Inflammatory bowel disease alters in vivo distribution of orally administrated nanoparticles: Revealing via SERS tag labeling technique
Talanta. 2024 Apr 27;275:126172. doi: 10.1016/j.talanta.2024.126172. Online ahead of print.ABSTRACTNanoparticles (NPs) could be uptake orally and exposed to digestive tract through various sources such as particulate pollutant, nanomedicine and food additive. Inflammatory bowel disease (IBD), as a global disease, induced disruption of the intestinal mucosal barrier and thus altered in vivo distribution of NPs as a possible consequence. However, related information was relatively scarce. Herein, in vivo distribution of typical silica (SiO2) and titania (TiO2) NPs was investigated in healthy and IBD models at cell and animal...
Source: Talanta - May 1, 2024 Category: Chemistry Authors: Mingyue Tan Yunqing Wang Yunxia Ji Rongchao Mei Xizhen Zhao Jie Song Jinmao You Lingxin Chen Xiaoyan Wang Source Type: research
Widespread Adoption of Microincision Vitrectomy Surgery Improves Visual Outcomes in Endogenous Endophthalmitis with Poor Initial Vision: A 21-Year Experience in Taiwan
CONCLUSION: In endogenous endophthalmitis patients presenting with poor initial visual acuity, vitrectomy was a better visual prognostic factor. MIVS has allowed more patients to undergo vitrectomy and improved visual outcomes.PMID:38691837 | DOI:10.1080/09273948.2024.2338272 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: Shih-Chou Chen Tsung-Tien Wu Chun-Hao Yin Jin-Shuen Chen Yao-Shen Chen Source Type: research
HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation
In conclusion, our results suggest that HSD17B13 LLPS triggers liver inflammation by promoting PAF-mediated leukocyte adhesion, and targeting HSD17B13 phase transition could be a promising therapeutic approach for treating hepatic inflammation in chronic liver disease.PMID:38692847 | DOI:10.1093/jmcb/mjae018 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 1, 2024 Category: Molecular Biology Authors: Jing Ye Xiyu Huang Manman Yuan Jinglin Wang Ru Jia Tianyi Wang Yang Tan Shun Zhu Qiang Xu Xingxin Wu Source Type: research
Prospective study of hepatitis B and D epidemiology and risk factors in Romania: A 10-year update
CONCLUSION: This study shows that HDV infection among those with HBV remains endemic in Romania and updates our understanding of HDV epidemiology and associated risk factors. It emphasizes the need for systematic screening for HDV infection and collaborative initiatives for controlling and preventing HBV and HDV infection.PMID:38689751 | PMC:PMC11056896 | DOI:10.4254/wjh.v16.i4.640 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Speranta Iacob Liana Gheorghe Mirela Onica Laura Huiban Corina Silvia Pop Ciprian Brisc Roxana Sirli Carmen Ester Cristina Mihaela Brisc Sorina Diaconu Ion Rogoveanu Larisa Sandulescu Deiana Vuletici Anca Trifan Source Type: research
Development and validation of a nomogram for predicting in-hospital mortality of intensive care unit patients with liver cirrhosis
CONCLUSION: The nomogram has high accuracy in predicting in-hospital mortality. Improving the included predictors may help improve the prognosis of patients.PMID:38689750 | PMC:PMC11056901 | DOI:10.4254/wjh.v16.i4.625 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Xiao-Wei Tang Wen-Sen Ren Shu Huang Kang Zou Huan Xu Xiao-Min Shi Wei Zhang Lei Shi Mu-Han L ΓΌ Source Type: research
Spectrum of COVID-19 induced liver injury: A review report
World J Hepatol. 2024 Apr 27;16(4):517-536. doi: 10.4254/wjh.v16.i4.517.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has caused changes in the global health system, causing significant setbacks in healthcare systems worldwide. This pandemic has also shown resilience, flexibility, and creativity in reacting to the tragedy. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection targets most of the respiratory tract, resulting in a severe sickness called acute respiratory distress syndrome that may be fatal in some individuals. Although the lung is the primary organ targeted by COVID-19 viruses...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Lokjan Singh Anil Kumar Maya Rai Bibek Basnet Nishant Rai Pukar Khanal Kok-Song Lai Wan-Hee Cheng Ahmed Morad Asaad Shamshul Ansari Source Type: research
Relative carcinogenicity of tacrolimus < em > vs < /em > mycophenolate after solid organ transplantation and its implications for liver transplant care
CONCLUSION: The contrasting carcinogenic risk profiles of tacrolimus and MPA demonstrated in previous experimental studies, and its application in solid organ transplantation, is yet to be confirmed in clinical studies. Thus, the optimal choice of immunosuppression drug to use as maintenance monotherapy in LT recipients is not supported by a strong evidence base and remains unclear.PMID:38689747 | PMC:PMC11056899 | DOI:10.4254/wjh.v16.i4.650 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Dorothy Liu Mark M Youssef Josephine A Grace Marie Sinclair Source Type: research
Quantitative hepatitis B core antibody and quantitative hepatitis B surface antigen: Novel viral biomarkers for chronic hepatitis B management
World J Hepatol. 2024 Apr 27;16(4):550-565. doi: 10.4254/wjh.v16.i4.550.ABSTRACTThe management of hepatitis B virus (HBV) infection now involves regular and appropriate monitoring of viral activity, disease progression, and treatment response. Traditional HBV infection biomarkers are limited in their ability to predict clinical outcomes or therapeutic effectiveness. Quantitation of HBV core antibodies (qAnti-HBc) is a novel non-invasive biomarker that may help with a variety of diagnostic issues. It was shown to correlate strongly with infection stages, hepatic inflammation and fibrosis, chronic infection exacerbations, an...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Wattana Leowattana Pathomthep Leowattana Tawithep Leowattana Source Type: research
