Lipid Nanoparticles as a Platform for miRNA and siRNA Delivery in Hepatocellular Carcinoma
Curr Drug Deliv. 2024 May 2. doi: 10.2174/0115672018292331240404070236. Online ahead of print.ABSTRACTLiver cancer is the sixth most common cancer and the fourth leading cause of death worldwide. Hepatocellular carcinoma (HCC) comprises 75-80% of liver cancer cases. Therapeutic strategies for HCC are available and have been shown to prolong survival but not treat HCC. Gene expression and regulation are responsible for the pathogenesis and progression of HCC. Altering these genetic networks can impact cellular behaviors and in turn cure HCC. Single-stranded and double-stranded non-coding ribonucleic acid known as microRNA a...
Source: Current Drug Delivery - May 3, 2024 Category: Drugs & Pharmacology Authors: Gaidaa Dogheim Sampath Chinnam Mohamed T Amralla Source Type: research
DDX39B protects against sorafenib-induced ferroptosis by facilitating the splicing and cytoplasmic export of GPX4 pre-mRNA in hepatocellular carcinoma
Biochem Pharmacol. 2024 May 1:116251. doi: 10.1016/j.bcp.2024.116251. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the main histological subtype of primary liver cancer and remains one of the most common solid malignancies globally. Ferroptosis was recently defined as an iron-catalyzed form of regulated necrosis. Because cancer cells exhibit higher iron requirements than noncancer cells, treatment with ferroptosis-inducing compounds may be a feasible strategy for cancer therapy. However, cancer cells develop acquired resistance to evade ferroptosis, and the mechanisms responsible for ferroptosis resistan...
Source: Biochemical Pharmacology - May 3, 2024 Category: Drugs & Pharmacology Authors: Qin Li Hang Yuan Gang Zhao Deqiong Ou Jie Zhang Liang Li Siqi Li Tianyu Feng Rui Gu Qiming Kou Qijing Wang Shan Li Guanru Wang Minghui Zhao Huayang Yu Jie Qu Ping Lin Kai Li Source Type: research
Comparison of Hospital Volume and Risk-Standardized Mortality Rate as a Proxy for Hospital Quality in Complex Oncologic Hepatopancreatobiliary Surgery
CONCLUSIONS: HVC and HPC have the lowest overall and risk-standardized 90-day mortality after oncologic hepatopancreatobiliary procedures, but RSMR may outperform volume as a measure of hospital quality.PMID:38700800 | DOI:10.1245/s10434-024-15361-2 (Source: Ann Oncol)
Source: Ann Oncol - May 3, 2024 Category: Cancer & Oncology Authors: William T Julian Mohamedraed Elshami John B Ammori Jeffrey M Hardacre Lee M Ocuin Source Type: research
Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study
CONCLUSION: Compared with DPV after HCC, DPV treatment before HCC can reduce the recurrence rate of HCC after early transplantation (TNM I-II). DPV before LT can reduce the recurrence of early HCC.PMID:38702621 | DOI:10.1186/s12885-024-12322-6 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Guo Wei Yong Zhao Shifeng Feng Jingsheng Yuan Gang Xu Tao Lv Jian Yang Lingxiang Kong Jiayin Yang Source Type: research
Evaluation of some proinflammatory cytokines and biochemical parameters in pre and postmenopausal breast cancer women
Cytokine. 2024 May 2;179:156632. doi: 10.1016/j.cyto.2024.156632. Online ahead of print.ABSTRACTThe study was planned to evaluate the differences in certain proinflammatory cytokines(IL-6, TNF-α) with CRP and biochemical parameters (E2, D3, LDH, GGT, TSB, Ca, Ph, uric acid), between women with pre- and postmenopausal breast cancer and seemingly healthy women in Iraqi women as controls; at medical city in teaching Oncology hospital,70 breast cancer patients women their ages ranged (47.51 ± 1.18) and 20 healthy women with age (44.45 ± 2.66) begun from September (2020) to February (2021). The aims of this study to investig...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Maryam Mohammed Bakheet Hiba Mohssin Ali Tabarak Jalil Talab Source Type: research
Metabolic dysfunction-associated steatotic liver disease and atherosclerosis
Curr Diab Rep. 2024 May 3. doi: 10.1007/s11892-024-01542-6. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To update information about the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis. This review emphasizes the potential mechanisms linking MASLD with atherosclerosis and the possible causal relationships between these conditions.RECENT FINDINGS: An increased risk of cardiovascular disease is related to MASLD. Several molecular, cellular, and metabolic mechanisms have been described to explain the development of atherothrombosis in MASLD patients. These include ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Yulino Castillo-N úñez Paloma Almeda-Valdes Guillermo Gonz ález-Gálvez Mar ía Del Rosario Arechavaleta-Granell Source Type: research
Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth
ACS Appl Mater Interfaces. 2024 May 3. doi: 10.1021/acsami.4c00999. Online ahead of print.ABSTRACTAtherosclerosis is the main risk factor for cardiovascular disease, which accounts for the majority of mortality worldwide. A significantly increased plasma level of low-density lipoprotein cholesterol (LDL-C), surrounded by a monolayer of phospholipids, free cholesterol, and one apolipoprotein B-100 (ApoB-100) in the blood, plays the most significant role in driving the development of atherosclerosis. Commercially available cholesterol-lowering drugs are not sufficient for preventing recurrent cardiovascular events. Developin...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Zhenzhou Li Yi Zhou Manlin Lai Jingna Luo Fei Yan Source Type: research
Palm oil as part of a high-fat diet: advances and challenges, or possible risks of pathology?
