID: 32364136 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 6, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Inadequate evaluation of potential side effects of sildenafil in preterm stopped Dutch trial.
Authors: Bijl D, Healy D Abstract Recently a drug trial in the Netherlands in which the efficacy of oral sildenafil was compared to placebo in women bearing children with fetal growth restriction was stopped early because of very harmful side effects to the babies. There were quite some unwanted and unscientific aspects related to this study and the way in which the side effects were communicated to the patients and the community. These have not gained the attention they ought to have. We therefore made an analysis of the basic problems which aims to prevent that the trust in medical research will be weakened. ...
Source: International Journal of Risk and Safety in Medicine - May 6, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19.
Authors: Alzoughool F, Alanagreh L Abstract The ongoing COVID-19 pandemic has infected nearly 400,000 individuals with 17000 deaths since it was first identified in human populations in December 2019, in Wuhan, China. No antiviral therapies or vaccines are available for their treatment or prevention. Passive immunization PI through broadly neutralizing antibodies that bind to the specific antigens of SARS-CoV 2 might be a potential solution to address the immediate health threat of COVID-19 pandemic while vaccines are being developed. The PI approach in treating COVID-19 is discussed herein, including a summary of ...
Source: International Journal of Risk and Safety in Medicine - April 22, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

News Item.
Authors: Edwards IR PMID: 32280066 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - April 15, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Risk and safety: What's the point?
Authors: Ralph Edwards I, Lindquist M PMID: 32176658 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 17, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

In Memoriam.
Authors: Ziganshina LE, Ralph Edwards I PMID: 32176659 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 17, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Presentation of benefits and harms of antidepressants on websites: A cross sectional study.
CONCLUSIONS: None of the websites met our predefined criteria. The information was generally inaccurate and unhelpful and has potential to lead to inappropriate use and overuse of antidepressants and reduce the likelihood that people will seek better options for depression like psychotherapy. PMID: 32144998 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Patient safety climate in a Brazilian general hospital.
CONCLUSION: There is a positive safety climate in health organizations from the perspective of the multiprofessional team. However, the domains Safety Climate, Working Conditions and Stress Perception constitute areas that need improvement, aiming to improve patient safety in the institution. PMID: 32144999 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Determinants of sleep habits in toddlers: Application of planned behavior theory.
CONCLUSION: While recommending more comprehensive studies, the findings of the study emphasize the application of the theory of planned behavior in identifying factors influencing sleep habits and designing child sleep improvement interventions. PMID: 32145000 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Alemtuzumab for relapsing multiple sclerosis in clinical practice: A four-year retrospective one-center study.
CONCLUSION: In clinical practice alemtuzumab showed an acceptable safety profile in selected patients even if all of them suffered at least one adverse effect. Thorough and prolonged follow-up is required to further confirm the safety of this drug. PMID: 32145001 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Pharmaceutical cost analysis of dental diseases: An Indian scenario.
Authors: Talreja P, Kalra R Abstract Medicines are an integral part of the health system and the accessibility hugely depends on affordability and availability of medicines. Oral health is an integral component of overall well-being but is ironically often one of the most neglected areas of healthcare. There is paucity of data on the pharmaceutical cost components of dental disease, so this study aims to address this lacuna on the pricing of medicines. This research study can be considered a partial economic evaluation that focuses on an estimation of costs associated with medicines used in treatment of selected or...
Source: International Journal of Risk and Safety in Medicine - March 9, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

PRIME study: Prescription review to impede medication errors.
CONCLUSIONS: The study was not only successful in highlighting the impact of medication error assessment on patient safety, but it also demonstrated that medication errors can be lowered with the help of clinical pharmacy services. Findings from the study conclude that medication errors can be prevented if healthcare professionals are educated appropriately to avoid recurrence of past mistakes. PMID: 32039861 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Introducing medical students to pharmacovigilance through a basic research skills special study module.
Authors: Gossell-Williams M, Paul T Abstract Pharmacovigilance is an important aspect of clinical practice; however, there is limited evidence that it exists as a theme in medical education curricula. We developed and used a Basic Research Skill Special Study Module to introduce pharmacovigilance to medical students in the early years of their programme. Students completing year one or two of the Faculty of Medical Sciences, Bachelor of Medicine, Bachelor of Surgery programme at The University of the West Indies, Jamaica participated in the four week experience from May 16th to June 12th 2019 to complete structured...
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Proficient until proven unproficient? Exploring attitudes and perceptions of medical specialists on proficiency, proficiency requirements and proficiency tests for electrosurgery.
CONCLUSIONS: When assuring proficiency of users of electrosurgery, the positive attitude towards proficiency requirements and the more negative attitude towards proficiency tests should be taken into account. PMID: 32039863 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