Molecular mechanism of nanomaterials induced liver injury: A review
World J Hepatol. 2024 Apr 27;16(4):566-600. doi: 10.4254/wjh.v16.i4.566.ABSTRACTThe unique physicochemical properties inherent to nanoscale materials have unveiled numerous potential applications, spanning beyond the pharmaceutical and medical sectors into various consumer industries like food and cosmetics. Consequently, humans encounter nanomaterials through diverse exposure routes, giving rise to potential health considerations. Noteworthy among these materials are silica and specific metallic nanoparticles, extensively utilized in consumer products, which have garnered substantial attention due to their propensity to a...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Sanjib Kumar Das Koushik Sen Biswatosh Ghosh Nabanita Ghosh Krishnendu Sinha Parames C Sil Source Type: research
Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine
World J Hepatol. 2024 Apr 27;16(4):494-505. doi: 10.4254/wjh.v16.i4.494.ABSTRACTThe endoplasmic reticulum (ER) is connected to mitochondria through mitochondria-associated ER membranes (MAMs). MAMs provide a framework for crosstalk between the ER and mitochondria, playing a crucial role in regulating cellular calcium balance, lipid metabolism, and cell death. Dysregulation of MAMs is involved in the development of chronic liver disease (CLD). In CLD, changes in MAMs structure and function occur due to factors such as cellular stress, inflammation, and oxidative stress, leading to abnormal interactions between mitochondria ...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Yang Zheng Yi-Hui Zheng Jia-Hui Wang Tie-Jian Zhao Lei Wang Tian-Jian Liang Source Type: research
Erdafitinib and checkpoint inhibitors for first-line and second-line immunotherapy of hepatic, gastrointestinal, and urinary bladder carcinomas: Recent concept
World J Hepatol. 2024 Apr 27;16(4):490-493. doi: 10.4254/wjh.v16.i4.490.ABSTRACTCancer immunotherapy is administered for first-line, second-line, neoadjuvant, or adjuvant treatment of advanced, metastatic, and recurrent cancer in the liver, gastrointestinal tract, and genitourinary tract, and other solid tumors. Erdafitinib is a fibroblast growth factor receptor (FGFR) inhibitor, and it is an adenosine triphosphate competitive inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4. Immune checkpoint inhibitors are monoclonal antibodies that block programmed cell death protein 1 (PD-1) and its ligand that exert intrinsic antitumor mec...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Mohamed Wishahi Source Type: research
Metabolic dysfunction-associated steatotic liver disease: A silent pandemic
World J Hepatol. 2024 Apr 27;16(4):511-516. doi: 10.4254/wjh.v16.i4.511.ABSTRACTThe worldwide epidemiology of non-alcoholic fatty liver disease (NAFLD) is showing an upward trend, parallel to the rising trend of metabolic syndrome, owing to lifestyle changes. The pathogenesis of NAFLD has not been fully understood yet. Therefore, NAFLD has emerged as a public health concern in the field of hepatology and metabolisms worldwide. Recent changes in the nomenclature from NAFLD to metabolic dysfunction-associated steatotic liver disease have brought a positive outlook changes in the understanding of the disease process and docto...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Arghya Samanta Moinak Sen Sarma Source Type: research
< em > Klebsiella pneumoniae < /em > infections after liver transplantation: Drug resistance and distribution of pathogens, risk factors, and influence on outcomes
CONCLUSION: KPIs occur frequently and rapidly after LT. Risk factors include female sex, pre-LT diabetes, increased post-LT ALT levels, and urethral catheter duration. CRKP infections, and not KPIs, affect mortality.PMID:38689752 | PMC:PMC11056902 | DOI:10.4254/wjh.v16.i4.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Long Guo Peng Peng Wei-Ting Peng Jie Zhao Qi-Quan Wan Source Type: research
Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy
CONCLUSION: Compared with the NP group, significant alterations were observed in the SCFAs of maternal serum and cord blood in the ICP group, although they displayed distinct patterns of change. Furthermore, the SCFA levels in maternal serum and cord blood were significantly positively correlated. Notably, certain maternal serum SCFAs, specifically caproic and acetic acids, demonstrated excellent diagnostic efficiency for ICP.PMID:38689740 | PMC:PMC11056904 | DOI:10.4254/wjh.v16.i4.601 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Shuai-Jun Ren Jia-Ting Feng Ting Xiang Cai-Lian Liao Yu-Ping Zhou Rong-Rong Xuan Source Type: research
Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases
Biol Pharm Bull. 2024;47(5):886-894. doi: 10.1248/bpb.b23-00837.ABSTRACTThe number of patients with lifestyle-related diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), has continued to increase worldwide. Therefore, development of innovative therapeutic methods targeting lifestyle-related diseases is required. Gene therapy has attracted considerable attention as an advanced medical treatment. Safe and high-performance vectors are essential for the practical application of gene therapy. Replicati...
Source: Biological and Pharmaceutical Bulletin - May 1, 2024 Category: Drugs & Pharmacology Authors: Kahori Shimizu Source Type: research