Nutr Rev. 2024 May 2:nuae038. doi: 10.1093/nutrit/nuae038. Online ahead of print.ABSTRACTNutritional status disorders have the most significant impact on the development of cardiovascular and oncologic diseases; therefore, the interest in the study of palm oil as among the leading components of nutrition has been increasing. The data examined in this review were sourced from the Scopus, SCIE (Web of Science), PubMed and PubMed Central, MEDLINE, CAPlus/SciFinder, and Embase databases; experts in the field; bibliographies; and abstracts from review analyses from the past 15 years. This review summarizes recent research data ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Natalia Kurhaluk Source Type: research
Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
Impact of sarcopenia on variceal rebleeding in patients after endoscopic therapy: a multicenter retrospective cohort study based on propensity score matching
CONCLUSION: Sarcopenia was significantly associated with a high 2-year rebleeding rate in liver cirrhosis patients after endoscopic treatment. Therefore, the precise evaluation of a patient's nutritional status, including sarcopenia becomes mandatory before endoscopic treatment.PMID:38699840 | DOI:10.1080/07853890.2024.2349180 (Source: Annals of Medicine)
Source: Annals of Medicine - May 3, 2024 Category: Internal Medicine Authors: Yongshuai Liu Huijun Chang Yunqing Zeng Yuanyuan Liu Jinhou Li Yong Chen Yanjing Gao Source Type: research
Peritoneal dialysis in an end-stage renal disease patient with massive ascites and primary liver cancer
We present a case of a 68-year-old male patient with ESRD who experienced various decompensated complications of liver cirrhosis, particularly massive ascites and hepatic space-occupying lesions. Peritoneal dialysis (PD) catheter insertion and continuous ambulatory peritoneal dialysis (CAPD) treatment were successfully performed. During meticulous follow-up, the patient survived for one year but ultimately succumbed to complications related to liver cancer. PD can serve as an efficacious therapeutic approach for such late-stage patients afflicted together with severe cirrhosis, massive ascites and primary liver cancer.PMID...
Source: Renal Failure - May 3, 2024 Category: Urology & Nephrology Authors: Lulu Sun Chunmei Liang Yuqin Wang Hui Li Lijun Yao Huajun Jiang Source Type: research
Effect of Nonpharmacological Methods on Pruritus in Patients with Liver Disease and Liver Cirrhosis: Systematic Review
CONCLUSIONS: Based on the findings, nonpharmacological methods have a positive effect on itching in individuals with liver disease and liver cirrhosis. It is recommended to conduct more studies with higher methodological quality, using larger sample groups, different interventions, randomization, and blinding methods, to examine the effectiveness of nonpharmacological methods in patients with liver disease and liver cirrhosis.PMID:38702165 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Yasemin Çayir Meral G ün Emine Kaplan Serin Source Type: research
Comparison of Whole Blood and Plasma for Monitoring Cytomegalovirus and Epstein-Barr Virus
New Microbiol. 2024 May;47(1):52-59.ABSTRACTMonitoring Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection after transplantation is recommended to enable preemptive therapy. However, the most suitable sample type remains unclear. Patients who underwent hematopoietic stem cell or liver transplantation were included in this study. Viral loads in sequential whole-blood and plasma samples were retrospectively analyzed. EBV DNA was detected more frequently in whole blood (55%) than in plasma (18%). The detection rate of CMV DNA was similar between the two sample types. The correlation of viral loads between the two sam...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Yuto Fukuda Yuka Torii Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Takako Suzuki Atsushi Narita Hideki Muramatsu Yasuhiro Ogura Yoshiyuki Takahashi Yoshinori Ito Jun-Ichi Kawada Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - May 3, 2024 Category: Stem Cells Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD
CONCLUSIONS: The grade of obesity affects the detection of MASLD-related AF. A sequential use of LSM/A3+ could improve AF detection in patients with BMI ≥ 35.PMID:38699960 | DOI:10.1002/oby.24033 (Source: Obesity)
Source: Obesity - May 3, 2024 Category: Eating Disorders & Weight Management Authors: Yasmina Chouik Adrien Aubin Marianne Maynard-Muet B érénice Segrestin Laurent Milot Val érie Hervieu Fabien Zoulim Emmanuel Disse Massimo Levrero Cyrielle Caussy Source Type: research
