BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Buprenorphine Affects the Initiation and Severity of Interleukin Induced Acute Pancreatitis in Mice
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00083.2024. Online ahead of print.ABSTRACTAcute pancreatitis (AP) is a common disease with no targeted therapy and has varied outcomes ranging from spontaneous resolution to being lethal. While typically painful, AP can also be painless. Various agents, including opioids are used for pain control in AP; the risks, and benefits of which are often debated. Since experimental AP in mice is used to study the efficacy of potential therapies, we studied the effect of a commonly used opioid buprenorphine on the initiation and progression of AP. For this we a...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Sarah Jahangir Biswajit Khatua Nabil Smichi Prasad Rajalingamgari Anoop Narayana Pillai Megan J Summers Bryce McFayden Sergiy Kostenko Naomi M Gades Vijay P Singh Source Type: research
Characterizing the Nonlinear Pharmacokinetics and Pharmacodynamics of BI 187004, an 11 β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Humans by a Target-Mediated Drug Disposition Model
This study aimed to construct a TMDD model to explain the complex nonlinear PK behavior and underscore the importance of recognizing TMDD in this small-molecule compound. Among the various models explored, the best model was a two-compartment TMDD model with three transit absorption components. The final model provides insights into 11β-HSD1 binding-related parameters for BI 187004, including the total amount of 11β-HSD1 in the liver (estimated to be 8000 nmol), the second order association rate constant (estimated to be 0.102 nM-1h-1), and the first-order dissociation rate constant (estimated to be 0.11 h-1). Our final ...
Source: The Journal of Clinical Pharmacology - April 23, 2024 Category: Drugs & Pharmacology Authors: Xuanzhen Yuan Guohua An Source Type: research
Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis
CONCLUSION: These findings highlight that the novel inflammatory biomarker, NAR, is a convenient and easily accessible non-invasive predictor for NAFLD and NAFLD with liver fibrosis.PMID:38650638 | PMC:PMC11033504 | DOI:10.3389/fnut.2024.1368459 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Banghe Bao Shuang Xu Peng Sun Liduan Zheng Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Effect of < em > P. corylifolia < /em > on the pharmacokinetic profile of tofacitinib and the underlying mechanism
Front Pharmacol. 2024 Apr 8;15:1351882. doi: 10.3389/fphar.2024.1351882. eCollection 2024.ABSTRACTThis work aimed to explore the mechanisms underlying the interaction of the active furanocoumarins in P. corylifolia on tofacitinib both in vivo and in vitro. The concentration of tofacitinib and its metabolite M8 was determined using UPLC-MS/MS. The peak area ratio of M8 to tofacitinib was calculated to compare the inhibitory ability of furanocoumarin contained in the traditional Chinese medicine P. corylifolia in rat liver microsomes (RLMs), human liver microsomes (HLMs) and recombinant human CYP3A4 (rCYP3A4). We found that ...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Yu Wang Quan Zhou Huihui Wang Wei Song Jianfeng Wang Abdullah Al Mamun Peiwu Geng Yunfang Zhou Shuanghu Wang Source Type: research
Case Report of a Hidden Intruder-Extremely Rare Presentation of Hydatidosis as a Nuchal Tumoural Mass
We report the case of a 68-year-old male patient, a zootechnic, who presented at the hospital with a tumoural mass (dimension: about 12/10 cm) located in the nuchal region. The complex approach needed consisted of surgical therapy along with histopathological confirmation of the diagnostic and antiparasitic medication, which led to a complete recovery with a low probability of recurrence. Discussion: Encounters with patients with primary soft tissue hydatidosis are exceptionally rare, but the surgeon must take into consideration this clinical diagnosis, especially for patients located in an endemic region with occupations ...