The effect of educational intervention on the knowledge and attitude of intensive care nurses in the prevention of pressure ulcers.
CONCLUSIONS: Since educational intervention improved the knowledge and attitude of nurses in preventing pressure ulcers, it is required to conduct appropriate educational interventions to improve their knowledge and attitude. PMID: 32039864 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 12, 2020 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Affordability versus innovation: Is compulsory licensing the solution?
Authors: Pandey E, Paul SB Abstract  In an era which marks an exceptional phase of growth in science and technology, the acute disparities in access to healthcare still persist. So where on one hand scientific advancement in medicine aims at increasing life expectancy, on the other hand there are millions who are denied access to existing medicines. Patents on medicines also pose a significant barrier to access new drugs, especially in low and middle income countries which already suffer from poor health financing mechanisms. The patent laws were built on the assumption of incentivizing the innovators by rewar...
Source: International Journal of Risk and Safety in Medicine - October 29, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Impact of increased focus on pharmacovigilance on knowledge and attitude towards adverse drug reaction reporting among medical students in India.
CONCLUSION: In spite of collaborative and synchronized efforts by various agencies there is a need to further improve the PV milieu in India by confidence building exercises, imparting training on PV programme, updating of the current knowledge on PV and also sustaining motivation. PMID: 31594254 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Global trigger tool in child psychiatry: A treatment safety evaluation in adolescents with an acute psychotic episode.
CONCLUSION: We recommend three triggers, "Abrupt medication stop", "Prescribing of extrapyramidal symptoms corrector", and "Hospital readmission within 30 days", with reasonable positive predictive value for incorporation into routine systems for patient safety monitoring in adolescents with an acute psychotic episode. Antipsychotic-induced extrapyramidal symptoms were more prevalent in older adolescents and patients with fewer lifetime hospital admissions. These patients need to be carefully monitored to ensure patient safety. PMID: 31594255 [PubMed - as supplied by publisher] (Source: In...
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Long-term use of antipsychotics and antidepressants is not evidence-based.
CONCLUSIONS: If we accept the evidence-based premises that antipsychotics and antidepressants do not have clinically relevant effects and that the patients dislike them, the data suggest massive overuse of the drugs, to a remarkably similar degree. We need to focus on helping patients withdraw slowly and safely from the drugs they are on instead of telling them that they need to stay on them. PMID: 31594256 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - October 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Mitigating risk in Norwegian psychiatric care: Identifying triggers of adverse events through Global Trigger Tool for psychiatric care.
CONCLUSIONS: There is a clear relationship between the presence of triggers in a patient record and the likelihood of adverse events. Particularly relevant for psychiatric patients is 'suffering' as a trigger and this may also be relevant to somatic care and has implications for inclusion in the GTT-P. PMID: 31561389 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Drop-out rates in placebo-controlled trials of antidepressant drugs: A systematic review and meta-analysis based on clinical study reports.
CONCLUSIONS: By using CSRs, we were able to demonstrate for the first time that more patients dropped out on active drug than on placebo. As it can be argued that the drop-out rate reflects the patients' overall assessment of the balance between benefits and harms, our review adds to the growing concern that SSRIs and SNRIs might not have the desired effect. Our review also highlights the importance of using CSRs for undertaking reviews of drugs. PMID: 31561390 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Prevalence and types of potentially inappropriate prescriptions among older and  middle-aged community-dwelling Albanian patients.
CONCLUSIONS: Prevalence of PIP is higher in elderly patients and slightly different according to the tool used for detection. However, PIP are also common in the middle-aged population. PMID: 31561391 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Benefits and harms of antipsychotic drugs in  drug-naïve patients with psychosis: A systematic review.
