GSE266077 Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from MCD and regular chow diet mice
Contributors : Chuanfei Zeng ; Huan Li ; Mingliang Wei ; Linxin Yu ; Ziqi Mu ; Ziyin Huang ; Yujia Ke ; Min Wu ; Ming-Kai Chen ; Lian-Yun Li ; Yong XiaoSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusChromatin immunoprecipitation DNA-sequencing (ChIP-seq) for the histone modifications H3K27ac and H3K9me3 in liver tissues from Methionine- and choline-deficient diet (MCD) and regular chow diet mice. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
GSE231487 RNA-seq of liver of DICER1 syndrome model mouse
Contributors : Shin-ichiro Ohno ; Masahiko KurodaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIn order to identify mRNAs involved in tumor development of DICER1 syndrome model mouse, next-generation sequencing analysis of RNA extracted from liver tissue was performed. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation
Liver transplantation is an effective treatment for liver failure. There is a large unmet demand, even as not all donated livers are transplanted. The clinical selection criteria for donor livers based on hist... (Source: BMC Genomics)
Source: BMC Genomics - May 2, 2024 Category: Genetics & Stem Cells Authors: Ankita Srivastava, Alexandra Manchel, John Waters, Manju Ambelil, Benjamin K. Barnhart, Jan B. Hoek, Ashesh P. Shah and Rajanikanth Vadigepalli Tags: Research Source Type: research
Reply to the Letter to the Editor on “Prolactin is a Key Factor for
Nonalcoholic Fatty Liver Disease in Obese Children”
Horm Metab Res DOI: 10.1055/a-2301-3272Dear Editor,The authors thank the writers 1 of the
letter for reviewing and assessing our article 2, “Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children”. Overall, we agree that possible selection bias must be considered.
However, in clinical studies, we found that hyperprolactinemia is mainly caused by
pathological and idiopathic hyperprolactinemia. The former includes hypothalamic
pituitary lesions (pituitary prolactinoma and empty sella syndrome, etc.), systemic
diseases (hypothyroidism, e...
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Zhang, Jianwei Tags: Letter to the Editor Source Type: research
Re: Prolactin is a Key Factor for Nonalcoholic Fatty Liver Disease in
Obese Children
Horm Metab Res DOI: 10.1055/a-2301-3225 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Hormone and Metabolic Research)
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Triebel, Jakob Bertsch, Thomas Tags: Letter to the Editor Source Type: research
Control Compounds for Preclinical Drug-Induced Liver Injury Assessment: Consensus-driven systematic review by the ProEuroDILI Network
Idiosyncratic drug-induced liver injury (DILI) is a complex and unpredictable event caused by drugs, herbal or dietary supplements. Early identification of human hepatotoxicity at preclinical stages remains a major challenge, in which the selection of validated in vitro systems and test drugs has a significant impact. This systematic review analyzed the compounds used in hepatotoxicity assays and established a list of DILI positive and negative control drugs for validation of in vitro models of DILI, supported by literature and clinical evidence and endorsed by an expert committee from COST Action ProEuroDILI Network (CA17...
