Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation
PeerJ. 2024 Apr 29;12:e17267. doi: 10.7717/peerj.17267. eCollection 2024.ABSTRACTExercise has many beneficial effects that provide health and metabolic benefits. Signaling molecules are released from organs and tissues in response to exercise stimuli and are widely termed exerkines, which exert influence on a multitude of intricate multi-tissue processes, such as muscle, adipose tissue, pancreas, liver, cardiovascular tissue, kidney, and bone. For the metabolic effect, exerkines regulate the metabolic homeostasis of organisms by increasing glucose uptake and improving fat synthesis. For the anti-inflammatory effect, exerki...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Nihong Zhou Lijing Gong Enming Zhang Xintang Wang Source Type: research
Palm oil as part of a high-fat diet: advances and challenges, or possible risks of pathology?
Nutr Rev. 2024 May 2:nuae038. doi: 10.1093/nutrit/nuae038. Online ahead of print.ABSTRACTNutritional status disorders have the most significant impact on the development of cardiovascular and oncologic diseases; therefore, the interest in the study of palm oil as among the leading components of nutrition has been increasing. The data examined in this review were sourced from the Scopus, SCIE (Web of Science), PubMed and PubMed Central, MEDLINE, CAPlus/SciFinder, and Embase databases; experts in the field; bibliographies; and abstracts from review analyses from the past 15 years. This review summarizes recent research data ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Natalia Kurhaluk Source Type: research
Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth
ACS Appl Mater Interfaces. 2024 May 3. doi: 10.1021/acsami.4c00999. Online ahead of print.ABSTRACTAtherosclerosis is the main risk factor for cardiovascular disease, which accounts for the majority of mortality worldwide. A significantly increased plasma level of low-density lipoprotein cholesterol (LDL-C), surrounded by a monolayer of phospholipids, free cholesterol, and one apolipoprotein B-100 (ApoB-100) in the blood, plays the most significant role in driving the development of atherosclerosis. Commercially available cholesterol-lowering drugs are not sufficient for preventing recurrent cardiovascular events. Developin...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Zhenzhou Li Yi Zhou Manlin Lai Jingna Luo Fei Yan Source Type: research
Metabolic dysfunction-associated steatotic liver disease and atherosclerosis
Curr Diab Rep. 2024 May 3. doi: 10.1007/s11892-024-01542-6. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To update information about the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis. This review emphasizes the potential mechanisms linking MASLD with atherosclerosis and the possible causal relationships between these conditions.RECENT FINDINGS: An increased risk of cardiovascular disease is related to MASLD. Several molecular, cellular, and metabolic mechanisms have been described to explain the development of atherothrombosis in MASLD patients. These include ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Yulino Castillo-N úñez Paloma Almeda-Valdes Guillermo Gonz ález-Gálvez Mar ía Del Rosario Arechavaleta-Granell Source Type: research
Peritoneal dialysis in an end-stage renal disease patient with massive ascites and primary liver cancer
We present a case of a 68-year-old male patient with ESRD who experienced various decompensated complications of liver cirrhosis, particularly massive ascites and hepatic space-occupying lesions. Peritoneal dialysis (PD) catheter insertion and continuous ambulatory peritoneal dialysis (CAPD) treatment were successfully performed. During meticulous follow-up, the patient survived for one year but ultimately succumbed to complications related to liver cancer. PD can serve as an efficacious therapeutic approach for such late-stage patients afflicted together with severe cirrhosis, massive ascites and primary liver cancer.PMID...
Source: Renal Failure - May 3, 2024 Category: Urology & Nephrology Authors: Lulu Sun Chunmei Liang Yuqin Wang Hui Li Lijun Yao Huajun Jiang Source Type: research
Impact of sarcopenia on variceal rebleeding in patients after endoscopic therapy: a multicenter retrospective cohort study based on propensity score matching
CONCLUSION: Sarcopenia was significantly associated with a high 2-year rebleeding rate in liver cirrhosis patients after endoscopic treatment. Therefore, the precise evaluation of a patient's nutritional status, including sarcopenia becomes mandatory before endoscopic treatment.PMID:38699840 | DOI:10.1080/07853890.2024.2349180 (Source: Annals of Medicine)
Source: Annals of Medicine - May 3, 2024 Category: Internal Medicine Authors: Yongshuai Liu Huijun Chang Yunqing Zeng Yuanyuan Liu Jinhou Li Yong Chen Yanjing Gao Source Type: research
Comparison of Whole Blood and Plasma for Monitoring Cytomegalovirus and Epstein-Barr Virus
New Microbiol. 2024 May;47(1):52-59.ABSTRACTMonitoring Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection after transplantation is recommended to enable preemptive therapy. However, the most suitable sample type remains unclear. Patients who underwent hematopoietic stem cell or liver transplantation were included in this study. Viral loads in sequential whole-blood and plasma samples were retrospectively analyzed. EBV DNA was detected more frequently in whole blood (55%) than in plasma (18%). The detection rate of CMV DNA was similar between the two sample types. The correlation of viral loads between the two sam...