CONCLUSIONS: The use of antipsychotics cannot be justified based on the evidence we currently have. Withdrawal effects in the placebo groups make existing placebo-controlled trials unreliable. PMID: 31561392 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 30, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Editorial.
Authors: Ralph Edwards I, Lindquist M PMID: 31524183 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 18, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Combined SNA and LDA methods to understand adverse medical events.
CONCLUSIONS: Communication and inattentiveness were the most common problems reported in medical adverse events regardless of healthcare professional reporting or harm levels. Findings suggested that an information-sharing and feedback mechanism should be implemented to eliminate preventable medical adverse events. Healthcare institutions managers and government officials should take targeted actions to decrease these preventable medical adverse events through quality improvement efforts. PMID: 31476171 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 4, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Post-SSRI sexual dysfunction: Patient experiences of engagement with healthcare professionals.
CONCLUSIONS: Healthcare professionals are nervous about or reluctant to engage with novel problems on a treatment. This is not widely appreciated and the reasons for this concern are not understood. PMID: 31450514 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 29, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Patent implications in the pharmaceutical industry: Are static high prices leading to dynamic innovations?
Authors: Pandey E, Paul SB Abstract Agreement on Trade Related aspects of Intellectual Property Rights (TRIPS) was laid on the premises of rewarding monopolistic patent rights to the innovator. Stronger patent protection was advocated to promote technology transfer from developed nations to the rest of the world. To boost domestic innovative potential and to maintain trade ties, most developing countries signed the TRIPS agreement. Impact of patent laws in the pharmaceutical industry was crucial as it posed threat to access health. This paper aims to analyze the impact of pharmaceutical product patent laws incorpor...
Source: International Journal of Risk and Safety in Medicine - August 29, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Effect of lithium on suicide and mortality in mood disorders: A systematic review.
CONCLUSION: According to our study, lithium reduces total mortality in mood disorders but not suicide. Because of small numbers and unreliable data, the findings should be interpreted with caution. PMID: 31381531 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 6, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Why health policies should be transnational: A case for East Asia Pacific countries.
We present transnational health policy recommendations for the EAP region based on both our use of robust methodology and the resulting comparative clusters. PMID: 31282430 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - July 10, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Knowledge, attitudes and practice preference regarding drug prescriptions of resident dental doctors: A quantitative study.
CONCLUSION: The results of this study indicate that resident dental doctors' knowledge, attitudes and behavior about the drug prescription need to be improved. More studies are needed to determine whether this issue affects the quality of patient care and the effectiveness and safety of treatments. PMID: 31256074 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - July 2, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Adverse pregnancy outcomes between the anti-malarial drugs: Is there a difference between the drugs recommended by World Health Organization? Results of a mixed treatment comparison analysis of randomized clinical trials and cohort studies.
CONCLUSION: WHO recommended anti-malarials in pregnancy have similar risk profiles with regard to abortion, stillbirth and neonatal deaths. PMID: 30714973 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 5, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.
CONCLUSION: The randomised trials currently available cannot be used to investigate persistent harms of antidepressants. PMID: 30714974 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - February 5, 2019 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

