Serum interleukin-10 and alpha-fetoprotein: A combined diagnostic approach for hepatocellular carcinoma in Egyptians with HCV
CONCLUSION: the reliability of AFP as a major HCC marker was poor. However, IL-10 levels are a novel biomarker for the degree of HCC inflammation, considering IL-10's potential role in HCV-HCC development. We suggest combining AFP with IL-10 to improve the diagnostic and prognostic value of HCC considerably. Future research on these biomarkers should prioritize their clinical validity, prognostic usefulness, and compatibility with other therapeutic approaches as immunotherapy.PMID:38692084 | DOI:10.1016/j.prp.2024.155327 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - May 1, 2024 Category: Pathology Authors: Mostafa A Sharafeldin Reda A Suef Adel A Mousa Dina H Ziadah Mohamed M S Farag Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Elevated cardiovascular risk and acute events in hospitalized colon cancer survivors: A decade-apart study of two nationwide cohorts
CONCLUSION: Colon cancer survivors hospitalized 10 years apart in the United States showed an increased CVD risk with an increased risk of acute cardiovascular events (stroke 28%, PE 47%, arrhythmia 41%, and cardiac arrest 63%). It is vital to regularly screen colon cancer survivors with concomitant CVD risk factors to curtail long-term cardiovascular complications.PMID:38689632 | PMC:PMC11056864 | DOI:10.5306/wjco.v15.i4.548 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Rupak Desai Avilash Mondal Vivek Patel Sandeep Singh Shaylika Chauhan Akhil Jain Source Type: research
Britanin - a beacon of hope against gastrointestinal tumors?
World J Clin Oncol. 2024 Apr 24;15(4):523-530. doi: 10.5306/wjco.v15.i4.523.ABSTRACTBritanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties. It also exhibits significant anti-tumor activity, suppressing tumor growth in vitro and in vivo. The current body of research on Britanin includes thirty papers predominantly related to neoplasms, the majority of which are gastrointestinal tumors that have not been summarized before. To drive academic debate, the present paper reviews the available research on Britanin in gastrointestinal tumors. It also outlines novel research ...
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Agnieszka Kajdanek Damian Ko łat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat Source Type: research
Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy
Transl Oncol. 2024 Apr 30;45:101975. doi: 10.1016/j.tranon.2024.101975. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been wid...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Seyedeh Setareh Samaei Mahshid Daryab Sarah Gholami Aryan Rezaee Navid Fatehi Romina Roshannia Saeed Hashemi Nazanin Javani Parham Rahmanian Reza Amani-Beni Mohammad Arad Zandieh Noushin Nabavi Mohsen Rashidi Neda Malgard Mehrdad Hashemi Afshin Taheriazam Source Type: research
MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer
This study explores the mechanistic role of fatty liver in CRC progression, focusing on macrophage polarization and lipid metabolism. A murine fatty liver model was created with a high-fat diet (HFD), and CRC was induced using AOM and DSS. Single-cell transcriptome sequencing (scRNA-seq) identified MAPKAP1 as a critical gene promoting CRC via M2 macrophage polarization and lipid metabolism reprogramming. Prognosis analysis on the TCGA-CRC dataset confirmed MAPKAP1's significance. In vitro and in vivo experiments demonstrated that EVs from fatty liver cells enhanced MAPKAP1 expression, accelerating CRC development and metas...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Bo Huang Zhenqiu Yu Dejun Cui Fawang Du Source Type: research
Analysis of tissue tropism of GCRV-II infection in grass carp using a VP35 monoclonal antibody
In this study, monoclonal antibodies against recombinant VP35 protein were generated in mice and characterized. The antibodies exhibited specific binding to the N terminal region (1-155 aa) of the recombinant VP35 protein expressed in the HEK293 cells, and native VP35 protein in the GCRV-II infected CIK cells. Immunofluorescent staining revealed that viruses aggregated in the cytoplasm of infected cells. In vivo challenge experiments showed that high levels of GCRV-II viruses were present in the gills, intestine, spleen and liver, indicating that they are the major sites for virus infection. Our study showed that the VP35 ...