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Antonio Segovia-Zafra, Marina Villanueva-Paz, Ana Sofia Serras, Gonzalo Matilla-Cabello, Ana Bodoque-Garc ía, Daniel Di Zeo-Sánchez, Hao Niu, Ismael Álvarez-Álvarez, Laura Sanz-Villanueva, Sergej Godec, Irina Milisav, Pierre Bagnaninchi, Raúl J. Andr Source Type: research
Hepatic phenotypes of EFL1-related Shwachman-Diamond syndrome in a biopsy-validated study
Shwachman Diamond Syndrome (SDS), an inherited bone marrow failure syndrome, is characterized by exocrine pancreatic deficiency, predisposition to myeloid malignancies, and skeletal dysplasia. Other symptoms also include hepatic and renal involvement. Hepatomegaly and aminotransaminase elevation can be observed at an early age in SDS patients, typically with an overall good prognosis. A follow-up with mild cholestasis may reflect primary alterations in liver metabolism in SDS. During the long follow-up, no major liver abnormalities appeared [1]. (Source: Journal of Hepatology)
Source: Journal of Hepatology - May 2, 2024 Category: Gastroenterology Authors: Bing Zhu, Yibing Guo, Sa Lv, Xiuxin Ling, Shaoli You Source Type: research
Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In a recent study published in Molecular Cell, Zhou and colleagues provide evidence to suggest that the energy-sensing gamma ( γ) subunit of AMPK regulates translation via phosphatase PPP6C independently of the catalytic AMPK alpha (α) subunit.1 The authors used HEK239T cells to demonstrate that energy stress by glucose deprivation sequesters PPP6C to AMPKβγ dimer complexes, which alleviates dephosphorylation of eukaryo tic translation elongation factor 2 (eEF2) Thr56 and arrests protein translation elongation to conserve energy. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Rasmus Kj øbsted, Jesper Bratz Birk, Nicolas Oldenburg Eskesen, Jørgen Frank Pind Wojtaszewski Tags: Letter Source Type: research
Response to: Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In our paper “Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha,”1 we demonstrated that knockout (KO) of AMPKγ, but not AMPKα, suppressed phosphorylation of eukaryotic translation elongation factor 2 (eEF2) induced by energy starvation. We further identified PPP 6C as a phosphatase of eEF2, and AMP-bound AMPKγ sequesters PPP6C, thereby blocking dephosphorylation of eEF2. These findings implicate diverse mechanisms of energy sensor AMPKγ in regulating cellular energy response. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Qi Zhou, Xiaolei Cao, Bin Zhao Tags: Letter Source Type: research
Multicenter PET image harmonization using generative adversarial networks
ConclusionsGANs are capable of performing image harmonization and increase reproducibility and predictive performance of radiomic features derived from different centers and scanners. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - May 2, 2024 Category: Nuclear Medicine Source Type: research
External validation of population pharmacokinetic models of tacrolimus in Thai adult liver transplant recipients
ConclusionBayesian forecasting is more accurate and precise than other testing methods for predicting drug concentrations. However, none of the evaluated models provides satisfactory predictive performance for generalization to Thai liver transplant patients. This underscores the need for future research to develop population PK models tailored to the Thai population. Such efforts should consider the inclusion of nonlinear pharmacokinetics and region-specific factors, including genetic variability, to improve model accuracy and applicability. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Source Type: research
Incidence, risk factors, and outcomes of acute liver injury in hospitalized adults with acute kidney injury: a large multicenter study
ConclusionsALI was not uncommon among patients with AKI, especially in patients who used vasopressors and had shock. This study highlights the association between AKI –ALI and a significantly increased risk of mortality. It suggests that dynamic monitoring of liver function is essential, particularly in patients with AST and GGT exceeding the normal upper limit, to improve the in-hospital prognosis of AKI patients. (Source: Hepatology International)
Source: Hepatology International - May 2, 2024 Category: Infectious Diseases Source Type: research
Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes
ConclusionRobotic ALPPS was safely implemented and showed potential for improved perioperative outcomes compared to open ALPPS in an experienced robotic center. The robotic approach might bring the perioperative risk profile of ALPPS closer to interventional techniques of portal vein embolization/liver venous deprivation. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - May 2, 2024 Category: Surgery Source Type: research
Augmented reality improving intraoperative navigation in minimally invasive liver surgery: an interplay between 3D reconstruction and indocyanine green
AbstractTechnology have helped surgeons to increase MILS feasibility, so that currently liver surgery evolution is strongly based on technological advances and the same trend is expected even further soon. Aim of the present technical report is to provide insights regarding the possible interplay between 3D reconstructions based on augmented reality and intraoperative navigation by indocyanine green fluorescence. Augmented reality methods based on reconstructions created through artificial intelligence interact synergistically. The better the understanding of the anatomy and characteristics of the lesion, the more accurate...
Source: Updates in Surgery - May 2, 2024 Category: Surgery Source Type: research
Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant < i > Staphylococcus aureus < /i > USA300
by Aravindh Nagarajan, Kristin Scoggin, Jyotsana Gupta, Manuchehr Aminian, L. Garry Adams, Michael Kirby, David Threadgill, Helene Andrews-PolymenisStaphylococcus aureus (S.aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistantS.aureus (MRSA) and monitored disease progression for seven days using a surgically implanted telemetry system. CC strains varied widely in thei...
Source: PLoS Genetics - May 2, 2024 Category: Genetics & Stem Cells Authors: Aravindh Nagarajan Source Type: research