The preoperative risk factors of postoperative self-extubation in elderly patients.
CONCLUSIONS: Elderly patients with a history of dementia and low preoperative hemoglobin are at a risk of postoperative self-extubation, especially after an abdominal operation. These predictors can contribute to the more effective prevention of perioperative self-extubation. PMID: 30175984 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 4, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Reporting of adverse drug reactions in  India: A review of the current scenario, obstacles and possible solutions.
Reporting of adverse drug reactions in India: A review of the current scenario, obstacles and possible solutions. Int J Risk Saf Med. 2018 Aug 31;: Authors: Mulchandani R, Kakkar AK Abstract Pharmacovigilance is a practice aimed to monitor drug safety in real life conditions and capture adverse drug events during the post marketing phase of drug's life cycle. But under reporting of adverse reactions is a major cause of concern and a threat to the pharmacovigilance systems. The present article looks into the major obstacles affecting the spontaneous reporting of adverse drug reactions (ADRs) in Ind...
Source: International Journal of Risk and Safety in Medicine - September 4, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

An intelligent algorithm for assessing patient safety culture and adverse events voluntary reporting using PCA and ANFIS.
CONCLUSIONS: The ANFIS algorithm was proposed for modeling and predicting of PSC for healthcare organizations. The results confirm the capability of the proposed model to predict patient safety grades in healthcare settings. PMID: 30175986 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 4, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Medication reconciliation and review for  older emergency patients requires improvement in Finland.
CONCLUSIONS: Medication reconciliation and review at admission of older ED patients requires improvement in Finland. PMID: 30103352 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - August 15, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Paediatric antidepressants: Benefits and risks.
Authors: Healy D, Le Noury J, Jureidini J Abstract The data supporting the use of "antidepressants" in children and adolescents is largely unavailable. Academic publications give a different picture as regards benefits and harms to publications from regulatory other sources. Despite disagreements about the data driving use of these medicines, in practice "antidepressants" may now be the most commonly used drugs by adolescent girls, and children's mental health services are attracting increasing attention.This paper reviews the difficulties surrounding the data. It outlines a case for benefits (a...
Source: International Journal of Risk and Safety in Medicine - June 6, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Underutilization of the reports of adverse events in an argentine hospital.
CONCLUSION: In the case of this hospital, this valuable tool is being underutilized. The reports should allow identifying the entire chain of events that lead to the incidents to address effective interventions in patient safety that involve all hospital staff, with greater emphasis on senior staff. PMID: 29843255 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 1, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Developing a model for hospital inherent safety assessment: Conceptualization and validation.
CONCLUSIONS: Moderation, simplification, and substitution, among the other dimensions, have more weight on the inherent safety, while minimization has the less weight, which could be due do its definition as to minimize the risk. PMID: 29843256 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 1, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

The monsanto papers: Poisoning the scientific well.
CONCLUSION: The use of third-party academics in the corporate defense of glyhphosate reveals that this practice extends beyond the corruption of medicine and persists in spite of efforts to enforce transparency in industry manipulation. PMID: 29843257 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - June 1, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Simulated medication errors: A means of evaluating healthcare professionals' knowledge and understanding of medication safety.
CONCLUSION: Simulated case studies had potential use to seek front-line healthcare professionals' understanding of the clinical significance and contributing factors to MEs, along with preventive measures. PMID: 29758950 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 19, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

SSRI and SNRI withdrawal symptoms reported on an internet forum.
CONCLUSIONS: People accessing antidepressant withdrawal websites report experiencing protracted withdrawal symptoms. There are some differences in the characteristics of withdrawal associated with different classes of antidepressants. PMID: 29758951 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 19, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Knowledge and attitudes of patients in primary care on off-label treatment.
CONCLUSION: Patients in primary care possess limited knowledge about off-label treatment. Most patients do not wish to be exposed to such treatment, and are particularly reluctant to have their children exposed to it. In case of serious side effects, half of the patients would sue doctors who had prescribed the off-label therapy. PMID: 29758952 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 19, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Enduring sexual dysfunction after treatment with antidepressants, 5 α-reductase inhibitors and isotretinoin: 300 cases.
CONCLUSIONSThese data point to a legacy syndrome or syndromes comprising a range of disturbances to sexual function. More detailed studies will require developments in coding systems that recognise the condition(s). Further exploration of these tardive sexual syndromes may yield greater understanding of tardive syndromes in general. PMID: 29733030 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 9, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Citizen petition: Sexual side effects of SSRIs and SNRIs.
Authors: Healy D PMID: 29733031 [PubMed - as supplied by publisher] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 9, 2018 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Continuing medical education and pharmaceutical industry involvement: An evaluation of policies adopted by Canadian professional medical associations.
CONCLUSION: These results suggest that Canadian PMAs' publicly available policies on industry involvement in CME are generally weak or non-existent; therefore, the accredited CME that is provided to Canadian physicians may be viewed as open to bias. We encourage all Canadian medical associations to strengthen their policies to avoid the potential for industry influence in CME. PMID: 28885217 [PubMed - in process] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 10, 2017 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Off-label use of medicines: The need for good practice guidelines.
CONCLUSIONS: Europe is seeing a growing trend the promotion of off-label prescription of medicinal products for reasons other than pure medical need, including motives such as cost-containment. This poses a numer of questions for the ethical and legal framework for medicine prescription and dispensing in Europe. PMID: 28885218 [PubMed - in process] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 10, 2017 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Recognition of possible risk factors for clinically significant drug-drug interactions among Indian people living with HIV receiving highly active antiretroviral therapy and concomitant medications.
Authors: Priyanka PSSL, Varma DM, Immadisetti K, Rajesh R, Vidyasagar S, Guddattu V Abstract BACKGROUND: Greatest challenges for clinician is to recognize risk factors for clinically significant drug interactions (CSDIs). There is a lack of awareness about CSDIs among healthcare professionals in India. OBJECTIVE: To recognize all possible risk factors for drug-drug interactions (DDIs) and to identify clinically significant drug interactions (CSDIs), the prevalence, pattern of occurrence of DDIs in People Living with HIV (PLW-HIV) receiving highly active antiretroviral therapy (HAART) and concomitant medications...
Source: International Journal of Risk and Safety in Medicine - September 10, 2017 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research