Source: Developmental and Comparative Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Yanan Lu Weihua Zhao Ning Ji Dan Xu Yaoguo Li Tiaoyi Xiao Junya Wang Jun Zou Source Type: research
Subdiaphragmatic phrenic nerve supply: a systematic review
CONCLUSIONS: This review provides the first systematic evidence of subdiaphragmatic phrenic nerve supply and connections. This is of interest to professionals who care for people suffering from neck and shoulder pain, as well as patients with peridiaphragmatic disorders or hiccups. However, there are controversies about the autonomic or sensory nature of this supply.PMID:38692333 | DOI:10.1016/j.aanat.2024.152269 (Source: Annals of Anatomy)
Source: Annals of Anatomy - May 1, 2024 Category: Anatomy Authors: Mar ía Pérez-Montalbán Encarna Garc ía-Domínguez Ángel Oliva-Pascual-Vaca Source Type: research
Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides)
This study offers theoretical support for applying teprenone in aquaculture to reduce financial losses caused by abiotic factors.PMID:38692348 | DOI:10.1016/j.cbpb.2024.110984 (Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology.)
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - May 1, 2024 Category: Biochemistry Authors: Hongyun Li Feifei Chen Mu Qin Chenlei Liao Yaqi Shi Sihan Wu Keming Rong Xuezhen Zhang Source Type: research
Trimethylamine N-oxide ameliorates hepatic damage including reduction of hepatic bile acids and cholesterol in < em > Fxr < /em > -null mice
This study aims to determine the effect of TMAO on NAFLD. A diet containing 0.3% TMAO was fed to farnesoid X receptor (Fxr)-null mice, a model of NAFLD, for 13 weeks. Fxr-null mice fed TMAO showed significant reductions in liver damage markers but not wild-type mice. Hepatic bile acid and cholesterol levels were significantly decreased, and triacylglycerol levels tended to decrease in TMAO-fed Fxr-null mice. Changes in mRNA levels of hepatic bile acid and cholesterol transporters and synthetic enzymes were observed, which could explain the decreased hepatic bile acid and cholesterol levels in Fxr-null mice given the TMAO d...
Source: International Journal of Food Sciences and Nutrition - May 1, 2024 Category: Nutrition Authors: Masaaki Miyata Kento Takeda Sayuri Nagira Yoshimasa Sugiura Source Type: research
Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF- κB and MAPK pathways in an Nrf2-dependent manner
Chem Biol Interact. 2024 Apr 29:111030. doi: 10.1016/j.cbi.2024.111030. Online ahead of print.ABSTRACTSepsis remains a serious public health issue that needs to be addressed globally. Severe liver injury caused by sepsis increases the risk of death in patients with sepsis. Liensinine (Lie) is one of the primary active components in Plumula nelumbinis and has anti-inflammatory and antioxidant effects. Nevertheless, the effects of Lie on septic liver injury are unclear. This research investigated the protective effect of Lie (10, 20 and 40 mg/kg) on liver damage via intraperitoneal administration of LPS (10 mg/kg) to C57BL/6...
Source: Chemico-Biological Interactions - May 1, 2024 Category: Molecular Biology Authors: Xiao Zhang Silong Yuan Hui Fan Wei Zhang Honggang Zhang Source Type: research
Comparative transcriptomics combined with physiological and functional analysis reveals the regulatory mechanism of rainbow trout (Oncorhynchus mykiss) under acute hypoxia stress
This study highlights the differences in the regulatory mechanism of rainbow trout under different concentrations of hypoxia stress and provides valuable data for further research on the molecular mechanisms of fish adaptation to hypoxic environments.PMID:38691881 | DOI:10.1016/j.ecoenv.2024.116347 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - May 1, 2024 Category: Environmental Health Authors: Shenji Wu Jinqiang Huang Yongjuan Li Lu Zhao Source Type: research
Update on the development of TGR5 agonists for human diseases
Eur J Med Chem. 2024 Apr 28;271:116462. doi: 10.1016/j.ejmech.2024.116462. Online ahead of print.ABSTRACTThe G protein-coupled bile acid receptor 1 (GPBAR1) or TGR5 is widely distributed across organs, including the small intestine, stomach, liver, spleen, and gallbladder. Many studies have established strong correlations between TGR5 and glucose homeostasis, energy metabolism, immune-inflammatory responses, and gastrointestinal functions. These results indicate that TGR5 has a significant impact on the progression of tumor development and metabolic disorders such as diabetes mellitus and obesity. Targeting TGR5 represents...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Wangrui Jin Mingyue Zheng Yihua Chen Hai Xiong Source Type: research