Source: British Journal of Biomedical Science - April 23, 2024 Category: Laboratory Medicine Authors: Drago ș F Voicu Constantin Popazu Delia Mihaela R âșnoveanu Daniela Mihalache Alexandra Toma Source Type: research
Continuous Shear Wave Elastography for Liver Using Frame-to-Frame Equalization of Complex Amplitude
This study addresses a crucial necessity in the field of noninvasive liver fibrosis diagnosis by introducing the concept of continuous shear wave elastography (C-SWE), utilizing an external vibration source and color Doppler imaging. However, an application of C-SWE to assess liver elasticity, a deep region within the human body, arises an issue of signal instability in the obtained data. To tackle this challenge, this work proposes a method involving the acquisition of multiple frames of datasets, which are subsequently compressed. Furthermore, the proposed frame-to-frame equalization method compensates discrepancies in t...
Source: Ultrasonic Imaging - April 23, 2024 Category: Radiology Authors: Naoki Tano Ren Koda Shunichiro Tanigawa Naohisa Kamiyama Yoshiki Yamakoshi Marie Tabaru Source Type: research
Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
This article reviews the recent research progress of GLP-1 in lipid metabolism.PMID:38650100 | DOI:10.4093/dmj.2023.0277 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Tong Bu Ziyan Sun Yi Pan Xia Deng Guoyue Yuan Source Type: research
Retrospective Dosimetry for Yttrium-90 Radioembolization with Resin Microspheres
The series of 3 articles entitled, “Predictive Dosimetry and Outcomes of Hepatocellular Carcinoma Following Liver Y90 Resin Microsphere Radioembolization Using 99mTc-MAA SPECT/CT and Planning Software: A Retrospective Analysis,” (1) “Partition Dosimetry and Outcomes of Metastatic Neuroendocrine Tumors Following Yttrium-90 Resin Microsphere Radioembolization,” (2) and “Predictive Partition Dosimetry and Outcomes after Yttrium-90 Resin Microsphere Radioembolization of Colorectal Cancer Metastatic to the Liver: A Retrospective Analysis,” (3) published in this and a previous issue of JVIR reports retrospective dosi...
Source: Journal of Vascular and Interventional Radiology : JVIR - April 23, 2024 Category: Radiology Authors: S. Cheenu Kappadath Tags: Commentary Source Type: research
Advancements in medical research using fetal sheep: Implications for human health and treatment methods
This study emphasizes the significant contributions of fetal sheep to advancing human disease understanding and treatment strategies, highlighting their unique characteristics that are not present in other animals. (Source: Animal Science Journal)
Source: Animal Science Journal - April 23, 2024 Category: Zoology Authors: Tomoyuki Abe,
Borjigin Sarentonglaga,
Yoshikazu Nagao Tags: REVIEW ARTICLE Source Type: research
Effects of bile acid metabolism on intestinal health of livestock and poultry
AbstractBile acids are synthesised in the liver and are essential amphiphilic steroids for maintaining the balance of cholesterol and energy metabolism in livestock and poultry. They can be used as novel feed additives to promote fat utilisation in the diet and the absorption of fat-soluble substances in the feed to improve livestock performance and enhance carcass quality. With the development of understanding of intestinal health, the balance of bile acid metabolism is closely related to the composition and growth of livestock intestinal microbiota, inflammatory response, and metabolic diseases. This paper systematically...
Source: Journal of Animal Physiology and Animal Nutrition - April 23, 2024 Category: Zoology Authors: Hongpeng Jia,
Na Dong Tags: REVIEW Source Type: research
GSE173566 AOS10-FMT could rescure the adverse effects induced by high fat diet on the kidney
We report the side-effects of High fat diet on the liver, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as lipid metabolism and oxidative stress (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE195829 miRNA seq mouse liver HFD, PCB126, Aroclor1260 exposure
Contributors : Belinda J Petri ; Kellianne M Piell ; Bandrida Wahlang ; Kimberly Z Head ; Kalina Andreeva ; Eric C Rouchka ; Jianmin Pan ; Shesh N Rai ; Matthew C Cave ; Carolyn M KlingeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusExposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated biphenyls (PCBs) is associated with liver injury in human populations and with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. Exposure of HFD-fed male mice to the non-dioxin-like (NDL) PCB mixture Aroclor1260 or to dio...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Socioeconomic Burden of Pyogenic Liver Abscess Caused by Klebsiella Pneumoniae from a Teaching Hospital in East China
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - April 23, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