Source: New Microbiologica - May 3, 2024 Category: Microbiology Authors: Yuto Fukuda Yuka Torii Ken-Ichi Iwata Kazunori Haruta Makoto Yamaguchi Takako Suzuki Atsushi Narita Hideki Muramatsu Yasuhiro Ogura Yoshiyuki Takahashi Yoshinori Ito Jun-Ichi Kawada Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - May 3, 2024 Category: Stem Cells Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
Umbilical Cord Blood and UC-MSCs Combined with Low-Dose Immunosuppressant in the Treatment of Elderly Patients with Pure Red Cell Aplastic: A Case Series
CONCLUSION: This report provides an effective regimen of using UCB and UC-MSCs combined with low-dose CsA (1-3 mg/kg/d) to treat PRCA, especially for elderly patients with multiple complications who cannot use the conventional dosage.PMID:38698745 | DOI:10.2174/011574888X290378240424075002 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Wei-Wei Zhu Sujing Zhuang Zhe Yu Xin Li Tian-Jie Han Yue Ma Li-Jun Li Zhi-Rui Zhao Source Type: research
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD
CONCLUSIONS: The grade of obesity affects the detection of MASLD-related AF. A sequential use of LSM/A3+ could improve AF detection in patients with BMI ≥ 35.PMID:38699960 | DOI:10.1002/oby.24033 (Source: Obesity)
Source: Obesity - May 3, 2024 Category: Eating Disorders & Weight Management Authors: Yasmina Chouik Adrien Aubin Marianne Maynard-Muet B érénice Segrestin Laurent Milot Val érie Hervieu Fabien Zoulim Emmanuel Disse Massimo Levrero Cyrielle Caussy Source Type: research
Metabolism of 11 ′‐α‐ and 11′‐γ‐Tocomonoenols in HepG2 Cells Favors the γ‐Congener and Results Predominantly in Carboxymethylbutyl‐Hydroxychromans
ConclusionThis is the first evidence that both αT1 and γT1 follow the same sidechain degradation pathway and exert similar rates of metabolism than tocopherols. Therefore, investigation into the biological activities of tocomonoenols is warranted. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - May 3, 2024 Category: Food Science Authors: Alexander Montoya ‐Arroyo,
Viola Brand,
Alexander Kröpfl,
Walter Vetter,
Jan Frank Tags: Research Article Source Type: research
Construction and validation of “WCH‐nomogram” for predicting the prognosis after resection of colorectal liver metastases
ConclusionsThe WCH-nomogram demonstrates superior prognostic stratification compared to prior scoring systems, effectively identifying CRLM patients who may benefit the most from neoadjuvant chemotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - May 3, 2024 Category: Cancer & Oncology Authors: Chuang Jiang,
Weixing Liu,
Zechuan Jin,
Ling Lan,
Lin Xu,
Ao Du,
Song Peng,
Yong Zeng,
Haichuan Wang,
Mingheng Liao,
Jin Zhou Tags: RESEARCH ARTICLE Source Type: research
GSE186769 Transcriptome profile of Stage 40 Oryzias latipes (Medaka) embryos II
Contributors : R De Cegli ; F ZappaSeries Type : Expression profiling by high throughput sequencingOrganism :In order to identify the effects of the absence of SEDL on Medaka transcriptome, we performed RNAseq experiments Transcriptome analysis of the liver of mice trated with CD95 activating antibody, compared with liver of mice trated with saline. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
GSE264546 RNA-seq analyses of periodontal tissue and liver of periodontitis-affected mice
ConclusionThese results suggest that, in the liver of periodontitis-affected mice, due to the reduced activity of omega-3 fatty acid epoxidation, pre-symptomatic state with pro-inflammatory status develop. Therefore, early intervention of periodontitis might contribute to the prevention of the onset of hepatic diseases. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Does depressurization of the portal vein before liver transplantation affect the recurrence of HCC? A nested case-control study
Portal hypertension (PHT) has been proven to be closely related to the development of hepatocellular carcinoma (HCC). Whether PHT before liver transplantation (LT) will affect the recurrence of HCC is not clear. (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Guo Wei, Yong Zhao, Shifeng Feng, Jingsheng Yuan, Gang Xu, Tao Lv, Jian Yang, Lingxiang Kong and Jiayin Yang Tags: Research Source Type: research
